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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 75 Documents
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Search results for , issue "JPS Volume 8 Nomor 3 (2025)" : 75 Documents clear
Pengaruh Edukasi Media Booklet Terhadap Pengetahuan Pasien Diabetes Melitus Tipe 2 Peserta Prolanis Di Puskesmas Lima Kaum I Kabupaten Tanah Datar. Rani, Jihan Shasika; Sari , Yelly Oktavia; Wahyuni, Fatma Sri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.945

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion or function. The prevalence of T2DM is increasing globally, including in Indonesia. However, patients’ knowledge regarding disease management remains relatively low. Continuous education is considered an essential strategy to improve disease control.  Objective: This study aimed to analyze the effect of education using booklet media on improving knowledge among T2DM patients enrolled in the Chronic Disease Management Program (Prolanis) at Lima Kaum I Public Health Center, Tanah Datar Regency. Methods: The study employed a pretest-posttest control group design involving a total of 48 respondents, divided into an intervention group (received the booklet) and a control group. The research instrument used was the SDKS INA 1 questionnaire to assess patients’ knowledge. Data were analyzed using the Chi-Square test and the Wilcoxon test. Results: showed a significant increase in patients' knowledge after the educational intervention using the booklet (p=0.000; p<0.05). Conclusion: Therefore, booklet media is proven to be an effective educational tool for enhancing knowledge among patients with Type 2 Diabetes Mellitus.
Analisis Hubungan Faktor Sosiodemografi dan Sosioekonomi Dengan Tingkat Kepatuhan Pengobatan Pasien Diabetes Melitus Tipe 2 di Puskesmas Damai Berdasarkan MMAS-8 Nuurositha, Nuurositha; Wahyuni , Fitri Ayu; Erwina , Wiwi; Rahman , Rifazul Aulia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.954

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease requiring long-term therapy. Patient adherence to medication plays a crucial role in preventing complications. Unfortunately, the level of medication adherence among T2DM patients remains suboptimal and is influenced by various factors, including sociodemographic and socioeconomic factors. This study aims to analyze the association between sociodemographic and socioeconomic factors and medication adherence in T2DM patients at Puskesmas Damai, Balikpapan City. A cross-sectional design was applied with total sampling of all T2DM patients at Puskesmas Damai meeting the inclusion criteria. The Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire was used to assess medication adherence. Data were analyzed using univariate and bivariate methods, with chi-square tests for associations. Bivariate analysis showed that gender (p = 0.021) and age (p = 0.039) were significantly associated with medication adherence. Meanwhile, education level (p = 0.428), employment status (p = 0.865), and income (p = 0.836) were not significantly associated. Understanding the factors influencing patient adherence can inform the design of more effective interventions to improve medication adherence and treatment outcomes in T2DM patients.
Drug-Related Problems Pada Penyakit Paru Obstruksi Kronis: Literatur Review Fahmi, Muhammad Zaini; Karuniawati, Hidayah; Ismail, Wan Ismahanisa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.955

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of global morbidity and mortality, with a continuously increasing health burden. The complexity of long-term therapy in COPD increases the risk of Drug-Related Problems (DRPs), which can affect patient clinical outcomes. This literature review was conducted descriptively by searching articles in the PubMed, Scopus, Google Scholar, and ScienceDirect databases using keywords related to DRPs and COPD. The selection was made on publications from the last 10 years (2015–2025) relevant to the topic and available in full text. Based on studies by Li et al., (2019) and Apikoglu-Rabus et al., (2016), the classification of DRPs according to PCNE V9.0 mainly included aspects of medication safety (54.2%), inappropriate drug selection (up to 8.7%), excessive dosage (19.9%), excessive duration of therapy (17.7%), and errors in the drug use process (up to 63.3%). Patient factors such as non-compliance (25%) and incorrect inhalation techniques were the main contributors to the occurrence of DRPs. Inappropriate use of medications, drug-herb interactions, and lack of therapy monitoring were also consistently found. The findings suggest that DRPs significantly worsen symptom control and increase the risk of exacerbations. Pharmacists are critical in identifying, preventing, and managing DRPs through patient education, therapy review, and ongoing therapy monitoring. DRPs in COPD patients are a serious challenge that requires a multidisciplinary approach. Ongoing education, monitoring of therapy rationality, and collaboration between healthcare professionals are needed to improve patient safety and the effectiveness of COPD treatment.
Kejadian Drug-Related Problems Pada Pasien Rawat Inap dengan Diabetes Melitus Berdasarkan Kriteria PCNE : Literatur Review Febriani, Rizkina Elistya; Karuniawati, Hidayah; Rahman, Anees Ur
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.956

Abstract

Non-communicable chronic diseases such as diabetes mellitus (DM) are a significant health burden worldwide. In the treatment of DM patients, long-term drug use is inevitable and increases the risk of Drug-Related Problems (DRPs). The presence of DRPs can affect the effectiveness of therapy and the risk of side effects in hospitalized DM patients. This review aims to evaluate various studies conducted on DRPs in hospitalized DM patients based on the Pharmaceutical Care Network Europe (PCNE) classification. A systematic search of relevant articles in the last 10 years through the SpringerLink, ScienceDirect, Scopus, and PubMed databases. Irrelevant studies, review articles, and no data on DRP classification using PCNE or outpatients will be excluded. The review found four articles discussing DRP classification using PCNE in hospitalized DM patients. The number of DRPs varied, ranging from 253 to 873 cases. The proportion of patients experiencing at least one DRP was also relatively high, ranging from 48.1% to 84.5%. The most common problem was treatment ineffectiveness (P1.2), which accounted for more than half of the DRPs in the three studies reviewed, namely 62.0%, 79.6%, and 52.7%. The most common cause of DRPs came from the patient-related domain (C7.1) at 71.85%. Other domains that caused DRPs were the Drug use domain (C6.1) at 62.0%, other domains (C9) at 40.9%, the drug selection domain (C1.6) at 26%, and the dose selection domain (C3.5) at 25.9%. The occurrence of DRPs is a significant problem in the management of diabetes mellitus, especially in the hospital environment. The ineffectiveness of therapy is the main problem of DRPs. The high number of DRPs from other domains indicates that many causes of DRPs are not classified explicitly in the PCNE category.
Analisis Hubungan Kepatuhan Farmakologis dan Kepatuhan Diet Rendah Natrium dengan Tekanan Darah Pasien Hipertensi di Beberapa Puskesmas Kabupaten Banyumas Ristiana, Zahra Amalia; Fauziah , Fauziah; Setianingsih , Siti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.967

Abstract

Introduction: Hypertension is a chronic condition that requires long-term management through adherence to pharmacological therapy and a low-sodium diet. Both factors play an essential role in controlling blood pressure and preventing complications. Methods: This study employed a quantitative observational design with a cross-sectional approach conducted in February 2025 at four public health centers in Banyumas Regency. A total of 70 hypertensive patients enrolled in the PROLANIS program were selected using purposive sampling. Data were collected through interviews and health status documentation, then analyzed using the Chi-Square test and odds ratio (OR). Results: No significant relationship was found between pharmacological adherence and blood pressure (p systolic = 0.131; p diastolic = 0.434). Conversely, a significant association was observed between adherence to a low-sodium diet and blood pressure (p systolic = 0.000; p diastolic = 0.003). Odds ratio analysis indicated that patients adhering to a low-sodium diet were 1.86 times more likely to achieve controlled blood pressure compared to those who were non-adherent. Conclusion: Adherence to a low-sodium diet has a greater influence on blood pressure control than medication adherence. Therefore, educational interventions emphasizing the importance of dietary management and consistent medication intake should be optimized to improve the effectiveness of hypertension therapy in primary health care settings.
Formulasi dan uji karakteristik tablet effervescent buah belimbing wuluh dengan variasi konsentrasi asam sitrat dan asam tartat Ambarwati, Nadya; Nur, Fikria Marfuatin; Hidayah, Fufut Nurul
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.989

Abstract

Background: Averrhoa bilimbi L. is a natural source of vitamin C with potential as an antioxidant. Effervescent tablets are a popular dosage form in which the choice of acid sources, such as citric acid and tartaric acid, is critical due to their hygroscopic properties that affect the physical characteristics and stability of both granules and tablets. Objective: This study aimed to formulate and evaluate the effect of varying concentrations of citric acid and tartaric acid combinations on the physical characteristics of granules and effervescent tablets of Averrhoa bilimbi powder. Methods: The study employed the dry granulation method. Four tablet formulas with different ratios of citric acid and tartaric acid were prepared. The granules were evaluated for flowability, angle of repose, and moisture content. The resulting tablets were tested for organoleptic properties, weight uniformity, size uniformity, hardness, friability, and dissolution time. Data were statistically analyzed. Results: The evaluation showed that all granule characteristics (flow time 1.36–1.56 seconds; angle of repose 9.95°–13.50°; moisture content 3.298%–4.622%) met the requirements. All tablet evaluation parameters (weight uniformity, size uniformity, hardness, and dissolution time 1.27–1.36 minutes) also complied, except for friability (1.401%–2.832%), which exceeded the specified limit (>1%). Statistical analysis indicated that acid concentration variations had a significant effect (p-value < 0.05) on all tested parameters except tablet friability (p-value > 0.05). Conclusion: It can be concluded that variations in citric acid and tartaric acid concentrations significantly affect the characteristics of Averrhoa bilimbi effervescent granules and tablets, except for friability. The nonconformity observed in friability testing is presumed to be influenced by other formulation factors such as the type and concentration of binders and lubricants. Further studies on formula optimization, vitamin C content analysis, and accelerated stability testing are recommended.
Review Article: Pharmacological Activities and Bioactive Potential of Chinese Betel Leaf (Peperomia pellucida L. (Kunth.)) Razoki, Razoki; Lister, INE; Mutia, Maya Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1000

Abstract

Background: Peperomia pellucida L. Kunth (sirih cina) is a traditional medicinal plant used to treat various ailments. Its broad pharmacological potential needs to be consolidated from various publications to provide a comprehensive overview. Objective: This review aims to analyze and synthesize recent scientific evidence on the pharmacological activities, bioactive compounds, and potential applications of Pperomia pellucida. Methods: This systematic review was conducted by searching electronic databases (Google Scholar, PubMed, ScienceDirect, Scopus) using relevant keywords. From the search results, 21 original research articles published between 2015-2025 that met the inclusion criteria were analyzed descriptively and qualitatively. Results: The analysis revealed that Peperomia pellucida possesses diverse pharmacological activities, including anti-inflammatory, antibacterial, antifungal, antioxidant, anticancer, antidiabetic, antihypercholesterolemic, and osteogenic effects. These activities are supported by bioactive compounds such as flavonoids, tannins, alkaloids, and saponins. Its ethanolic extract has proven effective in in vitro and in vivo tests, including in topical formulations like creams and acne serums. Preliminary safety profiles indicate non-toxic properties. Conclusion: Peperomia pellucida shows great potential as a natural raw material for developing herbal medicines and cosmetics. Further research, such as human clinical trials and the development of technology-based formulations, is necessary to ensure its long-term safety and efficacy.
Hubungan Dukungan Keluarga dan Kondisi Psikologis Ibu Dengan Tingkat Keberhasilan Pemberian ASI Eksklusif di Desa Paya Geli Sinaga, Onike Lavionika; Irfani, Putri; Wahyudi, Putri Salsabilla; Hasibuan, Rabiatul Adawiyah; Siregar , Debi Novita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1013

Abstract

Background: Breast milk (ASI) is the ideal source of nutrition, containing antibodies and bioactive substances that support infant growth, development, and immune function. Despite its substantial benefits, many mothers fail to exclusively breastfeed. Family support and maternal psychological conditions are strongly suspected to influence the success of exclusive breastfeeding. Objective: This study aims to analyze the relationship between family support and maternal psychological conditions with the success of exclusive breastfeeding in Paya Geli Village. Methods: This quantitative study employed a cross-sectional design involving 32 mothers with infants aged 0–6 months. Data were collected using questionnaires and analyzed through univariate and bivariate analyses with Chi-Square and Fisher’s Exact tests. Results: Analysis of this limited sample showed a statistically significant association between family support (OR = 106.8; 95% CI: 10.0–1149.0; p < 0.001) and maternal psychological conditions (OR = 53.3; 95% CI: 2.7–1046.6; p = 0.0003) with exclusive breastfeeding success. However, the wide confidence intervals (CIs) indicate considerable uncertainty in the estimates. Conclusion: Family support and maternal psychological conditions are critical determinants of exclusive breastfeeding success. Community-level health promotion programs should prioritize these factors to improve exclusive breastfeeding coverage. Policy implications warrant further investigation with larger and more representative samples.
Hubungan pemberian makanan pendamping air susu ibu (MP-ASI) dini dengan kejadian diare pada bayi usia 0-6 bulan di klinik Pratama Evi Azzahra, Nasywa Firja; Sari , Delia Permata; Sapitri , Anggiani; Simamora , Apriyanti; Tondang, Kesya Nirina; Paninsari, Debora
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1014

Abstract

Background: The global coverage of exclusive breastfeeding remains low (44%). The situation in Indonesia, particularly in North Sumatra, is concerning, where 68.4% of children under two years receive complementary feeding (CF) too early. This practice may increase the risk of diarrhea due to the immaturity of the infant’s gastrointestinal tract. Preliminary findings at Evi Primary Clinic showed that 17 out of 20 infants under six months experienced diarrhea, along with evidence of early CF practices. Objective: This study aimed to analyze the association between early complementary feeding and the incidence of diarrhea among infants aged 0–6 months at Evi Primary Clinic. Methods: An observational analytic study with a cross-sectional design was conducted. A total sampling technique was applied to 35 mothers with infants aged 0–6 months. Data were collected using questionnaires and analyzed using the Chi-Square test. Results: A total of 19 infants (54.3%) received early complementary feeding, and 18 infants (51.4%) experienced diarrhea. Bivariate analysis revealed that 15 out of 19 infants (42.8%) who received early complementary feeding suffered from diarrhea. The statistical test showed a p-value of 0.001 (α<0.05). Conclusion: There is a statistically significant association between early complementary feeding and the incidence of diarrhea among infants aged 0–6 months at Evi Primary Clinic. Therefore, education on the appropriate timing of complementary feeding is essential to prevent diarrhea in infants.
Pengaruh Program Pemberian Makanan Tambahan (PMT) Berkelanjutan Terhadap Perbaikan Gizi Stunting di Kota Binjai Manik, DiniLa Putri Olina Br.; Armansyah , Andini septiana; Gulo , Nanda Putri Berlian; Garamba, Indah Purnama Sari; Zai , Lady Angelita; Paninsari , Debora
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1016

Abstract

Background: Stunting remains a serious public health problem in Indonesia, including in Binjai City, with a prevalence rate that continues to fluctuate and requires effective intervention. Stunting is caused by chronic malnutrition and results in growth failure. The Supplementary Feeding Program (PMT) is a specific intervention expected to improve the nutritional status of toddlers. Objective: This study aims to analyze the effect of the continuous Supplementary Feeding Program (PMT) on improving the nutritional status of stunted toddlers in Binjai City. Methods: This study used a quasi-experimental design (one-group pretest-posttest). The research population was 44 stunted toddlers registered in the Binjai City Stunting Reduction Acceleration Team (TPPS) program. Data was collected through direct anthropometric measurements (body weight and height) before and after the 90-day PMT intervention. Data were analyzed using the Wilcoxon Signed Rank Test. Results: The results showed a statistically significant improvement in the toddlers' nutritional status after the PMT intervention. This was evidenced by an increase in the indicators of body weight (p < 0.001), height (p < 0.001), W/A index (p = 0.002), H/A index (p < 0.001), and W/H index (p < 0.001). Conclusion: The continuous Supplementary Feeding Program (PMT) was proven effective in improving the nutritional status of stunted toddlers. This program can be used as a reliable strategy in efforts to accelerate the reduction of stunting rates in Binjai City.  

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