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Herbal Medicine Journal
Published by Sekolah Tinggi Ilmu Kesehatan Senior Medan
ISSN : -     EISSN : 26212625     DOI : https://doi.org/10.58996
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology
Herbal Medicine Journal menerima artikel penelitian dalam 2 area utama di bidang farmasi: Sains Farmasi dan Farmasi Komunitas dan Klinis. Dalam bidang sains farmasi, artikel penelitian yang diterima meliputi Biologi Farmasi dan Farmakognosi, Kimia Farmasi, Farmasetika, Farmakologi dan Toksikologi, dan juga Bioteknologi. Sedangkan area Farmasi Komunitas dan Klinis mencakup Farmasi Rumah Sakit, Farmasi Klinis, Manajemen Farmasi, dan Farmasi Sosial.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 104 Documents
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Perbandingan Pengaruh Konsumsi Jus Terong Belanda Segar dan Komersil Terhadap Tikus Obesitas Syahputra, Hariyadi Dharmawan; Harahap, Daimah Wirdatus Sanaun; Iksen, Iksen; Gurning, Kasta
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.144

Abstract

Background: High yield carbohydrate diet is common in Indonesia mainly in North Sumatra province. In the long run consuming primary carbohydrate form rice may increase the risk for diabetic and its complication. Not only the amount of rice but certain beverages also such as tamarillo juice, though it’s rich amount of nutritious benefit, some product may yield more sugar to improve from its sour or bitter flavor. Objectives: studies aim to find the diet correlation between amount of carbohydrate total and Vitamin C intake in fresh and store brought tamarillo juice affect animal model with high sucrose induction. Material and Methods: Fresh tamarillo fruit grew in north Sumatra blended versus store brought juice are given daily towards obese female rats induced with 2 ml of lard and 5% sucrose orally for five weeks. Beforehand sample had its total carbohydrate and Vitamin C content with iodometric method. The last 2 weeks then rats treated with fresh blend and store brought product juice. Results: Total content value obtained from fresh compared with store brought tamarillo juice in vitamin C, (18.63 ± 7.16 mg/ml); (11.57 ± 6.8 mg/ml) and total carbohydrate (15.02 ± 2.35 mg/ml); (25.37 ± 28.17 mg/ml) respectively. During treatment increase in body weight significantly in store brought product. Histology remarks in pancreas do not show any significance damage in cell especially for fresh blend treatment group. Conclusion: Fresh blend tamarillo juice may improve health and can be considered safe for subject that like to consume high carbs in their diet.
Uji Potensi Probiotik Isolat Lactobacillus plantarum JBSxH.6.4 Asal Fermentasi Tigarun (Crateva nurvala Buch.-Ham.) Secara In Vitro Fasha, Gusti Nur Aida; Nur, Hasrul Satria; Rahmi, Nazarni
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.145

Abstract

Lactobacillus plantarum JBSxH.6.4 isolate was isolated from fermented food of Tigarun (Crateva nurvala Buch.-Ham.), a traditional fermented food from Kalimantan. This study aimed to evaluate its probiotic potential through a series of in vitro tests, including hemolysis analysis, tolerance to acidic pH and bile salt, inhibitory activity against pathogenic bacteria, and interactions with nonpathogenic bacteria. The results showed that Lac. plantarum JBSxH.6.4 exhibited γ-hemolysis, confirming its non-pathogenicity. The isolate survived at pH levels of 2.0, 3.0, and 4.0, demonstrating its acid tolerance. It also exhibited resistance to 0.3% (w/v) bile salt, indicating its ability to survive in the digestive tract. Furthermore, Lac. plantarum JBSxH.6.4 inhibited the growth of Escherichia coli ATCC25922 at 8,08 ± 0,34 mm and Staphylococcus aureus ATCC25923 at 8,95 ± 0,15 mm, suggesting its antimicrobial properties. Additionally, interaction tests indicated that it did not inhibit Lactobacillus acidophilus FNCC0051, supporting its compatibility with beneficial gut microbiota. These findings suggest that Lac. plantarum JBSxH.6.4 meets key probiotic criteria and has potential applications in functional foods and health industries. Further studies, including in vivo evaluations, are recommended to confirm its efficacy and safety for human.
Analisis Paracetamol dalam Sediaan Sirup X dan W dengan Metode Spektrofotometri UV-Vis Genesis 10s Purba, Hermawan; Gresela, Paula; Manalu, Tiodora; Mayranti, Dwi; Zalukhu, Historis
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.146

Abstract

Paracetamol is a medication that is safe for children to use to relieve pain and reduce fever, with minimal side effects. This medication is available in various forms, including syrup, which consists of a solution with a high sucrose content. Maximum Wavelength and Calibration Curve: In the study, the standard paracetamol was analyzed to determine that the obtained wavelength is at 246 nm. Several solutions with different concentrations (10, 15, 20, 25, and 30 ppm) were used to create a calibration curve, which shows the relationship between absorbance and concentration. Linear regression equation: Y = 0.0044x – 0.0166, R² = 0.9936. The absorbance of the syrup sample indicates a paracetamol concentration of approximately 24.23 ppm for sample X and 17.63 ppm for sample W, calculated using a calibration curve. Thus, the research shows an effective analytical method for determining the concentration of paracetamol in syrup preparations.
Analisis Asam Askobat dalam Sediaan Tablet A dan Minuman Suplemen B dengan Metode Spektrofotometri UV-Vis Genesis 10s Purba, Hermawan; Faneca, Egia; Anggreni, Wulan
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.147

Abstract

Vitamin C is one of the nutrients that acts as an antioxidant and is effective in fighting free radicals that can potentially damage cells or tissues, including protecting the lens of the eye from oxidative damage caused by radiation. Additionally, Vitamin C can also help reduce the risk of cancer and prevent damage caused by free radicals that can trigger cancer development. The purpose of this research is to determine the vitamin C content in tablet A and drink B using the UV-Vis spectrophotometry method with the Genesis 10S. This study is descriptive in nature, focusing on the determination of vitamin C levels in tablet A and drink B using the UV-Vis spectrophotometry method with the Genesis 10S. To prepare a concentration series of 2; 4; 6; 8; 10 ppm, pipette from the stock solution of Chloramphenicol at 1000 mg/L. Each sample is placed into a 10 ml volumetric flask and diluted with distilled water up to the mark.Then, an examination was conducted on each concentration using UV-Vis spectrophotometry. After the curve appeared, the calibration curve was obtained by examining the relationship between concentration (X) and the area under the chromatogram (Y) and determining its regression equation (y= ax + b). The results of the analysis of ascorbic acid in tablet preparation A and drink B using the UV-Vis Genesis 10s spectrophotometry method yielded a linear equation for the calibration curve between absorbance and the concentration of the standard solution, resulting in the equation Y = 0.0395x- 0.0443 with an r² value of 0.9853.
Gambaran Kadar Hb Pada Penderita Malaria Tropika di UPTD Puskesmas Kuala Makmur Manihuruk, Fani Nuryana; Akrama, Nurul
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.148

Abstract

Malaria is an infectious disease caused by Plasmodium falciparum. In people with malaria, Plasmodium attacks red blood cells. Malaria parasite infection destroys red blood cells, so the blood of malaria sufferers is always much lower than normal hemoglobin levels. Parasitic red blood cells can be destroyed by phagocytes trying to overcome this parasitic infection. The degree of anemia in malaria patients can affect the severity of the disease and also affect treatment efforts. This study used the POCT method or strip test with the Easy Touch device. This study aims to determine hemoglobin levels in malaria patients at the Kuala Makmur Public Health Center, Simeulue Regency in 2022 based on age, gender, and degree of anemia. The number of samples examined as many as 25 were taken by accidental sampling. The type of research used is quantitative research, that is, the type of research conducted with the aim of looking at the description of hemoglobin levels in patients with tropical malaria caused by Plasmodium falciparum. The results showed that the highest incidence of tropical malaria occurred in patients aged 21-30, female sex with normal degree of anemia 40%, mild 28%, moderate 12% and severe 20%. The average hemoglobin level in malaria patients is below normal with a percentage of 68%. From the results of the study, it can be concluded that hemoglobin levels in tropical malaria patients in the working area of ​​UPTD Puskesmas Kuala Makmur are below normal. Suggestions for health workers are expected to provide more frequent counseling about malaria about the meaning, symptoms, methods of prevention, modes of transmission, and treatment. For patients, so that patients check themselves more quickly if they have a fever and take anti-malarial drugs according to the instructions recommended by health workers.
Evaluasi Kadar Glukosa Darah Pada Pasien Hipertensi yang Menggunakan Obat Golongan Angiostensin Receptor Bloker (ARB) di Rumah Sakit Umum Daerah Undata Palu Susilawati, Ni Made; Fresha, Winda; Rumi, Amelia; Adisaputra, Arya Dibyo
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.151

Abstract

Hipertensi adalah kondisi medis yang ditandai dengan peningkatan tekanan darah arteri secara berkelanjutan. Salah satu golongan obat lini pertama pengobatan hipertensi adalah golongan Angiotensin Receptor Blocker (ARB). Obat ini berpotensi dapat dapat mempengaruhi metabolisme glukosa darah. Penelitian ini bertujuan untuk mengevaluasi kadar glukosa darah pada pasien hipertensi yang menjalani terapi menggunakan obat ARB, seperti losartan, candesartan, valsartan, dan telmisartan, di RSUD Undata Palu. Penelitian ini dilakukan dengan metode cross-sectional secara prospektif, melibatkan 30 pasien yang memenuhi kriteria inklusi. Pasien yang diteliti berusia ≥18 tahun, telah menjalani terapi ARB selama 3 bulan, memiliki hipertensi tanpa diabetes melitus, dan tidak menggunakan obat lain yang memengaruhi kadar glukosa darah. Pengukuran dilakukan menggunakan glucometer Accu-Chek Performa. Hasilnya menunjukkan penurunan kadar glukosa darah puasa dari rata-rata 113.83 mg/dl menjadi 107.83 mg/dl, dengan selisih 6.367 mg/dl. Uji statistik menunjukkan p=0.049 (p<0.05), yang mengindikasikan bahwa ARB dapat menurunkan kadar glukosa darah pada pasien hipertensi.
Uji Aktivitas Antibakteri Ekstrak Fermentasi Bawang putih tunggal (Allium sativum L.) Terhadap Bakteri Staphylococcus aureus dan Methicillin-resistant Staphylococcus aureus (MRSA) Sapitri, Alfi; Marbun, Eva Diansari; Arisetya, Dian
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.152

Abstract

The pathogenicity of S. aureus bacteria is often associated with purulent wound infections in both humans and animals, which is the main cause of pyemia cases. Methicillin-Resistant Staphylococcus aureus (MRSA) is a Staphylococcus aureus bacteria that is resistant or immune to methicillin-type antibiotics and its derivatives. This study aims to see the activity of extracts from single garlic fermentation (Allium sativum L) which have antibacterial effects against Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria. This study was conducted at the Pharmacy Laboratory of Sari Mutiara Indonesia University in June-August 2024. This research method was carried out experimentally, the extraction was maceration and the media was tested using MHA to see the bacterial inhibition power. Based on the results of phytochemical screening examinations of single garlic fermentation extracts, it showed the presence of chemical compound groups in the form of Alkaloids, Flavonoids, Tannins, and Saponins. Where the concentration of single garlic fermentation extract is 5%; 10%; 15%. The results of the inhibition test against Staphylococcus aureus bacteria were 9.74 mm; 11.48 mm; 12.19 mm, positive control (chloramphenicol) 12.35 mm. The results of the inhibition test against Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria were 8.49 mm; 10.58 mm, 11.33 mm, positive control (chloramphenicol) 11.42 mm. Ethanol extract from single garlic fermentation has weak antibacterial activity against Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria.
Formulasi dan Evaluasi Sediaan Obat Kumur Dari Ekstrak Fermentasi Bawang Lanang (Allium sativum L.) Marbun, Eva Diansari; Sapitri, Alfi; Arisetya, Dian; Thaib, Cut Masyithah; Haliza, Aipak; Purba, Elizabet Kristina; Helmi, Helmi
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.153

Abstract

Mouthwash is a dilute concentration of antibacterial solution used to fight oral microbes, fight oral infections, cleansers, to eliminate bad breath, fresh and antiseptic. Mouthwash plays an important role in an individual's oral hygiene, mouthwash helps to relieve symptoms of gingivitis, inflamed gums and can also be relied on to destroy pathogenic bacteria. (Banu & Gayathri, 2016). The purpose of this study was to see if the extract from fermented Bawang Lanang (Allium sativum L) can be formulated into a mouthwash. This research method is an experimental laboratory. By including preparation of materials, sample identification, Making fermented Bawang Lanang, making extracts, extract yields, phytochemical screening, then formulated into a mouthwash. After that, an evaluation of the physical preparation of the mouthwash was carried out (organoleptic test, pH test, viscosity test and stability test). The results of the evaluation of the mouthwash preparation starting from the organoleptic test, pH test did not exceed pH 7, viscosity test of the series was stable for 3 months. Conclusion: Mouthwash preparations containing fermented ethanol extract of male shallots can be used as mouthwash, with good stability.
Buah Pisang barangan (Musa acuminata linn) Sebagai Media Alternatif Perkembangbiakan Bakteri Lubis, Retnita Ernayani; Sapitri, Alfi; Arisetya, Dian; Marbun, Eva Diansari
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.155

Abstract

Barangan banana (Musa acuminata linn) has an energy content of 89 calories, 22.84 grams of carbohydrates, 1.09 grams of protein and 0.33 grams of fat. The nutritional content and bioactive substances of barangan bananas have phenolics, anthocyanins and phenols. The purpose of this study was to determine whether barangan bananas can potentially be an alternative medium for bacterial growth. The growth method used in this study was the scratch method, with the calculation of the number of colonies using the TPC (Total Plate Count) method. The results of the study on the scratch method at various concentrations were able to grow optimally on barangan banana-based media at a concentration of 36%. The shorter exponential phase (log) period in the 36% concentration media with a higher cell density than in the 12% concentration media. Conclusion: Barangan banana (Musa acuminata linn) can potentially be an alternative medium for bacterial growth.
Pengaruh Perbedaan Ketinggian Tumbuh Daun Miana (Coleus scutellarioides) di Daerah Bali Terhadap Kadar Flavonoid Total Puspita Sari, Dyah Ratna Ayu; Ugrasena, Putu Yudha; Indraswari, Putu Ika Indah
Herbal Medicine Journal Vol 8 No 2 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i2.156

Abstract

Miana (Coleus scutellarioides) contains flavonoids as its primary active components and is widely used in traditional medicine, particularly in Indonesia. In Bali, which is renowned for its traditional healing practices (Usada Bali), miana is commonly utilized as a herbal remedy. The leaves of miana possess various pharmacological activities, including anti-inflammatory, antiproliferative, antidiabetic, anthelmintic, and antipyretic effects. Geographical conditions, such as the altitude of the growing region, are among the factors that influence the flavonoid content in miana leaves. This study aimed to determine the total flavonoid content in miana leaves from three different altitudes in Bali: Bedugul (1273 masl), Klungkung (393 masl), and Sanur (11 masl). An experimental laboratory design was employed, using maceration with 96% ethanol as the extraction method. The total flavonoid content was quantified using UV-Vis spectrophotometry, with quercetin as the reference standard. The results showed that miana leaves from Klungkung exhibited the highest total flavonoid content (540.85 ± 7.97 mgQE/g), followed by Bedugul (488.68 ± 6.07 mgQE/g) and Sanur (368.53 ± 11.2 mgQE/g). Statistical analysis revealed that the total flavonoid content of miana leaves from Klungkung was significantly higher (P<0.05) than that from the other two regions. These findings indicate that the altitude of the growing region affects the total flavonoid content in miana leaves, with the highest levels observed at an intermediate altitude (393 masl).

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