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Herbal Medicine Journal
Published by Sekolah Tinggi Ilmu Kesehatan Senior Medan
ISSN : -     EISSN : 26212625     DOI : https://doi.org/10.58996
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology
Herbal Medicine Journal menerima artikel penelitian dalam 2 area utama di bidang farmasi: Sains Farmasi dan Farmasi Komunitas dan Klinis. Dalam bidang sains farmasi, artikel penelitian yang diterima meliputi Biologi Farmasi dan Farmakognosi, Kimia Farmasi, Farmasetika, Farmakologi dan Toksikologi, dan juga Bioteknologi. Sedangkan area Farmasi Komunitas dan Klinis mencakup Farmasi Rumah Sakit, Farmasi Klinis, Manajemen Farmasi, dan Farmasi Sosial.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 119 Documents
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Analisis Karakteristik Organoleptik, pH, dan Total Bakteri pada Yoghurt Susu Sapi Rahmiati, Rahmiati; Situmorang, Toberni S; Simanjuntak, Helen Anjelina; Pasaribu, Sudana Fatahillah; Lestari, Wanda; Sianturi, Ayu Enjelina; Amanzino, Regina Asmara
Herbal Medicine Journal Vol 8 No 2 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i2.185

Abstract

Yogurt is made from fermented milk with the help of lactic acid bacteria starter. Yogurt is known to contain nutrients and metabolites that are beneficial for health, such as protein, calcium, phosphorus, vitamins, lactic acid and bacteriocins. The quality of yogurt is influenced by various factors, such as incubation period (storage), substrate and starter. This study aims to analyze the organoleptic characteristics, pH value, and total bacterial colonies in cow's milk yogurt incubated for 24 hours. The type of research is descriptive quantitative with a pour plate method carried out in vitro in the laboratory. The study was carried out in 4 stages including sample preparation, making cow's milk yogurt, organoleptic testing and counting total bacteria using the TPC (total plate count) method. The results showed that the pH of the cow's milk yogurt formed after 24 hours was 4. With a characteristic sour taste, semi-solid texture and a distinctive aroma of lactic acid fermentation that is light, fresh, and not pungent. The average number of total bacterial colonies was 3.66 x 102 CFU. The test was continued by determining the hedonism scale for 15 panelists. As many as 80% said they liked it.
Uji Aktivitas Antibakteri Krim Ekstrak Etanol Daun Kitolod (Isotoma longiflora)(L).C.Presl Terhadap Staphylococcus epidermidis dan Pseudomonas aeruginosa Simanjuntak, Helen Anjelina; Nahampun, Laura Yunita; Purba, Hermawan; Simanjuntak, Herlina; Sinaga, Suharni Pintamas; Sembiring, Mahral Effendi; Rahmiati, Rahmiati; Situmorang, Toberni S
Herbal Medicine Journal Vol 8 No 2 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i2.186

Abstract

Kitolod plants are used to treat various types of diseases, such as eye pain, wound healing, asthma, bronchitis, rheumatism and others. This study aims to determine the antibacterial activity test of kitolod leaf ethanol extract cream (Isotoma longiflora) (L).C.Presl against Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria. This research stage includes determination, preparation of simplicia, extraction, phytochemical screening, cream formulation F0 (0%), F1 (4%), F2 (6%) F3 (8%), and antibacterial test. The results of the phytochemical screening showed that alkaloids, flavonoids, tannins, saponins and steroids were obtained. The results of the antibacterial activity test of the formula against Staphylococcus epidermidis in sequence F0 (0%), F1 (4%), F2 (6%) and F3 (8%) were 11.315 mm; 15.205 mm; 18.843 mm; 23.698 mm. Meanwhile, against Pseudomonas aeruginosa bacteria, the measurements were 6.04 mm, 8.19 mm, 12.46 mm, and 17.24 mm, respectively. In conclusion, all variations of the cream formula showed antibacterial activity in inhibiting the growth of Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria. The cream formulation was more sensitive to Staphylococcus epidermidis bacteria than Pseudomonas aeruginosa bacteria.
Tingkat Pengetahuan Konsumen di Apotek X Pabuaran Bojonggede, Kabupaten Bogor terhadap perilaku penggunaan Antibiotik Khoirunnisa, Amalia; Teodhora, Teodhora; Djuhariah, Yayah Siti; Wulandari, Ainun
Herbal Medicine Journal Vol 8 No 2 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i2.158

Abstract

Antibiotics are drugs used to treat or prevent bacterial infections. When used improperly, bacteria can adapt and develop resistance. Public awareness of appropriate antibiotic use plays a significant role in combating antibiotic resistance. To determine the relationship between antibiotic use behavior and the level of consumer knowledge at Jovita Pharmacy, Pabuaran, Bojonggede, Bogor Regency. This study employed a descriptive-analytic design with a cross-sectional approach. A total of 106 respondents who met the inclusion criteria were surveyed using a structured questionnaire. The data were analyzed using the Chi-Square test with a significance level of 0.05. Only 2.8% of respondents had good knowledge, and 33% demonstrated appropriate antibiotic use behavior. The Chi-Square test showed a significant correlation (p = 0.001) between knowledge and behavior in antibiotic use. There is a strong relationship between the level of knowledge and behavior in the use of antibiotics. Increased education and regulation are needed to promote rational use of antibiotics among the public.
Formulasi dan Uji Efek Sedatif Patch Transdermal Tipe Matriks Ekstrak Biji Pala (Myristica fragrans Houtt) dan Ekstrak Daun Selada (Lactuca sativa) Terhadap Mencit Jantan (Mus musculus L.) Sari, Annisa Kartika; Baroroh, Ziadatul; Solikah, Umrotus; Latifah, Bunaiya; Laila, Siti Rohmatul; Sharon, Nela
Herbal Medicine Journal Vol 8 No 2 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i2.170

Abstract

Insomnia merupakan gangguan tidur atau kondisi tidur non-restoratif. Tanaman herbal Biji Pala (Myristica fragrans Houtt) dan Daun Selada (Lactuca sativa) terbukti memiliki efek hipnotik-sedatif. Kombinasi kedua tanaman herbal tersebut diformulasikan menjadi patch transdermal untuk memaksimalkan efektivitas terapi dan mengurangi efek samping. Proses ekstraksi menggunakan metode maserasi etanol 96% dan skrining fitokimia dilakukan pada ekstrak untuk mengidentifikasi senyawa metabolit sekunder didalamnya. Patch transdermal diformulasikan menggunakan pemilihan matriks dengan perbandingan konsentrasi HPMC:PVP 5:7 (F1), 6:6 (F2), and 7:5 (F3). Evaluasi patch yang dilakukan meliputi pengamatan organoleptik, ketebalan patch, pH, dan ketahanan lipat. Uji efek sedatif dilakukan dengan traction test terhadap mencit jantan (Mus muculus L.). Rendemen ekstrak daun selada yang mengandung flavonoid, tanin, dan saponin sebesar 56,8%, sedangkan pada ekstrak Biji Pala sebesar 28,03%. Formula dengan karakteristik optimal adalah F2 yang mempunyai ketebalan 0,19 mm, pH 4,8, dan daya tahan lipat lebih dari 200 kali. Formulasi dengan respon sedatif yang bekerja paling baik adalah F2 dan F3. Dapat disimpulkan bahwa F2 diklaim sebagai formula optimal dari efek sedatif untuk terapi insomnia.
Uji Stabilitas dan Uji Aktivitas Antifungi Sediaan Krim Dari Fraksi Etil Asetat Daun Matoa (Pometia pinnata J.R Forst & G. Forst) Terhadap Pertumbuhan Jamur Trichophyton rubrum Rinaldi, Agus Rahman; Rosi, Devahimer Harsep; Hevira, Linda
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.198

Abstract

Matoa (Pometia pinnata) is one of the endemic plants of Papua that has pharmacological antifungal activity. This study aimed to determine whether the ethyl acetate fraction of Matoa leaves can be formulated into a cream preparation that meets the requirements for stability testing and antifungal activity testing. This study is an experimental study which includes stability testing and antifungal activity testing of the cream preparation made from the Matoa leaf fraction against the growth of the fungus Trichophyton rubrum. The yield of ethanol extract from Matoa leaves was 21.272%, which had organoleptic properties that did not differ among each cream formula. The cream formulas were homogeneous, with no coarse granules observed during homogeneity testing. The pH of the cream preparations was between 4 and 5. The adhesive and spreading power of the cream preparations met the requirements, except for formula F3. The antifungal activity of the ethyl acetate fraction cream preparations against Trichophyton rubrum showed inhibition zones as follows: F1: 18.28 mm, F2: 11.19 mm, and F3: 18.81 mm. All formulas (F1, F2, and F3) met the physical and stability requirements for a good cream preparation, except that the spreading power test for F3 did not meet the criteria for good cream physical properties. The best antifungal activity against Trichophyton rubrum was observed in formula F3, with an inhibition zone of 18.81 mm, categorized as strong antifungal activity.
Formulasi dan Evaluasi Sediaan Tablet Effervescent dari Ekstrak daun Andaliman (Zanthoxylum acanthophodium Dc.) dengan Variasi Asam dan Basa Naibaho, Novrika Desclarita; Bangar, Roy Indrianto; Lubis, Asyrun Alkhairi
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.206

Abstract

Andaliman leaves (Zanthoxylum acanthopodium) are a plant that has the potential to be used as a natural ingredient in the development of herbal preparations. Andaliman leaves are known to contain secondary metabolite compounds, including flavonoids, terpenoids, alkaloids, and tannins. This potential encourages the processing of Andaliman leaves into extracts which are then formulated in the form of effervescent tablets to increase practicality of use. This study aims to produce effervescent tablets of Andaliman leaf extract with good physical quality by making three formulas with varying concentrations of acid-base components. Extraction was carried out using 70% ethanol solvent, then an evaluation of the properties of the resulting granules and tablets was carried out. The test results showed that all formulas met the requirements for organoleptic tests, water content, flow time, and compressibility, but in the angle of repose test only F2 met the criteria. Tablet evaluation showed that all formulas met the organoleptic tests, hardness, friability, and dissolution time, while the uniformity and weight tests still showed discrepancies in some formulas. Overall, formula F2 is the best formula because it meets most of the evaluation parameters for granules and tablets, so it has the greatest potential to be developed as an effervescent tablet preparation from andaliman leaf extract.
Karakteristik Jamur Kontaminan Pascapanen pada Beberapa Jenis Umbi – umbian Rahmiati, Rahmiati; Situmorang, Toberni S; Simanjuntak, Helen Anjelina; Pratiwi, Dini; Sari, Indah
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.207

Abstract

The quality of tuber crops frequently deteriorates as a result of post-harvest fungal contamination. Fungal contamination of potatoes, sweet potatoes, and taro tubers during post-harvest handling and storage can significantly reduce their economic value and pose potential health risks through the production of mycotoxins. This study aimed to evaluate the post-harvest shelf life of potato, sweet potato, and taro tubers and to identify the fungal species contaminating these commodities. A qualitative descriptive approach was employed using the scratch plate isolation method. Fungal contaminants were characterized based on macroscopic colony morphology and microscopic features. The research procedures included sample preparation, assessment of physical quality changes during storage, fungal isolation, and identification. The results demonstrated that taro tubers maintained the highest physical quality after 14 days of storage, whereas potato tubers exhibited the most pronounced physical deterioration and the highest incidence of fungal contamination. A total of eight fungal isolates with distinct macroscopic and microscopic characteristics were obtained, designated as T1SP1, T1SP2, U1SP1, U1SP2, T2SP1, T2SP2, T3SP1, and T3SP2. These isolates were identified as belonging to the genera Aspergillus, Trichoderma, Colletotrichum, and Curvularia.
Aktivitas Antibakteri Ekstrak Etanol Umbi Porang (Amorphophallus muelleri Blume) terhadap Propionibacterium acnes dan Staphylococcus epidermidis Sapitri, Alfi; Marbun, Eva Diansari; Lubis, Retnita Ernayani; Arisetya, Dian
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.208

Abstract

Porang tubers, scientifically known as Amorphophallus muelleri Blume, have shown that they possess compounds like alkaloids, flavonoids, saponins, and tannins. Because of this, researchers are looking closely at porang tubers to see how they can fight bacterial growth. Among the bacteria being investigated are Propionibacterium acnes and Staphylococcus epidermidis, as scientists search for new treatments for skin infections. Aim of reserach to assess how effective the antibacterial properties are and to analyze how different levels of extract concentration affect the growth of Propionibacterium acnes and Staphylococcus epidermidis. The method used for testing involved a paper disc diffusion technique with extract concentrations of 5, 15, 25, 35, and 45%, as well as Clindamycin and 10% DMSO. The findings revealed that the ethanol extract from porang tubers displayed antibacterial effects at concentrations ranging from 5% to 45%, resulting in inhibition zones of 9. 65 mm to 13. 56 mm against Propionibacterium acnes. Additionally, it showed inhibition zones of 9. 95 mm to 16. 07 mm against Staphylococcus epidermidis in the same concentration range. According to the One Way Anova test, the results showed a significant difference indicating that varying concentrations of the ethanol extract from porang tubers greatly influenced the growth of both Propionibacterium acnes and Staphylococcus epidermidis. The ethanol extract of porang tubers begins to show antibacterial effects at a minimum concentration of 5% against both Propionibacterium acnes and Staphylococcus epidermidis, with observable differences in the average inhibition zones for each concentration tested.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Sirih Cina (Peperomia pellucida (L.) Kunth). Terhadap Bakteri Propionibacterium acnes, Staphylococcus epidermidis dan Staphylococcus aureus Purba, Hermawan; Hilleri Damanik, Geby
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.209

Abstract

Pathogenic bacteria have negative impacts if exposed to the human body for a certain period of time. It is necessary to inhibit bacterial growth from natural materials because they generally have non-toxic, environmentally friendly, and biodegradable properties. This study used Chinese betel leaf extract (Peperomia pellucida (L.) Kunth) as an antibacterial material against Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus. The results of the phytochemical screening analysis showed that there were secondary metabolites in the extract and simplicia such as tannins, alkaloids, and flavonoids. The antibacterial test pad with the largest concentration variation has a strong and very strong category on the three types of bacteria, namely against Staphylococcus epidermidis (diameter 19.9 mm) at a concentration of 5%, Staphylococcus aureus (diameter 22.92 mm) at a concentration of 7%, Propionibacterium acnes. (diameter 19.63 mm) at a concentration of 7%.
Analisis Cemaran Bakteri Coliform dan Escherichia coli pada Sampel Sari Tebu yang dijual di Pedagang Kaki Lima Situmorang, Toberni S; Simanjuntak, Helen Anjelina; Rahmiati, Rahmiati
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.210

Abstract

Sugarcane juice is a beverage extracted from sugarcane that is popular and widely consumed by the public. This condition creates business opportunities, particularly for street vendors. However, processing practices that do not adequately consider hygiene and sanitation aspects can increase the risk of contamination by pathogenic bacteria, especially Coliform bacteria and Escherichia coli. This study aimed to determine the level of contamination of Coliform bacteria and Escherichia coli in sugarcane juice sold by street vendors. This research employed a descriptive qualitative design using the spread plate isolation method. Samples were obtained from five street vendors located along the main roads of Tanjung Selamat Subdistrict, Medan Tuntungan District, Medan City. Bacterial contamination testing was conducted using the Most Probable Number (MPN) method, which consisted of three stages: presumptive test, confirmatory test, and completed test. The results showed that one out of five sugarcane juice samples tested were detected to contain Coliform bacteria and Escherichia coli. These findings indicate that one sugarcane juice samples sold by street vendors did not meet food safety standards and may pose potential health risks to consumers. Therefore, improved implementation of hygiene and sanitation practices in the processing and serving of sugarcane juice is necessary.

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