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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Intratumoral Co-Administration of Oncolytic Newcastle Disease Virus and Bacterial Hyaluronidase Enhances Virus Potency in Tumor Models Hasanain Sahib Salih
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Purpose: Bacterial hyaluronidase in co delivery evaluation effect with oncolytic Newcastle Disease Virus to determine spreading of the virus throughout Adenocarcinoma tumors Models in mice, and evaluate the reduction in tumor mass by efficacy of co delivery injection in tumor models. This study aimed to define the success of Combination effect between bacterial origin hyaluronidase and Newcastle Disease Virus and compare the invasion of this combination versus treatment with hyaluronidase enzyme or with oncolytic Newcastle disease virus only.Experimental Design:Newcastle disease virus (NDV) titration 6.3x105 injected in combined dose with 200 international unit (IU)  bacterial origin hyaluronidase to provide a mass invasion efficiency and spread of Newcastle disease virus within tumors that detected through the measurement of growth inhibition of tumor mass and  immunofluorescence detection assay. The experiment performed in vivo in mice bearing AMN3 tumor cell line model. Conclusion: The data presented in this study show that combination treatment of solid tumors with an NDV and bacterial origin hyaluronidase significantly improves spread of virus through the tumor mass, resulting in prolonged survival of the tumor-bearing animals and in vivo tumor mass reduction without increasing the metastatic potential. Thus, this combination of NDV and hyaluronidase may offer a novel and promising therapy for the treatment of patients with cancer.Keyword: NDV (Newcastle Disease Virus), HA (Hyaluronic Acid), AMN3 (Ahmed Murtatha Nahi 2003 Cell Line), ECM (Extra Cellular Matrix).
Prevalence of Hepatitis B Surface Antigen and Anti-hepatitis B Core Antibodies among Blood Donors in Diyala-Iraq Hadeel M. Fayyadh
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: In Diyala province and  since 2014, the anti-hepatitis B core antibodies (Anti-HBc Abs) was introduced beside the hepatitis B surface antigen (HBsAg) as seromarkers for blood donation screening  to reduce the residual risk of occult hepatitis B infection (OHBI). Objectives: this is a lookback study to explore the efficiency of HBc Abs versus HBsAg seromarkers in reducing the residual risk of OHBI through blood transfusion in Diyala province. Materials and methods: This follow-up study starting in January 2016 to August 2017. The results of HBsAg and anti-HBc Abs as blood units screening seromarkers were followed and abstracted from the records of the Central Blood Bank in Diyala Directory of Health. Simple statistical analysis was done using SPSS Version 18 and P value was considered significant wherever it is below 0.05. Results: The results found that the total number of blood units donated during the follow-up period was 47258. The total HBV positive was 2423 (5.12%), of which 213 (0.45%) were HBsAg positive and 2210 (4.67%) were anti-HBc total antibody positive. Totally, 2369 (5.012%) blood donors were positive for both markers. All the 213 blood donors who were positive for HBsAg recorded throughout the two years were male (100%). Whereas 2145 (99.48%) and 11 (0.51%) blood donors positive for anti-HBc Ab were male and female respectively. Cumulatively, 2358 (99.53%) males and 11 (0.46 %) female were positive for both HBV markers. Conclusion: The introduction of anti-HBc Ab along with  HBs Ag for screening of blood units  is remarkably increase the number of blood units with positive HBV infection and consequently improve the blood safety.Keywords: HBsAg, Anti-HBc Ab, Blood safety, Diyala.
Synthesis and Preliminary Antibacterial Activities of New 2, 3-Disubstituted-1, 3-Oxazepane-4, 7-Diones of Benzothiazole Zeid Hassan Abood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

2-aminobenzothiazole 1 was converted to analogues diazonium salt which reacted with alkaline solution of 2-hydroxybenzaldehyde to yield azo-benzothiazole derivative 2 bearing aldehyde group. The resulting aldehyde 2 was then condensed with some aromatic amines including (4-nitroaniline, 3-nitroaniline, 4-aminophenol, 4-methoxyaniline, 4-bromoaniline, 4-chloroaniline and 2, 4-dichloroaniline) using microwave irradiation technique in absolute ethanol to produce seven imine derivatives of benzothiazole 3a-g, respectively. Treatment of the resulting imines 3a-g with succinic anhydride using microwave irradiation in dry benzene afforded seven new 1, 3-oxazepane-4, 7-diones 4a-g bearing the benzothiazole moiety, respectively. Preliminary in vitro antibacterial activity of the target compounds were investigated using two types of bacteria, Staphylococcus aurous (Gram-positive) and Escherichia coli (Gram-negative). The results indicated that all oxazepane compounds exhibited better activity to gentamycin against Gram-positive bacteria. On the other hand, the oxazepane compounds (4a, 4e and 4g) showed greater activity against Gram-negative bacteria when compared with that of the control drug.Keywords: Benzothiazoles; Oxazepanes; Imines; Azo; Antibacterial activity.
Impact of IL1, IL6, IL8, IL17 and TGF Gene Polymorphisms in Bladder Cancer Patients Hamsa Ahmed Jasim
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Bladder cancer is one of the most common cancers worldwide and the most frequent malignancy of the urinary tract recently, several single nucleotide polymorphisms (SNPs) have been identified in cytokine gene sequences, particularly within the promoter region of these genes, and have been shown to be associated with the development of bladder cancer. The present study investigates the association of IL1, IL6, IL8, IL17 and TGF polymorphisms with the incidence of bladder cancer. Blood samples were collected from 50 histologically confirmed adult patients with bladder cancer and 28 apparently healthy individuals. DNA was extracted from each blood sample, and the genes were amplified using polymerase chain reaction (PCR) with gene-specific primers target. Systemic IL1β, IL6, IL8, IL17 and TGFβ, concentration was assessed in serum samples from each participant by enzyme-linked immunosorbent assay (ELISA). A appositive association between The allele T of the SNP rs 16944 of IL 1 gene (P=0.005, OR=4.263, 95%CI=1.566-11.603) and the allele G of the SNP rs 1800469 of TGF β gene (OR=0.19, 95% CI=0.035-1.02) were found. These data indicate an etiological role of IL-1β and TGF gene polymorphism in bladder cancer.Keywords: Single nucleotide polymorphism (SNPs), Interleukin, TGF, bladder cancer.
Prioritization of Selection Criteria for Sustainable Materials and Equipment in Construction Projects by Managing Energy Consumption Using TOPSIS Method Ashkan Khoda Bandeh Lou
Journal of Global Pharma Technology Volume 08 Issue 07
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Abstract

The use of conventional construction methods and considering the new technologies in this regard as well as using sustainable materials and equipment are inevitable to strengthen the constructions, achieving sustainable development, and improving living conditions. Choosing a suitable construction system due to the high uncertainties in the decision-making process is very complex. On the other hand, the knowledge of very broad construction systems has a structured weakness, which includes a variety of specialties. Hence, choosing sustainable equipment and materials in construction projects is an essential solution for designing and implementing an appropriate construction system using Multiple Criteria Decision Making. This research aims to determine and facilitate a criterion for equipment and material selection based on sustainability and productivity management approach in energy consumption in construction projects. Then, some of the important factors, which affect the decisions of engineers and designers in the selection of materials for sustainable design and energy management, are characterized by analyzing the information. Modeling will be used to evaluate and choose the most appropriate materials, which aims to provide an analytical decision support tool for achieving the goals of sustainable design in TOPSIS. Keywords: Project Management, Equipment Selection, Sustainable Materials, Multi-Criteria Decision Making, Topsis.
Vitamin D Receptor Gene Polymorphisms and Risk in Children with Recurrent Wheezy Chest among Babylon Province Naser Z. Al-Jourany
Journal of Global Pharma Technology .
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Abstract

Introduction: wheezing is continuous whistling happen from the chest in breathing; early childhood wheezing may develop later to asthma, this study aimed to make a genetic study to show the relationship between recurrence of wheezing, and polymorphism in vitamin D receptor. This has not been explored in Iraqi settings widely.  Aim: Present study investigated the association between VDR gene BsmI single nucleotide polymorphisms and recurrent wheeze in patients with a recurrent wheezy chest in Babylon children. Materials and Methods: Ninety patients with recurrent wheezy chest and ninety apparently healthy children as a control in Hilla City/Iraq were enrolled in this study. A questionnaire was used to obtain information. Estimation of VDR gene BsmI single nucleotide polymorphism was done using the PCR-RFLP method. Standard statistical tools were used, p-value <0.05 was considered to be statistically significant. And p-value <0.001 was considered to be statistically a highly significant SPSS software version 20.0 was used.  Results: The genotype and allele distribution of the VDR BsmI A/G SNP showed a significant difference between cases and controls with (p-value < 0.001).  Conclusion: The study concluded that BsmI gene polymorphism of vitamin D receptor associated with a recurrent wheezy chest in children beyond 5 years in Babylon province. Moreover, this study, conclude some risk factors that related to recurrent wheezing that the male gender is more affected and the children who breastfeed for less than six months is more vulnerable for wheezing and the family history of allergic rhinitis and maternal asthma also play role in patient wheezing.Keywords: Recurrent wheezing, Vitamin D receptor, SNPs, Babylon province. 
Histopathological and Hematological Effect of Silver Nanoparticles against acute Escherichia coli Infection in Male Rats Ghusoon A.A Alneamah
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The potential treatments of silver have known long time ago. Recently many researchers have used silver nanoparticles in the area of medication because their antimicrobial, bio affinities and their easy ways to synthesis. In the present study we have estimated the antimicrobial and hematological effect of silver nanoparticles (AgNps) against acute E.coli infection in male rats. firstly the Ag Nps was synthetic and characterization by SEM which reviled size in about 25 nm in diameter, UV-vis have shown peak absorption in 410 nm. (40) Male rats use in the experiment was divided equally into (4) groups as following (n=10): Group I: Rats served as control and gavage   0.4 ml/ rat from distilled waters   for three days. Group II: Rats served as experimental and gavage 0.4 ml/rats  from AgNps for three days .Group III: Rats  infected with E. coli  ( 0.2)ml/rat single dose  (I/P).Group IV: Rats  infected with1×10 9CFU of E.coli (0.2)ml/rat   single dose  (I/P ) +  gavage 0.4 ml/rats from AgNps  for three days. After three days the animals were sacrificed, the blood collected directly from the heart for hematological analysis, and the specimens from liver, and intestine were dissected out for histopathological examination. The hematological results showed significant decrease in RBCs, Hb compared with control group and increase in WBCs in infected group compared with infected group .While this value improved in group (II, IV). Regarding the histopathological results the infected group showed inflammatory cells infiltration, necrosis, and hemorrhage in both organs and micro thrombi in liver. After treatment with AgNps showed improvement in the both hematological and histological parameters.Keywords: Silver nanoparticles (AgNps), Escherichia coli, Histopathology, Rats.
Effect of Pregelatinization on Suweg Tuber Starch (Amorphophallus Paeonifolius) as Tablet Crusher Dwi Setyawan
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Background: Disintegrant tablet from starch is more often used to crush the tablet that has been swallowed. However, the material of this starch is tablet crusher which very weak. In contrast to the suweg starch (Amorphophallus paeonifolius) which has undergone pregelatinization where the content of amylose and amylopectin and the water absorption capacity that is high enough so that it can crush the tablet quickly. The aim of this study was to determine the influence of pregelatinization towards elephant foot yam (Amorpophallus paeonifolius) starch as disintegrant against tablet physical quality profile of the Paracetamol tablet. Method: The research was carried out by making suweg natural starch which then it made a suspension in the water with a concentration of 20% and heated to the temperature of 60 ± 5 0C and 70 ± 5 0C within 15 minutes. After the suweg pregelatin starch has been made, then a paracetamol tablet and a qualitative examination also made which includes the determination of the paracetamol infrared spectrum, the examination of moisture content, the testing with iodine, the testing with optical microscopy, X-ray diffraction analysis, the starch thermal analysis with DTA, and the examination of swelling power which then compared to each tablet formula made by the wet granulation method. after that, it was continued with the examination of the granule quality, including the examination of moisture content, the examination of granule particle size and number of fines, the examination of flow velocity and rest angle of the granule. Moreover, it was carried out an evaluation of the paracetamol tablet physical quality in the form of hardness test, friability test, and disintegration time test. The data obtained was further analyzed by One Way ANOVA. Result: Tablet formula with pregelatinization of suweg natural starch can reduce the hardness, increased the tablet disintegration time, and made no difference in friability compared to the formulas containing natural suweg tuber starch and SSG. The result of increased disintegration time was then compared with the result of the swelling power test, but did not indicate a correlation both of them. The different of disintegration was not showed a correlation with values of swelling power. Keywords: Suweg Tuber Starch, Starch Pregelatinization, Pregelatinized Starch Tablet.
Criminological Analysis of Sexual Slavery Mehdi Zakavi
Journal of Global Pharma Technology Volume 10 Issue 01
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Abstract

Sexual slavery as an organized crime in the 21st century has become a proplem for human societies and is expanding and due to the lack of strong implementation guarantee and comprehensive and restricted rules in order to give an answer to these uncontrolling conditions and disrespects to the extent of value and dignity of human, this phenomenon of the century is rising day by day. This study is aimed to investigate the reasons and factors of prevalence of sexual slavery in the present century which has been studied and analyzed by library and internet studies and news sites. According to obtained results several reasons have caused this global scourge to be occurred such as problems and poverty, unwariness, changing position and lack of prosecution due to the fear of prestige and such factors from the side of victims themselves, low cost, high profit of this dirty business, not getting caught the perpetrators of these crimes and their enjoyment of broad support. This dilemma, which is hated by all international societies, is sharply growing and is considered as a very important source of income. There is a need for a strong determination at national and international levels by concluding protocol and law and implementation guarantee and informing and training individuals through mass media as well as to support the victims of these crimes in order to serious fight agaist this problem.Keywords: Sexual slavery, Organizing, Crime against humanity, Human trafficking.
Measuring the Amount of AFM1 in Milk in Isfahan Province Iraj Javadi
Journal of Global Pharma Technology .
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Abstract

A Flatoxin (AF) is a toxic metabolite produced by fungi of Aspergillus flavus, Aspergillus Parasiticus and Aspergillus Nomius. Among them, AFB1 is the most toxic and potent agent. AFM1 and AFB1 are metabolites primarily produced by AFB2 and AFM2 which are found mostly in milk and meat from animals have been fed by AF-contaminated foods. Given the risks of AF for men and also due to the high consumption of milk and dairy products, the aim of this project is to examine the contamination of the food by measuring the toxin in milk in Isfahan province and compare it with international standards as well as take steps to reduce and prevent the contamination. In this study, a number of raw milk samples from a milk station, Shahreza dairy store, Isfahan diary and Pegah Milk factory of Isfahan were collected to measure AFM1. To measure AF in milk, AFM1 was extracted with chloroform and column chromatography on a silica gel 60 G with anhydrous sodium sulfate were used for purification. AFM1 was detected and measured using two methods; 1- TLC with silica stationary phase and mobile phase chloroform - acetone - isopropanol in a ratio of (87 + 3 + 10), 2- using C18 reverse-phase HPLC with columns and methanol - acetonitrile  water mobile phase in ratios (15:22:63) and UV detector at 350 nm. The results showed that 20% of the total samples collected from Shahreza milk station is contaminated with AFM1. Also, in 25% of samples taken from Shahreza dairy store, AFM1 was detected. The average amount of AFM1 in samples collected from Shahreza milk station and Shahreza dairy store was obtained 1.9 ± 0.26 and 2.9 ± 0. 59 ppb, respectively. In all the samples that the toxin has been detected in them, AFM1 was much higher than the limit set.  However, in the samples prepared from Najaf Abad, Tiran and Karvan and Shahin Shahr, AFM1 was below the acceptable level. According to results, high content of AFM1 in the raw milk is worrying and more attention should be paid to control and monitor the milk production and consumption.Keywords: Aflatoxin, Raw milk, Isfahan province.

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