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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Biochemical Study in Rats Hepatotoxicity with Carbon Tetrachloride and Treated with Camel Milk Alyaa Majid
Journal of Global Pharma Technology .
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Abstract

Objective: Carbon tetrachloride (CCl4) is a highly toxic chemical agent. Therefore, the present study was carried out to investigate the protective effects of camel's milk against CCL4 induced toxicity in male rats. Materials and methods:  Albino male rats (150-200 g) were divided into four groups of 6 rats: a control group fed only with diet and tap water for two weeks, the second group fed with standard diet and camel milk, the third group intoxicated with CCl4 on first two days of the experimental 14 days and fed with tap water and diet, and the fourth group intoxicated with CCl4 on first two days of the experimental 14 days and then treated with camel milk. Results: The results indicated that the CCl4 caused a significant increased in the level of  serum total cholesterol(TC) , triglycerides(TG), very low density lipoprotein (VLDL)and low density lipoprotein(LDL), lactate dehydrogenase(LDH), creatine kinase(CK)and aspartate aminotransferase (AST). Also, there was a significant decreased in the level of serum high density lipoprotein (HDL).Protective activity of camel's milk against toxicity of CCl4  observed in decreasing of TC, TG, VLDL, LDL, LDH, CK, AST and increased in the HDL levels. Conclusion:  These findings strongly prove that beneficial effects of Camel Milk clearly shown through the reduction of the CCl4 induced related damages and oxidative stressKeywords: Camel milk, Carbon tetrachloride, Lipid profile, Rats.
Molecular Detection of Lysinibacillus Fusiformis Isolated from Milk Samples of Cow in Iraq Aseel Mohammed Hamzah
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Raw milk  infected by bacteria can start from exceptional resources: air, milking devices, feed, soil, dangs and hays.The strategies of  nourishing and lodging cows may impact the germs pleasant of milk. Bacterial contaminants can cause infection, or deterioration of drain and its auxiliary items and the destructive impacts on the grade and security of dairy items as a result of oxygen consuming spore-forming bacteria got from crude drain were characterized by isolation of Lysinibacillus fusiformis from 90 milk samples of cow at 21.6l%, the bacteria were identified by routein bacteriological methods and Molecular distinguishing proof of the confines was carried out by 16S rRNA sequencing and the bacterial confines were taxonomically classified as Lysinibacillus fusiformis. The groupings were stored in NCBI GenBank with the accession number KY038703, KF916675. and KF916675.1 with identity of 100%, 96 and 99% respectively. Keywords: Raw milk, Lysinibacillus fusiformis, 16S rRNA PCR sequencing.
Erythrocyte Changes in Death after General Over Cooling Revo Z. Alekseev
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

In medicine, the problems of hypothermia and body ‘revitalization’ remain open. Insufficient knowledge of the mechanisms of dying at ultralow temperatures gives grounds to supplement the idea of the cellular-molecular mechanisms of deadly hypothermia. The aim of this study was to assess the morphology of red blood cells during fatal hypothermia at extremely low temperatures (i.e. below -40°C) using atomic force and scanning electron microscopy, high resolution JSM-7800F. The subject of the study was blood smears of people who died from hypothermia and from a gunshot wound. In a man who died of hypothermia at extremely low temperatures (i.e. -42°C), whose smear was taken within 1 day, red blood cells were characterized by minimal changes than when dying from a gunshot wound. The discocytic form of erythrocytes with a flat surface was preserved; however, we found an increase in the depth of the central concavity of red blood cells, which may be associated with an increase in the volume of red blood cells. It was found that even a slight difference in the temperature of the body regions (i.e. ∆ 2.4°C) at the time of blood sampling affects the ratio of different forms of red blood cells after complete thawing. The lower the temperature, the more degenerative forms of red blood cells appear. After complete thawing of the corpse on the 4th day, all red blood cells (100%) had a different degree of dysmorphism, a more flattened surface, an increase in diameter and heterogeneity and roughness of the plasma, indicating signs of hemolysis. Keywords: Red blood cells; Death from hypothermia; Atomic microscopy; Scanning electron microscopy.
Types and Determinants of Congenital Anomalies among Newborns in Bint Al-Huda Teaching Hospital in Thi-Qar Governorate at 2015-2017 Ghada Mansoor Abood Al-Asadi
Journal of Global Pharma Technology .
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Abstract

Background: Congenital anomalies are a major cause of neonatal and infant death, and disability around the world. The prevalence of congenital malformations differs widely between countries. Objectives: To determine the types of congenital anomalies among neonates and to identify the possible risk factors associated with congenital anomalies. Patients and Methods: A case-control study was carried out during 3years period (from the 1st of January 2015 to the 15th of December 2017). One hundred seventy-two neonates with congenital anomalies admitted to neonatal intensive care unit in Bint Al-Huda Teaching Hospital were involved in the study as a case group. A total of 305 neonates without congenital anomalies were randomly selected from neonates admitted to the same hospital for reasons other than congenital anomalies and including in the study as a control group.   Results: Neural tube defects are the predominant type of congenital anomalies (31.9%), followed by congenital heart diseases (14.5%), cleft lip and palate (6.9%), and upper and lower limbs deformity (5.9%). Both genders equally distributed among patient and control group p-value>0.05.The higher percentages of multiple congenital anomalies were detected among low birth weight neonates (30.6%), premature neonates (24.5%), neonates of mothers with advance age (> 35 years) (33.3%), grand multiparas (27.8%), and women with pregestational diabetes (37.5%).There is a significant positive association of low birth weight and premature neonates, young maternal age, chronic maternal illness, father occupation, and family history with the congenital anomalies, p-value < 0.05. Mother and Father Age, and prematurity were independent risk factors for congenital anomalies (OR 8.470, 17.367, 6.606, respectively). There is a highly significant association between congenital malformations with periconceptional folic acid intake, p-value <0.001, (OR 5.746). Conclusion: The commonest congenital anomalies are neural tube defects, followed by congenital heart diseases, cleft lip and palate, and upper and lower limbs deformity. There is a positive association of low birth weight, chronic maternal illness, father occupation, and family history with the congenital anomalies. Parental age and prematurity were independent risk factors for congenital anomalies. Periconceptional folicacidin take protect against congenital malformations.Keywords: Types, Risk factor, congenital anomalies.
Comparison of Pain Intensity in Mothers Undergoing Painless Delivery with and without Use of Entonox Hasan Zabetian
Journal of Global Pharma Technology Volume 08 Issue 03
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Abstract

Introduction: Pain relief in pregnant women is regarded an important issue in obstetrics and gynecology. Labor pain can affect mother’s decisions for having children in the future, and naturally it can also be effective in family relationships. Therefore, identification of a safe and efficient method seems essential. This study aimed to compare the severity of labor pain in mothers undergoing painless delivery with and without the use of Entonox. Methods: This randomized double-blind study was conducted in Motahari Hospital in Jahrom, Iran. The random sampling was used here. The sample consisted of all pregnant women who wanted to have vaginal delivery based on gynecologist’s diagnosis. In this study, subjects were randomly divided into two groups of 40 people, including intervention (receiving Entonox) and control (control) groups. Data analysis was conducted using descriptive and inferential statistics using non-parametric Mann-Whitney and Friedman tests and SPSS version 18. Findings: The median age was 25 in the case group (receiving Entonox) and 26 in the control group (not receiving Entonox). The majority of pregnant women had one child. The most common side effects of Entonox in the intervention group included xerostomia (13, 39.4%) and drowsiness (10, 30.3%). Mann-Whitney test results showed that the labor pain levels in the intervention and control groups was significant at first, third, and fourth and fifth hours (p-value<0.05). Labor pain was not reported in fourth and fifth hours. Changes in patient’s vital signs (systolic and diastolic blood pressure, heart rate, and Spo2) the group receiving Entonox did not change significantly over time (hour one to five) (p-value>0.05).Conclusion: Findings showed that Entonox, as a safe method with fewer side effects for the mother and her baby during labor, has a higher potential compared other methods. Its analgesic effectiveness was considerably higher compared to other methods.Keywords: Entonox, Pain, Anesthesia
Antimicrobial Properties of Snail Slime (Achatina Fulica) on the Growth of Actinobacilus Actinomycetemcomitans Bacteria Causing Periodontitis I Gusti Agung Ayu Putu Swastini
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

                                             Aim: The purpose of this study was to calculate the inhibition zones of the growth of A. actinomycetemcomitans by snail slime at concentrations of 12.5%, 25%, 50%, 100%. Methods: The study was an experimental randomized posttest-only control group design. This research was conducted in the oral biology laboratory of the Faculty of Dentistry, Airlangga University, Surabaya Indonesia. Variables in this study snail slime were made with concentrations of 12.5%, 25%, 50% and 100%. Take germ stock with osse, then plant on BHI broth media, then incubate 37C for 24 hours. Plant germs on BHI media so that with the swab technique to evenly spread on the surface, then contact the paper disc that has been given each concentration of 12,%, 25%, 50%, 100%, with tweezers on the surface as much as 10 micromillimeters, then incubate 37C for 2x 24 hours, eight repetitions are carried out. Results: The mean diameter of the inhibitory zone snail slime on the growth of A. actinomycetemcomitans bacteria in the treatment groups had significant differences p<0.05. The mean inhibition zone between controls and LB treatment group (LB 12.5%, 25%, 50%, 100%), were statistically different (p<0.05).In contrast with LB 12.5% (p>0.05) which significant difference with the control group. Conclusion: The concentration of 100% snail slime has the highest inhibitory power, against the growth of the A. actinomycetemcomitans bacteria, The 12.5% concentration snail slime showed no antibacterial activity against the growth A. actinomycetemcomitans.Keywords: Snail slime, Actinobacilus actinomycetemcomitans bacteria, Inhibition zone diameter.
Influence of Iron Nano Co-polymer Catalysts on the Liquid Hydrocarbons Production in the Synthesis Fischer Tropsch Abdulqadier Hussien Al-Khazraji
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this paper the synthesized composites were used in the Fischer - Tropsch reaction(FT) which compared the catalytic activity of catalysts based on Co-polymer (COP)such Styrene Butadiene Rubber (SBR)) and Polyethylene terephthalate (PET)) with catalysts. The COPS were supported within polypropylene (PP) in the system nano Fe-Paraffin-polymer. The behavior of Co-polymers gave significant effects in the creation of nano catalysts by stabilizing the nanoparticles, and producing new active sites for synthesized hydrocarbons from CO and H2as sources of energy. Catalytic materials shows sensitivity and selectivity in the Fischer-Tropsch process with three phase slurry reactors. The greatest conversion of CO was obtained in 66%, which forming hydrocarbons liquid reach to 60g/m3for catalysts copolymer(SBR) , whilst using catalyst with PP reduce the conversion of CO to 50% which also forming 38g/m3ofhydrocarbons.  The iron nano particles were characterized by AFM technique and XRD in the polymer-paraffin matrix.Keywords: Fischer-Tropsch (FT), Three phase slurry reactor, Polymers.
Biodegradable Polystyrene doped with N-Benzyl-4-Vinylpyridinium Chloride for Bio-Sensor Device Applications Abdullah Hasan Jabbar
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Waste polymers are recently getting higher research interest and one of the solutions is synthesizing synthetic biodegradable polymers where the focus is to modify polymer chemical structure without altering its intended application. Biodegradation of polystyrene is one of the major research concern and is extremely difficult to accommodate the best physical, chemical and optical properties of the desired polystyrene end products. Doping polystyrene with copolymer such as N-benzyl-4-vinyl pyridinium chloride, PSt-co-BVP(Cl), has been found able to be bio-degradable when treated with activated sludge in the soil. The biodegradation of polystyrene copolymer that contained 46.1-mol % BVP(C1) is found to follow first-order kinetic and with a half-life of 5.5 days when about 0.5 or 1.0 g/kg of polystyrene is utilized as basic materials. Polymeric base materials have gained a wide theoretical interest and practical application in sensor technology which motivated this research in finding ways to modify the PSt-co-BVP(Cl) and investigate its chemical structure modification by low dose laser irradiation. The laser photon modifies PSt-co-BVP(Cl) of its physical, chemical and surface morphology where the strong oncoming of BVP(Cl) with microbial cells and viruses can be tuned as bio-materials sensor.
Immunological Study for Patient with Verruca Vulgaris and Verruca Plana Caused by HPV in Hilla/ Iraq Nisreen Kaddim Radi
Journal of Global Pharma Technology Volume 9 Issue 10
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Verruca vulgaris and verruca planathey are benign growth  caused by human papilloma virus.Thirty six sample (biopsy, blood serum) collated from patient infected with Verruca  vulgaris  and Verruca  plana whom visit marjan hospital , twenty  blood sample collected from healthy individual person serve as control group .The diagnosis of infection  and the immunological study were  done by using ELISA test ,IgG to HPV and fasligand level (FASL) at blood serum of patient.The result reveled that: histological study for two types of wart show a distinct feature such as the presence of kilobyte in the tissue infected with hpv. There were a significant Mean Differences of FSAL Concentration by wart’s location at the hand 44.4% with Mean± SD of FASL [78.43± 12.46], presence of previous wart Mean± SD of FASL [84.22± 12.51]    and type of warts such as common wart 47.2% withMean± SD of FASL[87.47±11.84]. There was high significant Mean Difference of FSAL and IgG Concentration between patient and control group, (p value ≤ 0.05 is significant).Keywords:-HPV, FASL, IgG, Verruca vulgarus, Apoptosis, Wart.
Effectiveness of Peroxyacetic Acid as Disinfectant to Physico-chemical, Microbial and Organoleptic Characteristics of Fresh Pangasius Fillet during Chilling Storage Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
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Pangasius fillet is a good source of amino acids, low residue levels of heavy metals and polychlorinated biphenyls, high amounts of saturated fatty acids, low amounts of polyunsaturated fatty acids, low cholesterol levels. However, it is highly perishable.  During the processing of Pangasius fillets, washing could reduce the microbial loads on the fish fillets as much as possible.  Objective of this study focused on the efficacy of different concentrations of peroxyacetic acid (PAA) to the firmness (N), peroxide value (meq/kg), total plate count (cfu/g), sensory score of fresh Pangasius fillet during 20 days of preservation at cooling temperature. Our results showed that 75ppm PAA was appropriate to maintain physico-chemical, microbial and sensory characteristics of fresh Pangasius fillet during storage.Keywords: Pangasius fillet, Peroxyacetic, Firmness, Peroxide value, Total plate count, Sensory score.

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