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The Journal of Society Medicine (JSOCMED)
Published by PT. CoinReads Media Prima
ISSN : -     EISSN : 29645565     DOI : https://doi.org/10.47353/jsocmed.v2i1
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience
The Journal of Society Medicine (JSOCMED) | ISSN (e): 2964-5565 is a leading voice in the Indonesia and internationally for medicine and healthcare. Published continuously, JSOCMED features scholarly comment and clinical research. JSOCMED is editorially independent from and its The Editor-in-Chief (EIC) is Prof. dr. Aznan Lelo, PhD, SpFK. JSOCMED offers many attractive features for authors, including free online access to all research articles, online publication ahead of print, and online responses to articles published as Quick Comments. In addition, as befitting a publication of the Journal of Society Medicine, JSOCMED implements best practice in scientific publishing with an open peer review process, declarations of competing interests and funding, full requirements for patient consent and ethical review, and statements of guarantorship, contributorship, and provenance.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol. 4 No. 2 (2025): February" : 5 Documents clear
Effectiveness of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) on Life Expectancy in Non-Small Cell Lung Cancer Patients in Medan City Harahap, Putri Wulandari; Tarigan, Setia Putra; Soeroso, Noni Novisari; Ashar, Taufik
Journal of Society Medicine Vol. 4 No. 2 (2025): February
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i2.193

Abstract

Introduction: Non-small cell lung cancer (NSCLC) is strongly linked to epidermal growth factor receptor (EGFR) mutations, with tyrosine kinase inhibitors (TKIs) serving as a primary treatment. While TKIs demonstrate substantial antitumor effects, resistance differs across generations. This study evaluates the impact of first- and second-generation EGFR TKIs on the survival outcomes of NSCLC patients in Medan. Method: A retrospective cross-sectional study was conducted on 67 EGFR-positive NSCLC patients treated with TKIs between 2017 and 2022. Medical records from four hospitals-Haji Adam Malik Hospital, Elisabeth Hospital, Prof. Dr. Chairuddin Panusunan Lubis USU Hospital, and Pirngadi Hospital-were analyzed. Patients aged >18 years with EGFR mutations (exon 18, 19, or 21) and complete records were included. Survival outcomes, including Progression-Free Survival (PFS), Median Survival Time (MST), and Overall Survival (OS), were compared using the Mann-Whitney test. Results: All 67 patients received either first- or second-generation TKIs. Statistical analysis revealed that patients treated with second-generation TKIs had significantly better PFS, MST, and OS than those receiving first-generation TKIs (p < 0.05). Conclusion: This retrospective study faced limitations due to incomplete data and did not assess adverse effects. However, findings indicate that second-generation EGFR TKIs provide superior survival benefits for NSCLC patients compared to first-generation TKIs. Further prospective studies are needed to validate these results and explore the impact of treatment-related toxicity.
Relationship Between Asthma Therapy Types, Pulmonary Function, and Asthma Control in Primary Healthcare Facilities in Medan Darmawan, Nengah; Tarigan, Amira Permatasari; Pradana, Andika
Journal of Society Medicine Vol. 4 No. 2 (2025): February
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i2.194

Abstract

Introduction: Asthma is a chronic respiratory disease that affects millions globally. Effective asthma therapy is essential for improving pulmonary function and achieving asthma control. However, many patients remain uncontrolled despite treatment. This study aims to evaluate the relationship between asthma therapy types, pulmonary function, and asthma control in primary healthcare facilities in Medan. Method: This retrospective descriptive study utilized medical records of asthma patients from May 2022 to May 2023 at several primary healthcare centers in Medan. Data collected included demographic characteristics, asthma therapy types (inhaler vs. inhaler + oral), pulmonary function (APE prediction), and asthma control levels. Chi-Square tests were performed to assess statistical associations. Results: The study found that most asthma patients were female (83.3%) and over 50 years old (62.5%). Regarding pulmonary function, 73.0% of patients had an APE prediction of ≥60%, indicating relatively good lung function. However, asthma control remained poor, with 68.8% of patients classified as uncontrolled. The majority of patients (68.8%) used inhalers as their primary therapy, while 31.2% received a combination of inhaler and oral medication. Statistical analysis showed no significant relationship between the type of asthma therapy and pulmonary function (p = 1.000), nor between the type of therapy and asthma control level (p = 0.067). Conclusion: The study found no significant relationship between asthma therapy type, pulmonary function, and asthma control level. These findings suggest that other factors, such as therapy adherence, proper inhaler technique, and medication adjustments, may contribute to asthma control.
Reduction of 75% in the Psoriasis Area and Severity Index (PASI) for Moderate-to-Severe Psoriasis Vulgaris Nahrisyah, Nahrisyah; Nababan, Kristo A.
Journal of Society Medicine Vol. 4 No. 2 (2025): February
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i2.195

Abstract

Introduction: Psoriasis vulgaris is a chronic inflammatory skin disorder characterized by the presence of scaly, red plaques. The severity of the condition is often evaluated using the Psoriasis Area and Severity Index (PASI), which quantifies the extent and severity of skin lesions. A treatment is considered successful when a PASI 75 is achieved, indicating a 75% reduction in the PASI score. Case: A 26-year-old female presented with itchy and scaly red plaques covering nearly her entire body for the past month. Upon examination, her initial PASI score was 21.8. The patient was treated with a combination of systemic and topical therapies, resulting in a significant clinical improvement. Within two months, the patient achieved a PASI 75, demonstrating a 75% reduction in the PASI score. Conclusion: This case underscores the importance of achieving PASI 75 as a critical treatment goal in both clinical practice and research. It highlights the potential of effective therapy in managing psoriasis vulgaris and serves as a guide for dermatologists in optimizing treatment strategies for psoriasis patient.
Blood Eosinophil Count as a Predictor of Asthma Exacerbation Damanik, Rizki amaliah; Pradana, Andika; Pandia, Pandiaman
Journal of Society Medicine Vol. 4 No. 2 (2025): February
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i2.197

Abstract

Introduction: Asthma is a heterogeneous disease characterized by chronic airway inflammation, where eosinophils play a crucial role. Eosinophil levels are often considered a biomarker for asthma severity and treatment response. However, their relationship with asthma exacerbation severity remains unclear. This study aimed to evaluate the relationship between blood eosinophil levels and the severity of asthma exacerbations in patients at Prof. Dr. Chairuddin P. Lubis USU Hospital. Method: This study employed an analytic observational design with a retrospective cohort approach. Data were collected from 25 asthma patients through medical records, including demographic characteristics, blood eosinophil levels, and asthma exacerbation severity. The relationship between eosinophil levels and exacerbation severity was analyzed using the Whitney test. Results: The majority of asthma patients were in the 26-50 age group (44%) and predominantly female (80%). Most patients had blood eosinophil levels <100 (84%), and severe exacerbations were the most common (72%). Statistical analysis showed no significant relationship between blood eosinophil levels and asthma exacerbation severity (p = 0.976). Conclusion: This study found no significant correlation between blood eosinophil levels and asthma exacerbation severity. Other factors, such as corticosteroid use, delayed immune response, and non-eosinophilic asthma, may influence exacerbation severity. These findings emphasize the importance of a multidimensional evaluation in asthma management, including the identification of different asthma phenotypes to guide more precise treatment strategies.
Relationship Between Left Atrium Reservoir Strain and One-Year Mortality After Surgery in Patients with Severe Primary Mitral Regurgitation Undergoing Mitral Valve Replacement at Haji Adam Malik General Hospital, Medan Abimanyu, Roni; Ketaren, Andre Pasha; Nasution, Ali Nafiah
Journal of Society Medicine Vol. 4 No. 2 (2025): February
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i2.200

Abstract

Introduction: Severe primary Mitral Regurgitation (MR) is a public health program that continues to grow. Echocardiography is still a tool to assess the severity and prognostic of mitral valve disease. LASr assessment has the benefit of assessing the prognostic in patients who have undergone mitral valve replacement surgery. This study aimed to determine the relationship between LASr and mortality one year after surgery for severe primary MR undergoing valve replacement surgery Methods: This study is an analytic study with a cross-sectional design on 55 subjects with severe primary MR who met the inclusion and exclusion criteria at Haji Adam Malik General Hospital. LASr was measured before surgery and followed by the incidence of mortality one year after mitral valve replacement surgery. Data were analyzed univarite and bivariate as well by correlation tests to assess the relationship between LASr and one-year mortality in severe primary MR undergoing valve replacement surgery Results: The study subject totaled 55 patients with an average age of 39,35 ± 12,59 years, 28 patients (50.9%) were male and 11 patients (20%) experienced mortality. The main cause of mitral valve abnormalities in this study was rheumatic, namely 39 cases (70.9%). The LASr threshold value was found to be 18.8 (sensitivity: 90.9%; specificity: 70.5%). (AUC: 0.851; P = 0.0001 and 95% CI (0.751 – 0.952). Conclusion: LASr has a significant correlation to predict one-year mortality in patients with severe primary mitral regurgitation undergoing mitral valve replacement surgery.

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