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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 3 (2023)" : 60 Documents clear
Literature Review: Potensi Pemanfaatan Minyak Alami Dalam Inovasi Formulasi Kosmetik Arline Rahmadianti Kusumawardhani; Nur Komala Fitri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.178

Abstract

The utilization of natural oils as primary and additional raw materials has long been practiced in the cosmetics industry. Natural oils are known to be rich in nutrients and beneficial properties, making them suitable for the production of beauty and skincare products. The main objective of this literature review is to identify recent developments, identify and address issues that may arise in formulating products using natural oils, and explore opportunities in utilizing natural oils in cosmetic formulations. This literature review conducted by searching national and international journal articles from the period of 2012 to 2023, selecting those that were relevant to the topic and conducting a comprehensive analysis. Based on the literature review, it was found that natural oils have proven potential in innovating cosmetic formulations due to their natural and organic benefits, as well as being more environmentally friendly compared to chemical ingredients, although challenges that require solutions exist. Furthermore, through further research and innovation in the utilization of natural oils, superior and high-quality cosmetic formulations can be developed in the future.
Pemanfaatan Ekstrak Etanol Kulit Buah Naga Merah (Hylocereus polyrhizus) Dalam Sediaan Krim Lulur Sebagai Pelembab Alami Kulit Indra Ginting; Muhammad Andry
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.179

Abstract

Background: Flavonoid chemicals, vitamins A, C, and E, and polyphenols are found in the skin of red dragon fruit (Hylocereus polyrhizus), which may be utilized as a source of natural antioxidants to fight free radicals and give a moisturizing effect on the skin. Objective: In this study, an ethanol extract of red dragon fruit peel with concentrations of 1%, 3%, and 5% will be used to create a scrub cream preparation. Method: Experiments were used in this study. Organoleptic, homogeneity, dispersion, irritation, stability (cycling), and moisture efficacy tests were among the assessment procedures used to assess the scrub cream formulation. Results: The preparations all have a semisolid consistency, a vanilla scent, and a variety of hues, including white in the blank formula, cream in formulas F1 and F2, brownish cream in recipe F3, and light brown in formula F3. All of the prepared were uniform and did not bother the skin. With a pH range of 5.7–5.9, all preparations satisfied the criteria. With a dispersion of 5.6-7.9, the dispersive power of all preparations fulfilled the standards. There was no discernible change in the stability test during the riding test. The F3 scrub cream preparation had the biggest rise in skin water content from the F0, F1 and F2 preparations, which was 29.4% at week 4 after using the preparation, according to the findings of the moisture efficacy test. Conclusion: The study's findings indicated that red dragon fruit peel extract might be used to create a scrub cream preparation that can moisturize the skin and has passed physical assessment standards.  
Evaluasi tingkat pengetahuan pasien terhadap penggunaan obat diabetes mellitus tipe II dirawat jalan rumah sakit Advent Medan Windi Darantika; Rena Meutia
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.180

Abstract

The importance of one's health cannot be overstated, especially in today's world where many individuals suffer from numerous illnesses, including diabetes mellitus. Is there a correlation between patients' degree of awareness regarding the use of type II Diabetes Mellitus medications at Medan Adventist Hospital? is how the problem from this study is formulated. The goal of the study was to ascertain how patients' level of familiarity with the usage of type II Diabetes Mellitus medications at Medan Adventist Hospital correlated with their condition. This study is cross-sectional and analytical descriptive in nature. Patients with type II Diabetes Mellitus in the outpatient facility of Medan Adventist Hospital were surveyed prospectively in order to collect data. Data from patient medical records is also used in data collection. The study's findings include the knowledge of patients based on their age, gender, education level, occupation, length of suffering, medical history, and knowledge level. The findings are based on the knowledge levels of 100 respondents, of whom 42 (42%), 50 (50%), and 8 (8%), respectively, had good levels of knowledge, good levels of knowledge that were sufficient, and inadequate levels of knowledge. According to the findings of a study done at Medan Adventist Hospital, type II Diabetes Mellitus patients there had an average level of knowledge about drug use, with 50 respondents (or 50%) falling into this category.
Review artikel: Uji Efektivitas Ekstrak Daun Teh Hijau Sebagai Antibakteri Nur Komala Fitri; Arline Rahmadianti Kusumawardhani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.181

Abstract

Introduction: Tea is a plant that comes from the Theaceae family, the part of the tea plant that is commonly used as traditional medicine is the leaves, empirically drinking steeped tea leaves has properties for lowering blood pressure, preventing cancer and can reduce stress. Green tea is a type of tea leaf obtained by heating or using hot steam on older tea leaves compared to white tea. Purpose: the effectiveness of green tea leaf extract as an antibacterial based on several studies that have been conducted. Method: Article review with publication range 2013-2023. Results: Green tea leaf plants contain flavonoid compounds with the catechin subclass, catechins have antibacterial activity. Grkeen tea leaves will be extracted and then the catechin compounds will be separated from the main extract using KLT. Conclusion: From the awareness that has been made, it can be said that the catechin compounds contained in green tea leaf extract have antibacterial benefits, this is indicated by the presence of a clear zone in the experiment with the diffusion disc, then the clarity in the direct inoculation test, and the decrease in the number of bacterial colonies is measured by using a colony counter.
Uji efektitivitas sediaan gel ekstrak bonggol pisang goroho putih (Musa acuminafe, sp) terhadap penyembuhan luka bakar tikus putih (Rattus nornvegicus) Martina G. Laloan; Douglas N. Pareta; Selvana S. Tulandi; Yessie K. Lengkey; Christel N. Sambou
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.184

Abstract

Natural wealth has a variety of herbal plants, plants that are included in it efficacious as medicine. Traditional medicine, is an ingredient or herb that is usually used as traditional medicine and is used to accelerate the healing of diseases, one of the plants used to accelerate wound healing is the white goroho banana weevil (Musa acuminafe, sp). This study aimed to determine the effectiveness of banana weevil gel preparations against healing burns in white rats (Rattus norvegicus). The test animals used were 15 rats. A burn of 2.5 cm was made on the back of the mouse using metal coins. The method used in this study is in the form of laboratory experiments. This study used a Complete Randomized Design (RAL) consisting of 5 treatments, including 1 negative control, 1 positive control (bioplacenton), and 3 stratified concentrations, namely 5% concentration gel, 10% concentration gel and 15% concentration gel with 3 repetitions each. The treatment is carried out for 14 days. The results of measuring wound diameter in rats based on the results showed that banana weevil extract gel concentration of 15% provided a healing effect more effective than other extracts.
Uji skrining fitokimia dan pengukuran kadar total flavonoid pada ekstrak paku (Nephrolepis biserrata) dengan fraksi n-heksana, etil asetat, dan air Razoki; Ruth Gaby Syahanaya Butar-Butar; Elfia Neswita; Novitaria Br Sembiring; Erida Novriani; Nerly Juli Pranita Simanjuntak; Enni Halimahtussa’diyah Pakpahan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.185

Abstract

Nephrolepis Biserrata, including ferns and lycophytes, are a group of plants that have been around for a long time on Earth, with more than 12,000 different species. Ferns have an important role in the ecosystem, such as helping to form humus, protect the soil from erosion, maintain soil moisture, and act as pioneer plants in the early stages of forest ecosystem succession. Phytochemical screening tests can identify bioactives that are not yet visible through bags or tests that can quickly separate natural ingredients that contain certain phytochemicals and those that do not. Extraction is the activity of withdrawing soluble chemical compounds so that they are separated from insoluble materials. Extraction can be done in various ways including n-hexane which aims to remove fat, ethyl acetate which can extract semi-polar compounds, and water which is a universal solvent.The methods used in this study include maceration, phytochemical screening, fractionation, and data analysis. The results of this research conclude that secondary metabolite compounds are present in the leaves of the Nephrolepis Biserrata fern, based on positive phytochemical tests for alkaloids, phenolics, flavonoids, tannins, and triterpenoids in the ethanol fraction. The n-hexane fraction contains alkaloids, phenolics, flavonoids, tannins, steroids, and triterpenoids. The ethyl acetate fraction contains alkaloids, phenolics, flavonoids, saponins, and tannins, while the water fraction contains alkaloids, phenolics, flavonoids, and tannins. The total flavonoid content is 17.615 mg QE/g of extract. UV-Vis spectroscopy identification results indicate the presence of ???? → ????* and n→ ????* transitions.
Drug-related problem (DRP) penggunaan antidiabetik oral dan insulin pada pasien diabetes melitus tipe II rawat inap di RSU Royal Prima Medan Elfia Neswita; Brian Elberth Halu; Razoki; Asyrun lkhairi Lubis; Muhammad Yunus; Nurasni; Octavian Ashido Nababan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.186

Abstract

Diabetes mellitus is a group of metabolic disorders characterised by hyperglycemia which is the cause of death of up to 80% in low- and middle-income countries. Type 2 diabetes mellitus is the most common form of diabetes. The goals of managing type 2 diabetes mellitus therapy are to reduce the risk of microvascular and macrovascular complications, reduce mortality, and improve quality of life. Treatment of diabetes mellitus requires a long time. Problems arising from complications in diabetes mellitus will increase the difficulty in treating patients. This can potentially cause issues related to Drug Related Problems (DRP). Drug-Related Problems refers to unexpected events experienced by patients and can interfere with the success of the drug therapy given. The research method in this study was to determine the drugs to be evaluated in the form of oral antidiabetic drugs used while undergoing type 2 diabetes mellitus therapy and insulin therapy. The results showed that 26 patients experienced Drug-Related Problems or not (50%). Six patients experienced actual Drug Related Problems (10.2%). In comparison, those who experienced Potential Drug Related Problems were 24 patients (46.15%) of a total of 52 patients with type 2 diabetes mellitus who were the sample of this study. Two categories of Drug Related Problems occur, namely Drug Related Problems related to additional drug therapy with a total of 2 incidents (2.17%) and Drug Related Problems related to unwanted drug reactions (Adverse Drug Reactions) with a total of 4 incidents (7,7%).  
Standardization of specific and non-specific parameters of sambiloto (Andrographis paniculata. Burm.f) ethanol extract as standardized herbal medicine Heldi Candra; Indri Ayu Ningsih; Claudia Angelina Kurnia Bat
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.187

Abstract

This study's objective is to ascertain how to make Sambiloto simplicia that is good and right according to the second edition of the 2017 herbal pharmacopoeia standards, to find out non-specific and specific parameters, which consist of tests for water content, ash content, drying shrinkage, water-soluble extract content, and extract content. Soluble ethanol in Sambiloto simplicia and knowing the secondary metabolites of Sambiloto simplicia. This study employed a qualitative and quantitative observational methodology. The research object was the Sambiloto plant (Andrographis paniculata. Burm.f) which was planted within the home's yard in the Sungai Lekop Plot, Sungai Lekop Village, Sagulung District, Batam City. The results showed that Sambiloto extract contains secondary metabolites of tannins, alkaloids, saponins, terpenoids and flavonoids. Sambiloto viscous extract obtained by 5 ml from 500 ml extract parameter values for non-specific and specific test water content of Sambiloto is 9%, drying shrinkage is 18.5%, total ash content is 10%, water-soluble extract is 12.96%, and ethanol-soluble extract 8%, specific and non-specific parameter tests met the requirements for the 2017 herbal pharmacopoeia, the results showed that Sambiloto simplicia fulfilled the requirements as a standardized herbal medicine.  
Uji antidiabetes kombinasi ekstrak daun insulin (Tithonia diversifolia (Hems.) A.Gray) dan daun ubi jalar (Ipomoea batatas (L.) Lam) ungu pada tikus jantan akibat induksi streptozotocin Octavianing Yosephine; Galih Samodra; Khamdiyah Indah Kurniasih
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.189

Abstract

Diabetes mellitus is a condition in which blood glucose levels are high enough in the body. Insulin leaves contain tannins, flavonoids and saponins which play a role in fighting free radicals. Purple sweet potato leaves have anthocyanin and phenolic flavonoid compounds that function as anti-diabetics. The combination of the two is expected to produce a synergistic effect to increase the effectiveness of antidiabetics. This research aims to find out the antidiabetic effect and the effective dose of a combination of insulin leaf extract and purple sweet potato leaves. This study used 25 rats as test animals which were divided into 5 groups. The blood glucose levels of the rats were measured using the GOD-PAP method. The results showed that the combination dose of insulin leaf ethanol extract 30 mg/kgBB and purple sweet potato leaves 120 mg/kgBB (combination group 2) had an anti-diabetic effect, an average of 97.49 and a positive control (glibenclamide) mean of 116.83 in reducing blood glucose levels in streptozotocin-induced mice. The research show that based on the One Way ANOVA analysis, the sig. ie 0.000 <0.05, then in conclusion the average of the five test groups has a significant difference.
Faktor-faktor yang berhubungan dengan kejadian malaria Kecamatan Tanjung Tiram Kabupaten Batubara tahun 2023 Khodijah Tussolihin Dalimunthe; Tina Meirindany; Mutiara Nauli
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.190

Abstract

Malaria is an infectious disease transmitted to humans by the bite of a female Anopheles mosquito infected with a protozoan parasite of the genus Plasmodium. One of the determinants of the spread of malaria by the host is community knowledge and the behavior of using house wire screens. his type of quantitative research is with a cross-sectional design and will be carried out from April to June 2023 in Hamlet XII, Suka Maju Village, Tanjung Tiram District, Batubara Regency. The research sample was 72 respondents with a purposive sampling technique. Test analysis using chi-square and simple logistic regression. The results showed that there was a relationship between the two categories studied <0.05. There is a relationship between the use of wire gauze and the incidence of malaria with a value of p=0.004, as well as a relationship between knowledge and the incidence of malaria with a value of p=0.03. The incidence of malaria that occurred in Batu Bara was due to knowledge and behavior factors of not using wire mesh at home. It is necessary to carry out counseling about malaria and the importance of using wire gauze.  

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