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Herbal Medicine Journal
Published by Sekolah Tinggi Ilmu Kesehatan Senior Medan
ISSN : -     EISSN : 26212625     DOI : https://doi.org/10.58996
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology
Herbal Medicine Journal menerima artikel penelitian dalam 2 area utama di bidang farmasi: Sains Farmasi dan Farmasi Komunitas dan Klinis. Dalam bidang sains farmasi, artikel penelitian yang diterima meliputi Biologi Farmasi dan Farmakognosi, Kimia Farmasi, Farmasetika, Farmakologi dan Toksikologi, dan juga Bioteknologi. Sedangkan area Farmasi Komunitas dan Klinis mencakup Farmasi Rumah Sakit, Farmasi Klinis, Manajemen Farmasi, dan Farmasi Sosial.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 104 Documents
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Studi Literatur: Tanaman Herbal Indonesia yang Berkhasiat sebagai Penurun Hipertensi suci Wahyuni
Herbal Medicine Journal Vol 6 No 2 (2023): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v6i2.87

Abstract

Introduction: Hypertension or what is often referred to as high blood pressure is a degenerative disease or PTM that often appears without symptoms. Hypertension is a disturbance in blood circulation that can be life- threatening for individuals when blood pressure is above systolic and diastolic pressure which is unstable. Other hypertension treatments can use good herbal plants to treat various diseases. Various kinds of active substance components which have been widely studied have therapeutic effects derived from herbal plants. About 75- 80% of the worlds population, especially in developing countries, use herbal medicines for primary health care because of their better acceptance of the human body. Objective of the research: The purpose of this literature review is to find out the nutritious herbal plants in Indonesia as traditional medicines to reduce hypertension. Method: The method used in writing this article is a literature review approach by searching literature using the Google Schoolar website database. Result: The results of the study found 15 plants as herbal medicines as drugs to reduce hypertension, namely celery leaves (Apium graveolens L), ginger (Zingiber officinale), basil leaves (Ocimum basilicum), Moringa leaves (Moringa oleifera), garlic (Allium sativum), Turmeric (Curcuma longa), butterfly pea flower (Clitoriaternatea), papaya leaves (Carica papaya), betel leaves (Piper Betle Linn), cucumber (Cucumis sativus), gotu kola leaves (Centella asiatica), carrots (Daucus carota L), bay leaves (Syzygium polyanthum), meniran leaves (Phytallantus niruri), soursop leaves (Annona muricata Linn). Conclusion: Traditional medicine using herbal plants is believed to be able to treat hypertension which has been part of public belief from time to time. The utilization of these traditional plants takes into account aspects such as ease of obtaining, saving costs, and not containing chemicals that cause other side effects.
PEMANFAATAN EKSTRAK BUAH SALAK (Salacca zalacca (Gaertn.) Voss) SEBAGAI ANTI-AGING ALAMI DALAM SEDIAAN BODY SCRUB Dara, Riza Permata; Maimunah, Siti; Prayoga, Andre
Herbal Medicine Journal Vol 7 No 1 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i1.97

Abstract

This study was aimed at formulating Salak fruit extract in a cream formulation and testing its anti-aging effectiveness. Flavonoid compounds in salak fruit are efficacious as antioxidants that are able to neutralize free radicals so they can improve signs of aging on the skin such as dry skin and enlarged pores and wrinkles. This research was conducted at the Pharmaceutical Chemistry Laboratory of Sari Mutiara Indonesia University in June-August 2023. The tools used were skin analyzer and moisture checker. Salak fruit samples were obtained from the Sihopur village Tapanuli Selatan regency, North Sumatra. The irritation test of three volunteers used salak extract cream with the highest concentration of 7%. The anti-aging activity test used 15 volunteers. Parameters measured include moisture content, number of pores and wrinkles. Statistical data was analyzed using the SPSS method. The results show that the ethanol extract of Salak fruit leaves can be formulated in a homogeneous type A / M cream dosage form, with a pH of 6,3-5,2, a viscosity of 19.000-47.000 cps, non-irritating and stable in storage for 12 weeks. The results of the analysis with the skin analyzer showed that the skin condition changed for the better, namely increased water content 32,3%, reduced pores 10,4% and wrinkles 13,2%. Cream preparations with a concentration of 7% show the best anti-aging effectiveness.
PENETAPAN KADAR FLAVONOID DAN FENOLIK DARI EKSTRAK ETANOL BUAH LEMBA (Molinera latifolia Dryand. Ex W.T. Aiton) SECARA SPEKTROFOTOMETRI UV-VIS Deswanti, Wina R; D, Sari Dewi
Herbal Medicine Journal Vol 7 No 1 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i1.98

Abstract

The research was carried out by analyzing flavonoid and phenolic levels from ethanol extract samples of lemba fruit. The ethanol extract was prepared using the maceration method. Namely by soaking with 96% ethanol solvent. The extraction results were then analyzed for active ingredient levels, namely flavonoid levels and phenolic levels using UV-Vis spectroscopy. The analysis results showed that the flavonoid content and phenolic content were respectively 120 mg QE/g ethanol extract of lemba fruit and 56 mg GAE/g ethanol extract of lemba fruit.
ANALISA KADAR FENOLIK EKSTRAK ETANOL DAUN NANGKA (Artocarphus heterophyllus) DENGAN MENGGUNAKAN INSTRUMENTASI SPEKTROSCOPY UV-VIS Effendi S, Mahral
Herbal Medicine Journal Vol 7 No 1 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i1.99

Abstract

Research has been carried out to analyze the phenolic content of the ethanol extract of jackfruit leaves by carrying out the initial stages, namely selecting homogeneous jackfruit leaves and forming simplicia. The simplicia formed was then characterized microscopically and macroscopically and a phytochemical screen test was carried out to determine the active secondary metabolite ingredients contained therein. The method used in the secondary metabolite extraction process uses maceration with ethanol solvent, measuring phenolic content using a colorimetric method using UV-Vis spectrophotometry at a wavelength of 775 nm. Phenolic content was previously obtained by forming a standard curve to obtain a linear regression equation. The results of the analysis show that the linear regression equation formed is y = 0.001x + 0.0048. The results of sample analysis in this research show that the Phenolic concentration value is 60 mg GAE/g Jackfruit leaf ethanol extract.
VALIDASI METODE ANALISA KADAR FENOLIK EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) DENGAN MENGGUNAKAN SPEKTROSCOPY UV-VIS Syahputera, Rony
Herbal Medicine Journal Vol 7 No 1 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i1.100

Abstract

Validation research has been carried out on the phenolic content analysis method using the Gallic Acid method on red betel ethanol extract. Red betel leaves in this research were previously characterized microscopically and macroscopically and a phytochemical screening test was carried out to determine the secondary metabolite content in the ethanol extract of red betel leaves. Next, extraction is carried out using the maceration method. The resulting extract is then analyzed to determine the phenolic content in the sample. Determination of phenolic content uses a method that is first calibrated, which includes linearity, LOD and LOQ, precision, accuracy and sensitivity. The results of each analytical parameter analysis are as follows: linearity = 0.9909, precision = 0.046; 0.06; 0.019 recovery = 98 and 102 %, sensitivity = 1.02. 105 L. Mol-1 cm-1. Analysis of the phenolic samples showed a concentration value of 150.04 mg GAE/gram of red betel extract.
VALIDASI METODE ANALISA KADAR FENOLIK EKSTRAK ETANOL PATIKAN KEBO (Euphorbia hirta L) DENGAN MENGGUNAKAN SPECTROSCOPY UV- VIS Sari, Mesi Puspita
Herbal Medicine Journal Vol 7 No 1 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i1.101

Abstract

Validation research has been carried out on the phenolic content analysis method using the DPPH method on the ethanol extract of Patikan Kebo. In this research, the patikan kebo leaves were previously characterized microscopically and macroscopically and a phytochemical screening test was carried out to determine the secondary metabolite content in the patikan kebo leaves. Next, extraction is carried out using the maceration method. The resulting extract is then analyzed to determine the phenolic content in the sample. Determination of phenolic content uses a method that is first calibrated, which includes linearity, LOD and LOQ, precision, accuracy and sensitivity. The results of each analytical parameter analysis are as follows: linearity = 0.9909, precision = 0.046; 0.06; 0.019 recovery = 98 and 102 %, sensitivity = 1.02. 105 L. Mol-1 cm-1. Analysis of the phenolic sample showed a concentration value of 36.3 mg GAE/gram of patikan kebo extract.
Pemanfaatan Ekstrak Biji Kopi Arabika (Coffea arabica L.) Sebagai Anti Aging Alami dalam Sediaan Hand Cream Irfan, Muhammad; Maimunah, Siti
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.128

Abstract

Anti aging/Penuaan kulit merupakan penyokong terbesar pada berbagai masalah kulit seperti kulit kasar, kering, keriput, berjerawat dan lainnya. Untuk membuat sediaan handcream yang mengandung ekstrak etanol biji kopi (Coffea sp) sebagai anti aging serta menguji efektivitas anti aging terhadap sukarelawan. Pembuatan sediaan handcream menggunakan basis krim formula dengan konsentrasi ekstrak etanol biji kopi 5%,10%, dan 15% serta evaluasi sediaan handcream yang meliputi : pengujian organoleptis, homogenitas, viskositas, ph, daya sebar, tipe emulsi, pengamatan stabilitas serta uji iritasi. Pengujian efektivitas anti aging menggunakan skin-analyzer Aramo dengan parameter uji yaitu kadar air (moisture), pori (pore), dan keriput (wrinkle). Hasil evaluasi handcream ekstrak etanol biji kopi stabil dalam penyimpanan selama 4 minggu, menunjukkan sediaan yang homogen, mempunyai nilai viskositas 7.500-9.500 rpm, memiliki pH 6,6-7,0, mempunyai daya sebar yang baik sekitar 6-6,5 cm, bertipe emulsi m/a serta tidak menimbulkan iritasi. Handcream dengan konsentrasi 15% menunjukkan efektivitas anti aging yang efektif. Ekstrak biji kopi dapat diformulasikan dalam sediaan handcream. Sediaan handcream ekstrak biji kopi dengan konsentrasi 15% memiliki efektivitas anti aging yang paling baik yang menunjukkan peningkatan kadar air (moisture) sebanyak 16%, pengecilan pori (pore) sebanyak 24,32%, dan pengurangan keriput (wrinkle) sebanyak 47,61%.
Potensi Senyawa Kimia Ekstrak Etanol Kelakai (Stenochlaena palustris) sebagai Antitrombotik Saputri, Indah; Setiawati, Indah; Mukarramah, Mukarramah; An’nisa, Windy Sidratul; Afdella, Nor Afni; Komari, Noer
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.129

Abstract

Damage to blood vessels begins with the formation of platelet aggregation which then forms a thrombus in the artery, resulting in disruption of blood flow. Many efforts have been made to prevent platelet aggregation using herbal medicines. Kelakai is a typical Kalimantan plant thought to have antithrombotic potential. The aim of this research is to identify the potential of kelakai ethanol extract compounds as antithrombotics through in silico studies using virtual screening and molecular docking. The kelakai compound was obtained from GC-MS data taken from the ethanol extract of kelakai. The virtual screening results showed that the results of GC-MS analysis of ethanol extract found five compounds that had the potential to be antithrombotic. Molecular docking simulations with the antithrombin receptor protein (PDB ID: 1E04) show that the n-Hexadecanoic acid compound from kelakai ethanol extract has the lowest ∆G value of -8.72 kcal/mol. The n-Hexadecanoic acid compound from kelakai has potential as an antithrombotic.
Uji Daya Hambat Ekstrak Etanol Kulit Jeruk Nipis (Citrus aurantifolia (Christm.) Swingle) Sebagai Antibakteri Terhadap Escherichia coli S, Mahral Effendi
Herbal Medicine Journal Vol 4 No 2 (2021): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v4i2.131

Abstract

Diarrhea is one of the public health problems and is a major cause of morbidity and mortality in infants and children. One of the main causes of diarrhea is due to Escherichia coli bacterial infection. Medicinal plants are currently widely used by the community as an alternative treatment because the ingredients are easy to obtain, the price is relatively cheap and the side effects are relatively low compared to synthesized drugs such as lime (Citrus aurantifolia (Christm.) Swingle). The purpose of this study was to determine the effect of ethanol extract of lime peel (Citrus aurantifolia (Christm.) Swingle) on the growth of Escherichia coli bacteria and to determine the potential of ethanol extract of lime peel (Citrus aurantifolia (Christm.) Swingle) as an antibacterial and antibacterial cause of diarrhea. The extraction method with maceration using 96% ethanol solvent, while the antibacterial activity test was carried out using the paper disc diffusion method. The results showed that the ethanol extract of lime peel at concentrations of 10%, 30%, 50% and 70% had inhibition zone diameters of 7.30 mm, 7.48 mm. 8.71 mm and 12.80 mm respectively. The conclusion of this study is that the ethanol extract of lime peel is effective at a concentration of 70% with a strong category.
Efektivitas Ekstrak Etanol Buah Andaliman (Zanthoxylum acanthopodium DC) Sebagai Antibakteri Terhadap Escherichia coli S, Mahral Effendi
Herbal Medicine Journal Vol 5 No 2 (2022): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v5i2.132

Abstract

Zanthoxylum acanthopodium or Andaliman is a wild plant in North Sumatra, Indonesia that has been used as traditional medicine such as treating diarrhea, abdominal pain, dysentery, toothache, leprosy and abscesses. The purpose of this study was to determine the effect of andaliman fruit ethanol extract on the growth of Escherichia coli bacteria and to determine the effective concentration of andaliman fruit ethanol extract as an antibacterial causing diarrhea. The research method is experimental, which is carried out in stages. Extraction using the maceration method while the antibacterial activity test using the paper disc method. The extract concentration consisted of 70%, 50%, 30%, 10%, DMSO as a negative control and amoxicillin as a positive control. The phytochemical screening results consisted of alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids. The results of the antibacterial activity test showed that the ethanolic extract of andaliman fruit had the potential as an antibacterial at each concentration respectively 70%, 50%, 30%, 10% with the diameter of the inhibition zones being 17.28 mm, 14.87 mm, 13.69 mm and 10.35 mm, respectively. strong category. The ethanol extract of andaliman fruit has an effective antibacterial activity at a concentration of 10%.

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