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All Journal Indonesian Journal of Cancer Chemoprevention Folia Medica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Majalah Kedokteran Neurosains Kompleksitas: Jurnal Ilmiah Manajemen, Organisasi, dan Bisnis Cermin Dunia Kedokteran eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Ophthalmologica Indonesiana
Andhika Rachman
Division Of Hematology And Medical Oncology, Department Of Internal Medicine, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Benefit of Platinum-based Chemotherapy in Metastatic Triple Negative Breast Cancer Eveline, Ency; Rachman, Andhika
Cermin Dunia Kedokteran Vol 42, No 11 (2015): Kanker
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (389.095 KB) | DOI: 10.55175/cdk.v42i11.951

Abstract

Background. Management of triple-negative breast cancer (TNBC) is challenging because of a lack of targeted therapy, its aggressive behavior and relatively poor prognosis. Various studies showed that these tumors are highly chemosensitive and in some cases are represented by complete pathological response (pCR), but the results remains unsatisfactory1. Recent experimental data strongly suggest that platinum-based chemotherapy (PBC) could improve the outcome of TNBC, but clinical data is still lacking4. Objective. To evaluate the benefit of addition of platinum agents to metastatic TNBC therapy. Method. Several databases were searched. Comparative studies were identified using the following keywords: triple negative breast cancer, advanced, metastatic, metastases, platinum agents, cisplatin, and carboplatin. The search was not limited to controlled or randomized trials. The limitation used in searching the articles are human, english, and max.5 years publication. Articles were reviewed by two authors and selected if they described advanced triple negative breast cancer, use of platinum agents, and outcome. Results. Seven studies were included. Median survival of metastatic TNBC patients treated with PBC was 10.4 to 32.8 months. There was a significant survival benefit compared to non-PBC treated patients with overall survival 7.5 to 21.5 months. However PBC did not showed significant different benefit between TNBC and non TNBC patients. Conclusion. PBC demonstrated not only higher response rate but also remarkable improvement in PFS and OS. It is still premature to draw a conclusion on survival advantage merely from phase II trials, but for this subtype, platinum agents had extra clinical benefit compared to other agents.Pendahuluan. Topik Manajemen triple-negative breast cancer (TNBC) masih merupakan sebuah tantangan karena ketidaktersediaan target terapi hormonal, sifatnya yang agresif, dan prognosis yang lebih buruk. Beberapa studi menyimpulkan bahwa tumor ini sangat kemosensitif sehingga pada beberapa kasus menghasilkan complete pathological response (pCR), tetapi makna klinisnya kurang berarti1. Meskipun data eksperimental secara kuat mendukung platinum-based chemotherapy (PBC) sebagai kemoterapi yang dapat memperbaiki outcome TNBC, belum ada data studi klinis. Tujuan penelitian ini ialah untuk mengevaluasi manfaat penambahan agen platinum sebagai terapi pasien TNBC stadium lanjut. Metode. Beberapa database ditelusuri, Kata kunci yang digunakan: triple negative breast cancer, advanced, metastatic, metastases, platinum agents, cisplatin, dan carboplatin. Pencarian tidak dibatasi hanya controlled atau randomized trials untuk meminimalkan hilangnya studi yang bermakna. Pencarian artikel dibatasi pada human subject, english, dan max.5 years publication. Artikel dianalisis oleh dua penulis dan diseleksi sesuai dengan TNBC stadium lanjut, penggunaan agen platinum, dan hasil terapi. Hasil. Median survival empat studi yang ditemukan berada dalam rentang 10.4 hingga 32.8 bulan. Terdapat manfaat cukup signifikan dari penambahan agen kemoterapi platinum sebagai terapi pasien TNBC stadium lanjut, dibandingkan regimen tanpa platinum yang berada dalam rentang 8 hingga 21.5 bulan. Akan tetapi tidak ada perbedaan klinis penggunaan PBC antara pasien TNBC dan non-TNBC. Simpulan. PBC menghasilkan bukan hanya tingkat respon lebih tinggi tetapi juga perbaikan PFS dan OS. Meskipun belum adekuat untuk menyimpulkan adanya perbaikan survival pasien TNBC, platinum lebih memberikan perbaikan klinis daripada agen kemoterapi lain.
KORELASI KADAR SERUM INTERLEUKIN6 DENGAN GEJALA UMUM KEGANASAN PADA PASIEN TUMOR INTRAKRANIAL DI RSUPN CIPTOMANGUNKUSUMO Sheila Agustini, Tiara Aninditha, Lyna Soertidewi Kiemas, Teguh Asaad Suhatno Ranakusuma, Andhika Ra
NEURONA Vol 30 No. 1 Desember 2012
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION PROINFLAMMATORY CYTOKINES INDUCE HYPOTHALAMICPITUITARY AXIS HPA AND ACUTE PHASE RESPONSE WITH INTERLEUKIN6 IL6 BEING THE MOST POTENT STIMULATOR BRAIN TUMOR PATIENTS OFTEN SHOW NONSPECIFIC SYMPTOMS OF MALIGNANCY THAT MAY BE RELATED TO SICKNESS BEHAVIOR INDUCED BY CYTOKINES
Donor HLA Genotyping using Polymerase Chain Reaction- Sequence Specific Primers (PCR-SSP) as Method for Acquiring Donor Panel in Platelet Refractoriness Tubagus Djumhana Atmakusuma; Andhika Rachman; Ni Ken Ritchie
Molecular and Cellular Biomedical Sciences Vol 5, No 3 (2021)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v5i3.209

Abstract

Background: Evaluation and identification of HLA antibodies in the recipient’s serum is of utmost importance prior to transplantation and transfusion. HLA typing is a steppingstone in proposing a donor panel. In order to obtain the HLA typing, Polymerase Chain Reaction-Sequence Specific Primers (PCR-SSP) can be performed.Materials and method: This is a preliminary study to determine HLA polymorphism by HLA genotyping in 43 blood donors. DNA from the samples was isolated using commercial kits according to the standard protocol. The DNA then was amplified using PCR-SSP methods and analyzed using the provided set in the kit.Results: This study found that the most frequent HLA-A alleles was HLA-A*24 (41.9%). For HLA-B alleles, the most common was HLA-B*15 (28%). Most frequent HLA-A-B haplotypes was HLA-A*24-B*15 (11.3%). The results from this study concurs with that of previous study. However, some alleles might vary due to difference in study population. Determining HLA-typing is of paramount importance in an ethnically diverse country such as Indonesia. In contrast to homogenous caucassian country, difference in ethnicity might cause platelet refractoriness due to incompatibility. HLA-typing would also guide the diagnostic workup and required treatment strategy for platelet refractoriness.Conclusion: From the HLA typing using PCR-SSP in blood donors in Jakarta, we found that the most frequent alleles were HLA-A*24 and HLA-B*15; and the most frequent haplotypes were HLA-A*24-B*15. This study should be upscaled to include larger population and ethnic groups to obtain complete profile of Indonesian population.Keywords: platelet refractoriness, HLA, donor, PCR-SSP, transfusion medicine
Perbandingan Kadar Soluble Platelet-Selectin pada Berbagai Stadium Karsinoma Nasofaring dan Korelasinya dengan Hitung Trombosit Komala, Adi Surya; Harsal, Asrul; Rachman, Andhika; Rumende, Cleopas Martin
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

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Pendahuluan. Karsinoma nasofaring (KNF) merupakan jenis keganasan yang unik dengan distribusi geografis dan etnis tertentu. Daerah Cina Selatan dan Asia Tenggara memiliki insidens kejadian yang tinggi. Indonesia memiliki insidens 5,66 kasus per 100.000 penduduk per tahun. Salah satu penyebab kematian pada pasien dengan keganasan adalah trombosis. Kadar soluble Platelet-selectin (sP-selectin) yang tinggi dalam plasma, hasil dari aktivasi sel-sel endotel dan trombosit, adalah salah satu prediktor kejadian trombosis. Penelitian ini bertujuan untuk mengetahui kadar sP-selectin pada berbagai stadium karsinoma nasofaring dan korelasinya dengan hitung trombosit. Metode. Dilakukan studi potong lintang pada 60 kasus karsinoma nasofaring yang baru terdiagnosis di Rumah Sakit Cipto Mangunkusumo pada periode Maret hingga November 2012. Kadar sP-selectin pada berbagai stadium yang diukur dengan teknik Enzyme Linked Immunosorbent Assay akan dibandingkan dan dikorelasikan dengan hitung trombosit. Hasil. Dari 60 pasien KNF didapatkan rerata usia 43,9 tahun. Rasio laki-laki dengan perempuan 3:1 dan jenis patologi terbanyak adalah karsinoma tidak berdiferensiasi (83,3%). Sepuluh persen pasien mengalami trombositosis. Median kadar sP-selectin adalah 45,73 ng/mL dengan rentang interkuartil: 42,02-57,66 ng/mL. Secara statistik terdapat perbedaan kadar sP-selectin diantara stadium IVC dengan stadium lainnya (stadium IVB, p = 0,001 dan kelompok stadium I-IVA, p < 0,001). Hitung trombosit tidak berkorelasi dengan sP-selectin (r: 0,185; p = 0,158) pada karsinoma nasofaring. Simpulan. Terdapat perbedaan kadar sP-selectin pada berbagai stadium karsinoma nasofaring. Hitung trombosit tidak berkorelasi dengan kadar sP-selectin.
Correlation of Haemoglobin Platelet Ratio (HPR) and LeukocytePlatelet Ratio (LPR) with SYNTAX-2 Score in STEMI Patients Ikhsan, Muhammad; Nasution, Sally Aman; Rachman, Andhika; Muhadi, Muhadi
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Introduction. Various studies have concluded the association between various markers of inflammation with the clinical outcome in STEMI patients. However, most of these markers are quite expensive and not available in healthcare facilities. Hence, we aim to study the correlation between haemoglobin platelet ratio (HPR) and leucocyte platelet ratio (RPL) and the clinical outcomes of STEMI patients. Methods. This is a cross-sectional study performed in adult patients with STEMI who were hospitalized in Intensive Coronary Care Unit Cipto Mangunkusumo Hospital between January 2016 and October 2020. The data was analyzed by testing the correlation between HPR and LPR with SYNTAX-2 score. Results. There were 114 subjects in this study, with a mean age was 53.87 years and dominated by male (86.8%). We found no correlation between HPR and LPR with SYNTAX-2 Score. From the sub-group analysis, there was a moderate positive correlation between HPR and SYNTAX-2 score (r = 0.587; p= 0.005) and a strong positive correlation between LPR and SYNTAX-2 score (r = 0.606; p = 0.004) in subjects with normal body mass index (BMI). Additional results obtained a strong negative correlation between neutrophil lymphocyte ratio (NLR) with SYNTAX-2 score (r = -0.738; p= 0.0037) and a very strong negative correlation between platelet lymphocyte ratio (PLR) with SYNTAX-2 score (r= -0,857; p= 0,007) in subjects with low BMI. Conclusion. There is no correlation between HPR and LPR with SYNTAX-2 Score
Effectivity of Acupuncture Therapy in Reduction of Pain Intensity in Cancer Pain Affadhia, Hanna Lianti; Cahyanur, Rahmat; Wahdini, Sri; Rachman, Andhika
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
Publisher : UI Scholars Hub

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Pain is one of the most common complaints and interferes with the quality of life of cancer patients. Several studies recommend multimodal interventions that combine pharmacological and non-pharmacological therapies. Acupuncture therapy is one of the non-pharmacological treatment options that could be considered. This evidence-based case report aimed to examine the effectiveness of acupuncture therapy in reducing pain intensity in patients with cancer pain. Literature searching was performed on three databases (PubMed, Scopus, and Embase). The keywords used are cancer pain, malignant pain, acupuncture, acupuncture therapy, pain intensity, pain assessment, pain scale. The critical review was carried out using guidelines from the University of Oxford Center for Evidence-based Medicine. Four articles relevant to the clinical question were included in the study. Acupuncture therapy has been consistently shown to reduce pain intensity, shorter pain onset time, reduced dose and number of analgesics used, and better quality of life with minimal side effects, compared to drug therapy alone. Acupuncture therapy should be considered as a complementary therapy in the management of cancer pain, but not to replace standard regiment of pain protocols. Clinical decisions in applying acupuncture therapy need to assess patient preferences, accessibility, and cost-effectiveness.
Penanda Respons Imun Perifer pada Penyakit Kronik: Sudahkah Dapat Menjadi Pedoman Adanya Inflamasi Sistemik? Rachman, Andhika
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Trombositopenia refrakter Rachman, Andhika
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 4
Publisher : UI Scholars Hub

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Tranfusi trombosit berperan penting dalam manajemen kasus trombositopenia akibat kelainan hematologi dan onkologi. Namun, hampir sebagian besar pasien yang mendapatkan tranfusi trombosit berulang, sering mengalami kejadian tranfusi trombosit refrakter baik akibat faktor imunologi maupun non imunologi.
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) akibat Kemoterapi pada Pasien Lansia dengan Keganasan Herwanto, Velma; Siregar, Parlindungan; Effendy, Shufrie; Rachman, Andhika
Jurnal Penyakit Dalam Indonesia Vol. 1, No. 1
Publisher : UI Scholars Hub

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Hiponatremia merupakan suatu kondisi yang sering ditemukan pada pasien-pasien dengan keganasan. Keadaan hiponatremia dapat terjadi bersamaan atau mendahului diagnosis suatu keganasan. Hiponatremia terkait kanker bisa mempengaruhi respon terhadap terapi kanker maupun kesintasan pasien. Kami laporkan sebuah kasus hiponatremia pada pasien lansia dengan keganasan yang disebabkan oleh syndrome of inappropriate anti diuretic hormone secretion (SIADH).
A Five-Year Data in Descriptive Study of Systemic and Ocular Risk Factors of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) and The Correlation to The Clinical Condition Syntia Nusanti; M. Sidik; Andhika Rachman; Miratasya Zulkarnaen
Majalah Oftalmologi Indonesia Vol 47 No 1 (2021): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v47i1.100162

Abstract

Purpose: To acknowledge the demographic, clinical characteristic and the systemic and ocular risk factors in patients with Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) in 2012-2017 in Cipto Mangunkusumo Hospital. Methods: Retrospective descriptive study using the medical record data of 272 patients with NAION in the past 5 years (2012-2017). Results: In the past 5 years, most of the patient’s initial visit visual acuity was <3/60, most patient had 2-3 systemic risk factors, the most frequent risk factors were hypertension (73.9%), obesity(63.5.%), diabetes mellitus (54.6%), smoking habit (54.5%), dyslipidaemia (46%), hypercoagulable state (19%), history of cardiovascular disease (10.3%) and stroke (7.2%). The risk factors were similar in age range ? 50 or bellow. Based on the initial visit time, most of the patient came to CM hospital in average 15.16 (SD±38.3) weeks. Conclusion: This descriptive study showed classic demographic characteristic of NAION cases. Obesity as the second highest probable risk factor is rarely mention in the other studies. Should future detailed studies be done
Co-Authors A.R. Harahap, A.R. Adi Surya Komala Adi Surya Komala, Adi Surya Affadhia, Hanna Lianti Ahadini, Putri Aliya Alvina Widhani, Alvina Andree Kurniawan Andri Sanityoso Aninditha, Tiara Arif Mansjoer Arini Setiawati Aru W Sudoyo Asrul Harsal Asrul Harsal, Asrul Aulia Rizka, Aulia Cleopas Martin Rumende Cleopas Martin Rumende Cosphiadi Irawan E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eveline, Ency Harry Yusuf Hasudungan, Wicensius Parulian Ikhwan Rinaldi Juferdy Kurniawan Karmel L Tambunan, Karmel L Kuntjoro Harimurti Lugyanti Sukrisman M Bonar Marbun M. Sidik Marcellus Simadibrata Miratasya Zulkarnaen Muhadi Muhadi Muhadi Muhadi, Muhadi Muhammad Ikhsan Nata P Hardjo Lugito, Nata P Ni Ken Ritchie Parlindungan Siregar Parlindungan Siregar Pujiati, Herni R.M. Widhyasih, R.M. R.R., Aditia Rahmat Cahyanur Ranakusuma, Teguh A. S Rini Andriani Rizki Yaruntradhani RR. Ella Evrita Hestiandari Sadipung, Theresia Oktavia Sally Aman Nasution Sally Aman Nasution, Sally Aman Sari, Riska Nanda Sari, Sakinah Rahma Shufrie Effendi, Shufrie Shufrie Effendy Shufrie Effendy Siahaan, Billy Stinggo Sofyan, Henry Riyanto Sri Wahdini Sukamto Koesnoe Syntia Nusanti T. Djumhana Atmakusuma, T. Djumhana Tubagus Djumhana Atmakusuma Velma Herwanto Velma Herwanto Wijaya, Indra Wiratman, Winnugroho Yesnuar Safri, Ahmad