cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Puspawan Hariadi
Contact Email
puspawanhr@hamzanwadi.ac.id
Phone
+6287839493979
Journal Mail Official
sinteza@hamzanwadi.ac.id
Editorial Address
Jalan TGKH. Muhammad Zainuddin Abdul Majid No. 132 Pancor, Selong, Lombok Timur, Nusa Tenggara Barat KP: 83612 Telp/Fax: 6237622954, Kab. Lombok Timur, Provinsi Nusa Tenggara Barat, 83612
Location
Kab. lombok timur,
Nusa tenggara barat
INDONESIA
Sinteza
Published by Universitas Hamzanwadi
ISSN : -     EISSN : 27978133     DOI : https://doi.org/10.29408/sinteza
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Sinteza, ISSN (online) 2797-8133, is a peer-reviewed journal in pharmacy. Established 2021, the journal is an open access of published articles to support greater exposure of scientific knowledge. Sinteza published online twice a year by Faculty of Health, Universitas hamzanwadi. Sinteza accepts various fields of research in pharmacy including community and clinical pharmacy, pharmaceutics, pharmacology, toxicology, pharmacokinetics, pharmaceutical chemistry, and pharmaceutical biology. Manuscript accepted in Sinteza written in both Bahasa Indonesia and English
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 6 Documents
 1 
Search results for , issue "Vol. 4 No. 2 (2024): August" : 6 Documents clear
Pengaruh Swamedikasi Penyakit Kulit terhadap Tingkat Pengetahuan Siswa di Panti Asuhan Yatim Muhammadiyah Kabupaten Pekalongan Ningrum, Wulan Agustin; Awaludin, Muhammad Mahruj; Suryani, Irma
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.20309

Abstract

Skin disease is one of the many diseases that is still a problem in the world, including Indonesia. This fungal skin disease is not fatal, however, because it is chronic and residual, and many people are resistant to the use of antifungal drugs. In this day and age, accessing information related to medicines is easier, so many people choose to take self-medication even though the implementation can cause errors. The number of cases of self-medication for skin diseases carried out by respondents in Muhammadiyah Orphanages throughout Pekalongan Regency. The aim of this research is to determine the level of students' knowledge of self-medication among respondents in Muhammadiyah Orphanages throughout Pekalongan Regency, consisting of Pekajangan, Kedungwuni, Wuled orphanages. , Wonopringgo, and Kajen. The method used in this research is an analytical survey with a cross sectional design. The sampling technique uses total sampling. The sample for this study was 75 respondents, namely respondents who had a history of skin disease and had done self-medication. The research results showed that 86,7% of respondents had a level of knowledge in the very good category. It can be concluded from the research that students at the Pekalongan Regency Muhammadiyah Orphanage have very good knowledge in self-treatment of skin diseases. More in-depth research needs to be done so that we can find out the relationship.
Formulasi Sediaan Sabun Cair Ekstrak Daun Ramania (Bouea macrophylla Griffith) sebagai Antiseptik Mahdi, Nur; Rezekiah, Rezekiah; Ani, Agustina
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.25475

Abstract

Ramania leaves (Bouea macrophylla Griffith) are natural ingredients that have activity as an antiseptic. Ramania leaves contain flavonoids, alkaloids, steroids and tannins. This study aims to make antiseptic liquid soap from ramania leaf extract with a concentration of 5%, 10%, 15%. This study used experimental methods in the laboratory. three formulations were made (FI, FII, FIII with a concentration of 5%, 10%, 15%). Evaluation includes organoleptic, homogeneity, pH, specific gravity, foam height. Antiseptic test was carried out using the zigzag method. he antiseptic test was carried out using the replica method. The statistical test for evaluating preparations is One Way Anova, for antiseptic testing using Paired sample t-test. The results of several evaluations have met the requirements, except that the specific gravity does not meet the SNI criteria. The antiseptic test is indicated by the percentage of bacterial reduction. The percentage of bacterial reduction in FI, II, and III respectively was 40.5; 48.5; and 57.5%. It can be seen that increasing the extract concentration can reduce the number of bacterial colonies. The results of the One Way Anova statistical test (a = 0.05) showed that there was no difference in the results of the preparation evaluation, the results of the paired sample test (a = 0.05) showed a significant difference in the antiseptic test. Based on the results of research on the specific gravity test however all formulas do not meet the criteria. In the antiseptic test, all formulas were effective in inhibiting bacterial growth.
Telaah Potensi Antivirus Mitraginin terhadap Protease 3CLpro SARS-CoV-2 dengan Pendekatan Molecular Docking Setiawansyah, Arif; Susanti, Gita; Hidayati, Nurul; Gemantari, Baiq Maylinda; Alrayan, Reza; Hadi, Ismanurrahman; Luthfiana, Dewi; Hasanah, Nurul
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.25634

Abstract

SARS-CoV-2 is a novel coronavirus identified as a major caused of COVID-19. COVID-19 can be prevented and managed by preventing the SARS-CoV-2 infection through inhibition of SARS-CoV-2 main protease. Mitragynine is one of the major compounds found in Mitragyna speciosa leaves that has the potential to be developed as an anti-COVID-19 agent. This research was implemented to evaluate that potential by observing the molecular interaction of mitragynine with the essential amino acid residues of SARS-CoV-2 3CLpro. The study was undertaken by in silico method via molecular docking approach using Autodock 4.2. The potential of mitragynine in inhibiting the SARS-CoV-2 main protease was justified based on its free binding energy and Ki. The result revealed that mitragynine exhibited a lower free binding energy and Ki than remdesivir with the free binding energy and Ki value of -7.80 kcal/mol dan 1.92 µM dan -7.41 kcal/mol dan 3.72 µM, respectively. This concluded that mitragynine has the potential as a SARS-CoV-2 main protease inhibitor with the affinity was better than remdesivir. However, further in vitro research must be carried out to prove this potential. 
Formulasi dan Evaluasi Sifat Fisik Sediaan Lulur Ekstrak Etanol Kulit Pisang Kepok (Musa paradisiaca L) Yuliana, Tri Puspita; Zulda, Nurul Fitri Erlinda
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26049

Abstract

Banana peel is the part of the banana that has not been used. A body scrub is a semi-solid preparation that functions to clean dirt on the face and dead skin cells. Banana peel one of any plants can be used as the basic of formulated cream cosmetics has flavonoid and tanin compound content, in acts as an moisturizer skin. This research aims to determine the formulation and evaluation of the physical preparation of kepok banana peel (Musa Paradisiaca L) ethanol extract scrub. The research method used was the laboratory experimental method. Evaluation of the scrub preparation includes organoleptic testing, homogeneity, spreadability testing, adhesion testing, pH testing and skin moisturizing power testing. The results showed that the preparation of the ethanol extract of kepok banana peel from both formulas had organoleptic results of F1 (semi-solid cream form, light brown color, typical aroma of kepok banana peel extract), F2 (semi-solid cream form, dark brown color, typical aroma of peel extract banana kepok), the homogeneity test of the preparation produces an even preparation when smeared on the surface of a glass object in all formulas, testing acidity or pH F1: 5.45 and F2 = 6.42. The spreading ability test results were at F1: 5.80 cm and F2: 5.44 cm. Testing ability of sticking time F1: 2.44 seconds and F2: 2.57 seconds. The skin moisturizing ability test before application showed an average of 23.6%, on day 5 an average of 36.5% and on day 10 an average of 48.5%. The conclusion is that the Kapok banana peel scrub formulation has physical properties that meet standards and is able to significantly moisturize the skin after 10 days of use. Statistical data shows that there is no significant difference in each formula with significance values ​​of 0.327, 0.265 and 0.294 (P<0.05).
Analisis Efektivitas Biaya Penggunaan Insulin Lantus dan Apidra di RSUD Dr. R. Soedjono Selong Oktresia, Erma Ewisa; Sovia, Fitriwati; Ramadhan, Leny; Ramadani, Lalu Khilal
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26475

Abstract

Indonesia is one of the countries with the highest number of type II diabetes mellitus patients in the world, reaching 10.7 million people. Diabetes mellitus requires long-term treatment to control patients' blood glucose levels. The types of therapy used vary, leading to differences in costs and treatment outcomes. The use of insulin is a significant issue in diabetes mellitus therapy, especially at RSUD Dr. R. Soedjono, concerning its cost-effectiveness and therapeutic efficacy. This study aims to analyze the cost-effectiveness of using Lantus and Apidra insulin therapies.This research is an observational analytic study with a cross-sectional design, and data collection was conducted retrospectively at RSUD Dr. R. Soedjono Selong. The sample selection was based on predetermined inclusion and exclusion criteria. Observations were made on the Length of Stay (LOS) and Direct Medical Cost (DMC) for each sample. Based on LOS and DMC data, the Average Cost-Effectiveness Ratio (ACER) was calculated. The results showed that the average LOS for Lantus insulin use was 4 days, while for Apidra insulin use, it was 5 days. The average DMC for Lantus insulin was Rp.2,395,734, while for Apidra insulin, it reached Rp. 2,590,218. Based on LOS and DMC data, the ACER value for Lantus insulin was Rp 598,934/day, while for Apidra insulin, it was Rp 518,043/day. The use of Apidra insulin is more cost-effective because it has a lower ACER value.
Aplikasi Simplex Lattice Design untuk Optimasi Emulgator dalam Krim Minyak Atsiri Kulit Jeruk Manis Pratiwi, Puspa Dwi; Arnas, Deah Lestiana
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26539

Abstract

In order to obtain a perfect emulsified and stable preparation, choosing the right composition emulsifier is crucial. Formula optimization is needed to determine the best combination of ingredients in formulation process based on evaluation responses. Simplex Lattice Design (SLD) is an experimental design method for mixing materials with the proportion of the total number of materials 1 or 100%. This research was aims to obtained the optimal cream formula using tween 80 and span 80 as emulsifiers and determined their effect on the physical properties of cream preparation. SLD method was used as optimization method with tween 80 and span 80 as independent variables and pH, viscosity, spreadability, and stickiness as responses. The minimum limit for tween 80 and span 80 is 1% (w/v) and the maximum is 9% (w/v) with total 10%. The optimal formula was obtained from consideration of the response by entering the target value to obtain a formula with desirability value close to 1. There are 5 formulas based on SLD recommendations, with a concentration ratio of tween 80 and span 80 9:1 (run 1); 7:3 (run 2); 1:9 (run 3); 5:5 (run 4); and 3:7 (run 5). The relationship between concentration and response value can be explained based on the significance of the model and equations obtained. The optimal formula was the concentration ratio of tween 80 and span 80 8.6:1.34 with a desirability value of 0.953. The conclusion of this research was that SLD can be used to optimize the emulsifier with response predictions close to the results obtained.

Page 1 of 1 | Total Record : 6

 1 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol. 5 No. 2 (2025): August Vol. 5 No. 1 (2025): February Vol. 4 No. 2 (2024): August Vol. 4 No. 1 (2024): February Vol. 3 No. 2 (2023): August Vol. 3 No. 1 (2023): February Vol. 2 No. 2 (2022): August Vol. 2 No. 1 (2022): February Vol. 1 No. 2 (2021): August Vol. 1 No. 1 (2021): February