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Journal of Advances in Medicine and Pharmaceutical Sciences
Published by Lamintang Education & Training Centre
ISSN : 2964268X     EISSN : 29634253     DOI : https://doi.org/10.36079/lamintang.jamaps-xxxx.xxx
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Nursing Public Health
Journal of Advances in Medicine and Pharmaceutical Sciences (JAMAPS) scope are including but not limited to: ☛ Drug ☛ Chemistry ☛ Herbal Medicine ☛ Pharmaceutical Science ☛ General and Internal Medicine ☛ Pathology and Forensic Medicine ☛ Pharmacology, Toxicology and Pharmaceutics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 41 Documents
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Pharmacological Properties and Standardization of Ngoc Linh Ginseng using Ultrasonic-Assisted Extraction Trung Phung-Van; Nguyễn Ngọc Mai Thảo; Nguyen Tan Thuong
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 1: May 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0401.778

Abstract

This study aims to evaluate the pharmacological potential and standardize the bioactive compounds of Ngoc Linh Ginseng (Panax vietnamensis) as a candidate phytopharmaceutical. The study was conducted throughout 2024 using a multidisciplinary approach, including ultrasonic extraction, chemical analysis, and pharmacological tests. Samples were collected from the Kon Tum and Quang Nam mountains, Vietnam, then extracted by the Ultrasonic-Assisted Extraction (UAE) method using ethanol-water solvents. The total saponin content obtained was analyzed using High Performance Liquid Chromatography (HPLC), resulting in a level of 28.5% with the identification of the main ginsenosides Rg1 and Re. Pharmacological activity was tested in vitro on LPS-induced RAW 264.7 cells, showing a decrease in pro-inflammatory cytokine production by up to 50% and strong antioxidant activity with an IC50 value of 25 µg/mL. In vivo tests on Wistar rats showed a hepatoprotective effect against liver damage caused by a high-fat diet. These results support the potential of Ngoc Linh Ginseng as a candidate for plant-based therapy. Further studies are recommended to explore the pharmacokinetics, clinical efficacy, and optimization of extraction techniques to expand its therapeutic applications.
Effectiveness of Balance Exercise in Reducing Fall Risk Among the Elderly Melly Anisa Putri; Ahmad Nurwanto; Fauziyah Rezkyati
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 1: May 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0401.814

Abstract

As individuals enter old age, they typically experience a decline in physical condition, characterized by reduced muscle strength that subsequently impairs bodily movement and functionality. These age-related physical changes often result in mobility impairments, limiting the elderly’s ability to maintain postural stability necessary for performing daily activities, and thereby increasing the risk of falls. Balance disorders are among the primary factors contributing to the elderly’s vulnerability to physical injuries from falls. This study, presented in the form of a literature review, aims to explore strategies for enhancing postural stability as a means to mitigate fall risk among older adults. Employing a scoping review methodology, this research investigates the effectiveness of balance exercise interventions in fall prevention. The literature search was conducted systematically following the PRISMA 2020 Flow Diagram guidelines and utilized three primary databases: PubMed, ScienceDirect, and SAGE Journals. The findings indicate that several exercise-based interventions, such as the Balance-Enhancing Exercise Program (BEEP), Walking Meditation, and Multi-system Physical Exercise (MPE) are effective in reducing the likelihood of falls in the elderly. It is concluded that fall risk is a significant concern among older individuals; however, this risk can be managed, particularly in those who engage in regular physical training and possess sound mental health. Among the evaluated interventions, the Self-Administered Balance-Enhancing Exercise Program (BEEP) appears to be the most effective in minimizing fall risk in elderly populations.
Acupuncture as a Complementary Therapy for Stroke Risk Reduction in Rheumatoid Arthritis Hilde Juzeniene Torhild; Kjennerud Carlet; Linda Juzeniene Torhild
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 1: May 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0401.818

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with increased inflammation and increased risk of stroke. In Norway, where acupuncture is widely practiced, there is growing interest in its potential role in reducing cardiovascular complications. This study explored the effectiveness of acupuncture in reducing stroke risk factors among RA patients and its potential integration into healthcare practice. Conducted in 2024 in Oslo, Bergen, and Trondheim, the study included 200 RA patients aged 18–75 years who met the 2010 ACR/EULAR criteria and received regular acupuncture treatment. Quantitative data were collected through clinical evaluation of blood pressure, inflammatory markers (CRP, TNF-α), and stroke risk indicators at baseline and post-treatment, while qualitative data were obtained through semi-structured interviews. The findings showed significant reductions in inflammatory markers and improved blood pressure regulation following acupuncture therapy. Participants also reported improved quality of life, supporting the role of acupuncture as a complementary therapy. These findings are in line with similar studies in Sweden but offer local insights specific to Norway. Mechanistically, acupuncture appears to reduce inflammation and improve vascular health through modulation of the autonomic nervous system. This study underscores the importance of integrating acupuncture into RA management to reduce cardiovascular risk. Future studies should focus on long-term effects, larger sample sizes, and explore a wider range of cardiovascular markers. Cost-effectiveness studies and assessment of cultural acceptability are also recommended to support its inclusion in the public health care system.
Bioactive Methoxyflavones from Kaempferia parviflora Induce Apoptosis in Breast Cancer Cell Line Supawadee Watcharin; Namuangruk Prathep; Sorawit Karnchanatat; Rittidech Tanomtong; Jittima Mahayothee; Piriyapongsa Srisuwan
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.884

Abstract

Kaempferia parviflora is commonly known as Black Ginger. It is a traditional Thai herbal plant rich in methoxyflavones and other bioactive compounds with promising anticancer properties. Breast cancer remains a leading cause of mortality worldwide, and current therapies face challenges such as toxicity and drug resistance. This study aims to evaluate the cytotoxic effects of ethanol extract of Kaempferia parviflora on human breast cancer cell lines (MCF-7 and MDA-MB-231) and to identify the main bioactive compounds responsible for its anticancer activity. Rhizomes were collected from Central Thailand, extracted using 70% ethanol via maceration, and concentrated with rotary evaporation. Breast cancer cells were cultured and treated with varying extract concentrations for 24 to 72 hours. Cytotoxicity was assessed using the MTT assay, and active compounds were quantified via HPLC. Results show a dose-dependent decrease in cell viability, with IC50 values ranging from 60 to 85 μg/mL. Apoptosis induction was confirmed by fluorescence microscopy and increased caspase-3 activity (up to 4.1-fold). HPLC analysis revealed significant concentrations of 5,7-dimethoxyflavone and 3,5,7-trimethoxyflavone, suggesting their role in ROS-mediated apoptosis. Future research should focus on detailed molecular mechanisms, in vivo toxicity and efficacy, and clinical translation. This study supports Kaempferia parviflora as a potential natural adjuvant in breast cancer therapy.
Antimicrobial Resistance in Escherichia coli and Staphylococcus aureus After the COVID-19 Pandemic Edgardo Joseph Bacabac; Rubenito Gomez; Pompe Cruz Festin; Florencio Abesamis; Andrew Huttley
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.921

Abstract

Antimicrobial resistance (AMR) has emerged as one of the most pressing post-pandemic health threats, particularly in low- and middle-income countries such as the Philippines. During the COVID-19 pandemic, widespread empirical use of antibiotics accelerated selective pressure on bacterial pathogens, potentially intensifying resistance trends. This study aims to analyze changes in the resistance patterns of Escherichia coli and Staphylococcus aureus to first-line antibiotics before (2018–2019) and after (2022–2023) the pandemic, and to evaluate the implementation of Antibiotic Stewardship Programs (ASP) in government hospitals. A retrospective observational design was applied using WHONET microbiological data from three public hospitals across Luzon, Visayas, and Mindanao, combined with semi-structured interviews involving infectious disease physicians and clinical pharmacists. Statistical and thematic analyses revealed a significant increase in resistance: E. coli resistance to ciprofloxacin rose from 32% to 48%, and MRSA prevalence increased from 15% to 27%. Hospitals with active ASPs reported smaller resistance increases (Δ = +8%) compared to those without consistent stewardship activities (Δ = +18%). These findings highlight the critical role of structured ASPs, robust microbiology infrastructure, and real-time data integration in mitigating AMR escalation. Strengthening ASP implementation, expanding diagnostic capacity, and integrating surveillance systems into national health information frameworks are essential policy priorities. Future research should explore genomic approaches and digital ASP models to enhance precision in antibiotic governance and resistance control in the post-pandemic era.
Exploratory Clinical Study on Controlled álak Microdosing for Post-Detoxification Recovery Roland Mario; Festin Bermudez; Mary Fresthel; Dominic Calingasan Agoncillo; Jamora Santos; Ann Monica Espaldon
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.922

Abstract

Post-detoxification phases of methamphetamine dependence are often characterized by neurophysiological instability, including tremors, insomnia, and anxiety, due to suppressed GABAergic activity and hyperdopaminergic rebound. Traditional Filipino distilled spirit, álak or lambanog, contains trace levels of ethanol and minor fusel alcohols which may exert mild GABA-A receptor agonism when microdosed under medical supervision. This exploratory clinical study investigates the potential of controlled álak microdosing as an adjunct for stabilizing central nervous system function in post-detoxified methamphetamine patients. Twelve post-detoxification patients (n=12) from rehabilitation centers in Quezon and Batangas were administered álak microdoses (≤10% ethanol, 5–10 ml/day) for 14 days under medical supervision. Physiological and psychological parameters including sleep quality, tremor frequency, and anxiety, were measured using the Clinical Opiate Withdrawal Scale (COWS) adapted for stimulant recovery and the Beck Anxiety Inventory (BAI). Data were analyzed descriptively and statistically using paired t-tests. Eight out of twelve participants (66.7%) demonstrated marked improvement in sleep continuity (p<0.05), tremor reduction (p<0.05), and decreased anxiety scores (mean reduction 23.4%, p<0.05). No signs of ethanol intoxication, craving substitution, or hepatic distress were observed. Mild headache was reported in one participant but resolved spontaneously. Controlled álak microdosing exhibits promising GABAergic modulatory effects that may facilitate neurophysiological stabilization in methamphetamine recovery. While preliminary, these findings support further biochemical validation and integration of ethnopharmacological knowledge into harm-reduction frameworks.
Neuroprotective Effects of Rosmarinus officinalis and Its Pharmacological Potential Against Neurodegenerative Diseases Fu-Yuan Chen; Wei Yunquan; Qu Jian Lau; Wang Xiang-Li
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.926

Abstract

This study investigates the neuroprotective effects of Rosmarinus officinalis (rosemary) in a rodent model of neurodegeneration, focusing on its potential to enhance motor coordination, cognitive function, and reduce oxidative stress and inflammation. The research employs behavioral tests (rotarod, open field, Morris water maze), biochemical analysis (MDA, NO, SOD, CAT), and histological examination to assess the effects of rosemary extract. The results show that rosemary-treated rats exhibit significant improvements in motor coordination and cognitive performance, as well as reduced oxidative stress and inflammation, compared to the vehicle-treated group. Biochemical analysis reveals a marked reduction in MDA and NO levels and an increase in antioxidant enzyme activity (SOD and CAT) in the rosemary-treated rats. Histological examination confirms the preservation of neuronal integrity and a reduction in amyloid-beta plaques and tau tangles, indicating the potential of rosemary to mitigate neurodegenerative pathology. These findings suggest that rosemary extract may provide a natural therapeutic approach for neuroprotection and cognitive enhancement, particularly in conditions like Alzheimer's and Parkinson’s disease. However, further research, including long-term studies and human clinical trials, is necessary to fully explore the efficacy and mechanisms of rosemary in treating neurodegenerative disorders.
Stability and Controlled Release of Amoxicillin Trihydrate in Novel Biopolymer Matrices Malinee Namuangruk; Loilome Sriariyanun; Supawadee Prathep
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.928

Abstract

Amoxicillin trihydrate is a widely prescribed β-lactam antibiotic, suffers from chemical instability that limits its therapeutic efficacy and shelf life. This study investigates the formulation of controlled-release systems using locally sourced biopolymers in England, specifically alginate, chitosan, and pectin, to enhance drug stability and optimize release profiles. Microspheres were prepared via ionic gelation with varying polymer-to-drug ratios and characterized for particle morphology, thermal properties, crystallinity, and drug–polymer compatibility using SEM, DSC, XRD, and FTIR. Accelerated stability studies were conducted at 40°C and 75% relative humidity for 90 days, while in vitro release was assessed in simulated gastrointestinal fluids at pH 1.2 and 6.8. The results indicated that alginate–chitosan matrices provided superior encapsulation efficiency (>85%), structural integrity, and prolonged stability, reducing the degradation rate by up to fourfold compared to unencapsulated drug. Pectin-based formulations, although biodegradable, exhibited higher moisture sensitivity and faster initial drug release. In vitro release studies demonstrated a biphasic release pattern in alginate–chitosan systems, characterized by an initial burst followed by sustained release, predominantly governed by diffusion and polymer relaxation mechanisms. These findings highlight the potential of natural biopolymer matrices for improving the physicochemical stability and controlled release of amoxicillin, providing a sustainable alternative to conventional synthetic excipients. The study underscores the dual benefits of enhanced therapeutic performance and environmental sustainability, aligning with contemporary UK pharmaceutical priorities. Future work should explore in vivo pharmacokinetics and clinical translation to validate the therapeutic advantages of these formulations.
Phytochemical and Neuropharmacological Evaluation of Banisteriopsis caapi, Paullinia cupana, and Turnera diffusa for Potential Anti-Addiction Activity Fernando Benevenuto; Iscia Martha Franco; Antonio Eizirik; Loureiro Gilberto; Adriana Martinez
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 5 No 1: May 2026
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0501.935

Abstract

Addiction remains a major neuropsychiatric challenge, with dopaminergic, serotonergic, and GABAergic dysregulation underlying maladaptive behaviors. Traditional Brazilian medicinal plants offer a rich source of neuroactive compounds, yet their multi-target mechanisms remain underexplored. This study aimed to evaluate the neuropharmacological potential of harmine, caffeine, and damianin through an integrated computational and experimental approach. Plant materials (Banisteriopsis caapi, Paullinia cupana, Turnera diffusa) were collected, authenticated, and processed using standardized extraction and preparative HPLC purification. Structural characterization was confirmed via NMR spectroscopy. In silico molecular docking targeted D2, 5-HT2A, and GABA-A receptors, complemented by ADMET profiling and network pharmacology simulations. Control ligands; selegiline, haloperidol, and fluoxetine provided pharmacological benchmarks. In vitro assays using HEK293, SH-SY5Y, and HepG2 cells evaluated cytotoxicity and neuroactivity. Docking results revealed harmine as a selective D2 receptor partial agonist (−10.2 kcal/mol), caffeine as a moderate 5-HT2A modulator (−8.1 kcal/mol), and damianin as a GABA-A agonist-like compound (−9.5 kcal/mol). Network simulations suggested synergistic modulation of dopaminergic–serotonergic–GABAergic axes. ADMET predictions indicated favorable BBB permeability, oral bioavailability, and low toxicity, with caution for harmine’s moderate CYP2D6 inhibition. These findings underscore a triadic pharmacodynamic model where dopaminergic stabilization, serotonergic normalization, and GABAergic inhibition collectively mitigate craving and withdrawal symptoms. Future research should integrate receptor-binding validation, in vivo behavioral studies, and clinical pharmacokinetics to translate these computational insights into novel plant-based adjunct therapies for substance dependence. The study provides mechanistic and ethnopharmacological rationale supporting Brazilian botanicals as promising multi-receptor neurotherapeutics.
Urbanization and the Rising Burden of Diabetes Mellitus through an Epidemiological Analysis of Urban Population Risk Factors Nguyễn Ngọc Mai Thảo; Huy-Thanh Nguyen; Quang Cuong Tran
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 5 No 1: May 2026
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0501.1029

Abstract

This research investigated how diabetes spreads and what triggers it within Vietnam’s urban centers. Our team used a quantitative cross-sectional design to get a clear epidemiological snapshot. Between January and April 2025, the gathered data from 1,250 residents across Hanoi, Ho Chi Minh City, and Da Nang. A direct measurement of BMI, waist-to-hip ratios, and fasting blood glucose, while also using questionnaires to track participant lifestyles. To round out the analysis, we pulled secondary figures from WHO databases and national health reports. The results are concerning. By 2025, diabetes prevalence in these cities hit 7.2%, but prediabetes is the bigger story, affecting 14.8% of the population. Geographically, Ho Chi Minh City leads with an 8.2% rate, followed by Hanoi at 6.9% and Da Nang at 6.0%. When looking at why these numbers are climbing, obesity (OR 3.45) and sedentary habits (OR 2.80) stand out as the primary culprits, alongside hypertension and genetics. It is clear that Vietnam’s rapid shift to urban living is driving this metabolic crisis. Moving forward, we need deeper research into how long-term city environments and changing diets specifically accelerate this disease.

Page 4 of 5 | Total Record : 41

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