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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Assessment of Fungal Filtrates Efficiency against Escherichia coli in Comparison with Common Artificial Antibiotics Nihad Habeeb Mutlag
Journal of Global Pharma Technology .
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Abstract

The study aim to isolate ,  identify and characterize the Escherichia coli and look for their antibiotics resistance in children with diarrhea in najaf , the study includes 60 samples of stools gathered from patients children visiting Educational AL_Zahraa hospital for the period  beginning of November 2016 to mid-January of the same year,  the age of these children were less than ten years , specimens were phenotypic assays , microscopically examined and diagnosed by biochemical tests , the highest bacterial pathogens isolated  were Escherichia coli. The sensitivity of isolates of E.coli were examined for 11 types of antibiotics, E. coli exhibite different pattern of resistance to different antibiotics ,it is have highest resistance to penicillin (ampicillin and carbenicillin), and it is have higher resistance for ceftazidime and cefepime , while have  moderate resistance for aztreonam.it is have lowest resistant rate to imipenem ,meropenem and ertapenem.Also the same  isolates of E.coli  were examined by the Pleurotus ostreatus fungi filterates which appeare a significant values in the inhibition of growth of  E.coli in petri dish which reach  8 cm in compare with antibiotics that  used  in the study .
Relationship between BMI with the Anthropometric Measurements and the Eating Habits of the Preclinical Medical Students of Universiti Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), Malaysia ATM Emdadul Haque
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Background: In recent decades’ changes in Malaysians’ dietary habits and sedentary lifestyles due to the rapid acceleration of urbanization and industrialization leads to an increase in the prevalence of chronic diseases. BMI is used to calculate weight ranges from underweight to obese while an anthropometric measurement is a measurement for purposes of assessing growth and body fat distribution. Methods: This cross-sectional study was aimed at correlating BMI with the Anthropometric Measurements (AM) and the eating habit to see the trend of obesity and overweight. The study was done on the pre-clinical first and second-year medical students of UniKL RCMP. The study adopted a simple random sampling method on 172 students. A questionnaire was used, and BMI and AM were taken. Results: Students’ BMI revealed 18% underweight, 58.1% normal, 16.9% overweight and 7% obese. Although 38% students thought their eating habit was healthy, only 60% of students included all classes of the food pyramid in their daily meals and 95% did not even count their food calories.  Moreover, 56% of students tend to eat more than usual when they became depressed. AM showed positive correlations between height and upper-arm-length; upper-arm-length and arm-circumference; arm-circumference and triceps-skinfold; triceps-skinfold and waist-circumference; triceps-skinfold and hip-circumference; and BMI and triceps skinfold.  Conclusions: As various findings on eating habits had been discovered both supporting and contradictory, a more comprehensive study, if possible on all medical students would be helpful in finding out the actual prevalence of overweight and obesity among adolescents and providing more informative health education.Keywords: BMI, AM, Eating Habits, Medical Students, UniKL RCMP, Malaysia.
Using Rapid and ELISA Test for Detection Hepatitis C Virus and Human Immunodeficiency Virus among Healthy and Renal Failure Population Huda J.B. Al-Khilkhali
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Human immunodeficiency virus (HIV)-infected, hepatitis c virus (hcv)-uninfected sufferers are at risk for incident hcv infection, however little is understood approximately screening practices for incident hcv among HIVinfected individuals in HIV primary care clinics. The current study aimed at detecting the prevalence of HCV and human immunodeficiency virus (HIV) infection among haemodialysis patients that suffering from chronic kidney disease and healthy people using the Rapid Immunochromatographic Test (ICT) and enzyme linked immunosorbent assay (ELISA) In In the detection of these viruses .This study was carried out during the period from the November (2017) to January (2018), , a total of (28) patient on HD was collected from Specialized Center for Diseases and Kidney Transplant in AL-Sadder Medical City in AL- Najaf Governorate, and(30) samples Represented healthy people collected from the University of Kufa Faculty of Science.All samples ranged in age (20- 45) years. There were 35 male and 23 female. Viral detection revealed that there were 11(19%) was positive and 47(81%) was negative in Rapid (ICT). We further tested samples with ELISA for confirmed results Similarly 58 samples were tested for HCV out of which 16(28%) were ELISA positive and 42(72%) were negative for anti- HCV antibody but the age group(20- 28)year revealed high significant(p<0.05) in the ratio of infection with hepatitis C virus 71% (5:7)  than other age groups. the results of this study showed  high sensitivity and specificity for rapid (ICT) in present study represent good result for depend rapid test for detection of hcv antibodies and  first-line tests in screening and prognosis of hcv infection..in all groups of patient's seropositive anti-HCV antibodies and seronegative anti-HCV tested for anti-HIV Ab typ1 and typ2 by Rapid (ICT) were negative (0.00%) in all age groups in both sexes. The current study showed that males are more affected with HCV (56%) than females (44%) and the prevalence of hcv contamination amongst kidney failure patients in this study was 57%. Results of the current study showed that the healthy groups were negative anti-HCV Ab by both methods.Keywords: Hepatitis C virus, Chronic kidney disease, Hemodialysis patients, ELISA, Rapid (ICT).
Formulation Development and Characterisation of Perfluorocarbon Nanobubbles for Sorafenib Delivery Subramanian Selvamuthukumar
Journal of Global Pharma Technology Volume 11 Issue 12 (2019) December 2019
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Abstract

Nanobubbles (NBs) are novel drug delivery systems with combination of ultrasound contrast agents and drug carrier that could potentially act at specific target sites. Sorafenib is an anticancer drug for the treatment of hepatocellular carcinoma. In this study, sorafenib loaded nanobubbles were prepared by the thin film hydration method. Morphology was examined by Scanning electron microscopy and Atomic force microscope. Particle size and Zeta potential were determined by laser- scattering method. Ultrasound imaging was performed on a digital ultrasonic imaging system. The drug content in the sorafenib loaded NBs was determined by using HPLC method.  The in vitro release profile of sorafenib loaded NBs was determined using a Franz diffusion cell method with absence and presence of Ultrasound exposure. The sorafenib NBs expected a spherical shape with a uniform particle size (170 nm), negative zeta potential (-52.47 mV) and polydispersity index (0.289). Ultrasound imaging confirmed the acoustical activity of perfluoropropane nanobubbles. Drug content was found to be 96 %. A slow and prolonged spontaneous drug release was observed in vitro, which was enhanced upon ultrasound stimulation. This result suggests that sorafenib loaded NBs can be considered a novel chemotherapeutic approach for treating liver cancer in combination with an ultrasound contrast agents.Keyword: Nanobubbles, Sorafenib, Perfluorocarbon, Ultrasound, Hepatocellular carcinoma
Analytical Method Development and Validation for Simultaneous Estimation of Nebivolol and Valsartan in Tablet Dosage Form by RP-HPLC K. Veditha
Journal of Global Pharma Technology Volume 10 Issue 10 (2018) October 2018
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Abstract

A rapid, sensitive, simple and precise reverse-phase high-performance liquid chromatographic (RP-HPLC) method for the simultaneous estimation of nebivolol and valsartan in tablet dosage forms has been developed. The compounds were well separated on Waters HPLC 2965 system using Alltima C18 column (150 mmX4.6 mm, dp=5 mm) and PDA detector with mobile phase consisting of buffer containing 3.3pH Potassium di hydrogen phosphate: acetonitrile: methanol in the ratio 45:35:20 at a flow rate of 1.0 mL/min with injection volume at 20ml and wavelength monitered at 280 nm, The Rt for Nebivolol & Valsartan were found to be 2.463& 4.017mins, respectively. Validation of the proposed method was carried out according to International Conference on Harmonisation (ICH) guidelines. Linearity range was obtained for NB and VT over the concentration range of 2.5-15 and 40-240mg/mL and the r2 values were 0.999 for both drugs. The calculated %RSD and recoveries of the Nebivolol and Valsartan were 0.62, 0.63 and 100.54%, 101.02% correspondingly. The calculated LOD and LOQ values were 0.09ppm, 0.31ppm and 0.28ppm, 0.95ppm correspondingly. Thus the present study showed that the developed RP-HPLC method is sensitive and selective for estimation of Nebivolol and Valsartan in combined dosage form.Keywords: Nebivolol, Valsartan, RP-HPLC, ICH guidelines.
Determination of the Excretion of TSH, T3, T4 Hormones in Blood According to the Pulse Index (160) for Female Tennis Players of Kufa University Nazar Hussein al-Naffakh
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The research included a number of axes focused on these axes on the analysis of the hormones involved in the study and this is by giving a particular effort to raise the pulse to 160 N / d where the pulse is measured after an exercise or effort to raise the pulse of the player and when the completion of exercises The pulse is measured by the player through a device to measure the pulse and when the arrival to the pulse specified blood is drawn to the player and then the analysis of the hormones involved to study at the pulse of the specific measurement and know what changes in these hormones at this pulse and after the analysis in the laboratory allocated and a special device The results are collected Obtained and then deal with these results statistically to extract what extent attributed the changes that have taken place for these hormones for each player. The results showed that there were clear changes in hormone levels at pulse 160 and these changes vary from one player to another.Keywords: Sports Performance, Thyroid hormone analysis (T3, T4), Thyroid stimulating hormone (TSH) and effect of hormones on pulse index (160).
Evaluation of the Level of Health Awareness of the Players of the Iraqi Premier League in Handball Ahmed Kadhim Abdulkareem
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The objective of researchSetting levels of the health awareness measure and its application to the players of the Iraqi Premier League handball applicants.Recognition of the level of health awareness of the players of the Iraqi Premier League handball applicants.Evaluation of the level of health awareness of the players of the Iraqi Premier League handball applicants.The researchers used the descriptive method in the survey method to determine the level of health awareness. The scale was applied in the final form to a sample of the players of the Iraqi Premier League in handball for the 2017-2018 sports season. The researchers then set levels for the health awareness measure and applied it to the players of the Iraqi league Hand, and used the researchers Statistical Bulletin of Social Sciences (SPSS) version XVII. The following conclusions were reached:Five levels of health awareness measure have been developed.The ability of the health awareness scale to be applied by the researchers in measuring health awareness.The majority of the players of the Iraqi Premier League handball a poor level in the health awareness measure.Keywords: Health awareness, Premier League and handball.
Post-Spinal Anesthesia Hypotension during Cesarean Delivery, A Review Ghalib J Al-asadi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Maternal hypotension is a common complication after spinal anesthesia for cesarean delivery. Prevention and treatment of post-spinal hypotension (PSH) in cesarean delivery has been frequently investigated. Fluid loading is superior to no-fluid regimen; however, the incidence of PSH is still high with all fluid loading protocols; thus, the use of fluid loading as a sole method for prophylaxis might be not satisfactory for many anesthetists. Phenylephrine is the preferred vasopressor for prevention and management of PSH in most cases. Ephedrine may be more beneficial in patients with bradycardia, patients with uteroplacental insufficiency and pre-eclamptic patients. Norepinephrine infusion was recently investigated as an alternative for prophylaxis of PSH with minimal cardiac side effects. The high incidence of PSH with most of the pharmacological and non-pharmacological methods suggests the need for multimodal protocols for prevention and management of this problem. PSH in cesarean delivery is a common daily situation facing all anesthetists; thus, future research should focus on simple and rapid protocols that can be easily applied by anesthetists with moderate and low experience with minimal need to complex devices or costly drugs.Keyword: Hypotension, Spinal anesthesia, Cesarean delivery.
Potential Protective Effect of Atriplex halimus Extract toward the Doxorubicin - Induced Apoptotic Gene Expression, Genetic and Hepatic Toxicity in Mice Shenouda M. Girgis
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective: The anthracycline doxorubicin (DOX) is widely used in chemotherapy as an anticancer drug due to its efficacy in fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers. However, it can induce injury to non-targeted organs after cancer treatment. Thus, exploration of effective drug targets or active lead compounds against DOX-induced organ damage is necessary. Method: In this study the protective effect of Atriplex halimus (Ah) extract towards DOX-induced genetic and hepatic toxicity and apoptosis in male mice was investigated. Animals were divided into 7 groups (10 animals each): 1- Control group treated with physiological saline. 2- Animals treated with DMSO. 3- Low dose of Ah (0.5 mg/kg bw) extracts. 4-high dose of Ah (5mg/kg bw) extracts. 5- Animals were injected i.p with DOX. 6- DOX + low dose of Ah (0.5 mg/kg bw) extracts for 1 week. 7- DOX + high dose of Ah extracts for 1 month. Results: DOX treatment induced a significant increase in the chromosomal aberrations either in the bone marrow or in the spermatocyte cells, increase the DNA fragmentation, malondialdehyde (MDA) level and the expression of apoptosis-related genes, Bax and caspase 3 genes. However, the treatment with Ah declined these negative effects. Conclusion: The findings demonstrated that Ah extract had protected the mice against the negative effects of DOX-induced genetic, hepatic toxicity and apoptosis and could be used as natural antioxidant product for scavenging the reactive oxygen species and to attenuate DOX-induced genetic and hepatic toxicity. Keywords: Doxorubicin (DOX), Atriplex halimus (Ah), Apoptosis, Gene expression, Genotoxicity, Hepatic, mice.
The Effect of Special Vital Exercises to Force the Opposing Team to Commit Mistakes and Legal Irregularities in Handball Thaerah Abdul Jabbar Saleh
Journal of Global Pharma Technology .
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Abstract

That the multiplicity of skills and plans offensive individual and collective handball players was also accompanied by the development of defensive aspects, which led researchers to use and experimenting methods that are highly influential on the performance of individual defense and collective and offensive, so the importance of research by finding some exercises, The ball directly, but also affect the competitor and push him to commit errors and legal irregularities to benefit from the contribution studied in the increase of penalties and progressive suspension cases . In this case, the problem of research was not to exploit the imposition of individual and individual punishments imposed by the law, but to limit the interest in directing the players not to make these irregularities and mistakes to avoid penalties. Therefore, exercises were put in place for forcing the players of the opposing team to commit violations and legal errors. The effect of some exercises in forcing the opposing team players to commit mistakes and legal irregularities the researchers hypothesized that there were significant differences between the tribal and remote tests of the two groups and for the benefit of the remote tests. There were also significant differences between the tests of the two groups of research and for the experimental group. The researchers used the experimental method. The research community was determined by the players of the Karbala University team for the academic year 2011/2012 and for the Karbala youth handball players for the handball at the age of 18-20 years. A sample of (30) players from this society were selected and divided equally into two control groups. The results came in favor of the experimental group, and the researchers concluded that the special exercises used were of interest to the players in forcing the opposing team to commit legal errors and irregularities. This type of exercise has a great positive impact on the outcome of the game and thus achievement especially for players of age groups. The researchers recommended that trainers adopt this type of exercise in their training and use it for younger age groups, which are likely to have greater results because they are less aware of the law and its applications.Keywords: Vital exercises, force, opposing team, commit mistakes and legal irregularities.

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