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DEPIGMENTING AGENT MELANOTOKSIK PADA PENGOBATAN MELASMA Winawati Eka Putri; Yuli Kurniawati; Tantawi Djauhari
Jurnal Ilmu Kesehatan dan Kesehatan Vol 2 No 2 (2018): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v2i2.584

Abstract: Human skin color is determined by melanin pigment,either eumelanin or feomelanin.Melanogenesis is a melanin synthesized process that is initiated with tirosin oxidation to DOPAquinoneby tirosinase, and then auto-oxidation to DOPA and DOPAchrome. Eumelanin are formed fromDOPAchrome, while pheomelanin from DOPAquinone with the presence of cysteine or gluthathione.Hyperpigmentation disorders like melasma, are difficult to treat especially in dark skinned individuals.Treatment of melasma can be topical or physical. Topical agent can use depigmenting agent, eitherindividual or combination with other. Depigmenting agent can be melanotoxic or toxic to melanocytewhich can be cell killing or cell damage. Hydroquinone, monomethyl of hydroqunone, N-acetyl-4-Scysteaminylphenol ,and azelaic acid are depigmenting agents melanotoxic. Majority of those agents actas tirosinase inhibitors which cause deactivation of tirosinase. The use of those agents in combinationare better to minimalize side effect of agents.

Hubungan Hasil Uji Tusuk Kulit Alergen Nyamuk Terhadap Keparahan Klinis Dermatitis Atopik di RSUP Dr. Mohammad Hoesin Palembang Indah Permata Sari; M.Athuf Thaha; Yuli Kurniawati; R.M. Suryadi Tjekyan
Majalah Kedokteran Sriwijaya Vol 46, No 2 (2014): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v46i2.2689

Dermatitis atopik (DA) merupakan inflamasi kulit yang kronik residif. Salah satu etiologi DA yaitu sensitisasi alergen. Alergi nyamuk disebabkan sensitisasi terhadap alergen nyamuk (protein saliva nyamuk) yang menimbulkan respon IgE spesifik sehingga dapat didiagnosis dengan uji tusuk kulit. Respon IgE spesifik diduga berperan terhadap keparahan klinis DA. Meneliti hubungan hasil uji tusuk kulit alergen nyamuk dengan keparahan klinis DA di RSUP Dr. Mohammad Hoesin Palembang. Penelitian observasional analitik laboratorik dengan rancangan penelitian potong lintang dilaksanakan mulai Agustus hingga Oktober 2011 di Poliklinik IKKK Divisi Alergo-Imunologi RSUP MH Palembang. Total pasien 80 orang yang memenuhi kriteria inklusi dan ekslusi dipilih secara consecutive random sampling. Uji tusuk kulit alergen nyamuk dilakukan pada semua pasien kemudian dinilai keparahan klinis berdasarkan Scoring Atopic Dermatitis (SCORAD). Uji tusuk kulit alergen nyamuk yang positif ditemukan pada 75% pasien dan terdapat perbedaan proporsi hasil uji tusuk kulit alergen nyamuk pada berbagai tingkat keparahan klinis DA (p=0.000). Terdapat hubungan yang kuat antara hasil uji tusuk kulit alergen nyamuk dengan keparahan klinis DA (p=0.000). SCORAD dapat diprediksi menggunakan rumus regresi ganda 16.394 + (4.792 x hasil uji tusuk kulit alergen nyamuk). Alergi nyamuk mempengaruhi keparahan klinis DA.

Diagnosis and Management of Female Pattern Hair Loss Sarah Diba; Maria Mayfinna Gozali; Yuli Kurniawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 1 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i1.111

Abstract Female pattern hair loss (FPHL) is the most common hair loss in post-puberty female. Prevalence of this nonscarring alopecia increases with age. The etiology of FPHL is still unclear, but hormonal and genetic factors are associated with pathogenesis of FPHL. Hormonal factor in FPHL is not as strong as in male pattern hair loss (MPHL). Clinical manifestations of FPHL are characterized by nonscarring baldness with shortening anagen phases and miniaturization of hair follicles, predominantly occur at the vertex, middle, and frontal regions. Hair shedding occurs progressively. The diagnosis of FPHL is established based on clinically. Classification of FPHL is according to Ludwig's criteria. Current FDA-approved FPHL therapy is topical minoxidil 2%, hair transplantation, and low level laser therapy (LLLT). Anti-androgen therapy still needs to be investigated further. The prognosis of FPHL is poor because the progressiveness continues with age. Long term treatment required for FPHL because it is a chronic residif disease. The treatment only prevents the progression of hair loss and does not cure.

PENGARUH AKUNTABILITAS PENGELOLAAN KEUANGAN ALOKASI DANA KAMPUNG, KEBIJAKAN KAMPUNG DAN KELEMBAGAAN KAMPUNG TERHADAP KESEJAHTERAAN MASYARAKAT (Studi Pada Kampung Distrik Sentani Kabupaten Jayapura) Yuli Kurniawati; Bill J. C. Pangayow
JURNAL AKUNTANSI DAN KEUANGAN DAERAH Vol 12 No 2 (2017)
Publisher : Jurnal Akuntansi dan Keuangan Daerah

Tujuan dari penelitian ini untuk menguji pengaruh akuntabilitas pengelolaan keuangan alokasi dana kampung, kebijakan kampung, dan kelembagaan kampung terhadap kesejahteraan masyarakat. Penelitian ini dilakukan pada kampung Distrik Sentani Kabupaten Jayapura. Jumlah sampel yang diambil sebanyak 65 responden masyarakat yang mendapatkan alokasi dana kampung dari berbagai latar pendidikan dan pekerjaan yang berbeda-beda. Penelitian ini menggunakan metode purposive sampling dengan menyebarkan kuesioner kepada responden. Teknik analisis menggunakan SmartPLS (Partial Least Square). Hasil penelitian ini menunjukkan bahwa Alokasi Dana Kampung, Kebijakan Kampung, dan Kelembagaan Kampung tidak berpengaruh signifikan terhadap Kesejahteraan Masyarakat.

KULTUR PRIMER FIBROBLAS: PENELITIAN PENDAHULUAN Yuli Kurniawati; Sudigdo Adi; Achadiyani Achadiyani; Oki Suwarsa; Dimas Erlangga; Tenny Putri
Majalah Kedokteran Andalas Vol 38, No 1 (2015): Published in May 2015
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakKultur sel fibroblas banyak digunakan untuk penelitian proses penyembuhan luka dan penuaankulit. Metode ini digunakan untuk melihat perkembangan sel, proliferasi kinetik seluler, sertabiosintesis komponen matriks ekstraseluler. Penelitian pendahuluan ini dilakukan untuk optimasiteknik laboratorium serta berbagai kendala yang didapatkan saat kultur fibroblas. Kultur primerfibroblas dibagi menjadi 2 jenis sampel yaitu sampel yang berasal dari embrio mencit usia 7,5–9,5 hari, dan kulit pasien keloid. Sampel dari embrio mencit dilakukan kultur primer denganmetode dissociated fibroblast. Sampel jaringan keloid dan kulit normal dikultur dengan metodeskin explant. Fibroblas yang berasal dari kultur primer embrio mencit tumbuh baik sehinggadapat dilakukan subkultur dan disimpan di dalam nitrogen cair suhu -198°C. Fibroblas yangberasal dari sampel keloid pertama tumbuh sesuai pola pertumbuhan fibroblas, namun padasampel kedua terdapat kontaminasi Paecilomyces sp. yang merupakan salah satu jenis jamurkontaminan. Sel fibroblas mudah untuk dikultur karena memiliki kemampuan tumbuh danmelekat yang tinggi serta regenerasi cepat, namun penelitian lebih lanjut untuk optimasi teknikkultur dan pencegahan kontaminasi masih dibutuhkan sehingga sel dapat tumbuh baik.AbstractFibroblast cell culture method has been used for wound healing and skin aging studies. Thismethod was used for cell development imaging study, celullar kinetic proliferation andextracelullar matrix component biosynthesis. This preeliminary study was done for laboratoricaltechnic optimation as well as problems appeared in fibroblast culture. Fibroblasts primary culturewas divided into 2 type of samples, from 7.5-9.5-day-mice embryo and keloid-patient skin.Primary culture with dissociated fibroblast method was done for mice embryo sample. Keloidtissue sample and normal skin were cultured with skin explant method. Fibroblasts that weretaken from mice embryo primary culture grew well therefore subculture can be done and kept in -198°C liquid nitrogen storage. Fibroblasts that were taken from first keloid sample grewaccording to fibroblast growth pattern, but, there was contamination with Paecilomyces sp. whichwas one of the contaminating fungi. Fibroblast cells are easy to be cultured as they have growthability and high adhesion capability as well as rapid regeneration, but, further study for culturedtechnical optimation and contamination prevention are still neededthereforethe cells can growwell.

Diagnosis and Management of Female Pattern Hair Loss Sarah Diba; Maria Mayfinna Gozali; Yuli Kurniawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 1 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i1.111

Abstract Female pattern hair loss (FPHL) is the most common hair loss in post-puberty female. Prevalence of this nonscarring alopecia increases with age. The etiology of FPHL is still unclear, but hormonal and genetic factors are associated with pathogenesis of FPHL. Hormonal factor in FPHL is not as strong as in male pattern hair loss (MPHL). Clinical manifestations of FPHL are characterized by nonscarring baldness with shortening anagen phases and miniaturization of hair follicles, predominantly occur at the vertex, middle, and frontal regions. Hair shedding occurs progressively. The diagnosis of FPHL is established based on clinically. Classification of FPHL is according to Ludwig's criteria. Current FDA-approved FPHL therapy is topical minoxidil 2%, hair transplantation, and low level laser therapy (LLLT). Anti-androgen therapy still needs to be investigated further. The prognosis of FPHL is poor because the progressiveness continues with age. Long term treatment required for FPHL because it is a chronic residif disease. The treatment only prevents the progression of hair loss and does not cure.

Pengaruh Game Online terhadap Prestasi Belajar Peserta Didik Yuli Kurniawati
Social, Humanities, and Educational Studies (SHEs): Conference Series Vol 3, No 3 (2020): Social, Humanities, and Educational Studies (SHEs): Conference Series
Publisher : Universitas Sebelas Maret

Game online atau sering disebut dengan Online Games adalah sebuah permainan (games) yang dimainkan di dalam suatu jaringan (baik LAN maupun internet), permainan ini biasanya di mainkan secara bersamaan dengan pemain yang tidak terbatas banyaknya. Maraknya game online yang dipopulerkan kalangan peserta didik, dikarenakan perkembangan era globalisasi yang sangat pesat dan perkembangan teknologi yang semakin canggih yang bisa berdampak negatif terhadap prestasi belajar peserta didik. Tujuan dari penelitian ini adalah untuk memberikan gambaran terhadap dunia pendidikan bagaimana akan besarnya pengaruh game online tersebut terhadap prestasi belajar peserta didik.

PENGARUH LIKUIDITAS, PROFITABILITAS, SOLVABILITAS, DAN KEBIJAKAN DIVIDEN TERHADAP HARGA SAHAM PADA PERUSAHAAN LQ45 Virgin Ayu Fera Dahliawati; Yuli Kurniawati; Wulandari Harjanti
Media Akuntansi dan Perpajakan Indonesia Vol. 5 No. 1 (2023): MEDIA AKUNTANSI DAN PERPAJAKAN INDONESIA
Publisher : Accounting Study Program, Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/mapi.v5i1.4163

The era of industrial revolution 4.0 drives the competition among companies to be more aggressive. Companies are competing to increase the valuation in order to draw investor’s attention. Based on that situation, a research is conducted aiming to examine whether or not liquidity, profitability, solvability, and dividend policy are influential toward the stock price in LQ45’s indexed company that is listed in Indonesian Stock Market (BEI). This research uses secondary data which is an annual report published in the official website of BEI. The sampling technique used is purposive sampling method which collects 105 companies for the last 3 years. The secondary data is measured using the ratio of CR, ROA, DER, and DPR which is then processed with SmartPLS software and analyzed using multiple linear regression by utilizing t test and F test to seek result based on the problem formulation. Results show that the significance value of probability is 0.009 meaning that profitability influences positively and significantly towards the stock price in LQ45 list of BEI. Meanwhile, the significance value of liquidity is 0.634, solvability is 0.417, and the dividend policy is 0.757 which means that liquidity, solvability, and dividend policy do not influence the LQ45 stock price in Indonesian Stock Market (BEI).

The Primary School LearnersÃ¢â‚¬â„¢ Mathematics Communication Skill Improvement through PBL and TGT Models Melyana Indiarsih; Eko Purwanti; Yuli Kurniawati
Educational Management Vol 10 No 3 (2021): December 2021
Publisher : Educational Management

Show Abstract | Download Original | Original Source | Check in Google Scholar

This research aims to find out the primary school learnersÃ¢â‚¬â„¢ mathematics communication skills through PBL and TGT models. This research is a quantitative approached research. The research method is a quasi-experimental method with a non-equivalent pre-test and post-test control group design. The technique of collecting data was cluster random sampling. The sample consisted of the fifth graders of Primary School in Jatinangor. The school has applied the 2013 curriculum. The fifth graders of Sinargalih Public Primary School were taken as the experimental group while the fifth graders of Mekarsari Public Primary School were taken as the control group. The data collection were done by distributing the Mathematics Communication Skill Test (MCST), observation sheet, and interview. The applied data analysis was an Independent simple T-test and hypothesis test. The findings showed that there was the learnersÃ¢â‚¬â„¢ mathematics communication skill improvements taught by PBL or TGT, and the significant improvement the learners taught by PBL. The results obtained an average score of students taught by PBL was higher with 70.23 than TGT with a score of 65.30. It could be concluded there was significant improvement of learnersÃ¢â‚¬â„¢ mathematics communication skills taught by PBL or TGT models. Keywords: PBL, TGT, Mathematics Communication Skill

DIAGNOSIS DAN TATA LAKSANA NEVUS HORI Sarah Diba; Cayadi Sidarta Antonius; Yuli Kurniawati; Soenarto Kartowigno; Susanti Budiamal
Media Dermato-Venereologica Indonesiana Vol 49 No 4 (2022)
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i4.284

Nevus Hori (NH) merupakan hipermelanosis dermal didapat yang ditandai bercak coklat keabuan. NH bermanifestasi terutama di daerah fasial seperti zigomatikum, dahi, pelipis, kelopak mata dan pangkal hidung, tetapi dapat juga di ekstra fasial. NH memengaruhi kualitas hidup penderitanya karena dapat menganggu penampilan. Awitan NH bervariasi, dapat terjadi antara usia 12-72 tahun. Genetik memegang peran penting dalam patofisiologi NH. Beberapa faktor pencetus yang telah diidentifikasi terkait NH antara lain, inflamasi, radiasi ultraviolet, kehamilan, kontrasepsi, dan kosmetik. Manifestasi klinis NH sering menyerupai kelainan hiperpigmentasi dermal lain seperti melasma, nevus Ota, dan melanosis Riehl, sehingga masih sering terjadi kesalalahan diagnosis. Penegakan diagnosis dilakukan dengan mempertimbangkan manifestasi klinis pasien. Pemeriksaan penunjang tidak rutin dilakukan pada kasus NH. Bila diperlukan, pemeriksaan baku emas berupa pemeriksaan histopatologi dapat dilakukan. Tata laksana NH memiliki tantangan tersendiri. Tata laksana NH yang utama adalah menghindari tersediri. Tata laksana defenitif untuk kasus MH dilakukan dengan terapi kombinasi, baik terapi farmakologis dan non-farmakologis. Pilihan terapi yang dapat digunakan adalah terapi topikal, dan tindakan invasif seperti dermabrasi, krioterapi dan laser.

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