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Unesa Journal of Chemistry

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Published by Universitas Negeri Surabaya

ISSN : - EISSN : 22528180 DOI : https://doi.org/10.26740/ujc.v11n2

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

UNESA Journal of Chemistry is online Journal covering all aspects of Chemistry. The journal publishes original research paper and review articles.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 93 Documents

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REVIEW ARTIKEL: KARAKTERISTIK DAN PERANAN ENZIM LIPASE PADA PRODUKSI DIACYGLYCEROL (DAG) DARI VIRGIN COCONUT OIL (VCO) Emilisia Fatimah
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Lipase enzyme is an acyl hydrolase that functions in the digestion and processing of fat. Lipase enzyme have activities that can hydrolyze various fats and oils, each one unit per mL (U/mL) of lipase enzyme activity can release 1 µmol of free fatty acids per minute. Lipase enzyme activity at optimum conditions obtained from measurements of enzymatic activity at modification of temperature and pH. Lipase enzyme can be found in plants, animals, and microorganisms. Coconut (Cocos nucifera L.) is a plant that produces lipase enzymes which can produce Virgin Coconut Oil (VCO). VCO can be converted into diacylglicerol (DAG) by hydrolysis or trans-esterification using chemical or enzymatic methods. DAG is a type of healthy oil that can reduce the content of Low Density Lipoprotein (LDL), triglycerides (TG) and become a plasminogen inhibitor. Key words: Lipase, Diacyglycerol (DAG), Virgin Coconut Oil (VCO)

REVIEW: POTENSI SECANG (Caesalpinia sappan L.) DALAM TERAPI ARTRITIS REUMATOID Fauzia Indah Sabila; Tukiran Tukiran
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Artritis reumatoid (AR) is a chronic inflammatory disease caused by inflammatory mediators that migrate to synovial and particular tissues. The disease is characterized by synovial inflammation that leads to the destruction of cartilage and joint damage. Although conventional treatments of AR such as NSAID, corticosteroid and DMARDs commonly alleviate the symptoms of AR, but the high edverse of these treatments leads AR patients toward alternative medicine. The purpose of the present review is to evaluate the potential of secang in rheumatoid arthritis therapy. Various phytochemical components of secang provide pharmacological effects such as antioxidant activity in suppressing oxidative stress as a promoter for disease, including inflammation. Anti-inflammatory and anti-arthritis activities of secang are able to inhibit pro-inflammatory cytokine regulation and cartilage degradation in AR. The pharmacological effect of secang has the potential to be used as a functional food or supplement in the therapy of AR by preventing, treating and repairing the damage caused by AR.. Key words: Anti-arthritis, Anti-infammatory, Anti-oxidant, Artritis Reumatoid, Caesalpinia sappan L.

PENGARUH SUHU KALSINASI TERHADAP UKURAN KRISTAL DAN KOMPOSISI FASA PADA SENYAWA TiO2 Amos Tigor Tobing; Dina Kartika Maharani
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

TiO2 or commonly called Titanium dioxide is a semiconductor transition metal. This metal is commercially shaped white powder. This material is often used in research into the development of photocatalysts effects in material. TiO2 is used in paints as compounds that give rise to self-cleaning properties. This property is the nature of a material to clean itself from impurities. Self cleaning works with the help of the photocatalyst effect, which is where with the help of photon energy. Therefore semiconductor material can be used in these properties. This is because Titanium dioxide is a semiconductor compound which has a band gap energy of 3.2 eV for the anastase phase, and for the rutile phase of 3.0 eV. This study aims to determine the effect of calcination temperature on the characteristics of TiO2 compounds. In this research, TTiP is a precursor of TiO2 synthesis, and the method used is the sol-gel method. After synthesis, TiO2 is calcined at 400°C, 450°C, 500°C, and 550°C. The characterization carried out in this research is to use the Fourier Transform Infra Red (FTIR) instrument that functions to determine the functional groups formed and the X-Ray Diffraction (XRD) instrument which functions to determine the phase composition of the compound. From the research that has been carried out obtained functional groups -OH, Ti-O, and Ti-O-Ti. This shows that TiO2 was successfully formed through the sol-gel method. In the phase analysis, the results showed that TiO2 is in the anastase phase. This shows that TiO2 can function well when applied to photocatalysts Keywords: Titanium Dioxide (TiO2), Calcination Temperature, photocatalysts, Self cleaning

REVIEW ARTIKEL : POTENSI FRUKTOOLIGOSAKARIDA DAN INULIN BAHAN PANGAN LOKAL SEBAGAI SUMBER PREBIOTIK Farindya Dwi Cahyaningtyas; Prima Retno Wikandari
Unesa Journal of Chemistry Vol 11 No 2 (2022)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Prebiotics are a component of food that cannot be digested by human digestion, but can be used as growth nutrients for the intestinal microflora and can provide health benefits. Inulin and fructooligosaccharides (FOS) are types of prebiotics that are widely developed for now. This review aims to determine (1) the potential of inulin and FOS as prebiotics, (2) lactic acid bacteria that can grow on inulin and FOS, and 3) the potential of local food as a source of inulin and FOS. Inulin and FOS are prebiotics because they have β(2-1) bonds so that they have resistance to hydrolysis by acids and enzymes found in the digestive tract and can only be utilized by the intestinal microflora. The results of inulin and FOS metabolism by lactic acid bacteria are able to provide health benefits such as lowering cholesterol and blood sugar levels, lowering blood pressure and inhibiting the growth of pathogenic bacteria. Inulin and FOS can be utilized by several strains of lactic acid bacteria such as Lactobacillus plantarum B1765, Lactobacillus fermentum, Lactobacillus casei, Lactobacilus acidophilus, Leuconostoc mesentroides, Bifidobacterium breve, and Bifidobacterium longum. Inulin and FOS can be found in easily found local foodstuffs such as sweet potatoes, arrowroot, gembili, yam, garlic, dahlia tubers and taro, can be used as growth media for several strains of lactic acid bacteria and provide several health effects so that they can be used as alternative sources of prebiotics

PENGARUH PEMBERIAN SIRUP PREBIOTIK UMBI YAKON TERHADAP AKTIVITAS ENZIM PENCERNAAN PADA DUODENUM Rattus norvegicus Leny Yuanita; Eka Yulia Maulidah
Unesa Journal of Chemistry Vol 11 No 1 (2022)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Prebiotics are compounds that cannot be digested by digestive enzymes and can stimulate the growth of probiotics. Fructooligosaccharides are the most commonly used prebiotics. The purpose of this study was to determine the effect of giving prebiotic syrup of yakon tuber to the activity of amylase, protease, and lipase enzymes in the duodenum of Rattus norvegicus. The samples of this research were yakon tubers from the Wonosobo area and the experimental animal Rattus norvegicus. Experimental animals were divided into 4 groups. The group that was fed with water supplements (P0 = negative control), prebiotic syrup of yakon tuber S0 (P1), prebiotic syrup of yakon tuber S1 (P2), and commercial FOS (P3). Determination of enzyme activity of amylase, lipase, and protease using UV-Vis spectrophotometer instrument. Statistical analysis used was ANOVA and Post Hoc = LSD. The results showed that the administration of prebiotic syrup of yakon tubers S1 could significantly increase the activity of amylase, lipase and protease enzymes (P < 0.05). In the provision of prebiotic syrup of yacon tubers S0 can increase the activity of amylase and protease enzymes, while the lipase enzyme has no significant effect. Key words: yakon tuber prebiotic syrup, amylase, protease, lipase

PENGARUH PEMBERIAN SIRUP UMBI YAKON TERHADAP KADAR KALSIUM TULANG FEMUR TIKUS PUTIH (Rattus Norvegicus) Leny Yuanita; Kelvin Rio K
Unesa Journal of Chemistry Vol 11 No 1 (2022)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

The research objectives were to determine: 1) the effect of yacon tuber syrup supplementation on on rat bone calcium levels 2) the correlation of the total amount of short chain fatty acids (ALRP) to the calcium levels of the femur. The experimental animal used was 36 Rattus norvegicus. Were divided into 3 groups of supplement treatment: 1) aquadest, 2) yacon tubers syrup, 3) commercial FOS. After 48 days of treatment, the femur bone was analyzed for calcium levels by the digestion method. The instruments used were HPLC to test ALRP levels, GC to test FOS levels, and AAS to test calcium levels. Data analysis was done through the One Way Anova test (α = 0.05), the Post Hoc LSD, and the product moment correlation. The results of the analysis showed 1) The increase in average calcium levels from the K(-) group to P1 was 1.211 mg/mL and the post hoc statistical test between the K(-) and P1 (p>0.05) groups showed no significant difference between yacon tuber syrup supplementation on calcium levels. mouse bones. 2) Correlation analysis shows the correlation coefficient of r = 0.394 so that there is a low relationship between the total amount of ALRP and calcium levels in the femur bones of experimental animals. Keyword : yacon, FOS, calsium, absorption

PENGARUH JUMLAH CROSSLINKER PADA SINTESIS MOLECULARLY IMPRINTED POLYMER (MIP) TERHADAP KEMAMPUAN ADSORPSI KLORAMFENIKOL Maria Monica Sianita; Magdalena Butar Butar
Unesa Journal of Chemistry Vol 11 No 1 (2022)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

This study aims to determine the effect of variations in the amount of crosslinker on the adsorption capability of Molecularly Imprinted Polymer (MIP)-Chloramphenicol (CAP) which was analyzed using the High-Performance Liquid Chromatography (HPLC) instrument and identify the –NO2 functional group in the polymer with the best variation in the amount of crosslinker using the instrument. Fourier Transform Infrared Spectroscopy (FTIR). In this study, MIP was synthesized using CAP as a template, ethylene glycol dimethacrylate (EGDMA) as a crosslinker, methacrylic acid (MAA) as a monomer, benzoyl peroxide (BPO) as an initiator, and acetonitrile as a porogen. The results showed that the variation in the number of crosslinkers affected the adsorption capability of MIP with the composition between CAP: MAA: EGDMA, namely 1:3:18, resulting in the largest adsorption capability of 2,2 mg/g with an extraction percentage of 66.11%. The results of functional group identification with FTIR showed that NIP contained –NO2 group at wave number 1524.27 cm-1 while in MIP no –NO2 group was detected because most of the CAP had been extracted, and PB was made as a control polymer without adding template CAP. Keywords: Chloramphenicol, Molecularly Imprinted Polymer, Crosslinker, Adsorption Capability

Karakterisasi dan Uji Efektivitas Sediaan Gel Aloe vera Kombinasi Kitosan sebagai Antibakteri Staphylococcus aureus Sari Edi Cahyaningrum; Perintis Gita Susanti
Unesa Journal of Chemistry Vol 11 No 1 (2022)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

The study about development synthesis gel of Aloe vera combination chitosan as Staphylococcus aureus antibacterial has been done. This study has the aim to determine the effect of composition comparison of Aloe vera with chitosan on the characterization and effectiveness of Staphylococcus aureus antibacterial as a candidate for wound healing. The synthesis the gel of Aloe vera combination chitosan was made by mixing of Aloe vera and chitosan solution with weight variated 2:1; 1:1; and 1:2 (AvK1, AvK2, and AvK3), and addition of Na-CMC, glycerin, and propylene glycol, which the gel was neutralized until it reached pH 6,5–7,0. The gel preparation were characterized by organoleptic, measuring viscosity, functional groups identification, and effectiveness test of Staphylococcus aureus antibacterial by diffusion method. The results were shown based organoleptic observations by color, smell, and texture. The lowest viscosity measurement characterization was showed by AvK3 gel, which was 13.0412 mPa.s. The result functional groups identification of all gel preparations was indicated the presence of O–H and N–H stretching vibrations, C=O stretching vibrations, C–H bending vibrations, and C–O stretching vibrations. Staphylococcus aureus antibacterial test from gel of Aloe vera combination chitosan with various variations were shown effective result, which the strongest was shown by AvK1 gel with an inhibition zone of 26 mm. Key words: chitosan, Aloe vera, antibacterial, Staphylococcus aureus

ANALISIS KADAR FENOLIK, FLAVONOID DAN AKTIVITAS ANTIOKSIDAN UMBI BAWANG BOMBAI (Allium cepa L.) Mirwa Adiprahara Anggarani; Rizki Amalia
Unesa Journal of Chemistry Vol 11 No 1 (2022)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Onions are included in the Alliaceae that is often used as a spice in cooking. Onions have potential as a natural antioxidants. The active compounds that act as antioxidants in onions are phenolic and flavonoid contents. The study aimed to determine the water content, ash content, secondary metabolite compounds, total phenolic contents, total flavonoid contents, and antioxidant activity of the onion bulbs (Allium cepa L.). The extraction method chosen was the multilevel maceration method using three different solvents according to their polarity. The solvents are dichloromethane, ethyl acetate, and 96% ethanol. The total extract obtained from dichloromethane, ethyl acetate, and 96% ethanol solvent was 3,661; 1,476; 72,612. The results showed that onions bulb had a moisture content of 64.7% in the wet form and 5.2% in the powder form. The ash content obtained was 5.64%. Phytochemical screening of onion bulb extracts revealed the presence of flavonoids, saponins, tannins, phenolics, quinones, steroids and triterpenoids. The total phenolic and total flavonoid contents of the onion bulb ethanol extract were 18,245 mg GAE/g extract and 3,381 mg QE/g extract. The IC50 value of the onion bulb ethanol extract is 78.723 μg/mL, which includes in the strong antioxidant group. Key words: onion bulb, total phenolic contents, total flavonoid contents, antioxidant activities

KARAKTERISASI FILM PVA/KITOSAN/ZEOLIT TERSUBTITUSI ION Ag+ BERPOTENSI SEBAGAI KEMASAN AKTIF Dina Kartika Maharani; Rizka Dwi Safitri
Unesa Journal of Chemistry Vol 11 No 1 (2022)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

The need for fresh food continues to increase. Fresh food has a short shelf life. This can be overcome by active packaging containing antimicrobial substances. Zeolite is modified by ion exchange with silver, where silver acts as an antimicrobial agent. This study aims to study the changes in the mechanical properties of the PVA/chitosan mixture with the addition of zeolite-Ag compared to without the addition of zeolite-Ag. The variation in this study is the addition of zeolite-Ag to the PVA/CS composite, namely (0.025; 0.05; 0.1; 0.2)%. The films that have been made were analyzed in terms of mechanical properties, FTIR, and surface morphology microstructure. Composite films containing zeolite-Ag showed an increase in tensile strength and elasticity, where confirmed zeolite can be used as a reinforcing material in polymer matrices. The composite film with 0.025% zeolite-Ag content has a tensile strength value of 46.534 MPa, because zeolite-Ag can be homogeneously dispersed in the polymer matrix. FTIR analysis showed that the mixture of PVA and chitosan proved to be uniformly mixed. Morphological microstructural analysis showed homogeneous surface results, there was no visible appearance of zeolite-Ag aggregates on the PVA/CS film, whereas on films containing 0.025% zeolite-Ag there was a heterogeneous surface and the appearance of black circles indicating the presence of zeolite-Ag. Key words: characterization, film composite, zeolit, silver

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Editorial Address Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia. 60231

Location Kota surabaya, Jawa timur INDONESIA

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Contact Name
Dina Kartika Maharani

Contact Email
dinakartika@unesa.ac.id

Phone
+628174140131

Journal Mail Official
dinakartika@unesa.ac.id

Editorial Address
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia. 60231

Location
Kota surabaya,

Jawa timur

INDONESIA