Media Dermato-Venereologica Indonesiana
Media dermato Venereologica Indonesiana adalah jurnal open access dan peer-reviewed yang fokus di bidang dermatologi dan venereologi. Jurnal ini menerbitkan artikel asli, laporan kasus, tinjauan pustaka dan komunikasi singkat mengenai kesehatan kulit dan kelamin, diagnosis dan terapi pada bidang kulit dan kelamin dan masalah lainnya di bidang kesehatan kulit dan kelamin.
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<![CDATA[EFIKASI LASER FRAKSIONAL ERBIUM-DOPED YTTRIUM-GARNET (Er:YAG) 2940 NM PADA PASIEN SKAR AKNE ATROFI DENGAN USIA YANG BERBEDA: LAPORAN KASUS SERIAL ]]>
<![CDATA[ Media Dermato Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
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DOI: 10.33820/mdvi.v49i4.274
<![CDATA[Skar akne terjadi sebagai akibat penyembuhan lesi akne inflamasi. Skar atrofi merupakan jenis yang paling banyak ditemukan. Laser fraksional erbium-doped yttrium-garnet (Er:YAG) 2940nm memiliki target kerja di epidermis dan dermis dengan cara membuat zona mikrotermal, sehingga proses penyembuhan lebih cepat dan efek samping paska laser lebih minimal. Dilaporkan efikasi laser fraksional Er:YAG 2940nm pada pasien dengan usia yang berbeda. Empat pasien dengan skar akne atrofi tingkat 3-4 menurut sistem penilaian global kualitatif Goodman dan Baron, tipe kulit Fitzpatrick’s IV, dilakukan laser fraksional Er:YAG 2940nm dengan tip 7x7, parameter mode sedang dan energi 800mJ. Aplikasi anestesi topikal sebelum laser. Dipastikan bahwa semua pasien tidak ada riwayat infeksi, keloid, fotosensitifitas, dan alergi anestesi. Perawatan paska laser yaitu penggunaan tabir surya rutin dan diberikan topikal campuran moisturizer-antibiotik selama lima hari. Penilaian efikasi laser dilakukan dengan membandingkan foto sebelum dan setelah laser. Semua pasien menunjukkan perbaikan klinis yang baik, tetapi jumlah pengulangan laser lebih banyak pada pasien usia di atas 40 tahun. Tidak ditemukan efek samping paska laser. Berdasarkan hasil ini maka laser fraksional Er:YAG 2940nm memberikan efikasi yang baik untuk pasien usia muda.]]>
<![CDATA[DIAGNOSIS DAN TATA LAKSANA NEVUS HORI ]]>
<![CDATA[ Media Dermato Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
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DOI: 10.33820/mdvi.v49i4.284
<![CDATA[Nevus Hori (NH) merupakan hipermelanosis dermal didapat yang ditandai bercak coklat keabuan. NH bermanifestasi terutama di daerah fasial seperti zigomatikum, dahi, pelipis, kelopak mata dan pangkal hidung, tetapi dapat juga di ekstra fasial. NH memengaruhi kualitas hidup penderitanya karena dapat menganggu penampilan. Awitan NH bervariasi, dapat terjadi antara usia 12-72 tahun. Genetik memegang peran penting dalam patofisiologi NH. Beberapa faktor pencetus yang telah diidentifikasi terkait NH antara lain, inflamasi, radiasi ultraviolet, kehamilan, kontrasepsi, dan kosmetik. Manifestasi klinis NH sering menyerupai kelainan hiperpigmentasi dermal lain seperti melasma, nevus Ota, dan melanosis Riehl, sehingga masih sering terjadi kesalalahan diagnosis. Penegakan diagnosis dilakukan dengan mempertimbangkan manifestasi klinis pasien. Pemeriksaan penunjang tidak rutin dilakukan pada kasus NH. Bila diperlukan, pemeriksaan baku emas berupa pemeriksaan histopatologi dapat dilakukan. Tata laksana NH memiliki tantangan tersendiri. Tata laksana NH yang utama adalah menghindari tersediri. Tata laksana defenitif untuk kasus MH dilakukan dengan terapi kombinasi, baik terapi farmakologis dan non-farmakologis. Pilihan terapi yang dapat digunakan adalah terapi topikal, dan tindakan invasif seperti dermabrasi, krioterapi dan laser.]]>
<![CDATA[PERKEMBANGAN TERKINI PATOGENESIS DAN TATALAKSANA SELULIT ]]>
<![CDATA[ Media Dermato Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
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DOI: 10.33820/mdvi.v49i4.388
<![CDATA[Cellulite is characterized by skin topography alterations that have been described as peau d'orange, cottage cheese or mattress-like appearance. All age groups and both sexes could have cellulite, especially post-puberty females. Cellulite is more common seen in Caucasian than Asian woman. Based on the study of woman skin anatomy, fat cells and connective tissue are aligned vertically so that fat cells could protrude into the skin layer and cause cellulite. The pathogenesis of cellulite is controversial and the etiology are multifactorial. If the etiopathogenesis are already known, more effective treatments could be developed. Three main cellulite theories are adipocyte accumulation, water retention and septa fibrosis. Several combination theories associated with cellulit include genetic, hormonal, vascular insufficiency, chronic inflammation, dietary and neurological effects. Clinical evaluation and associated conditions are important for assessing the severity of cellulite and are useful for determining various treatment options. To date, cellulite treatment still a challenge, require long-term stability of influencing factors.]]>
<![CDATA[PORFIRIA ERITROPOETIK KONGENITAL: STUDI KASUS DI LOMBOK ]]>
<![CDATA[ Media Dermato Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
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DOI: 10.33820/mdvi.v49i4.399
<![CDATA[Introduction: porphyria is a group of disorders caused by enzyme deficiency in heme synthesis pathway. Congenital erythropoietic porphyria (CEP) is an extremely rare cutaneous porphyria caused by mutations in the gene encoding uroporphyrinogen III synthase leading to accumulation of porphyrins in erythrocytes and tissues such as skin, teeth and bone resulting in hemolytic anemia, photosensitivity and erythrodontia. Case: we present two cases of CEP with typical manifestation of blistering neonatal-onset photosensitivity, erythrodontia and red-colored urine, as well as one case with hemolytic anemia. Both had no prior history of acute neurological episodes or abdominal pain that establish the cutaneous porphyria diagnosis. Pink fluorescence was visible on the teeth and urine under the Wood's lamp. Further investigations were not conducted. Discussion: the diagnosis of CEP can be established on its typical clinical manifestations and simple investigations with Wood's lamp, confirmed by examination of urine and feces porphyrins, identification of UROS or X-linked GATA 1 gene mutations. CEP management is in the form of comprehensive photoprotection and treatment with various disciplines because the clinical manifestations and severity of CEP vary in each patient. Early age of onset and severity of haematological symptoms are factors that determine poor prognosis. Keywords: congenital erythropoietic porphyria, bullous porphyria, cutaneous porphyria, uroporphyrinogen III synthase.]]>
<![CDATA[EFEK TERAPI PURIFIED PROTEIN DERIVATIVE TERHADAP KADAR INTERLEUKIN-12 SERUM PASIEN KUTIL ANOGENITAL ]]>
<![CDATA[ Media Dermato Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
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DOI: 10.33820/mdvi.v49i4.413
<![CDATA[Anogenital warts (AGWs) are benign epithelial proliferation of the skin/mucosa, caused by human papillomavirus (HPV), with clinical manifestation of warts in the genital/perianal areas. Cellular immunity plays a role in the elimination of HPV, which characterized by the expression of cytokines with Thelper (Th)-1 cell pattern, namely interleukin (IL)-12 which will increases Tcell proliferation and differentiation into Th-1, pro-inflammatory cytokines secretion, also induce natural killer cells to increase proliferation and pro-inflammatory cytokines. In in vitro studies, PPD increased IL-12 expression in serum verruca vulgaris patients (p<0,05) compared to control. There are no study of serum IL-12 levels in AGWs petients who received intralesional PPD injection in Indonesia, so this is the aim of this study. This research isone group pre- and post-test design based on an experimental analytic study. The samples were 14 serum of AGWs patients before and after receiving PPD therapy. Serum IL-12 levels meassured by enzyme linked immunosorbent assay. Results showedserum IL-12 levels before receiving therapy was 45.73±53.186pg/ml. After receiving PPD therapy, serum IL-12 levels increased by an average of 45.9pg/ml, became 91.68±79.321pg/ml (p=0,158). As conclusion,level of IL-12 in the serum of AGWs patients does not increase after receiving PPD therapy.]]>
<![CDATA[EFIKASI LASER FRAKSIONAL ERBIUM-DOPED YTTRIUM-GARNET (Er:YAG) 2940 NM PADA PASIEN SKAR AKNE ATROFI DENGAN USIA YANG BERBEDA: LAPORAN KASUS SERIAL ]]>
<![CDATA[Ninda Sari]]>
<![CDATA[ Media Dermato-Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
Show Abstract
|
Download Original
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Original Source
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DOI: 10.33820/mdvi.v49i4.274
<![CDATA[Skar akne terjadi sebagai akibat penyembuhan lesi akne inflamasi. Skar atrofi merupakan jenis yang paling banyak ditemukan. Laser fraksional erbium-doped yttrium-garnet (Er:YAG) 2940nm memiliki target kerja di epidermis dan dermis dengan cara membuat zona mikrotermal, sehingga proses penyembuhan lebih cepat dan efek samping paska laser lebih minimal. Dilaporkan efikasi laser fraksional Er:YAG 2940nm pada pasien dengan usia yang berbeda. Empat pasien dengan skar akne atrofi tingkat 3-4 menurut sistem penilaian global kualitatif Goodman dan Baron, tipe kulit Fitzpatrick’s IV, dilakukan laser fraksional Er:YAG 2940nm dengan tip 7x7, parameter mode sedang dan energi 800mJ. Aplikasi anestesi topikal sebelum laser. Dipastikan bahwa semua pasien tidak ada riwayat infeksi, keloid, fotosensitifitas, dan alergi anestesi. Perawatan paska laser yaitu penggunaan tabir surya rutin dan diberikan topikal campuran moisturizer-antibiotik selama lima hari. Penilaian efikasi laser dilakukan dengan membandingkan foto sebelum dan setelah laser. Semua pasien menunjukkan perbaikan klinis yang baik, tetapi jumlah pengulangan laser lebih banyak pada pasien usia di atas 40 tahun. Tidak ditemukan efek samping paska laser. Berdasarkan hasil ini maka laser fraksional Er:YAG 2940nm memberikan efikasi yang baik untuk pasien usia muda.]]>
<![CDATA[DIAGNOSIS DAN TATA LAKSANA NEVUS HORI ]]>
<![CDATA[Sarah Diba]]>;
<![CDATA[Cayadi Sidarta Antonius]]>;
<![CDATA[Yuli Kurniawati]]>;
<![CDATA[Soenarto Kartowigno]]>;
<![CDATA[Susanti Budiamal]]>
<![CDATA[ Media Dermato-Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
Show Abstract
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DOI: 10.33820/mdvi.v49i4.284
<![CDATA[Nevus Hori (NH) merupakan hipermelanosis dermal didapat yang ditandai bercak coklat keabuan. NH bermanifestasi terutama di daerah fasial seperti zigomatikum, dahi, pelipis, kelopak mata dan pangkal hidung, tetapi dapat juga di ekstra fasial. NH memengaruhi kualitas hidup penderitanya karena dapat menganggu penampilan. Awitan NH bervariasi, dapat terjadi antara usia 12-72 tahun. Genetik memegang peran penting dalam patofisiologi NH. Beberapa faktor pencetus yang telah diidentifikasi terkait NH antara lain, inflamasi, radiasi ultraviolet, kehamilan, kontrasepsi, dan kosmetik. Manifestasi klinis NH sering menyerupai kelainan hiperpigmentasi dermal lain seperti melasma, nevus Ota, dan melanosis Riehl, sehingga masih sering terjadi kesalalahan diagnosis. Penegakan diagnosis dilakukan dengan mempertimbangkan manifestasi klinis pasien. Pemeriksaan penunjang tidak rutin dilakukan pada kasus NH. Bila diperlukan, pemeriksaan baku emas berupa pemeriksaan histopatologi dapat dilakukan. Tata laksana NH memiliki tantangan tersendiri. Tata laksana NH yang utama adalah menghindari tersediri. Tata laksana defenitif untuk kasus MH dilakukan dengan terapi kombinasi, baik terapi farmakologis dan non-farmakologis. Pilihan terapi yang dapat digunakan adalah terapi topikal, dan tindakan invasif seperti dermabrasi, krioterapi dan laser.]]>
<![CDATA[PERKEMBANGAN TERKINI PATOGENESIS DAN TATALAKSANA SELULIT ]]>
<![CDATA[Ira Armayanti]]>;
<![CDATA[Nelva Karmila Jusuf]]>
<![CDATA[ Media Dermato-Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
Show Abstract
|
Download Original
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Original Source
|
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|
DOI: 10.33820/mdvi.v49i4.388
<![CDATA[Cellulite is characterized by skin topography alterations that have been described as peau d'orange, cottage cheese or mattress-like appearance. All age groups and both sexes could have cellulite, especially post-puberty females. Cellulite is more common seen in Caucasian than Asian woman. Based on the study of woman skin anatomy, fat cells and connective tissue are aligned vertically so that fat cells could protrude into the skin layer and cause cellulite. The pathogenesis of cellulite is controversial and the etiology are multifactorial. If the etiopathogenesis are already known, more effective treatments could be developed. Three main cellulite theories are adipocyte accumulation, water retention and septa fibrosis. Several combination theories associated with cellulit include genetic, hormonal, vascular insufficiency, chronic inflammation, dietary and neurological effects. Clinical evaluation and associated conditions are important for assessing the severity of cellulite and are useful for determining various treatment options. To date, cellulite treatment still a challenge, require long-term stability of influencing factors.]]>
<![CDATA[PORFIRIA ERITROPOETIK KONGENITAL: STUDI KASUS DI LOMBOK ]]>
<![CDATA[Yunita Hapsari]]>;
<![CDATA[Dinie Ramdhani K]]>
<![CDATA[ Media Dermato-Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.33820/mdvi.v49i4.399
<![CDATA[Introduction: porphyria is a group of disorders caused by enzyme deficiency in heme synthesis pathway. Congenital erythropoietic porphyria (CEP) is an extremely rare cutaneous porphyria caused by mutations in the gene encoding uroporphyrinogen III synthase leading to accumulation of porphyrins in erythrocytes and tissues such as skin, teeth and bone resulting in hemolytic anemia, photosensitivity and erythrodontia. Case: we present two cases of CEP with typical manifestation of blistering neonatal-onset photosensitivity, erythrodontia and red-colored urine, as well as one case with hemolytic anemia. Both had no prior history of acute neurological episodes or abdominal pain that establish the cutaneous porphyria diagnosis. Pink fluorescence was visible on the teeth and urine under the Wood's lamp. Further investigations were not conducted. Discussion: the diagnosis of CEP can be established on its typical clinical manifestations and simple investigations with Wood's lamp, confirmed by examination of urine and feces porphyrins, identification of UROS or X-linked GATA 1 gene mutations. CEP management is in the form of comprehensive photoprotection and treatment with various disciplines because the clinical manifestations and severity of CEP vary in each patient. Early age of onset and severity of haematological symptoms are factors that determine poor prognosis. Keywords: congenital erythropoietic porphyria, bullous porphyria, cutaneous porphyria, uroporphyrinogen III synthase.]]>
<![CDATA[EFEK TERAPI PURIFIED PROTEIN DERIVATIVE TERHADAP KADAR INTERLEUKIN-12 SERUM PASIEN KUTIL ANOGENITAL ]]>
<![CDATA[Oki Suwarsa]]>;
<![CDATA[Pati Aji Achdiat]]>;
<![CDATA[Rasmia Rowawi]]>;
<![CDATA[Yudi Mulyana Hidayat]]>;
<![CDATA[Muhammad Nasir Shafiee]]>;
<![CDATA[Hendra Gunawan]]>;
<![CDATA[Reiva Farah Dwiyana]]>;
<![CDATA[Reyshiani Johan]]>
<![CDATA[ Media Dermato-Venereologica Indonesiana Vol 49 No 4 (2022) ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI) ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.33820/mdvi.v49i4.413
<![CDATA[Anogenital warts (AGWs) are benign epithelial proliferation of the skin/mucosa, caused by human papillomavirus (HPV), with clinical manifestation of warts in the genital/perianal areas. Cellular immunity plays a role in the elimination of HPV, which characterized by the expression of cytokines with Thelper (Th)-1 cell pattern, namely interleukin (IL)-12 which will increases Tcell proliferation and differentiation into Th-1, pro-inflammatory cytokines secretion, also induce natural killer cells to increase proliferation and pro-inflammatory cytokines. In in vitro studies, PPD increased IL-12 expression in serum verruca vulgaris patients (p<0,05) compared to control. There are no study of serum IL-12 levels in AGWs petients who received intralesional PPD injection in Indonesia, so this is the aim of this study. This research isone group pre- and post-test design based on an experimental analytic study. The samples were 14 serum of AGWs patients before and after receiving PPD therapy. Serum IL-12 levels meassured by enzyme linked immunosorbent assay. Results showedserum IL-12 levels before receiving therapy was 45.73±53.186pg/ml. After receiving PPD therapy, serum IL-12 levels increased by an average of 45.9pg/ml, became 91.68±79.321pg/ml (p=0,158). As conclusion,level of IL-12 in the serum of AGWs patients does not increase after receiving PPD therapy.]]>
