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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Smoking on Ratio of K, Na, Ca, P & CL of Baghdad City Smokers Nahlah F. Makki
Journal of Global Pharma Technology Volume 09 Issue 12
Publisher : Journal of Global Pharma Technology

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Abstract

In this present paper  ,the effect of cigarette smoking for several years ranging from 5 to 30 years on the levels of K,NA, CA,P and CL in blood of smokers were  performed   by  C 4000 Auto analyzer .Two hundred of samples  were included  in this study , hundred specimen as a control group (non-smoking ),mean age 37 years  and other hundred as smokers group mean age 38 years  . The results elucidated that the ratio of Ca, P and CL   were not affected by smoking while sodium ions decrease in the serum of smokers compared to non-smokers and found that potassium ions are increasing at normal rates, it was also not found relationship between the period of smoking and the concentration of elements.  Therefore, you must avoid smoking, causing a change in the normal rates of essential elements of the body sodium and potassium and thus change in the work of hormones related to those elements Such as the hormone aldosterone, which leads to the occurrence of various diseases such as kidneys and stomach.Keywords: Cigarette, smoking, sodium, potassium.
Effect of Physical Exertion in Some of Antioxidant concentrations for Young Player's in Handball Ahmed Kadhim Abdulkareem
Journal of Global Pharma Technology .
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Abstract

The study aimed to identify the effect of physical effort in some concentrations of antioxidants for young handball players. The study also revealed that there are statistically significant differences in physical exertion in some antioxidant concentrations of young handball players. It has been shown that the importance of research helps to detect the degrees of emotional arousal and knowledge of its relationship with antioxidants that work to get rid of the free radicals causing fatigue for young basketball players. The researchers used the training curriculum to suit the nature of the problem on the players of Kufa Sports Club youth handball for the season (2017-2018) and the number of (12) players, was adopted method of comprehensive inventory in the selection of the sample were identified two players for the purpose of conducting the pilot, The main sample is (10) players. After the tests of pretest and posttest, data were collected and processed statistically to obtain the results through which reached the most important conclusions, the physical effort at the heart rate 180 beat/second was affected by the antioxidants taken by the researcher and the component of Selenium (Se) and (Vitamin E And C) was the result of good preparation and systematic training of young handball players. The rate of change of vitamin(C) was higher than that of vitamin (E) and the lower selenium was achieved after the physical exertion at 180 beat/second for youth players in handball.Keywords: Physical exertion, Antioxidants and handball.
Effect of Extract Cocor Bebek (Bryopyllum pinnatum) to the Amount of Th17 Cells Spleen and Levels of IL-17A Serum in Mice Balb/C Pregnant Model of Systemic Lupus Erithematosus Umi Kalsum
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

This study aims to determine a way to reduce the number of Th17 cells spleen and serum levels of IL 1A heart in mice Balb /C pregnant models with Systemic Lupus Erythematosus. This was studied, using mice Balb / C pregnant models with SLE. This study is divided into 5 groups: negative control, positive control, and treatment provision Bryophyllum Pinnatum dose of 10.5 mg/day, 21 mg/day and 42 mg/day.  The Th cell number 17 was measured through flow cytometry. Levels of IL 17A were measured using the ELISA method. The data was analyzed using the Kruskal Wallis test. Giving bryophyllum Pinnatum dose 21mg / day (2.79 ± 1.484) has been proven to reduce the number of Th17 cells in mice Balb / C pregnant models with SLE when compared to the other dose treatment. Although, it did not significantly affect (p> 0.05).There was no difference with the increased levels of IL bryophyllum Pinnatum 17A in Balb / C mice pregnant models with SLE (p> 0.05). Conclusion: Giving bryophyllum Pinnatum has been proven to reduce the number of Th 17 cells in mice pregnant models with SLE.Keywords: Systemic Lupus Erythematosus (SLE), Bryopillum Pinnatum, Th17, IL 17A.
Pharmacoeconomic Analysis - The Way to Optimization of Using the Health Budget Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Reforming the drug supply system requires the introduction of modern scientific approaches to quality management of pharmacotherapy, the main principle of which is the individual selection of the drug taking into account its effectiveness and safety. Introduction: To analyze the literature on the need and feasibility of using pharmacoeconomic methods to provide medicines. Materials and methods: The basis for research is the methods of pharmacoeconomics. Results: The analysis of the data of literature sources was carried out and the necessity of using pharmacoeconomic methods in the field of health care was determined. Conclusions: As a result of the review, it was determined that pharmacoeconomic analysis is an effective method that facilitates the adoption of optimal decisions in the field of drug supply. Keywords: Arterial hypertension; Health care, Antihypertensive drugs; Form system.
Assessment Effective Factors on Clinical Application of Nursing Continuing Education from the Viewpoints of Nurses Mohsen Hojat
Journal of Global Pharma Technology .
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Abstract

Introduction Ongoing continuing education program with the present methods and conditions is inadequately helpful and applicable. There are various factors, which influence the efficiency and efficacy of such programs for nurses. The present study aimed to investigate the effective factors in application of continuing education from the viewpoints of nurses. Methods This is a cross- sectional descriptive study. Sampling was census, conducted on nurses in Jahrom, Iran in autumn 2015. Data were collected by Dehghan Nayeri and Khosravi checklist with reliability of α=0.949. Data were analyzed by descriptive statistical tests (frequency distribution and mean), independent t- tests and Spearman correlation coefficient. Results In the present study, 176 subjects were recruited of whom 72.7% were female. Subjects' mean age was 21.64 (14.18) years. From the viewpoints of the nurses, the most effective factors for application of continuing clinical education were "the scientific characteristic of the training nurse" and " enough accountability in applications of the learned materials" while the lowest effective factors were" financial reward of the organization for newly learned materials" and "application of distant learning in the ward". Mean overall score of factors effectiveness was 3.07(0.53). Conclusion The level of various factors effectiveness in use and application of continuing education programs should be considered. The most important goal of administration of continuing education programs is improvement of nurses' knowledge and awareness to promote the quality of the given services.Keywords: Continuing education, Nurse, Clinical application.
Influence of the Combined Oral and Injectable Contraceptives on the Level of Creatinine, Urea, and Some Electrolyte Haider Mahmooed Jasim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

This study was conducted to investigate the effect of combined oral contraceptives and injectable contraceptives on the Urea, Creatinine, Sodium and Potassium level. The study included 40 women used hormonal contraceptives who attending the family center of planning at the feminine and children hospital in Al- Muthanna Governorate. They were divided into two groups (combined oral contraceptives group and injectable contraceptives group) and were compared with control group (20 women do not use of contraceptives). The blood samples were collected to determine of serum Urea, Creatinine, Sodium and Potassium level. The results showed no significant differences in the level of Urea, Sodium and Potassium between the three study groups, while Creatinine showed a significant increase (0.01) in combined oral contraceptives group compared with injectable contraceptives and control groups. In conclusion, combined oral contraceptives and injectable contraceptives did not affect the level of Urea, Sodium and Potassium, except Creatinine, showed significant increase in women who used Compound oral contraceptives group.Keywords: Combined oral contraceptives, Injectable contraceptives, Serum electrolytes, Urea, Creatinine.
Combination of Pandan (Pandanus Amaryllifolius) Extract and Dragon Fruit (Hylecereus Polyhizus) Pulp for Jam Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Leaves of Pandanus amaryllifolius are used as natural colourant due to presence of high chlorophyll content. Not only dragon fruits or pitayas (Hylocereus sp.) are believed to be rich in antioxidants but also they have high economic potential in domestic and foreign market. In order divesify different products from these sources, a research was conducted to combine pandan extract and pitaya pulp for jam production. The search focused on the effect of modified starch concentration, ratio of pandan extract: pitaya pulp, sugar supplementation, temperature and time during condensation to the shear stress and appearance of jam. Results showed that 1.5% modified starch, 3% of pandan extract: pitaya pulp, 10% sugar supplementation, 95oC and 10 minutes during condensation will give the best quality of jam.Keywords: Pandan, Dragon fruit, Modified starch, Sugar, Condensation, Jam.
Isolation and Characterization of Probiotics from Various Food Samples P. V. Kamala Kumari
Journal of Global Pharma Technology Volume 11 Issue 05 (2019) May 2019
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Abstract

Probiotics are living organisms that are used as food additives with beneficial effects on the healthy body by setting microbial balance in gastrointestinal tract. Lactic acid bacteria (LAB) as protective cultures are common probiotic organisms that are considered safe due to having specific characteristics. Main genera of LAB are Leuconostoc, Enterococcus, Lactobacillus, Lactococcus, Bifidobacterium, Pediococcus, and Streptococcus. These bacteria cause reduction of gastrointestinal diseases by increasing benefit microorganisms growth and reducing pathogens population mechanisms.Several therapeutic applications for probiotics can be cited protection against traveller's diarrhea, prevention of urogenital diseases, reduction of hypercholesterolemia, alleviation of constipation, prevention of food allergy and osteoporosis and protection against bladder and cancer.  In addition to, probiotics can be prevention or treatment of some disorders, such as lactose malabsorption, irritable bowel syndrome, acute diarrhea, mild forms of inflammatory bowel disease and necrotizing enterocolitis.The present study aims in isolation of probiotics from various daily household food samples available easily in Indian market.
Lactoferrin as a Marker of Chronic Telogen Effluvium in Premenopausal Women Alaa F Hasseeb
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Aim: Evaluation of serum Lactoferrin, Hb and ferritin levels in females with chronic telogen effluvium (CTE) or acute telogen effluvium (ATE), in order to validate their role in these common hair loss diseases. Methods: Fifty three females (aged range 18 - 45 years) with hair loss, in the form of TE (ATE=27 as G2, group aged range18-35), (CTE=26 as G3 group aged range 18-45), and 26 age-matched females with no hair loss (as G1 group), were included in the study. Diagnosis was based upon clinical examination as well as dermoscopy. Serum Lactoferrin and ferritin levels were determined for each participant. Results: Serum lactoferrin levels showed highly significant differences (p= 0.00) in the comparison of chronic TE (G3) and Acute TE (G2) (7.68±2.13 ng/ml vs.  4.65±2.18 ng/ml), Also between (G1) and (G3) (5.21±1.03 ng/ml vs. 7.68±2.13 ng/ml), but there is no significant difference between (G1) and (G2) (5.21±1.03 ng/ml vs.4.65±2.18 ng/ml).Plasma ferritin level showed highly significant decrease (p=0.001) in comparison  (G1) group and (G2) group(50.72±11.17 µg/dl vs. 36.49 ±15.04µg/dl ) respectively ,Also showed highly significant decrease (p=0.00) between (G1) group and (G3)( 50.72±11.17 µg/dl vs.31.98± 15.98 µg/dl) but there is no significant difference(P=0.47)  between (G2) and (G3) (36.49 ±15.04 µg/dl vs. 31.98± 15.98 µg/dl).Hemoglobin level showed highly significant decrease (p=0.028) in (G1) and (G2) (12.89±0.70 mg/dl vs. 12.15±1.19 mg/dl) respectively, Also showed highly significant decrease (p=0.00) between (G1) and (G3) (12.89±0.70 mg/dl vs. 11.60±1.09 mg/dl ), but there is no significant difference(P=0.12) between (G2) and (G3) (12.15±1.19 mg/dl vs. 11.60±1.09 mg/dl). Conclusion: High serum Lactoferrin is associated with hair loss in females with CTE, while low levels of ferritin are associated in ATE and CTE. Screening to establish ferritin levels in cases of hair loss and supplementing with them when they are deficient may be beneficial in the treatment of disease.Keywords:  Lactoferrin, Telogen effluvium, Ferritin, Transferrin
Formulation, Development Optimization of Miconazole Tablets for Buccal Drug Delivery System Sunil Reddy
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

Objective the main objective of the present study was to develop sustained release formulation of Miconazole to maintain constant therapeutic levels of the drug for over 10 hrs.  Method various grades of HPMC were employed as polymers. Miconazole   dose was fixed as 100 mg. Total weight of the tablet was considered as 250 mg. Polymers were used in the concentration of 50 mg, 75mg and 100 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits.  Results From the dissolution studies it was evident that the formulation (F2) showed better and desired drug release pattern i.e., 98.56 % in 10 hours. Conclusion From the dissolution data it was evident that the formulations prepared with HPMC K100M as polymer were unable to retard the drug release up to desired time period i.e., 10 hours. Whereas the formulations prepared with HPMC K4M retarded the drug release in the concentration of 75 mg showed required release pattern i.e., retarded the drug release up to 10 hours and showed maximum of 98.56% in 10 hours with good retardation. It followed zero order release kinetics mechanism.Keywords:  Miconazole, HPMC, Buccal Tablets.

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