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Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 9 Documents
 1 
Search results for , issue "Vol. 3, No. 2" : 9 Documents clear
Hiperimunoglobulin E, Atopi dan HIV Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
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The Correlation of Depression Level with Tumor Necrosis FactorAlpha (TNF-α) Concentration in Uncontrolled Bronchial AsthmaPatients Apriansyah, Muhammad Ali; Putranto, Rudi; Salim, Eddy Mart; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
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Introduction. Depression occurs at high rates in people with chronic diseases, including bronchial asthma, with the prevalence of depression approaches 50% in tertiary care asthma clinic. Tumor necrosis factor alpha (TNF-α) is known to play a critical role in the pathogenic mechanism of a number of chronic inflammatory disease, including bronchial asthma and depression. There has not been any research data on the subject in Indonesia. The objective of this study was to investigate the correlation between depressive level and TNF-α level in uncontrolled bronchial asthma. Methods. This was a cross sectional study conducted in 40 patients with uncontrolled bronchial asthma at the allergy immunology clinic outpatient of Dr Moh Hoesin Hospital Palembang, during June 2014 until August 2014. Uncontrolled bronchial asthma was assessed using the Asthma Control Test (ACT) questionnaire, whereas depressive symptoms were assessed by Beck Depression Inventory (BDI) questionnaire, and diagnosis was confirmed by the criteria of the Diagnostic and Statistical Manual for Psychiatry-IV Text Revision (DSM-IV TR) / International Code Diagnose 10 (ICD-10). Serum levels of TNF-α was measured by the method of quantitative enzyme-linked immunosorbent assay (ELISA). Results. The median value of the level of depression and serum TNF- α in this study were 16 (10 - 45) and 4.09 (1.29 - 19.57) pg/mL. There was no significant correlation between depressive level and TNF-α level ( r = -0.265 , p = 0.098 ). Conclusions. There was no significant correlation between depressive level and TNF-α level in uncontrolled bronchial asthma
The Role of Duke Treadmill Score as a Predictor of CoronaryArtery Disease in Patients with Positive Treadmill Test Results Ikhsan, Muhammad; Nasution, Sally Aman; Wijaya, Ika Prasetya; Rumende, Cleopas Martin
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
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Introduction. Coronary Artery Disease (CAD) is one of the disease entity that leading cause of morbidity and mortality in worldwide. Treadmill test is part of the diagnostic modality which readily available to assess possibility of narrowing coronary artery and guiding us whether we need for the further investigation. Despite of that, treadmill test has limitation in diagnostic accuracy. Duke Treadmill Score (DTS) was also tested as a diagnostic score, and shown to predict significant CAD better than the ST-segment response alone. Methods. This is a cross-sectional study performed in adult patients with stable CAD that underwent treadmill test and coronary angiography in outward patient clinic of the Integrated Cardiac Service in Cipto Mangunkusumo Hospital between January 2011 and December 2013. Results. A total of 103 patients in this study, thirty nine patients (37,9 %) had significant CAD in coronary angiography. Briefly, mean age was 54,71 years and 55 patients (53,4 %) were females. The most common CAD risk factor was hypertension (51,5 %). A mean of DTS score was -3.53, which mostly categorized as intermediate risk (89,3 %). Based on DTS results, cut-off point was determined by using Receiver Operator Curve (ROC) method, in which value of -8,85 considering as a cut-off point. Sensitivity and specificity value of DTS were 28 % (CI 95 %: 17 % to 44 %), and 95 % (CI 95 %: 87 % to 98 %). Positive and negative predictive value were 79 % (CI 95 %: 52 % to 92 %) and 69 % (CI 95 %: 58 % to 77 %). Positive and negative likelihood ratio were 6.02 and 0.75. Conclusions. DTS has a good performance in predicting significant CAD at cut-off point -8,85 in patients with positive treadmill test.
HIV in Geriatrics Ainun, Nur; Yunihastuti, Evy; Roosheroe, Arya Govinda
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
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Through both prolonged survival and late acquisition of the disease, numbers of older adults with HIV are climbing. Along with ageing process is an accumulation of HIV-associated non-AIDS related comorbidities, creating a complex patient group affected by multi-morbidity along with polypharmacy, functional decline and social issues.
Five-Year Survival in Patients with 3-Vessels Coronary ArteryDisease and Diabetes Mellitus Undergoing Coronary ArteryBypass Graft, Coronary Percutaneus Intervention, or ReceivingPharmacological Therapy in Cipto Mangunkusumo Hospital Setiawan, Andreas Arie; Panggabean, Marulam; Yamin, M; Setiati, Siti
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
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Introduction. Revascularization results in patients with diabetes mellitus (DM) and coronary artery disease involving 3 vessels (CAD 3VD) undergo coronary artery bypass surgery (CABG) are better compared with those undergo percutaneous coronary intervention (PCI) or medical therapy. However, CABG is not always done despite being recommended in accordance with Syntax Score because some patients unwilling to undergo CABG or PCI . This trial determined whether the choice of revascularization affect 5-years survival. Methods. This was a retrospective cohort study with survival analysis to examine the 5-years survival rate of CAD 3VD DM patients undergoing CABG, PCI, or medical therapy. The study was conducted using secondary data of 126 CAD 3VD DM patients who underwent CABG, PCI, or medical therapy at Cipto Mangunkusumo Hospital in 2006-2007 and followed up to 2011-2012 if there any incident died. Results. Best survival was seen in the CABG group (93.5%). The largest proportion of death occured in the medical therapy group (36.1%). The CABG survival was significantly better than the IKP (p=0.01) and medical therapy (p=0.001). PCI group had better survival than medical therapy (69.5% vs. 63.9%). Although not statistically significant, but the proportion of complaints after revascularization in PCI group were found less than medical therapy group (52% vs. 38%). Syntax score that assesses the complexity of stenosis had a significant association with survival (p 0.039). Conclusions.5-years survival of CAD 3VD DM patients is best obtained in the group that underwent CABG. 5-year survival of CAD 3VD DM patients who underwent PCI better than medical therapy but was not statistically significant. Factor that affect the 5-years survival is the complexity stenosis viewed by the Syntax score.
Comparison of Chemotherapy Regiments between CisplatinEtoposide and Cisplatin-Docetaxel on 2-Year and ProgressionFree Survival in Late-Stage Non-Small Cell Lung Cancer Patients Harahap, Salman Paris; Sutandyo, Noorwati; Rumende, Cleopas Martin; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
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Introduction. Chemotherapy is one of therapy choices for the advanced Non-Small Cell Lung Cancer (NSCLC). The success in therapy is measured with the 1-year survival, 2-year survival and the Progression Free Survival (PFS). The success is influenced by many factors: resistant to the citostatic, dosage, administer intensity, chemotherapy regiment, type histology, stage, performance status, comorbidity and social economic. In Indonesia, funding and chemotherapy regiment become the challenge for the success of therapy. Methods. The study used the Retrospective Cohort study with survival analysis. The Patients included in this study were the advanced NSC Lung Cancer (At least Stadium IIIa) who came to RSKD and RSCM during Jan 2006 – December 2010 for their first chemotherapy until finished the cycle (6 times) and had monitored for 2 years. Data was analyzed using cox regression analysis SPSS 16.0, and featured on the Kaplan Meier Curve. Results. Fifty five patients used EC and the other 55 patients used DC. There’s difference on survival where 1 year survival EC is 30,9% and DC is 47,3%, with p 0.030. Two year survival CE is 0% and for DC is 5.5%, with p 0.003. Also with the Median time survival between EC for 27 weeks and DC for 38 weeks with p < 0.016. Compared to DC, EC chemotherapy can increase the death risk by HR 1,684 (CI 95% 1,010-2,810), twenty four weeks PFS with EC is 54.5%, DC is 32.7% with p= 0.022. Conclusions. The survival with cisplatin-docexatel is better compared to cisplatin-etoposide, this applies to PFS as well.
Diagnostic Value and the Role of Inferior Vena Cava DiameterCollapsibility Index to Evaluate Dry Weight in HemodialysisPatients Yussac, Muhammad Artisto Adi; Dharmeizar, Dharmeizar; Abdullah, Murdani; Antono, Dono; Muhadi, Muhadi
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
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Introduction. In daily clinical practice, fluid status in Hemodialysis (HD) patients is well correlated with dry weight calculation. Dry weight calculation is commonly practiced by clinical observation, which is not accurate. Because of these, few methods has been suggested to calculate the dry weight non-invasively. Bioelectrical Impedance Analysis (BIA) is widely available in overseas but not readily available in all dialysis center in Indonesia, while inferior vena cava diameter is a relatively inexpensive method, and readily available in all dialysis center because it can be performed with ultrasonography (USG) instrument. Methods. A cross-sectional study was performed in a group of regular HD patients at the Haemodialysis Unit, Cipto Mangunkusumo Hospital in Jakarta, June 2011. Dry weight was evaluated with bioelectrical impedance analysis, while the inferior vena cava collapsibility index was evaluated using USG performed by two different observer. Results. We have recruited 30 HD patients, in which 18 (60%) of the subjects were overload according to the bioelectrical impedance analysis, while 21 (70%) were overload according to the inferior vena cava collapsibility index. The mean age of the subjects is 52 years old with the minimum 24 and maximum 69 years. In this research, we found negative correlation (r = -0.957, P<0.0001) between inferior vena cava colapsibility index and BIA. We found a 94.4% sensitivity and 66.7% specificity for inferior vena cava colapsibility index. Both of USG operators showed a κ coefficient value of 0.92, which reflected a very strong agreement between them. Conclusions. The inferior vena cava colapsibility index have a good role as a screening method in determining dry weight in dialysis patients
Prevalence and Predictors of Atopy in HIV/AIDS Patients Tesiman, Jimmy; Sundaru, Heru; Karjadi, Teguh H.; Setiati, Siti
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
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Introduction. HIV infection attacks the center of immune control system resulting opportunistic infection, malignancy and death. Immune system dysregulation plays the central role in the progression of the disease. Some studies reported that HIV-infected patient prone to have allergic disease such as sinusitis, asthma and atopic dermatitis. Elevated serum immunoglobulin E (IgE) and increased prevalence of atopy had also been reported in HIV-infected patient. Methods. A cross sectional study was performed in 92 HIV-infected persons and 90 non-HIV persons. Atopy diagnosis was based on immediate hypersensitivity to six common aeroallergen using skin prick test. CD4 cell count, total serum immunoglobulin level and medical history were taken. Results. Among total of 92 HIV/AIDS patients and 90 non-HIV persons, there were 65 males (70.7%) and 27 female (29.3%) in HIV group and 40 males (44.4%) and 50 females (55.6%) in non-HIV group. Age of all subjects range from 20 to 55 years old, mean age of HIV-infected patients was 29.3 (SD 5.7) years while mean age of controls was 27.9 (4.5) years old. Based on HIV route transmission, there were 56.5% subjects infected from intravenous drug user, 38% from heterosexual intercourse and 5.5% subjects had both risk. CD4+ lymphocyte counts of the subject range from 2-674 cells, median 160 cells/uL. Serum total IgE levels range from 3-20.000 IU/mL with median 283.5 IU/mL. Atopy was higher in subjects with HIV than non-HIV (p= 0,001). The most common aeroallergen is Dermatophagoides farinae (50%) and Dermatophagoides pteronyssinus (30%). There was a negative correlation between CD4+ lymphocyte count and total IgE level (r=-0,544, p<0,001), but there is no relation between gender, HIV route of transmission, allergic history in family and CD4+ lymphocyte count with atopy. Conclusions. Prevalence of atopy based on skin prick test among HIV/AIDS patients was higher than non-HIV group. There was a negative correlation between CD4+ lymphocyte count and total IgE level.
Hyper-IgE Syndrome with Bullous Pemphigoid and EsophagealStricture Budiyani, Laras; Idayu, Adeputri Tanesha; Wijaya, Ika Prasetya; Widhani, Alvina
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
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Laras

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