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Ahmed Abdillah
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Journal of Advances in Medicine and Pharmaceutical Sciences
Published by Lamintang Education & Training Centre
ISSN : 2964268X     EISSN : 29634253     DOI : https://doi.org/10.36079/lamintang.jamaps-xxxx.xxx
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Nursing Public Health
Journal of Advances in Medicine and Pharmaceutical Sciences (JAMAPS) scope are including but not limited to: ☛ Drug ☛ Chemistry ☛ Herbal Medicine ☛ Pharmaceutical Science ☛ General and Internal Medicine ☛ Pathology and Forensic Medicine ☛ Pharmacology, Toxicology and Pharmaceutics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 38 Documents
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Antihyperglycemic Effect of Gymnema inodorum in Type 2 Diabetes Management Kongcharoen, Watis; Jaturaporn, Ananya; Chavalit, Kittisak; Charoensup, Nathirat
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.686

Abstract

This study investigates the antihyperglycemic effects of Gymnema inodorum (Chiang Da), a traditional medicinal plant from northern Thailand, commonly used for managing blood glucose levels. The goal was to evaluate its pharmacological effects, including the inhibition of alpha-glucosidase and its ability to lower blood glucose levels in Type 2 diabetic rats. Ethanol maceration was used to extract bioactive compounds from Chiang Da leaves, yielding gymnemic acids, saponins, and flavonoids. The in vivo study involved administering Chiang Da tea to diabetic rats for 8 weeks, measuring fasting and postprandial blood glucose levels. Results showed a significant reduction in blood glucose levels in the Chiang Da-treated group, comparable to the synthetic drug metformin. In vitro tests also revealed the extract’s concentration-dependent inhibition of alpha-glucosidase, with an IC50 value of 45 µg/mL, indicating moderate potency in delaying glucose absorption. Descriptive and inferential statistics confirmed that Chiang Da tea significantly reduced blood glucose levels, though its effects were less pronounced than metformin’s. These findings support the potential of Chiang Da as a natural alternative for managing Type 2 diabetes, particularly for individuals seeking plant-based treatments. Future research should focus on clinical trials to further evaluate the efficacy and safety of Chiang Da for diabetes management, as well as explore its potential for combination therapy with conventional drugs to enhance therapeutic outcomes.
Exploring the Anticancer Potential of Ferula assa-foetida Bioactive Compounds and Molecular Mechanisms in Breast Cancer Treatment Marcecal, Korthiby; Hashemi, Ramin Hazemi; Jafari, Niloofar; Karimi, Mohammad Reza; Pouran, Leila
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.695

Abstract

Breast cancer is a major global health issue, with limited treatment options that often come with adverse side effects. Ferula assa-foetida, a medicinal plant known for its anti-inflammatory, antioxidant, and antimicrobial properties, has shown potential as an anticancer agent. This study investigates the anticancer effects of Ferula assa-foetida extracts on breast cancer cell lines (MCF-7 and T47D). The research identifies key bioactive compounds, such as ferulic acid and flavonoids, and explores their molecular mechanisms. In vitro assays, including cytotoxicity assays (MTT and Alamar Blue) and apoptosis detection (Annexin V/PI staining), were conducted to measure cell proliferation and apoptosis induction. Furthermore, PCR and Western blot analyses were used to examine the expression of apoptosis-related genes (p53, Bcl-2, and caspase-3). The results indicate that Ferula assa-foetida extracts significantly inhibit cell growth and induce apoptosis in breast cancer cells. This study provides insights into the potential of Ferula assa-foetida as a complementary treatment for breast cancer and supports further research to evaluate its clinical applicability.
Pharmacological Evaluation of Sambong Blumea balsamifera on Diuretic and Kidney Stone Dissolution Effects Jose, Stefhene; Garcia, Maria; Lopez, Juan; Reyes, Ana; Cruz, Luis
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.734

Abstract

This study investigates the pharmacological effects of Blumea balsamifera (Sambong), a plant traditionally used in Filipino medicine for its diuretic and kidney stone-dissolving properties. Using Soxhlet and maceration extraction methods, Sambong extracts were obtained from the leaves and roots of the plant with ethanol as the solvent. Phytochemical analysis revealed bioactive compounds including flavonoids (luteolin, quercetin) and terpenoids (β-caryophyllene), known for their anti-inflammatory, antioxidant, and diuretic effects. The diuretic activity was tested in rats, where Sambong extracts (50 mg/mL and 100 mg/mL) were administered and the urine output was measured over 24 hours. The results showed a dose-dependent increase in urine output, with the 100 mg/mL dose producing a significant increase compared to the control group treated with furosemide. In addition to its diuretic effects, Sambong’s potential to dissolve kidney stones was evaluated by treating rats with calcium oxalate stones. The results indicated a significant reduction in stone size, with the 100 mg/mL dose achieving a 38% reduction. The comparative analysis with furosemide demonstrated that Sambong is a promising natural alternative for managing conditions such as hypertension, kidney stones, and urinary disorders, particularly in areas with limited access to pharmaceutical treatments. These findings validate Sambong’s traditional uses and highlight its therapeutic potential in modern healthcare. Future research should focus on clinical trials to assess its safety, optimal dosage, and efficacy in humans. Further investigation into its pharmacological mechanisms, including its anti-inflammatory and antimicrobial properties, could expand its use in treating various conditions, integrating Sambong into contemporary healthcare systems, especially in underserved areas.
Pharmaceutical Innovations and Stewardship Programs in Combating Antimicrobial Resistance Merddy, Ousu; Rahul, Amit; Gupta, Sharma; Martin, James; Taylor, Sarah; Wilson, Matthew
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.736

Abstract

This study evaluates the effectiveness of the UK’s AMR Strategy 2019-2024 in combating antimicrobial resistance (AMR), focusing on pharmaceutical innovations. By analyzing trends in human and veterinary antibiotic use alongside resistance rates, the research identifies improvements in reducing antibiotic consumption and resistance, with MRSA resistance declining from 10% in 2016 to 6% in 2023. Despite these positive trends, the research highlights ongoing challenges in the development and implementation of new antibiotics and alternative therapies. Semi-structured interviews with stakeholders, including policymakers and pharmaceutical experts, reveal barriers such as regulatory issues, slow innovation, and insufficient funding for new drug development. The study also examines case studies of pharmaceutical innovations, including β-lactamase inhibitors, bacteriophage therapies, and antimicrobial peptides, noting progress in some areas, but significant gaps in others. The research concludes that while the UK’s AMR Strategy has led to some positive outcomes, further efforts are needed to accelerate the development of novel therapies and address structural barriers in the pharmaceutical sector. Future research should focus on enhancing international collaboration, improving regulatory frameworks, and incentivizing innovation to combat AMR more effectively. Comparative analysis with other countries' strategies could also provide valuable insights for improving the UK’s response to the AMR crisis.
Activity Test of Matoa Leaves on Angiotensin II as an Increasing SOD and GPx Oentari, Octaviana Dyah; Peranginangin, Jason Merari; Purwidyaningrum, Ika
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.752

Abstract

The leaves of the matoa are plants that can be used for hypertension. Matoa leaves were assume to have thought to have hypertensive activity because they contain flavonoids (quercetin-3-O-rhamnosida). Flavonoids can lower blood pressure which is modulated by the Renin-Angiotensin-Aldosterone System (SRAA). Was to fine out about the giving process of matoa leaf extract and fractions in increasing levels of SOD and GPx. This research used the maceration method with 96% ethanol solvent and fractionated by liquid-liquid method using n-hexane fraction solvent, ethyl acetate fraction, and water fraction. In this study, 21 male white rats with Wistar strain were divided into 7 groups, group I named as normal control, group II as negative control (CMC-Na 1%), group III as positive control (Irbesartan), and Group IV. (matoa leaf extract), Group V (n-hexane fraction group VI (ethyl acetate fraction) group VII (water fraction). The data obtained were analyzed with the Shapiro Wilk test, Levene's test and ANOVA. The results showed that the matoa leaf extract a dose 300mg/kg BB lower blood pressure in angiotensin II induced rats incrase SOD and GPx levels in the liver induced by Angiotensin II.
Assessing the Feasibility and Challenges of CRISPR-Cas9 for Treating Genetic Disorders Fernández, Maria; Madriñan, Valmore; Santiago, Palacio; Bermudez, Andrés
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.774

Abstract

This study explores the potential applications of CRISPR-Cas9 technology in treating genetic disorders in Colombia, with a specific focus on thalassemia and sickle cell anemia, which disproportionately affect Afro-Colombians. Given the country’s rich genetic diversity, which includes Afro-Colombians, mestizos, and indigenous populations, the study examines how CRISPR could be tailored to address region-specific genetic mutations and improve health outcomes. The objective of this research is to assess the feasibility, challenges, and strategic implications of CRISPR for genetic disorders in Colombia, considering factors such as healthcare infrastructure, social resistance, and genetic variation. The methodology employed includes a comprehensive review of existing literature, comparative analysis of global CRISPR applications, and a synthesis of data from genetic studies specific to Colombia’s population. The findings indicate that while CRISPR offers significant promise for addressing genetic diseases, challenges such as healthcare accessibility, high costs, and the country’s genetic diversity must be overcome. Furthermore, ethical concerns regarding genetic modification must be addressed through public education and engagement. Future research should focus on expanding genetic databases, particularly for underrepresented populations, and exploring the economic and social implications of CRISPR therapies in Colombia's rural and marginalized communities. These efforts will help ensure that CRISPR technology is effectively and equitably applied to improve public health outcomes.
Ethnopharmacology Study and Therapeutic Potential of Cassia alata for Skin Diseases Khampheng, Vongphachanh; Phoummixay, Nanludet; Sythanonxay, Onmavong
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.775

Abstract

This study explores the ethnopharmacological knowledge of Cassia alata in the treatment of skin diseases in rural Laotian communities. Traditional practices highlight the use of the plant to treat fungal infections, eczema, and other skin conditions, driven by its antimicrobial and anti-inflammatory properties. This study aimed to document and scientifically validate the therapeutic applications of Cassia alata, with a focus on its safety, efficacy, and potential for dermatological product development. A mixed methods approach was used, involving ethnographic interviews with members of a rural Laotian community, laboratory tests to assess antimicrobial activity, and dermatological safety testing. The findings revealed that Cassia alata is widely used in rural areas, with a high degree of confidence in its ability to treat a variety of skin conditions. Microbiological tests confirmed its effectiveness against common pathogens such as Trichophyton and Candida, while dermatological tests demonstrated its safety with minimal side effects. The potential of the plant for dermatological product development is significant, with potential for commercialization and economic benefits to the local community. However, further research is needed to identify active compounds, assess long-term use, and optimize product formulations. This study provides a basis for future research on the global application of Cassia alata as a natural dermatological treatment.
Policies, Progress and Challenges in Addressing Antimicrobial Resistance Torhild, Hilde Juzeniene; Geisler, Andreas; Kirstin, Agnete Olga
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.804

Abstract

Antimicrobial Resistance (AMR) poses a critical challenge to global healthcare systems, including Norway, despite its relatively low antibiotic consumption rate. This study aims to evaluate antibiotic resistance rates, analyze government policies, and explore progress in the development of antibiotics and alternative therapies in Norway. A qualitative descriptive design with a case study approach was used, combining data from policy documents, research articles, and semi-structured interviews with 30 respondents, including microbiologists, healthcare professionals, and policymakers from Oslo, Bergen, and Tromsø. Findings reveal that although Norway’s antibiotic resistance rate is lower than other European countries, certain bacteria, such as MRSA, Enterococcus faecium, and ESBL-producing E. coli, remain problematic in hospitals. The Norwegian government’s strict management policies, including prescription restrictions and diagnostic mandates, have effectively reduced resistance. In addition, research on new antibiotics and alternative therapies, such as phage therapy and probiotics, shows promise but requires further exploration. Challenges such as high R&D costs, resource constraints, and the global spread of resistant bacteria hinder progress. This study highlights the need for international collaboration, innovative funding models, and expanded research into alternative therapies. Future studies should address hospital-specific resistance challenges and strategies to accelerate antibiotic development. Norway’s experience provides valuable insights for global AMR management and policy.
Transforming Peperomia pellucida into a Modern Pharmaceutical Tablet for Gout Zittelli, Eva Chiara; Pabayo, Prudente Estabaya; Julieta, Maria Eva; Chakthranont, Thanarat; Pongkarn, Busarakorn
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 1: May 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0401.702

Abstract

Ulasimang Bato is a plant endemic to the Philippines, which is known in Latin as Peperomia pellucida. Ulasimang Bato has been widely used in the Philippines as a conventional treatment for gout. This study sought to assess the conversion of Ulasimang Bato into a contemporary pharmaceutical tablet for the treatment of gout, by examining its efficacy, safety, and use in the formal health care system alongside Allopurinol, a conventional therapy. The study was conducted from February to April 2025, a clinical trial was conducted with 300 participants, consisting of 150 people taking Ulasimang Bato tablets and 150 people taking Allopurinol, from rural areas of the Philippines. Laboratory tests validated the presence of active constituents, including flavonoids, tannins, and phenolic acids, which are thought to play a role in the anti-inflammatory, analgesic, and antioxidant properties. The study revealed that Ulasimang Bato tablets offered similar symptom relief to Allopurinol, with significantly fewer side effects, especially those related to gastrointestinal problems. This suggests that Ulasimang Bato could be a safer option for gout sufferers, especially those who cannot tolerate the side effects of Allopurinol. Furthermore, the integration of traditional medicine into the formal healthcare system shows significant community acceptance, although there are still obstacles in terms of regulation and training for healthcare practitioners. Future research should focus on extensive clinical trials to ensure the long-term safety and efficacy of Ulasimang Bato, while addressing the obstacles to its integration into the healthcare system.
Navigating the Rise of Cannabidiol: Trends, Challenges, and Future Directions Johansson, Erik; Quennerstedt, Joakim; Langer, Anneli Eva; Kullander, Stenberg
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 1: May 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0401.771

Abstract

The use of cannabidiol (CBD) as an alternative treatment for chronic pain and anxiety is experiencing a rapid rise in Sweden. This study explores current trends, patient and healthcare provider perceptions, regulatory challenges, and barriers to broader CBD adoption. Employing a mixed-methods design, quantitative surveys and qualitative interviews are conducted with CBD users and healthcare professionals across various regions in Sweden. Findings indicate that CBD usage is highest in urban areas, driven by greater accessibility and wellness culture. Patients report moderate to high satisfaction, particularly for chronic pain management, although self-medication practices and lack of professional guidance are common. Healthcare providers exhibit cautious optimism, citing the need for further clinical validation and regulatory clarity. Safety concerns such as inaccurate product labeling and financial barriers, including the absence of insurance coverage for CBD, emerge as significant obstacles. Demographic analysis reveals differing usage patterns based on age but minimal gender differences. The study highlights the urgent need for standardized dosing guidelines, rigorous randomized controlled trials (RCTs), and stronger regulatory frameworks to ensure quality and equity in CBD treatment. Sweden’s progressive healthcare landscape positions it to play a leading role in global efforts to integrate CBD responsibly into mainstream medicine. Future research must bridge clinical, regulatory, and economic gaps to support CBD’s evolution as a legitimate therapeutic option worldwide.

Page 3 of 4 | Total Record : 38

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