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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Technical Indicators and Assessment of Energy Expenditure Indifferent Tillage Methods and Planting Wheat Mahmood Kaboli
Journal of Global Pharma Technology Volume 08 Issue 04
Publisher : Journal of Global Pharma Technology

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Abstract

The objective of this work was to study the effects of tillage and planting methods on technical indicators, energy and other properties. In this research, which was carried out in khatam area in 2014-2015, different tillage and planting methods included conventional tillage, conservation tillage by chisel plow, conservation tillage by combined plow and no tillage based on randomized complete block design with three replication? Factors that were used as a measure of comparison, include the average number of plants per square meter, uniform planting depth (vertical distribution uniformity of seeds), a uniform distribution of seeds (uniform distribution of seed surface), the percentage of green seeds, the measurement of time the actual capacity and practical calculation tools, power tools and fuel energy consumption in any way. The results of this research, no tillage with fuel consumption of 15 liters per hectare, the lowest fuel consumption and therefore less fuel energy of 671 MJ, most stored soil moisture 30.4 percent, the lowest since the 33/67 minutes per hectare and thus the maximum capacity of the machine's actual position was higher than the other treatments. Conventional tillage with the highest fuel consumption of 47 liters per hectare fuel consumption rate, the lowest percentage of soil moisture 61/20% and a maximum operating time of 33/295 minutes per hectare respectively.Keywords: Tillage methods, Energy, Wheat, Fuel.
Isolation, Screening, and Identification of Bacillus sp. Produced L- Glutaminase and Optimization of its Production by Submerged Fermentation Hameed Abbood Jebur
Journal of Global Pharma Technology .
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Abstract

In this study L-glutaminase produced by locally Bacillus sp. isolated from different local of Iraqi soil.  Fourteen isolates were selected to produce L-glutaminase by submerged fermentation. The isolate C13     showed a maximum L- glutaminase activity (28.08 U/ml). This isolate was identified according to morphological, cultural, Vitek 2 system and genetic analysis using 16srRNA gene. The microorganism was closely related to Bacillus subtilis according to gene bank database in NCBI, and signed as Bacillus subtilis MH049477.1. The L-glutaminase production pattern was studied under submerged fermentation and increased their yield after optimization of fermentation parameters. The highest L-glutaminase activity (61.12 U/ml) was achieved by using  3 % of galactose as the carbon source and 2% of yeast extract as nitrogen source at pH = 8, after 48 h of incubation at  37o C  by using 2ml of inoculum contains 1x106   cfu /ml of Bacillus subtilis MH049477.1  . Fermentation was achieved in an incubator shaker at 120 rpm.Key words: Identification, Bacillus sp., L- glutaminase, Optimization, Submerged Fermentation
Assessment OF Ki-67 and Bcl-2 Immunohistochemical Markers in Gingival Pyogenic Granuloma: A Comparison with Peripheral Giant Cell Granuloma Ameera Kamal Khleel
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Background and objectives: Pyogenic granuloma (PG) and peripheral giant cell granuloma (PGCG) are common focal reactive hyperplastic lesions affecting the gingiva.  The aim of the present research was to study the clinical and the immunohistochemical expressions of Ki-67 and Bcl-2 for gingival pyogenic granuloma in comparison with peripheral giant cell granuloma. Materials and Methods: Formalin fixed, paraffin-embedded biopsy specimens of (48) gingival pyogenic granuloma and (39) peripheral giant cell granuloma were used in the study.  Clinical and immunohistochemical analysis for Ki-67 and Bcl-2 were studied in pyogenic granuloma and peripheral giant cell granuloma. Results: The female to male ratio of pyogenic granuloma and peripheral giant cell granuloma was (1.18:1 and 1.43:1) respectively. The mean age was (32.47±19.575 and 35.03±18.22) year respectively. The pyogenic granulomas were mostly affecting the maxillary gingiva, while peripheral giant cell granulomas were mostly affecting the mandibular gingiva. Reactivity percentages for Ki-67 and Bcl-2 markers were significantly higher in peripheral giant cell granuloma compared to pyogenic granuloma (21.71±8.596% vs. 12.68±6.117 %, and 38.77±20.396% vs. 3.547±1.59%) respectively. Conclusion: PGCG showed more proliferative and anti apoptotic activity compared with PG.  This can add insight to the clinical behavior and might reflect the differences in pathogenesis of these lesions.Keywords: Pyogenic granuloma, Peripheral giant cell granuloma, Ki-67, Bcl-2.
Efficacy, Safety, Quality Assurance of Isomers of Non-Steroidal Anti-Inflammatory Drugs: Dexketoprofen and Dexibuprofen Elena Litvinova; Mariya Zarichkova; Svitlana Kovalenko; Olga Posylkina; Olena Tkachenko; Anastasiia Lisna
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

The aim of this work is to analyze and systematize data on efficacy, safety, and quality assurance for NSAID isomers – dexketoprofen and dexibuprofen. Studies were conducted using databases on the Internet: PubMed; Food and Drug Administration, European Medicines Agency. It has used retrospective, logical, systematic and analytical methods. The results of a multifaceted analysis of sources of data of clinical use proved the high analgesic efficacy of dexketoprofen and dexibuprofen in acute and chronic pain of various etiologies, such as toothache, dysmenorrhea, pain after surgery, muscle pain, headache, back pain, pain from bone metastases, etc. To achieve the effect obtained with the use of 1 dose of racemic NSAIDs, half the dose of their active isomers is sufficient. The high clinical effectiveness of dexketoprofen, dexibuprofen combines with their relative tolerance, in particular from the gastrointestinal tract. In large part, the safety of dexketoprofen is due to the presence of only the active S (+) - enantiomer of ketoprofen, dexibuprofen is due to the presence of only active S (+) - ibuprofen, which eliminates the side effects associated with the influence of the R (-) - enantiomers. The results of the analysis of quality assurance of generic dexketoprofen (class 1 of biopharmaceutical classification system) and dexibuprofen (class 2 of biopharmaceutical classification system) during the biowaiver procedure are systematized. It has been shown that not only high permeability and high solubility, but also the composition of the drug excipients are important for pharmaceutical equivalence in vitro. Based on the results research findings presented, it is possible to optimize the technological process and analytical methods, which allows taking into account critical factors and ensuring the quality of the medicine and its bioequivalence to the reference drug.
Prevalence and Risk Factors of Senile Cataract in Balinese Population Age 50 Years Old or Older Anak Agung Mas Putrawati Triningrat; Putu Adhi Surya Pradana; Ariesanti Tri Handayani; Gde Ngurah Indraguna Pinatih; Made Agus Kusumadjaja; Wayan Gede Jayanegara
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Objective: Cataract is the leading cause of blindness in the world with increasing trend both in prevalence and incidence. Surgery is the only definitive treatment for cataract but often unaffordable for society in developing countries. The incidence of cataract could be prevented by understanding its risk factors and formulate health programs according to them. The purpose of this study was to assess the prevalence and risk factors of senile cataract among 50 years old or older Balinese population. Method: The population-based cross-sectional study was conducted from September 2015 until July 2016 in Bali province. The variable’s data were obtained through direct examination and interview. Poisson regression analysis was used to assess the definitive correlation between risk factors and cataract. A p-value <0.05 or value which falls within 95% confidence interval were considered significant. Result: 550 subjects were enrolled during the study. The number of cataracts found in this study was 231 (42%). According to the analyses, cataract was significantly associated with older age (PR: 3.05; p=0.001), low educational level (PR: 2.18; p=0.04), diabetes (PR: 2.96; p=0.001), and the rate of ultraviolet exposure (PR: 1.92; p=0,002). Conclusion: The prevalence of cataract among 50 years old or older in Balinese population was 42%. Older age, low education, diabetes mellitus, and ultraviolet exposure were found to be significant and independent risk factors for cataract in 50 years old or older Balinese population.Keywords: Cataract, Prevalence, Risk factor.
Review of Pharmacokinetics of Levothyroxine, with Specific Focus on Patient with Thyroid Carcinoma Vasudev Shenoy
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Total or near to Total thyroidectomy with Radio Iodine treatment is current therapy for Thyroid cancer. Post thyroidectomy the patients are on Levothyroxine as a supplement therapy to maintain the Thyroid hormone levels. Levothyroxine has been considered as a narrow therapeutic index drug. In Thyroid cancer patients, radio-iodine ablation procedure causes hypothyroid state which will be further elongated by the administration of sub optimal doses and hyperthyroid symptoms with higher doses. This article would evaluate the pharmacokinetics of levothyroxine and in specific focus in patients with papillary carcinoma followed with thyroidectomy with Radio iodine treatment.Materials and Methods: The references are review from published literature and web based information.Results: Levothyroxine is considered as a narrow therapeutic index drug and hence individualization of the dose in a particular patient is important for optimal therapeutic effect.Conclusion: Review of pharmacokinetics of levothyroxine in various disease condition, coexisting disease and concomitant medication suggested for optimization of the dose of levothyroxine for avoiding the toxic adverse effects due to hypothyroid or hyperthyroid conditions.
Spectrophotometric Determination of Atenolol via Oxidative Coupling Reaction with 2, 4 - Dinitrophenyl Hydrazine Raed M. Hussein
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

 An correct and sensitive spectrophotometric methodology has been developed for the determination of beta-adrenergic blocker (ATN) in pure and dose forms. the strategy is predicated on the oxidization of 2,4-dinitrophenylhydrazine (2,4-DNPHz) by metallic element per iodate than coupling with beta-adrenergic blocker (ATN) in a calescent  medium  to create actable, Yellow colored  , soluble dye with a most absorption at 403 nm. The variables that have an effect on the completion of reaction are fastidiously optimized. Beer’s law is obeyed over the concentration vary of (2-30 μg.mL-1) with molar absorption factor of (3.515×104 L.mol-1.cm1).The limit of detection was (0.07575μg.mL-1) and Sandal's sensitivity price was 0.0350 μg.cm-1. The projected methodology has been applied with success to the determination of antihistamine in pharmaceutical preparation.
Probiotic potential of Lactobacillus plantarum with the cell adhesion properties Abhinandan Patil
Journal of Global Pharma Technology Volume 10 Issue 12 (2018) December 2018
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Abstract

The use of microbes as functional food maintain health and prevent many disease and disorder. The isolation and research of new strains of probiotic strains especially lactobacilli proven to be useful to satisfy the increasing demand of the population. In the current study, the probiotic potential of Lactobacillus strains isolated from sheep milk was investigated. The Lactobacillus strains were identified and evaluated for tolerance against gastric acidity and bile toxicity, along with the adhesion to HT-29 cells. The study proved the antimicrobial activities and antibiotic susceptibility. Survival of the strains through the host intestine was examined by the 12 week Wister rat feeding and faecal analysis trial. The in-vivo trials not only proved the adhesion but also the survival of the Lactobacillus plantarum MCC 3595 inside the intestinal lumen of the host. Thus, the isolated strain can act as the functional food by the further clinical investigation. 
Using Mathematical Models within the Cosmetological Aid Organization in the Context of Botulinum Toxin Therapy of Upper Face Skin Age-Related Changes Olga Nikolaevna Krasilnikova
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Mathematical modeling is the language of modern science. This paper describes the application of the mathematical evaluation of the clinical efficiency of botulinum toxin therapy of age-related changes in the skin of the upper half of the face on the example of correcting the three zones of the patient. For this purpose, we used the scoring scale; schedules that help the doctor get new information about the effectiveness and quality of the procedure throughout the observation period, and master practical skills of quality examination. Such an approach in cosmetology will make it closer to evidence-based medicine, contributing to the objectification and systematization of the accumulated data.Keywords: Cosmetological care, Botulinum toxin therapy, Evaluation of the efficiency of injection correction of age-related facial skin changes, Quality of medical care, Integral quality factor.
Antidepressant Effects of Cleistocalyx nervosum Extract Consumption in a Rat Model of Post Stroke Depression Wathita Phachonpai
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The aim of this study was designed to evaluate whether Cleistocalyx nervosum (C. nervosum) extract improved depression-like behaviors induced by middle cerebral artery occlusion (MCAO) in post-stroke-depression (PSD) rats. Right MCAO procedure was performed on day 1 in male Wistar rats. C. nervosum was thereafter administered (250, 500 and 750 mg/kg), daily for 28 days. Neurological functions after ischemia were determined by the forelimb grip force and the hot plate tests. Tail suspension (TST) and forced swimming (FST) tests were used to assess depression-like symptoms. Plasma corticosterone (CORT) level, and brain oxidative status, and scavenging enzymes were also investigated. Our results showed that three doses of C. nervosum treatment were able to diminish neurological impairments and exert antidepressant effects in PSD rats. This was accompanied by the decrease in stress hormone level and brain oxidation indices, and increase in antioxidant enzymes activities. It suggested that C. nervosum could improve the depression-like emotional status and promote recovery of motor and sensory functions in PSD, and can be applied as a complementary agent for treatment of PSD.

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