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Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 9 Documents
 1 
Search results for , issue "Vol. 6, No. 2" : 9 Documents clear
Survival Kidney Transplantation from Related and Emotionally Related Living Donors in Cipto Mangunkusumo Hospital 2010-2015 Susilowati, Utami; Sutrisna, Bambang; Marbun, Maruhum Bonar H; Susalit, Endang
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Conn’s Syndrome Due to Adrenal Adenoma Rasyid, Haerani; Bakri, Syakib; Kasim, Hasyim; Hidayat, Andi Rahmat; Syarif, Syarif; Azis, Abd
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Conn’s syndrome is characterized by an increase in aldosterone level causes sodium retention and an increase in urine excretion of potassium. This syndrome is characterized by trias hypokalemia, hypertension, and metabolic alkalosis. This article discussed a case report of a patient with uncontrolled hypertension with neuromuscular symptoms caused by recurrent hypokalemia. After an evaluation of the imaging test, we found a left adrenal tumor then we performed unilateral adrenalectomy surgery. Histopathology examination from the excised tumor revealed the adrenal adenoma. After unilateral adrenalectomy, the patient showed clinical and laboratory improvement.
Peripheral Arterial disease and Cardiovascular Mortality in Type-2 Diabetes Mellitus Esa, Dekta Filantropi; Prahasary, Adelia Nova; Tahapary, Dicky L.; Yunir, Em
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Peripheral arterial disease (PAD) is one of the macrovascular complications of type 2 diabetes mellitus (T2DM), which increases the risk of cardiovascular mortality. Ankle-brachial index (ABI) is one of the simple and widely available tool to diagnose PAD. The authors aim to find out the cardiovascular mortality in T2DM patient with PAD. Bundo et al. study found HR 2.45 (95% CI: 0.84 to 7.17). Mostaza et al. study reported HR 1.64 (95% CI: 0.64 to 4.49). Aboyans et al. study declared HR 2.21 (95% CI: 1.16 to 4.22). Mohammedi K et al. claimed HR 1.35 (95% CI: 1.15 to 1.60). Quiles et al. found HR 6.61 (95% CI: 2.47 to 17.72). Mueller et al. study reported RR 3,53 (95% CI: 1.80 to 6.91). Mueller et al. study reported RR 4,06 ( 95% CI: 2.67 to 6.18). In conclusion, the mortality risk in T2DM patients with PAD is higher compared to those without PAD. Moreover, an ankle-brachial index can be used as an independent stratification tool to predict the risk of cardiovascular mortality
Gastroesophageal Reflux Risk Factor Analysis at Saiful Anwar Hospital in Malang Tarigan, Ricky C; Pratomo, Bogi
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Introduction. Gastroesophageal reflux disease (GERD) is a pathological condition as a result of reflux of stomach contents into the esophagus with various symptoms that arise due to the involvement of the esophagus, larynx, and airways. The prevalence of GERD has increased lately. In Indonesia, 22.8% cases of esophagitis were reported. Analysis of the risk factors for GERD is very important in reducing the prevalence of GERD. This study aimed to identify the most influential risk factors for GERD patients so that it could become a reference to reduce the prevalence of GERD in the following year. Methods. This study was a cross-sectional study where data was taken based on data from medical records of patients undergoing the endoscopic procedure in the division of Hepatology Gastroenterology at Saiful Anwar Hospital Malang during 2016. The diagnosis was obtained from history, physical examination, and GERD diagnostic criteria from endoscopy according to the Los Angeles criteria. Results. Among 57 patients, there were 20 female (32.5%) and 37 male (67.5%), 63.16% of them are >40 years old. This study found that 28 patients (49.12%) consumed herbs, 31 patients (54.38%) found smoking, and those who consumed alcohol were 18 patients (31.48%). The analysis showed that factors related to the incidence of GERD were herbal consumption (p=0.007; OR 4.586 (95% CI: 95%: 1.386-15.177)) and alcohol consumption (p 0.027; OR 4.846 (95% CI: 1.024-22.929)). Conclusion. Consumption of herbal and alcohol appear to be risk factors of the incidence of GERD in this study.
Peripheral Blood Count Characteristics, Neutrophil-Lymphocyte Ratio, and Platelet-Lymphocyte Ratio Pulmonary Tuberculosis Patients with Depression Shatri, Hamzah; Alexander, Reinaldo; Putranto, Rudi; Rumende, Cleopas Martin
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Introduction. Patients with pulmonary tuberculosis (TB) had an increased risk for depression up to 1.53 times from a large cohort study. Studies have found an increase in the neutrophil - lymphocyte ratio (NLR) in various mood disorders including depression, also the value of the platelet-lymphocyte ratio (PLR) associated with major depression accompanied by psychotic symptoms. This study aimed to describe the peripheral blood characteristics, NLR, and PLR in pulmonary TB patients with depression. Methods. A cross-sectional study of 106 non-multidrug-resistant pulmonary TB patients was done at outpatient department of Cipto Mangunkusumo General Hospital, Jakarta from August to October 2018. The diagnosis of depression was made by interview according to Diagnostic and Statistical Manual of Mental Disorder-V (DSM-V) criteria, and severity of depression is determined using Beck Depression Inventory-II (BDI-II). The laboratory tests were done to obtain complete peripheral blood results, NLR, and TLR. Parametric test was used for numeric variables with even distribution, and nonparametric test for variables with uneven distribution. Results. From 106 patients with non-multidrug-resistant pulmonary TB, the proportion of depression was 32%. White blood cell count (p=0.024), and absolute lymphocte count (p=0.004) is lower in depressed TB patients compared to nondepressed TB patients. There were no significant relationship between NLR and TLR and the severity of depression in depressed pulmonary TB patients (p>0.05). Conclusion. White blood cell count and absolute lymphocyte count are lower in depressed pulmonary TB patients. Meanwhile, RNL and PLR are higher in depressed pulmonary TB patients eventhough not statistically significant.
Penanda Respons Imun Perifer pada Penyakit Kronik: Sudahkah Dapat Menjadi Pedoman Adanya Inflamasi Sistemik? Rachman, Andhika
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Correlation between Glycemic Control in Type 2 Diabetes Mellitus Patients with Natural Killer Cell Activity Ristanti, Dian; Soegiarto, Gatot; Novida, Hermina
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Introduction. Most of the previous studies showed decreased polymorphonuclear cells and monocytes/macrophages in type 2 diabetes mellitus (T2DM). Natural killer (NK) cell functions were rarely studied in T2DM. This study aimed to evaluate NK cell activity and determine its correlation with glycemic control in T2DM patients. Methods. Type 2 diabetes mellitus (T2DM) patients who regularly visit the diabetes outpatient clinic of Dr. Soetomo General Hospital during July – August 2018 and fulfill the inclusion-exclusion criteria were recruited to the study. The HbA1c level was measured according to the standard procedure. The NK cell activity was measured using flow cytometry and expressed as the percentage of activated NK cells from total NK cell numbers. Correlation between the two variables was determined. Results. There were 38 subjects eligible for this study, consisted of 15 males and 23 females, with mean of age 52 (standard deviation [SD] 6) years. The subjects routinely received OAD (36.8%), insulin (44.7%), or OAD-Insulin combination therapy (18.4%). Median HbA1c was 7.8% (range: 5.5 – 13%). Median NK cell activity was 7.08% (range: 2.95 – 21.55%). Using a Spearman test, there was no significant correlation between HbA1c levels and NK cell activity (r=0.292; p=0.075). Conclusions. The glycemic control in T2DM did not significantly influence NK cell activity. Further exploration and research should be done to determine whether there were changes in NK cells that contribute to innate immune dysfunction in T2DM patients.
Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry Workers Wijaya, I Putu Eka Krisnha; Rai, Ida Bagus Ngurah; Andrika, I Putu
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Introduction. Silicosis is a disease that most often occurred as a result of silica dust exposure. Silica dust particles will stimulate alveolar macrophages to secrete proinflammatory mediators for fibroblast proliferation and collagen deposition. TGF-ß1 is one of the most extensively involved mediators in the development of fibrosis. To date, several studies have not shown consistent results regarding the association between silica dust exposure and TGF-β1. This study examined silica dust exposure and serum TGF-β1, which aims to determine the risk of silicosis in stone quarry workers. Methods. An analytic cross-sectional study was conducted at Company X, Karangasem in March 2016. The studied variables were silica dust exposure using nephelometer dust monitoring, serum TGF-β1 using ELISA method, nutritional status from weight scales, with age, smoking, and use of personal protective equipment (PPE) from an interview. Spearman correlation test is used to determine the correlation between silica dust exposure with serum TGF-β1. Multivariate linear regression analysis was used to asses the effect of silica dust exposure, age, nutritional status, cigarette smoking, and use of PPE with TGF-β1 serum. Results. There were 55 samples of stone quarry workers in this study. From the Spearman correlation test, there was a significant correlation between silica dust exposure with serum TGF-β1¬, (r) = 0.319, p = 0.018. In multivariate regression analyzes test, there were significant associations between silica dust exposure and nutritional status with serum TGF-β1, p = 0.042 and p = 0.012. Conclusions. There was an association between silica dust exposure and increasing serum TGF-β1 of stone quarry workers.
Correlation between Proper Antibiotics Administration to Community Acquired Pneumonia Patients Based on Alur Gyssens with Clinical Response Rumende, Cleopas Martin; Chen, Lie Khie; Karuniawati, Anis; Bratanata, Joyce; Falasiva, Rezyta; Sitorus, Truly Panca; Susanto, Erwin Christian
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Introduction. The proper of antibiotics treatment will increase the improvement of the patient with community-acquired pneumonia (CAP) and also counteract antimicrobial resistance. Community-Acquired Pneumonia is commonly found in Indonesia with an incidence of 2.4%. This study aimed to determine the proper of antibiotic selection for CAP based on IDSA-ATS 2007 guidelines with Gyssens method and evaluate the relationship between the proper of antibiotic treatment with the clinical response of patients. Methods. A retrospective cohort study was conducted with secondary data from the previous study. Study was conducted in three hospitals in Jakarta, namely Cipto Mangunkusumo General Hospital, Budhi Asih Hospital, and Gatot Subroto Hospital between September 2016 and November 2017. Results. From 151 patients, the appropriate of the first antibiotic treatment, including category 0 and 1 was found in 38 patients (25.2%), while for inappropriate one (category II-V) was in 113 patients (74.8%) mainly due too short antibiotic treatment. For the second antibiotic given to 54 patients, appropriate treatment was found in 15 patients (9.9%). There was no correlation between the accuracy of both antibiotics treatment in CAP based on Gyssens method with clinical response of the patients (first antibiotic treatment: RR=0,970 (95% CI: 0,80 – 1,16), p=0,738; second antibiotic treatment: RR=1,194 (95% CI: 0,648 – 2,20), p=1,00). Conclusion. There was no correlation between the accuracy of antibiotics treatment in CAP based on Gyssens method with clinical response of the patients.

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