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Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 9 Documents
 1 
Search results for , issue "Vol. 5, No. 1" : 9 Documents clear
Left Ventricular Diastolic Dysfunction in Liver Cirrhotic Patients: Proportion, Correlation, and Relationship of Diastolic Parameters with Stage of Liver Dysfunction Mondrowinduro, Prionggo; Hasan, Irsan; Alwi, Idrus; Abdullah, Murdani
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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Introduction. Cardiovascular complication of liver cirrhosis is relatively obscure. Pathophysiology of liver cirrhosis, involving portal hypertension made the possibility of cirrhosis complication manifested as left ventricular diastolic dysfunction. This study aims to determine proportion of left ventricular diastolic dysfunction among liver cirrhotic patients according to American Society of Echocardiography-European Association of Echocardiography (ASE-EAE) 2009 and conventional approach, to determine any correlation between left ventricular diastolic dysfunction severity stages with severity stages of liver dysfunction in cirrhotic patients represented by Child Turcotte Pugh (CTP ) score, also to asses relationship between severity stages of parameters of diastolic function according to ASE-EAE 2009 with liver cirrhosis severity evaluated by numerical CTP score. Methods. A cross sectional study was conducted among 96 liver cirrhotic patients within age of 18-60 years old consecutively due to any causes who admitted to ambulatory unit of Hepatology and Internal Medicine Cipto Mangunkusumo General Hospital wards into intended sample. The study started in November 2013 until proper sample size was obtained. Echocardiography examination was performed by two operators. Interobserver validity was assesed with level of Kappa aggrement and mean difference. Data were extracted to determine prevalence, normality test, Spearman correlation test, and multivariate linear regression test using SPSS for Windows. Results. Left ventricular diastolic dysfunction proportion among liver cirrhotic patients according to ASE-EAE 2009 was 34,3% and 21,9% of normal diastolic function subgroup has left atrial volume index ≥34 mL/m2. Meanwhile, conventional approach resulted in 68,8% of diastolic dysfuncation. All diastolic parameter showed abnormalities on CTP B 8-10. Spearman’s r values of stage of diastolic dysfunction severity according to ASE-EAE 2009 with severity of numerical CTP score was 0,42 (p<0,001) and 0,54 based on conventional approach. Exclusion of diabetic patients and spironolactone treated patients resulted in r=0,51 (p <0,001) based on ASE-EAE 2009 and 0,63 (p<0,001) based on conventional approach.. Parameters of diastolic function that had relation with liver dysfunction severity in cirrhosis measured by numerical CTP were Ar-A (p=0,004), left atrial volume index (p=0,005), and laterale e’ (p=0,026). Conclusion. Severity of left ventricular diastolic dysfunction with severity of liver cirrhosis is positively correlated. Diastolic parameters relate with severity of liver cirrhosis are diastolic ventricular filling pressure with left ventricular chamber stiffness, left atrial remodelling and regurgitant of pulmonary venous flow velocity to oppose filling pressure. Early detection for diastolic dysfunction can be started on CTP B 8. Keywords: Child Turcotte Pugh Score, diastolic dysfunction, liver cirrhosis, liver dysfunction
Management of Antithrombotic in Endoscopic Procedures Suseno, Dwi; Syam, Ari Fahrial
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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The use of antithrombotic medicine has increased along with the growing number of cardiovascular disease in the world. Endoscopy procedure often done to the patients who use antithrombotic medicine. Eventhough most of endoscopies are safe for those patients, there are some main things related to antithrombotic treatment management that have to be noted such as the kind of antithrombotic that being used, stratification of bleeding risk on the procedure, the risk of future thromboembolic, and the process of antithrombotic treatment re-initiation. So that, patient’s safety in undergoing endoscopy procedure is guaranteed.
Pemeriksaan Bilasan Lambung: Alternatif Diagnostik Tuberkulosis pada Pasien HIV Dewasa? Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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Association of Clinical Features and Hematological Laboratoriesbetween Ph (+)/BCR-ABL (+) Chronic Myeloid Leukemia and Other Type of Ph/BCR-ABL Chronic Myeloid Leukemia Rajabto, Wulyo; Harryanto, A.; Tadjoedin, Hilman; Harimurti, Kuntjoro
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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Introduction. Patients with chronic phase Chronic Myeloid Leukemia (CML) at Hematology-Medical Oncology Clinic Department of Internal Medicine dr. Cipto Mangunkusumo National Hospital who haveperformed cytogenetic and RTPCR BCR-ABL examination showed: Ph (+)/BCR-ABL (+) CML and other type of Ph/BCR-ABL CML. This study aims to identify the clinical features and hematological laboratories of chronic phase CML, the proportion of Ph (+)/BCR-ABL (+) CML, and association of clinical features and hematological laboratories between Ph (+)/BCR-ABL (+) CML and other type of Ph/ BCR-ABL CML. Methods. This is a cross-sectional study. The samples were taken by consecutive method. We used Chi-square test and logistic regression analysis. Association between variables considered significant when p value <0.05. Results. There were 80 subjects with chronic phase CML. Mean of age was: 39.4 (standard deviation 13.1) years. The comparison of clinical features and hematological laboratories between Ph (+)/BCR-ABL (+) CML and other type of Ph/ 12 | Jurnal Penyakit Dalam Indonesia | Vol. 5, No. 1 | Maret 2018 Wulyo Rajabto, A. Harryanto, Hilman Tadjoedin, Kuntjoro Harimurti BCR-ABL CML were: Symptomatic 80.6% : 100%; splenomegaly 82% : 92.3%; median of Hb 10,3 g/dL : 10,3 g/dL; median of white blood cell 124.620 : 127.050; median of thrombocyte 455.000 : 487.000. Bivariate and multivariate analysis showed no significant association of clinical features and hematological laboratories between Ph (+)/BCR-ABL (+) CML and other type of Ph/BCR-ABL CML. Conclusion. There was no significant association of clinical features and hematological laboratories between Ph (+)/BCRABL (+) CML and other type of Ph/BCR-ABL CML.
Validation of C-Reactive Protein and CURB-65 in The FirstHospital Admission Community Acquired Pneumonia Patient asA Predictor 30 Days Mortality Buharman, Borries Foresto; Pitoyo, Ceva Wicaksono; Singh, Gurmeet; Koesnoe, Sukamto
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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Child Turcotte Pugh Score, diastolic dysfunction, liver cirrhosis, liver dysfunction
Association between Stigma, ARV Therapy and Complications ofPsychiatric Disorders iIn HIV / AIDS Patients Wicaksono, Yamaji Adi; Fitrikasari, Alifiati; Sofro, Muchlis Achsan Udji; Peni, Hari
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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Introduction. Stigma and discrimination among HIV/AIDS patients cause varrious problems such as physical, psychological, and social. Therefore, its management requires comprehensive intervention. Antiretroviral therapy improves the patient’s clinical course, but may lead to neuropsychiatric complications especially anxiety disorders, depression, and psychotic disorders. This study aimed to know the associationbetween stigma,ARV therapy and complications of psychiatric disorders of HIV patients. Methods. A cross-sectional study was conducted among HIV/AIDS patients undergoing antiretroviral therapy in VCT-CST RSUP dr. Kariadi and RSUD RAA Soewondo Pati. Subjects were recruited using consecutive sampling method. Asessment of disorders and stigma was conducted using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and Questionnaire scale perception of PLWHA on community HIV/AIDS stigma. Analysis was performed using SPSS program. Correlation test analyzed with chi square test. Results. Total of 102 subjects were included in this study. The majority of subjects was male (51%) and the age mean value was 35.88 (SD 8.24) years. The most common type of antiretroviral drugs bas lamividine+zidovudine) + nevirapine (52.9%). The highest stigma scale of PLHIV was 95.1% positive stigma. Characteristics of psychiatric disorders consisted of 89.2% experienced psychiatric disorders, most depression 30.4%, and 6.9% psychotic disorders. Analysis showed that there was a statistically significant association between type of ARV therapy and psychiatric disorder. There was no statistically significant association between stigma and psychiatric disorders. Conclusions. There is an association between type of ARV therapy andpsychiatric disorders, but no association found between stigma and psychiatric disorders
Performance of Xpert MTB/RIF by Using Gastric Lavage Samplein The Diagnosis of Pulmonary Tuberculosis in HIV Patients withSuspected Pulmonary Tuberculosis Mboeik, Manuel Lamberto Willem; Pitoyo, Ceva Wicaksono; Karjadi, Teguh Harjono; Karuniawati, Anis; Dewiasty, Esthika
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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Introduction. Xpert MTB/RIF test on gastric lavage sample may improve pulmonary tuberculosis (TB) case finding, but its performance as a diagnostic test for pulmonary TB in HIV-infected adults patients has not been studied widely, including in Indonesia. This study aims to determine the performance of the Xpert MTB/RIF test in diagnosing pulmonary tuberculosis 30 | Jurnal Penyakit Dalam Indonesia | Vol. 5, No. 1 | Maret 2018 Manuel Lamberto Willem Mboeik, Ceva Wicaksono Pitoyo, Teguh Harjono Karjadi, Anis Karuniawati, Esthika Dewiasty among HIV-infected adult patients with suspected pulmonary tuberculosis by using gastric lavage sample. Method. A cross-sectional study was conducted on adult HIV-infected patients with suspected pulmonary tuberculosis in Cipto Mangunkusumo hospital Jakarta between February 2016 and June 2017. Gastric lavage sample and sputum sample collection were performed for Xpert MTB/RIF test and acif fast bacilli (AFB) smear examination. Results. Among total of 117 subjects, 81 (69,2%) subjects were unable to expectorate sputum. M tuberculosis was detected on Xpert MTB/RIF using gastric lavage samples in 34 (29,1%) subjects, AFB in 4 of 36 sputum samples and 2 of 117 gastric lavage samples. The drug sensitivity test on all 34 Xpert MTB/RIF positive subjects showed no rifampicin resistance. Fifty-one (43.6%) subjects were diagnosed as clinical pulmonary tuberculosis, 26 subjects among them were positive on Xpert MTB/ RIF assay, 4 subjects were smear sputum positive and 1 subject was gastric lavage smear positive. Using clinical diagnosis of pulmonary TB as gold standard, a single Xpert MTB/RIF assay using gastric lavage sample showed sensitivity of 50.98% (95% CI: 36.6-65.25), specificity 87.88% (95% CI: 77,1-94,62), positive predictive value 76,47% (95%CI: 61,67-86,78) and negative predictive value 69,88% (95% CI: 63,36-75.68). Conclusion. Xpert MTB/RIF performed on gastric lavage samples showed sensitivity of 50.98% and specificity 87.88% in clinical diagnosis of pulmonary tuberculosis in HIV-positive patients with pulmonary tuberculosis.
Association between Thyroid Status and Glucose Intolerance inHyperthyroid Patients Wisnu, Wismandari; Soewondo, Pradana; Subekti, Imam
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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Introduction. The most common endocrinopathy in adults are diabetes mellitus (DM) and thyroid disease. Hyperthyroidism decreases blood glucose control and increased the need of insulin. However, the mechanism of abnormal glucose metabolism in hyperthyroidism is not fully understood. This study aims to determine the relationship of thyroid status with incidence of glucose intolerance in hyperthyroid patients compared to hyperthyroid patients who have achieved clinical status of eutyroid and normal population. Methods. This study was cross sectional design in outpatients with hyperthyroidism in hyperthyroid and euthyroid/subclinical hyperthyroid status, and healthy volunteers who had matching age and sex. An oral glucose test and Homeostatic Model Assesment Insulin Resistance was performed after the diagnosis of hyperthyroidism by FT4 and TSH measurement. Data analysis was performed using SPSS for Windows version 20.0. Results. There were 114 eligible patients (40 case hyperthyroid, 40 case euthyroidism/subclinical hyperthyroidism and 34 healthy subjects). Proportion of glucose intolerance in hyperthyroidism is 52,5% (10% DM, 32,5% impaired glucose tolerance (IGT), and 10% impaired fasting glucose (IFG)), in euthyroidism/subclinical hyperthyroidism was 20% (5% DM, 15% IGT, and 0% IFG), and in healthy subjects was 11,8% (0% DM, 8,8% IGT, and 2,9% IFG). Glucose intolerance in hyperthyroidism was significantly different than euthyroidism/subclinical hyperthyroidism (p=0.002). We also found that the association between thyroid status and glucose intolerance in the group without insulin resistance was significantly different (p=0.004). Conclusions. Our study conclude that there is association between hyperthyroidism and glucose intolerance. Hyperthyroid patients in euthyroidism/subclinical hyperthyroidism status have the same risk as the healthy subject to became glucose intolerance.
Rino-orbital-cerebral Mucormicosys in A Patient Type 1Diabetic: A Case Report Marpaung, Hamka Gunawan; Baso, Gery Dala Prima; Rizka, Aulia; Nelwan, Erni Juwita; Wardani, Retno S; Wahyuningsih, Retno
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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Mucormycosis is an opportunistic andfrequently fulminating fungal infection causedby members of the family Mucoraceae, orderMucorales and class Zygomycetes which highly invasive and high mortality. Mucormycosis occurs in diabetic patients with poor blood glucose control. We reported a case of rhinocerebral mucormycosis in 20-year-old female patient with type 1 diabetes. The patient was treated for diabetic ketoacidosis and swollen symptoms in the left eye and out secretions from the left nose containing blackish spots. The probable diagnosis of rhinocerebral mucormycosis is made based on the results of direct examination and culture of nasal and palate tissue biopcywhich result suitable for Mucor sp. She was given systemic antifungal therapy with amphotericin B and symptoms of swelling of the left eye and secretions of the left nose with patches of blackness improved.

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