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Herbal Medicine Journal
Published by Sekolah Tinggi Ilmu Kesehatan Senior Medan
ISSN : -     EISSN : 26212625     DOI : https://doi.org/10.58996
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology
Herbal Medicine Journal menerima artikel penelitian dalam 2 area utama di bidang farmasi: Sains Farmasi dan Farmasi Komunitas dan Klinis. Dalam bidang sains farmasi, artikel penelitian yang diterima meliputi Biologi Farmasi dan Farmakognosi, Kimia Farmasi, Farmasetika, Farmakologi dan Toksikologi, dan juga Bioteknologi. Sedangkan area Farmasi Komunitas dan Klinis mencakup Farmasi Rumah Sakit, Farmasi Klinis, Manajemen Farmasi, dan Farmasi Sosial.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 104 Documents
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Validasi Metode Analisa Kadar Fenolik Ekstrak Etanol Patikan Kebo (Euphorbia hirta L) dengan Menggunakan Spectroscopy UV- Vis S, Mahral Effendi
Herbal Medicine Journal Vol 6 No 2 (2023): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v6i2.133

Abstract

Validation research has been carried out on the phenolic content analysis method using the DPPH method on the ethanol extract of Patikan Kebo. In this research, the patikan kebo leaves were previously characterized microscopically and macroscopically and a phytochemical screening test was carried out to determine the secondary metabolite content in the patikan kebo leaves. Next, extraction is carried out using the maceration method. The resulting extract is then analyzed to determine the phenolic content in the sample. Determination of phenolic content uses a method that is first calibrated, which includes linearity, LOD and LOQ, precision, accuracy and sensitivity. The results of each analytical parameter analysis are as follows: linearity = 0.9909, precision = 0.046; 0.06; 0.019 recovery = 98 and 102 %, sensitivity = 1.02. 105 L. Mol-1 cm-1. Analysis of the phenolic sample showed a concentration value of 36.3 mg GAE/gram of patikan kebo extract.
Uji Aktivitas Antibakteri Ekstrak Daun Sirsak (Annona muricata L.) Terhadap Bakteri Staphylococcus aureus dan Salmonella typhi Siahaan, Marshal Duva
Herbal Medicine Journal Vol 6 No 2 (2023): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v6i2.134

Abstract

Soursop plants (Annona muricata L.) have been used for generations by some Indonesian people to treat diseases. Differences in environmental conditions where a plant grows can cause differences in the types and amounts of secondary metabolites contained in the plant. This study aims to determine the antibacterial activity of ethanol extract of soursop leaves against Staphylococcus aureus and Salmonella typhi and to determine the content of secondary metabolite compounds. The type of research is a laboratory experiment, extraction was carried out on soursop leaves using the maceration method using 70% ethanol solvent. The ethanol extract of soursop leaves was then screened for phytochemistry. Antibacterial activity tests were carried out using the disc paper diffusion method. This study used 5 concentrations, namely DMSO; Chloramphenicol; 10; 30; 50, 70%. The results of phytochemical screening of ethanol extract of soursop leaves contain secondary metabolite compounds in the form of saponins, terpenoids, steroids, flavonoids, tannins, alkaloids. Ethanol extract of soursop leaves can inhibit the growth of Staphylococcus aureus bacteria at a concentration of 30-70% while Salmonella typhi at a concentration of 70%.
Identifikasi Komponen Minyak Atsiri Daun Salam (Syzygium polyanthum (Wight Walp.) dengan GC-MS dan Potensinya Sebagai Antibakteri Sihotang, Santyria; Simanjuntak, Helen Anjelina; Purba, Hermawan; Iksen, Iksen; Sembiring, Mahral Effendi
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.137

Abstract

Essential oils, known as volatile oils or essential oils, are oils produced from plants and have the property of easily evaporating at room temperature without undergoing decomposition. The bay leaf plant (Syzygium polyanthum (Wight.) Walp.) is one of the plants that is very often used as an alternative medicine. There is evidence that bay leaves, which contain compounds such as niacin, fiber, tannin, and vitamin C, have the ability to lower serum triglyceride levels. This research aims to determine the essential oil content in bay leaves using the steam distillation method and its potential as an antibacterial. The results of the research show that bay leaves contain essential oils which have antibacterial properties against the bacteria Helicobater pylori and Bacillus cereus. Bay leaf essential oil (Syzygium polyanthum (Wight.) Walp) with varying concentrations of 10%, 30%, 50%, 70% and 100% showed the highest inhibitory zone diameter for Helicobater pylori bacteria, namely at a concentration of 100% with a diameter of 5, 25 mm and in Bacillus cereus bacteria with a diameter of 7.95 mm.
Identifikasi Bakteri Gram Positif Pada Saliva Penderita Diabetes Melitus Tipe 2 Di Puskesmas Simalingkar Gultom, Atri Gustiana; Pohan, Yuyun Angraini
Herbal Medicine Journal Vol 7 No 1 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i1.154

Abstract

Hyperglycemia is a decrease in insulin secretion by pancreatic beta cells or impaired insulin function (insulin resistance) is a sign of a metabolic disease known as type 2 diabetes mellitus. This study used a descriptive method by collecting saliva samples from 25 type 2 diabetes patients who were regularly examined at the Simalingkar Community Health Center. This study aims to identify Gram-positive bacteria in the saliva of type 2 diabetes mellitus sufferers at the Simalingkar Community Health Center or using Gram staining and bacterial identification through Blood Agar Plate (BAP) culture and biochemical tests (catalase test). Gram staining results showed that 10 of the 25 samples (40%) contained Gram positive bacteria, with details of 1 Streptococcus isolate (4%), 3 Staphylococcus isolates (12%), and 6 Bacillus subtilis isolates (24%). A total of 15 samples (60%) contained Gram negative bacteria. Microscopic identification showed that Gram-positive cocci bacteria included 3 isolates of Staphylococcus aureus and 1 isolate of Streptococcus mutans, while Gram-positive rod bacteria included 6 isolates of Bacillus subtilis. For Gram-negative bacteria, 3 isolates were found in the form of cocci and 12 isolates in the form of rods. Biochemical tests showed that Staphylococcus aureus was catalase positive with foam results, while Streptococcus mutans was catalase negative without foam formation. This study shows a significant prevalence of Gram-positive bacteria in the saliva of type 2 diabetes mellitus sufferers, which is likely caused by hyperglycemia conditions that support the growth of pathogenic bacteria. These results provide important insights into the relationship between type 2 diabetes mellitus and changes in oral flora, as well as the need for more intensive oral health care in people with diabetes.
Studi In Silico Senyawa Bahan Alam Terhadap Biomarker Pembelahan Sel Kanker Iksen, Iksen; Sari, Hesti Yola
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.138

Abstract

Uncontrolled cancer cell division causes a high risk of death for cancer patients. One of the proteins that control cell division is CDK 4 and CDK6. The use of natural compounds as supporting therapy can reduce the toxicity symptoms of conventional chemotherapy. This study aimed to analyze the possible interactions of natural compounds such as allicin, alpha-mangoestin, curcumin and hesperetin on cancer cell division biomarkers (CDK4 and CDK6). This research process was carried out in silico using the Pyrx 0.8 program and Discovery Studio 2022. The parameters tested included binding energy, number of interactions and types of interaction. The results found that allicin, alpha-mangoestin, curcumin and hesperetin can interact with CDK4 and CDK6. The types of interactions formed between the ligand and the target protein are hydrogen bonds, hydrophobic bonds, and electrostatic bonds. In this study, it can be concluded that natural compounds such as allicin, alpha-mangoestin, curcumin and hesperetin are able to interact with CDK4 and CDK6 proteins in silico so that they are considered potential candidates for cancer drugs
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Ranti (Solanum nigrum L.) dengan Metode DPPH Sembiring, Mahral Effendi; Nainggolan, Tumpak V
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.139

Abstract

Ranti (Solanum nigrum L.) leaf is a solanaceae plant. This ranti leaf contains alkaloid, saponin, flavonoid and tannin compounds. Flavonoids in the human body function as antioxidants so it is very good for preventing anti-cancer diseases. This study aims to determine the antioxidant activity of ethanol extract of ranti leaves, Vitamin C and calculate the IC50 value of ethanol extract of ranti leaves and vitamin C using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results of measuring antioxidant activity in the DPPH method showed that the ethanol extract of ranti leaves had very weak antioxidant activity with an IC50 value of 245.128 ppm, while the measurement results of vitamin C had very strong antioxidant activity with an IC50 value of 16.9235 ppm.
Identifikasi Tipe Trikoma dan Stomata pada Tumbuhan Famili Myrtaceae Sinaga, Fnesia; Purba, Fransiska; Kembaren, Gita Br.; Sinaga, Florenita; Kasih, Indah; Simanjuntak, Helen Anjelina
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.140

Abstract

The Myrtaceae family is a group of flowering plants that includes various species known for having certain characteristics, such as aromatic leaves, flowers with many stamens, and varied fruits. This is supported by the characteristics of the structure of the stomata and trichomes. This study aims to determine the characteristics of the stomata and trichomes of five species of the Myrtaceae family that grow in the environment that is often found. The five species are guava (Psidium guajava), clove (Syzygium aromaticum), water apple (Szygium aqueum), nutmeg (Myristica fragrans), and red tip tree (Syzygium myrtifolium). Leaf epidermis anatomical preparations were made using the paradermal section method. The results showed that the characteristics of the stomata of the five species are parasitic, diacytic, and anomocytic stoma types. In the five species that have trichomes is the guava plant (Psidium guajava) which is multicellular and non-glandular.
Analisis Sidik Jari Variasi Metode Ekstraksi Kulit Batang Tanaman Tammate (Lannea coromandelica) Menggunakan Analisis Densitometri dan Kemometrik Syahrir, Muhammad; AR, Muh. Azwar; Khairuddin, Khairuddin; Pabunga, Chachalia; Yasir, Budiman
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.141

Abstract

Lannea coromandelica plant, commonly called tammate, is one plant that can be used as traditional medicine to treat various diseases. This plant contains metabolites that are active as antioxidants, antimicrobials, and antibacterials. This study aims to determine the fingerprint profile of L. coromandelica bark extract metabolite compounds with variations in densitometric and chemometric extraction methods. The extraction techniques used are maceration, reflux, and sonication, and the types of solvents used are aquades, 70% ethanol, ethyl acetate, and n-hexane. Each extract was analyzed by Thin Layer Chromatography (KLT)-Densitometry, and then the results were analyzed by chemometric analysis using Principle Component Analysis (PCA) and Cluster Analysis (CA). Densitometric results of almost all samples contain the same three metabolites, namely autogenerated1 (Rf 0.72, 0.76, and 0.77), autogenerated3 (Rf 0.90, 0.93, 0.94, and 0.95) and autogenerated5 (Rf 0.10, 0.11, 0.12, 0.13 and 0.15). From this study, it can be concluded that there is a similarity of L. coromandelica bark extract with a similarity value of 29,68% to 99,99%.
Pengaruh Konsentrasi Surfaktan Sodium Lauryl Sulfate (SLS) Terhadap Karakteristik Fisik Sediaan Facial Wash Minyak Biji Kelor (Moringa seed oil) Sharon, Nela; Ibrahim, Nurlina; Sativa, Oriza
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.142

Abstract

Moringa seed oil contains high oleic acid, which can provide a moisturizing effect, so it can be used for making cosmetics, one of which is facial wash. Moringa seed oil facial wash can be used to cleanse facial skin from exposure to dust, pollution, dirt, and to moisturize the face. This study aimed to determine the effect and optimum concentration of sodium lauryl sulfate (SLS) on the physical characteristics of moringa seed oil facial wash preparations. The research method used was an experimental method. Facial wash was made in 3 formulas with the composition: F1: SLS 0.5%, F2: 0.75%, F3: 1%. The evaluations carried out included organoleptic, homogeneity, pH, viscosity, spreadability, foam stability and stability tests. The evaluation results of F1, F2 and F3 met the test parameters and were stable during storage. The conclusion of the study was that the higher the concentration of sodium lauryl sulfate (SLS), the higher the foam produced and the optimum formula of the facial wash preparation was F3 with an SLS concentration of 1%. According to the SNI 06-3532-1994 quality standard, the higher the foam produced, the better foam's stability.
Efek Ultrasonic Assited Extraction Tumbuhan Subclass Asteridae Sebagai Antibakteri Rahmiati, Rahmiati; Simanjuntak, Helen Anjelina; Br. Sembiring, Heylen Sebryna
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.143

Abstract

Asteridae is a group of flowering plants with many species. The UAE method is used to produce high-quality extracts more quickly and reduce the use of solvents. This study aims to determine the effectiveness of Asteridae subclass plants in fighting bacteria. Antibacterial tests were carried out using the diffusion method using disc paper by looking at the clear zone around the disc. The results showed that Erigeron sumatrensis leaf extract can inhibit the growth of staphylococcus aureus bacteria. At a concentration of 30%, the effect is classified as weak, while at concentrations of 50% and 70%, the effect is classified as moderate and a concentration of 100% is classified as strong. Salmonella typhi bacteria at concentrations of 30%, 50%, and 70% are classified as moderate, while at a concentration of 100% it is classified as strong. Stachytarpheta mutabilis leaf extract is effective against Escherichia coli bacteria at concentrations of 30% and 50%, including the moderate category. While at concentrations of 70% and 100% the effect is included in the strong category. Coleus scutellarioides and Strobilanthes crispus leaf extracts had equally strong effects against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Salmonella typhi at concentrations of 30%, 50%, 70%, and 100%.

Page 8 of 11 | Total Record : 104

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