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Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 405 Documents
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SARS-CoV-2 Infection Complicated by Acute Pericarditis Concurrent with Malaria Infection Hocin, Kevin; Kusuma, Yudha; Dewi, Atit Puspitasari
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Coronavirus disease 19 (COVID-19) can present as various symptoms, which range from asymptomatic to severe symptoms. We report a case of COVID-19 female patient with malaria co-infection who developed pericarditis complication. In this pandemic era, it is mandatory to rule out COVID-19. Coinfection with malaria will result in higher cytokine levels which lead to atypical complication, such as pericarditis. Prompt identification of atypical COVID-19 complications is essential as it can lower the mortality rate and reduce the duration of hospitalization.
Update in Laboratory Diagnosis of Urinary Tract Infection Rinawati, Weny; Aulia, Diana
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Urinary tract infection (UTI) is an infection caused by the entry of pathogens into the urinary tract. Symptoms of a UTI are not always obvious, and some are asymptomatic or atypical. Urinary tract infections must be distinguished from other diseases that have a similar clinical appearance. Many UTIs resolve spontaneously, but often cause significant morbidity and mortality. With the unpredictable nature of the disease, laboratory tests are required for accurate diagnosis and identification of the cause of infection. Thus, it is necessary to understand the interpretation and limitations of urinalysis and urine culture results. To assist in the diagnosis of urinary tract infections, flowcytometry is currently being developed. With the ability to detect bacteria, this tool can be used for UTI screening in the pre-analytic phase of urine culture
Characteristics of Patients with Non-Malignant Pleural Effusion in dr. Zainoel Abidin Hospital Banda Aceh in 2019 Putra, Teuku Romi Imansyah; Maya, Price; Hasan, Maryatun; Pranata, Agung; Salsabila, Safira; Sariningrum, Hesti Ariandani
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 1
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Introduction. Pleural effusion occurs when there is a pathological process causing fluid to accumulate in the pleural cavity. Pleural effusion is still the main cause of respiratory distress and can also be caused by many diseases either from pleural, lungs, or even extrapulmonary problems. The morbidity and mortality of this condition are directly associated with the underlying causes. The aim of this study is to investigate the profile of the patients, etiology, location, fluid characteristics, comorbidities, and also the bacteria pattern of non-malignant pleural effusion. Methods. This is a retrospective descriptive study thatused patient’s medical records from January to December 2019 in Zainoel Abidin Hospital, Banda Aceh as the source of data for this study. Results. There were 118 patients with non-malignant pleural effusion from January to December 2019. In this study, it was found that the highest gender was male (66.9 %) and in the age group of 46-55 and >65 years old in male, and 56-66 years old in female. The most frequent etiology of non-malignant pleural effusion was pneumonia. The majority (72.9%) of pleural effusion were exudate and mostly happened in the right lung (53.4%). Comorbidities were found in 104 patients and the main comorbiditywas tuberculosis (11.3%). The result of the pleural fluid culture test showed that there were 33 samples with positive results. Staphylococcus hominis was the bacteria found in most of the isolates (22.9%).Conclusion. Non-malignant pleural effusions are generally exudates with Staphylococcus hominis being the most common bacterial growth
Kidney Disease and Its Impact on COVID-19 Patients at Sanglah Hospital Denpasar, Bali, Indonesia in 2021 Upadhana, Putu Satyakumara; Sastrawan, I Gede Gita Sastrawan; Chintya Cahyarini, I Gusti Agung Ayu; Umam, Anbiya Khairul; Putri, Amanda Trisliana Dwi; Adhyatma, I Gede Raka; Somia, I Ketut Agus
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 1
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Introduction. Besides having an impact on the respiratory system, COVID-19 also has an impact on other organ such as the kidneys. The systemic inflammatory response thought to be associated with bad prognosis of COVID-19 patients with kidney disease. This study aimed to determine the impact of kidney disease on COVID-19 patients. Methods. This study is an observational analytic study with a cross-sectional approach. The data used is secondary data from the records of confirmed COVID-19 patients who were treated at Sanglah Hospital from 1 May 2021 to 31 August 2021 using total sampling technique.Results. There were 248 patients included in this study. The majority of patients were male (52.4%) with the median overall age of the patients was 59 (range 20–92) years. Most of the patients were severe COVID-19 (65.3%). A total of 77 patients had kidney disease (31.0%) which the most common kidney disease found in patients was acute on chronic kidney disease (n=33; 42.8%). There were significant differences in hemoglobin (p<0.001), blood urea nitrogen (BUN) (p<0,001), serum creatinine (p<0.001), and procalcitonin (p<0.001) in patients classified based on kidney disease. Chi-square analysis showed that COVID-19 patients with kidney disease was correlated with sepsis [PR=2.587 (95%CI 1.750-3.824); p<0.001)], mortality [PR=1.696 (95%CI 1.114-2.583); p=0.018)], and severe COVID-19 [PR=1.513 (95%CI 1.077-2.342); p=0.040)]. Logistic regression analysis showed that COVID-19 patients with kidney disease was correlated with sepsis [PR=4.318 (95%CI 1.767-10.553); p<0,001] and mortality [PR=1.413 (95%CI 1.664-3.005); p=0.045)].Conclusion. Kidney disease increases the risk for sepsis and mortality in COVID-19 patients.
Mutation and Variant of Coronavirus Disease 2019 (COVID-19): Review of Current Literatures Susilo, Adityo; Jasirwan, Chyntia Olivia Maurine; Wafa, Syahidatul; Maria, Suzy; Rajabto, Wulyo; Muradi, Akhmadu; Fachriza, Ihza; Putri, Myranda Zahrah; Gabriella, Stacy
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 1
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Since March 2020, the Coronavirus Disease 2019 (COVID-19) pandemic has engulfed the world, including Indonesia, for nearly two years. SARS-CoV-2 has undergone several mutations during its evolution as a pathogen, resulting in various variants of global concern. Variants of this virus are suspected to impede the outbreak resolution and possibly causing the outbreak to spiral out of control. There is still considerable debate and research underway regarding the new SARS-CoV-2 variants. Rapid transmission mechanisms and widespread vaccination coverage have accelerated the virus’s mutation rate and resulted in numerous new variants. To date, this has resulted in the discovery of a new variant Omicron (B.1.1.529) in November 2021 in South Africa, which has since spread to 103 countries. Omicron is designated a Variant of Concern (VoC) due to its more powerful transmission than the previous variant. Although some information indicates that the symptoms associated with this variant are typically mild, the rapid transmission of Omicron can increase the next wave of COVID-19 cases. Additional research is required to determine transmissibility, pathogenesis, diagnosis, and proper management. As a result, we conducted an adjunct to studies on various COVID-19 mutations and variants until January 2022.
The difference in Nutrition Intake Adequacy AmongInstitutionalized Elderly Residents with and without Sarcopeniaat Nursing Homes in Bandung, West Java Tirtadjaja, Delia Anastasia; Apandi, Muhamad; Dwipa, Lazuardhi
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 4
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Introduction. The changes in the elderly’s daily routine including dietary intake and nutritional pattern may cause them to be more susceptible to malnutrition. The changes also increase the risk of sarcopenia that may lead to poor health outcomes such as fall injury, fracture, hospitalization, disability, or even death. Sarcopenia is more likely to occur in a nursing home compared to community settings. This study aimed to determine the difference in nutrition intake adequacy between institutionalized elderly subjects with and without sarcopenia in Bandung, West Java. Methods. A cross-sectional study was held in Ciparay and Budi Istri Nursing Home, Bandung, West Java, Indonesia. Sarcopenia was determined based on the Asian Working Group of Sarcopenia (AWGS) criteria. Nutritional intake was assessed with two non-consecutive 24-hour food recalls and nutritional adequacy was defined based on the American Geriatric Society (AGS) recommendation, which included a total energy intake of ≥ 25kcal/kg BW/day and protein intake of ≥1g/kg BW/day. Results. The present study included 65 older adults, who were categorized into 2 groups, i.e. sarcopenic (31 subjects) and non-sarcopenic groups (34 subjects). Despite the food served having already met daily dietary reference intakes, the sarcopenic elderly subjects showed inadequate nutritional intake (p=0.001) compared to non-sarcopenic elderly subjects. Conclusion. There are differences in nutrition intake adequacy between sarcopenic and non-sarcopenic institutionalized elderly subjects in Bandung. Elderly subjects with sarcopenia had more inadequate nutrition intake than non-sarcopenic elderly subjects.
Depressive Symptoms as a Predictor Factor of All-Cause Mortality within Six Months in Elderly Hemodialysis Patients Perdhana, Langgeng; Chasan, Shofa; Mupangati, Yudo Murti; Nuraini, Siti
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 4
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Introduction. Depression is a mental disorder that is often found in the elderly and hemodialysis patients, resulting in bad effects on patients. There is no study on the relationship between depression and all-cause mortality risk in elderly hemodialysis patients in Indonesia. This study aimed to determine the role of depression as a predictor factor of all-cause mortality within 6 months in elderly hemodialysis patients. Methods. A prospective cohort study was conducted from February to August 2020 at the hemodialysis unit of Roemani Muhammadiyah Hospital, Semarang. The inclusion criteria were elderly patients (aged ≥60 years), undergoing hemodialysis ≥3 months, hemodialysis frequency twice a week, willing to participate in this study, able to communicate well, and has no history of mental disorders include a history of psychotic disorders and mental disorders due to substance use. Meanwhile, patients whose data were incomplete, transferred to another hemodialysis unit, HBsAg +, hemoglobin level /dl. FRAILTY score >2, and had other stressors not related to hemodialysis or chronic kidney disease (CKD) such as social, family, and work factors were excluded from this study. Depression was assessed using the Beck Depression Inventory-II questionnaire. The collected data was then analyzed using Kaplan Meier and Cox Regression.Results. Of 32 respondents, most of them were male (81.3%). The mean age was 67.2 (SD 7) years. There were 6 (18.7%) respondents categorized into a depression group and 26 (81.3%) respondents into a non-depression group. Cox Regression analysis showed that depression was a predicting factor of all-cause mortality within six months in elderly hemodialysis patients (p value=0.012, and Hazard ratio=10.149). Conclusion. Depression is a predictor factor of all-cause mortality within six months in elderly hemodialysis patients.
Management of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Nugroho, Pringgodigdo
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 4
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Chronic kidney disease (CKD) is still a burden on worldwide health issues affecting about 11-13% of the general population. Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in CKD, which occurs early in the disease, and progresses as kidney function deteriorates. With declining kidney function, mineral homeostasis becomes progressively dysregulated, including alterations in several parameters such as calcium, phosphate, intact parathyroid hormone (iPTH). Changes in these parameters are associated with bone disorders and vascular abnormalities, which are strongly correlated with increased cardiovascular (CV) morbidity and mortality, and overall mortality. Currently, CKD-MBD and its complication management have been focusing on correcting biochemical and hormonal abnormalities to limit their potential effects. All therapeutic decisions are based on circulating levels of calcium, phosphate and PTH considered together. CKD-MBD management should also be individualized since it might differentially benefit the patients.
Predictors of Handgrip Strength Changes in Elderly Patients Madina, Ummi Ulfah; Setiati, Siti; Laksmi, Purwita Wijaya; Mansjoer, Arif
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 3
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Introduction. The increasing elderly population throughout the world has been related to the increased prevalence of sarcopenia and frailty. Handgrip strength is a component of sarcopenia, one of frailty syndrome phenotypes. Previous studies have assessed the association of age, sex, nutritional status, functional status, mental status, and comorbidity, but varied results. No longitudinal study has been done to determine the correlation of handgrip strength changes with age, sex, nutritional status, functional status, mental status, and comorbidity in Indonesia. The aim of this study was to determine the correlation between age, sex, nutritional status, functional status, depressive symptoms, comorbidity, and handgrip strength changes in elderly patients. Methods. A prospective cohort study using secondary data of elderly patients who were routinely visiting Geriatric OutPatients Clinic at Cipto Mangunkusumo Hospital, Jakarta, from the INA-FRAGILE register observed for one year (2013- 2014). The multivariate logistic regression analysis was used to assess the correlation between sex, age, nutritional status (MNA score), functional status (ADL score), depressive symptoms (GDS-SF score), comorbidities (CIRS score), and handgrip strength changes. Results. From 162 subjects which were included in the study, the mean age was 72.9 (SD 5.9) years, predominantly female (57.41%), with good nutrition (83.9%), independent (median 9- 20), not depressed (median 0-11), has average comorbidity index 11.8 (SD 3.7), and 53.1% experienced decreased handgrip strength. Nutritional status (OR = 2.7, p = 0.033) and comorbidity (OR 0.3, p <0.002) correlated with handgrip strength changes
The Influence of Characteristics and Behavior on the Incidence of Pulmonary Tuberclosis in Al-Hidayah Pesantren, Kejuruan Muda Subdistric Tamiang District, Aceh Province, 2019 Anggraini, Indah; Hutabarat, Basaria
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 3
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Introduction. Pulmonary tuberculosis is a chronic infectious disease that is a global issue. Some factors influence the occurrence of pulmonary tuberculosis, among others, the source of infection, a high amount of virulence bacilli, and decreased endurance. This study aims to determine the effect of characteristics and behavior on the incidence of pulmonary TB disease in Al-Hidayah Islamic Boarding School, Vocational School, Aceh Tamiang Regency. Method. This research is analytic with a cross-sectional research design. Data analysis uses Chi-Square test and Logistic Regression) to determine the influence of the most dominant risk factors with pulmonary TB disease incidence. Results. The results showed that the incidence of pulmonary TB had a significant relationship with the variables of age (p=0.002) gender (p=0.031), education (p=0.021), length of stay (p=0.018), knowledge (p=0.020), attitude (p=0.018), and action (p=0.016). Action variable (p=0.025) is the most dominant variable on the incidence of pulmonary TB disease. Conclusion. In order to prevent the occurrence of pulmonary tuberculosis, an increase in outreach activities is carried out. Counseling or IEC to Islamic boarding school students was giving by disseminating information about prevention and prevention of pulmonary TB by using interesting media and easily understood by students such as film screenings so that students can independently live in boarding school and behave healthy life in the prevention of tuberculosis.

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