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Analisis Kaplan Meier terhadap Perbaikan Klinis Batuk pada Pasien Pneumonia Anak yang Diberikan Terapi Tambahan Vitamin D Arief Rafsanjani; Endang Darmawan; Nurcholid Umam Kurniawan; Tri Puspita Yuliana; Aditya Noviadi Rakhmatullah
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2632

Pneumonia is the leading cause of death in children under five years of age and contributed to 14% of total global child deaths in 2013. Pneumonia is an inflammation of the lungs caused by bacteria, viruses, fungi, parasites and attacks the lung parenchyma. After receiving antibiotic therapy, the cure rate for pneumonia is relatively high, but the mortality rate due to pneumonia infection is still high. Therefore there needs to be an effort to add therapy to improve patient clinical outcomes. Vitamin D plays a role in the body's defense function, both in natural and adaptive immunity and in the body's defense in cases of infection, malignancy, and autoimmunity. This study was an experimental double-blind, randomized clinical trial that was analyzed using Kaplan Meier. The research subjects were children aged six months to 18 years divided into two treatment groups, namely the treatment group (n = 35) and the control group (n = 35). The treatment group received vitamin D, while the control group a placebo. The data taken included the results of clinical studies of patients. This study indicates that vitamin D is effective in accelerating the cough frequency of patients infected with pneumonia.

FORMULASI GEL EKSTRAK KULIT BUAH RENGGAK (Amomum dealbatum Roxb) SEBAGAI SEDIAAN ANTI JERAWAT: GEL FORMULATION OF FRUIT PELL EXTRACT OF RENGGAK (Amomum dealbatum Roxb) AS ANTI ACNE PREPARATION Puspawan Hariadi; Muhlisun Azim; Tri Puspita Yuliana; Yuyun Febriani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 1 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Tanaman renggak (Amomum dealbatum Roxb) merupakan tanaman lokal pulau Lombok yang masih belum banyak dimanfaatkan. Tanaman ini dilaporkan mengandung senyawa flavonoid, alkaloid, tannin dan terpenoid. Penelitian ini bertujuan untuk membuat gel dari ekstrak kulit buah renggak dan uji aktivitas terhadap bakteri Propionibacterium acnes. Gel ekstrak kulit buah renggak dibuat dengan variasi konsentrasi 2% dan 4%, uji aktivitas bakteri menggunakan metode difusi agar dengan cara sumuran. Hasil penelitian menunjukan gel ekstrak kulit buah renggak dengan konsentrasi 2% memiliki pH 6, daya lekat 1,64, daya sebar 4,43 serta daya hambat bakteri 2,34 mm. Untuk konsentrasi 4% memiliki pH 6, daya lekat 1,57, daya sebar 4,36 serta daya hambat bakteri 3,20 mm. Gel ektrak kulit buah renggak memiliki zona hambat bakteri dengan kategori lemah, pH dan daya lekat sesuai parameter sediaan gel, sedangkan daya sebar tidak memenuhi persyaratan. Semakin tinggi konsentrasi ekstrak semakin tinggi zona hambat yang dihasilkan.

Combination of Traditional Medicine and Synthesis Medicine Therapy for Hypertension and Diabetic Patients Ersi Arviana Ihsan; Fitriwati Sovia; Erma Ewisa Oktresia; Tri Puspita Yuliana; Sulistia Ardyati; Arief Rafsanjani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.9348

Hypertension and diabetic are interrelated diseases affect atherosclerosis. This study aims to analyze the combination of traditional medicines and synthetic medicine with a job background for patients with hypertension and diabetic. Case-control study method retrieves patient data with medical records. Sampling was done with a purposive sampling technique of 30 respondents conducted in March-June at Labuhan Lombok Health Center. The results showed the percentage of diabetic patients was 26.67% for men and 73.33% for women with a background of 60% of traders, 20% of farmers, 13.3% of fishermen, and housewives of 6.7%. Furthermore, for hypertension patients, the percentage was 13.33% for men and 86.67% for women with a background of 40% of traders, 53.3% for farmers, 6.7% for fishermen. For traditional medicine used are Moringa oleifera L., Cucumis sativus L., jamu gendong, Averrhoa bilimbi L., Curcuma longa L., and Artocarpus camansi Blanco. Based on this, the risk factors for women are more generous than for men, and the use of a combination of drugs gives positive results in improving health.

Pengetahuan masyarakat dan pemanfaatan tanaman obat keluarga di desa toya aikmel utara Muhlisun Azim; Arief Rafsanjani; Tripuspita Yuliana; Puspawan Hariadi
Lentera Negeri Vol 2, No 1 (2021): Lentera Negeri
Publisher : Indonesian Institute For Counseling, Education and Therapy

Family Medicinal Plants (TOGA) is an alternative in achieving GERMAS (Healthy Living Community Movement) as an effort to achieve traditional independent health. The success of the use of TOGA is strongly influenced by the level of public knowledge about the benefits of the type of medicinal plants which has been empirically investigated. The data obtained is qualitative data with descriptive approach analysis method. Data collection was carried out by conducting observations, interviews and technical training to the community in an effort to provide knowledge about TOGA and the creation of a TOGA demonstration plot. The results obtained from this activity are the emergence of public awareness of the use of home yard land for the manufacture of living pharmacies as an effort to achieve independent health and the emergence of public interest in the use of TOGA as a UMKM product in the form of packaged drink sachets as a pilot. The importance of public knowledge about TOGA is needed in supporting the success of achieving independent health and efforts to utilize local biological resources in initiating the manufacture of herbal plant-based UMKM products.

SKRINING EKSTRAK JAMUR ENDOFIT DARI TANAMAN MELINJO (Gnetum gnemon L.) SEBAGAI KANDIDAT ANTIBAKTERI, ANTIJAMUR DAN ANTIOKSIDAN Muhlisun Azim; Puspawan Hariadi; Yuyun Febriani; Tri Puspita Yuliana
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Endophytic fungi are potential microorganisms in lead compounds investigation as research objects for antibacterial and antifungal drug candidates. These microorganisms are able to produce various secondary metabolites, moreover they can even be regulated according to the needs of researchers. This is an advantage of endophytic fungi with good adaptability response. This study aims to explore the antibacterial, antifungal and antioxidant activity of endophytic fungi from the branch of the Melinjo tree (Gnetum gnemon L.) by qualitative analysis. This study resulted in 13 potential endophytic fungi extracts to be explored further for their compounds. Based on the results of the TLC test of the fungal extracts with 10% vanillin in H2SO4 as a reagent, it showed that the dominant compounds were alkaloids and polyphenols. The antibacterial activity test of extracts of the endophytic fungi was carried out by the disc diffusion agar method against Staphylococcus aureus and Pseudomonas aeruginosa bacteria, while antifungal agents were used for Candida albicans and Aspergillus clavatus.. Meanwhile, the qualitative test of antioxidants from fungal extracts using the DPPH spray reagent showed positive results of 8 fungal extracts. Screening of endophytic fungi from melinjo represented a source of endophytes potential as antibacterial, antifungal and antioxidant to be developed in exploration of secondary metabolites from natural products of microbial.

Endophyte Extract From Nattle (Urtica dioica L.) Against Staphylococcus aureus and Escherichia coli Azim, Muhlisun; Novasari, Novasari; Hariadi, Puspawan; Febriani, Yuyun; Yuliana, Tri Puspita
ALKIMIA Vol 6 No 1 (2022): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Endophytes are microorganisms that colonize the plant host tissue. Endophytic colonies are able to produce secondary metabolites in accordance with their host plants, endophytes have been found in every plant species studied to date and are recognized as a source of new natural compounds that have the potential to be exploited in medicine. This study aims to isolate and obtain endophytic fungi and to test secondary metabolites that have the potential as antibacterial against Staphylococcus aureus and Escherichia coli. Plant samples were taken around the village of Mamben, Wanasaba. The research method used is experimental laboratory. This research was conducted by isolating and identifying endophytic fungi from nettle stems. Obtained a type of endophytic fungal strain using Potato Dextrose Agar (PDA) media. The production of secondary metabolites of endophytic fungi was obtained by fermentation method using brown rice for a month then macerated for 3 days using methanol solvent and tested for secondary metabolites and antibacterial activity. The endophytic fungal extract of nettle stem contains alkaloids and flavonoids and is able to inhibit the growth of Staphylococcus aureus bacteria with the highest concentration of 60% with an inhibition zone of 18 mm. whereas, the extract of nettle stem endophytic fungus on Escherichia coli has not an inhibition zone.

Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Semangka Merah Sebagai Krim Antijerawat Tri Puspita Yuliana; Hasratul Kusuma; Puspawan Hariadi; Baiq Maylinda Gemantari
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.19590

Acne is a problem caused by Propionibacterium acnes bacteria. Red watermelon rind contains lycopene compounds, antioxidants, has tannin and flavonoid compounds and is very good for skin care, free from acne, functions as an antibacterial. The purpose of this study was to formulate ethanol extract of red watermelon rind into anti-acne cream preparation and determine the inhibition zone and determine the red watermelon rind cream has the best antibacterial activity against Propionibacterium acnes bacteria. The method used in this study was experimental, extract concentration of 15%, 20%, 25%. The antibacterial activity test was conducted using the pitting method and evaluated the physical properties of the cream preparation including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results showed that the evaluation of the physical properties of the cream preparation had characteristics in accordance with the evaluation of the preparation carried out at each concentration, including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results of the antibacterial activity test of ethanol extract of red watermelon rind F1, F2, F3 are: 6.76 mm, 8.33 mm, 8.73 mm. The results of the antibacterial activity test of the cream preparation of ethanol extract of red watermelon rind F1, F2, F3 are: 4.47 mm, 6.04 mm, 8.17 mm. It can be concluded that the cream preparation of ethanol extract of red watermelon rind meets the characteristics of cream preparation stability, meets the criteria of good physical properties at concentrations of 15%, 20%, 25%, has weak to moderate category antibacterial activity against Propionibacterium acnes bacteria.

The students learning habit and online learning improvement during covid-19 pandemic Yuyun Febriani; Hartini Haritani; Tri Puspita Yuliana; Puspawan Hariadi; Erma Ewisa Oktresi
Jurnal EDUCATIO: Jurnal Pendidikan Indonesia Vol 8, No 2 (2022): Jurnal EDUCATIO: Jurnal Pendidikan Indonesia
Publisher : Indonesian Institute for Counseling, Education and Therapy (IICET)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29210/1202222459

Coronavirus disease (COVID-19) has rapidly spread around the world, including in Indonesia. Some precautionary health protocol measures have been implemented due to this high infection virus, including campus class suspension. This condition made up the students learning habits has been changed. This research aimed to analyse their learning habit and educator's Improvement in online learning during this pandemic. Qualitative research by observation and questionnaires was used in this study. For observation, this research used controlling and evaluating health faculty and university instruments. One hundred and twenty-seven responses participated in this survey. The inquiries were divided into three significant questions: language and information technology skills, duration time for learning, independent and instructional, and student participation. The research obtained that there was a decline in students learning habits during this pandemic. Thereby the educator’s Improvement, including the learning material, educational delivery method, and evaluation and assessment, must be required. Accordingly, the development and innovation of learning improvement should be continuously done.

FORMULASI GEL EKSTRAK KULIT BUAH RENGGAK (Amomum dealbatum Roxb) SEBAGAI SEDIAAN ANTI JERAWAT: GEL FORMULATION OF FRUIT PELL EXTRACT OF RENGGAK (Amomum dealbatum Roxb) AS ANTI ACNE PREPARATION Puspawan Hariadi; Muhlisun Azim; Tri Puspita Yuliana; Yuyun Febriani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 1 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i1.296

Tanaman renggak (Amomum dealbatum Roxb) merupakan tanaman lokal pulau Lombok yang masih belum banyak dimanfaatkan. Tanaman ini dilaporkan mengandung senyawa flavonoid, alkaloid, tannin dan terpenoid. Penelitian ini bertujuan untuk membuat gel dari ekstrak kulit buah renggak dan uji aktivitas terhadap bakteri Propionibacterium acnes. Gel ekstrak kulit buah renggak dibuat dengan variasi konsentrasi 2% dan 4%, uji aktivitas bakteri menggunakan metode difusi agar dengan cara sumuran. Hasil penelitian menunjukan gel ekstrak kulit buah renggak dengan konsentrasi 2% memiliki pH 6, daya lekat 1,64, daya sebar 4,43 serta daya hambat bakteri 2,34 mm. Untuk konsentrasi 4% memiliki pH 6, daya lekat 1,57, daya sebar 4,36 serta daya hambat bakteri 3,20 mm. Gel ektrak kulit buah renggak memiliki zona hambat bakteri dengan kategori lemah, pH dan daya lekat sesuai parameter sediaan gel, sedangkan daya sebar tidak memenuhi persyaratan. Semakin tinggi konsentrasi ekstrak semakin tinggi zona hambat yang dihasilkan.

Efek Ramuan Tradisional Kaliputih terhadap Kadar Glukosa Darah Puasa, SOD, HbA1c, dan Histopatologi Pankreas pada Tikus Diabetes yang Diinduksi Streptozotocin) Kusumo, Djati Wulan; Efendi, Yuli Nurullaili; Kintoko, Kintoko; Yuliana, Tri Puspita; Waznah, Urmatul; Muldiyana, Tya; Pulhehe, Hasni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1229

Prevention of DM by controlling sugar and lipid levels is the main therapy. The traditional medicine diabetes herb from Kaliputih Batur, Banjarnegara, Central Java consists of 11 kinds of medicinal plants that are empirically proven to be efficacious for diabetes mellitus. The potion is prepared by the infundation method. Three control groups (normal, positive, and negative) and three test groups with different doses (18, 36, and 54 mL/kg BW) that had previously been induced by streptozotocin were created using Sprague Dawley (SD) albino rats. Using HE staining, observations were obtained on fasting blood glucose (FBG), superoxide dismutase (SOD), HbA1c, and pancreatic organs. At doses of 36 and 54 mL/kg bw, results analysis of biochemical parameters of FBG levels revealed a substantial decline (P<0.05). At all dosages of the herb, there was a significant change in SOD activity (P<0.05), and at a dose of 18 mL/kg BW compared to negative control, there was a significant difference in HbA1c levels (P<0.05). HE staining results revealed no distinctpathological alterations in pancreatic organ at the test dose compared to negative control with necrosis in the Langerhans insula. Herbal medicine for diabetes traditional medicine from Kaliputih Batur, Banjarnegara, Central Java has decreased blood glucose.

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