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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 885 Documents
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Hubungan Konsumsi Serat Harian Dengan Kadar Gula Darah Sewaktu Pada Pasien Diabetes Melitus Tipe 2 Tanpa Komplikasi Di Kecamatan Banda Sakti Kota Lhokseumawe Afiqah Divaulhaq; Cut Sidrah Nadira; Noviana Zara
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1506

Abstract

Introduction: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Indonesia ranks fifth globally for DM prevalence, with 19.5 million cases (10.8%) reported in 2021. Dietary fiber intake plays a crucial role in glycemic regulation through mechanisms involving delayed gastric emptying and enhanced insulin sensitivity. However, evidence regarding the association between daily fiber consumption and glycemic control in type 2 DM patients without complications remains inconclusive, particularly in primary care settings. Objective: This study aimed to examine the association between daily fiber intake and random blood glucose (RBG) levels among patients with uncomplicated type 2 diabetes mellitus in Banda Sakti District, Lhokseumawe City. Methods: A cross-sectional analytical study was conducted at Banda Sakti and Mon Geudong Primary Health Centers from May 2023 to February 2024. A total of 51 participants with uncomplicated type 2 DM were recruited using total sampling. Daily fiber intake was assessed through 24-hour food recall and analyzed using Nutrisurvey software, while RBG levels were measured using a standardized glucometer (ISO 15197:2013). Data analysis employed univariate descriptive statistics and bivariate analysis using Fisher's Exact test, with statistical significance set at p<0.05. Results: The majority of respondents were female (66.7%, n=34), elderly (>60 years, 51.0%, n=26), with higher education levels (60.8%, n=31), and normal body mass index (54.9%, n=28). Suboptimal daily fiber intake (<20 g/day) was observed in 80.4% (n=41) of participants, and poor RBG control (>200 mg/dL) was found in 68.6% (n=35). Although a trend indicated better RBG levels among those with adequate fiber intake (60% had good RBG vs. 24.4% in the insufficient group), statistical analysis revealed no significant association (p=0.054, Fisher's Exact test). Conclusion: Despite the absence of a statistically significant correlation between daily fiber intake and random blood glucose levels in this study, the observed trend suggests the potential clinical relevance of adequate fiber consumption for glycemic management. Future studies with larger sample sizes, prospective designs, and consideration of confounding factors including medication adherence, physical activity, and comprehensive dietary patterns are warranted to further elucidate this relationship.
Tren Penelitian Pengobatan Herbal untuk Penyakit Radang Usus: Analisis Bibliometrik dengan Penekanan pada Kolitis Ulseratif Muhammad Amin Nasution; Muhammad Andry; Sry Ulina Karo-Karo; Indah Pertiwi Nasution; Meiva Amelia Lubis; Damayanti S Damayanti S
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1538

Abstract

Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), is a chronic gastrointestinal disorder that significantly affects quality of life. Despite advances in conventional therapy, some patients experience adverse effects, relapse, high treatment burden, or inadequate response, contributing to interest in complementary approaches, including herbal medicine. This study aims to map the development of herbal medicine research in IBD, specifically UC, by examining publication trends, key contributors, collaboration patterns, and emerging themes. This study analyzed 518 English-language journal articles indexed in Scopus from 2016 to 2025. VOSviewer (version 1.6.20) and Biblioshiny (R package version 5.0) were used to analyze source productivity, country collaboration, citation relationships, and keyword co-occurrence. Among the ten most productive sources, the Journal of Ethnopharmacology (44 articles), Frontiers in Pharmacology (24), and Phytomedicine (22) contributed 90 of 160 articles (56.3%) in the top-ten-source subset; this percentage does not represent the entire 518-document corpus. Among records with identifiable corresponding-author countries, China contributed 46.0%, followed by India (11.1%) and South Korea (8.3%). The thematic structure centered on anti-inflammatory pathways, immune modulation, DSS-induced colitis, intestinal-barrier function, gut microbiota, and emerging systems approaches such as network pharmacology and metabolomics. The journal profile and keyword network suggest that the evidence base remains predominantly preclinical and translational. Clinical validation, extract standardization, safety reporting, and multinational collaboration are therefore priorities before wider clinical adoption
Evaluasi Penggunaan Obat Mood Stabilizer pada Pasien Bipolar Rawat Jalan di Rumah Sakit Jiwa di Kota Padang Dian Ayu Juwita; Fatma Sri Wahyuni; Fatiyah Nurazizah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1540

Abstract

Bipolar disorder is a chronic psychiatric condition that requires long-term pharmacotherapy to control symptoms and prevent relapse. Mood stabilisers play a central role in its management; however, inappropriate use may reduce treatment effectiveness and increase the risk of adverse outcomes. This study aimed to evaluate the appropriateness of mood stabiliser use among outpatients with bipolar disorder at a psychiatric hospital in Padang City. This retrospective descriptive study used medical record data from January to December 2023. A total of 28 patients who met the inclusion criteria were included, with 220 outpatient visits analysed. Data collected included sociodemographic characteristics, clinical conditions, and medication use. The appropriateness of therapy was assessed based on four criteria: indication, patient suitability, drug selection, and dosage, using established pharmacotherapy guidelines as the reference standard. The results showed that most patients were female (78.57%) and aged 18–59 years (75%). The evaluation of drug use demonstrated that the appropriateness of indication, patient suitability, and drug selection each reached 83.18%. However, dosage appropriateness was considerably lower at 54.55%, indicating that nearly half of the prescriptions involved suboptimal dosing. While most aspects of mood stabiliser use were generally appropriate, dosing remains a critical issue that may affect treatment effectiveness and patient safety. These findings highlight the importance of improving adherence to clinical guidelines and conducting regular evaluations of pharmacotherapy to optimise outcomes in patients with bipolar disorder.
Tren Terkini dan Arah Masa Depan Penelitian Camellia sinensis tentang Manajemen Berat Badan dan Luaran Terkait Obesitas: Tinjauan Dua Puluh Tahun dan Analisis Bibliometrik Muhammad Amin Nasution; Didi Nurhadi Illian; Hanifa Rifdah Aiman; Muhammad Andry; Cindy Marcelia; Nia Novranda Pertiwi; Syilvi Rinda Sari; Hindri Syahputri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1550

Abstract

Camellia sinensis (tea) is widely consumed and has been extensively investigated for its potential to support weight management, particularly because of the bioactive catechin epigallocatechin-3-gallate (EGCG). We conducted a bibliometric analysis to map the scope, productivity, collaboration patterns, citation impact, and thematic evolution of research on Camellia sinensis and obesity-related outcomes. We retrieved records indexed in Scopus for 2005–2024 using terms for Camellia sinensis, major tea types, and obesity. After excluding non-original publications, we analysed 897 original research articles with VOSviewer (version 1.6.20) and the Biblioshiny R package, including co-occurrence, collaboration, and citation networks. Annual output increased from 21 articles in 2005 to a peak of 80 in 2020. China produced the most publications (n = 182), while the United States achieved the greatest total citation impact. The leading sources were Nutrients, Journal of Nutritional Biochemistry, and Food & Function; the most prolific authors were Wang Y, Liu Z, and Zhang Y; and Anhui Agricultural University was the most productive institution. Keyword analysis identified four interconnected themes: green tea catechins and lipid metabolism, oxidative stress and polyphenols, gut microbiota and thermogenesis, and obesity-related metabolic syndrome. Recent research increasingly emphasises multi-omics, microbiota interactions, and precision nutrition. These bibliometric findings indicate expanding scientific interest in the potential contribution of Camellia sinensis to weight management and obesity-related metabolic health, while underscoring the need for standardised clinical trials, improved EGCG bioavailability, and cautious translation into clinical and policy settings
Aktivitas Ekstrak Batang Akar Laka (Dalbergia parviflora Roxb.) Terhadap Pertumbuhan Jamur Trichophyton rubrum Amran Rexana Djumaty; Irwandi Irwandi; A.M. Muslihin
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1590

Abstract

Akar laka (Dalbergia parviflora Roxb.) is a traditional medicinal plant used by communities in North Maluku to treat various types of wounds and skin conditions; however, scientific research on the antifungal activity of this plant’s stem is still limited. This study aims to identify the content of secondary metabolites and evaluate the antifungal activity of akar laka stem extract against the growth of Trichophyton rubrum in vitro. This is a laboratory experimental study conducted using the maceration method with 95% ethanol as a solvent to obtain a concentrated extract, followed by phytochemical screening to identify the classes of secondary metabolites. Antifungal activity testing was performed using the disk diffusion method with extract concentrations of 5%, 10%, and 15%, with ketoconazole used as the positive control and aqua pro injection as the negative control. The results showed that from 200 grams of crude drug, 43 grams of concentrated extract were obtained with a yield of 21.5%. Phytochemical screening results indicated the presence of alkaloids, saponins, and tannins, while flavonoids were not detected. In the antifungal activity test, the extract did not form an inhibition zone at any of the tested concentrations against T. rubrum, whereas the positive control exhibited a very strong inhibition zone of 26.7 mm. Based on the research results, it can be concluded that the extract of the akar laka stem (D. parviflora Roxb.) contains several secondary metabolites but did not exhibit antifungal activity against T. rubrum at the tested concentrations.
Nilai Viral Load dan Cluster of Differentiation 4 (CD-4) pada Pasien Human Immunodeficiency Virus (HIV) sebagai Penanda Infeksi Menular Seksual Utiya Nur Laili; Endra Yustin Ellistasari; Putri Jati Utami; Larisa Sabrina Rahadiyanti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1615

Abstract

Human immunodeficiency virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) infection is a major problem in developing countries. Co-infection with sexually transmitted infections (STIs) in HIV patients is a comorbid factor increasing the risk of HIV and STI transmission. CD4 T lymphocyte cell levels and viral load are used for immunologic and virologic success of HIV/AIDS patients. Studies linking CD4 T lymphocyte counts, viral load and STI incidence in HIV/AIDS patients are few and variable. This research aim to evaluate the CD4 and viral load values in HIV/AIDS patients at Dr. Moewardi Hospital with the incidence of STIs. Retrospective study using secondary data from the medical records of the Voluntary Counseling and Testing (VCT) clinic at Dr. Moewardi Hospital for the period January 2022 - December 2024. Sexually transmitted infections diagnosis was based on syndromic approach. Data CD4 of STI patients with HIV/AIDS were recorded for statistical processing using SPSS version 26. Numerical data were tested for normality using the Kolmogorov-Smirnov test (p>0.05). Normally distributed data were subjected to unpaired t-test, non-normally distributed data were subjected to Mann-Whitney test, categorical data were subjected to chi-square test with a significance of p<0.05. CD4 data were then assessed for sensitivity, specificity and cut-off values. Cases of HIV patients with STIs were predominantly male with an average age of 33.94 years. Statistical analysis showed gender (p=<0.001), occupation (p=0.018) age (p<0.001), and ARV duration (p=0.037), while education level (p=0.448) and viral load (p=0.417). CD4 count (p=0.027) had p<0.05, AUC for CD4 was 0.648 with p=0.030, cutoff 459.5, sensitivity 66.7% and specificity 62.5%, OR=3.33 and p=0.013. There is an association between CD4 levels and the incidence of STIs in HIV patients with a sensitivity of 66.7%, specificity of 62.5% and a cutoff value of 459.5, HIV patients with CD4 <459.5 have a risk of STIs by 3.33 times compared to HIV patients who have CD 4 ≥459.5 (OR = 3.33; p = 0.013).
Pengaruh Krim Kombinasi Asam Traneksamat 4%, Nikotinamida 3%, Asam Hialuronat 1%, dan Laktobasilus 1% pada Skor MASI Pasien Melasma Ivani Ivani; Prasetyadi Mawardi; Nurrachmat Mulianto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1635

Abstract

Melasma is a chronic recurrent hyperpigmentation disorder characterized by brownish-to-gray facial patches that may negatively affect patients' quality of life. Its multifactorial pathogenesis involves ultraviolet radiation, hormonal influences, genetic predisposition, inflammation, and oxidative stress, highlighting the need for therapies targeting multiple biological pathways. This study aimed to evaluate the effect of a combination cream containing 4% tranexamic acid, 3% nicotinamide, 1% hyaluronic acid, and 1% Lactobacillus on Melasma Area and Severity Index (MASI) scores in patients with melasma. A double-blind randomized controlled trial was conducted in 28 subjects randomly allocated into two groups (combination cream, n=14; modified Kligman's formula, n=14) using computer-generated randomization. The primary outcome was the MASI score, while treatment safety, assessed from local skin reactions, was evaluated as a secondary outcome. Evaluations were performed at weeks 2, 4, 6, and 8 using MASI scores. Pre- and post-treatment analyses were conducted using repeated measures ANOVA and Friedman's test, while between-group comparisons were performed using an independent t-test. The combination cream group demonstrated a reduction in MASI score from 12.90±5.47 to 6.62±3.00 at week 8 (mean change ΔMASI = −6.28) , although statistical significance was not reached (p=0.054). The modified Kligman's formula group showed a significant reduction in MASI score from 13.94 to 7.93 at week 8 (mean change ΔMASI = −6.01) (p<0.001). Comparative analysis demonstrated no significant differences between groups regarding MASI score improvement (p>0.05). Local skin reaction scores were consistently lower in the combination cream group from week 4 to week 8 (all p≤0.004). The combination cream showed a trend toward MASI improvement that did not differ significantly from the modified Kligman's formula, with a more favourable tolerability profile
Analisis Kuantitatif Penggunaan Antibiotik pada Pasien Infeksi Saluran Pernapasan Akut Menggunakan Metode ATC/DDD dan DU90% di Puskesmas Bulango Kabupaten Bone Bolango Periode Januari–Desember 2025 Mohamad Rizaldy Hiola; Misgiati Misgiati; Nanang Ardianto; Prisca Safriani Wicita
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1638

Abstract

settings and a major driver of antimicrobial resistance (AMR). This study aimed to evaluate the quantitative pattern of antibiotic use in ARTI patients at Bulango Health Center, Bone Bolango Regency, during January–December 2025, using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) and Drug Utilization 90% (DU90%) methods. A descriptive observational retrospective study was conducted on 179 samples using the ATC/DDD and DU90% methods. Five antibiotics were identified: cefadroxil (J01DB05), amoxicillin (J01CA04), cotrimoxazole (J01EE01), ciprofloxacin (J01MA02), and metronidazole (P01AB01). Total antibiotic consumption was 356.7 DDD. Cefadroxil had the highest consumption at 210.9 DDD (3.23 DDD/1000 patient-days; 59.13%), followed by amoxicillin at 132.2 DDD (2.02 DDD/1000 patient-days; 37.06%). DU90% analysis identified cefadroxil and amoxicillin as the antibiotics within the DU90% segment, with a cumulative percentage of 96.2%. Cefadroxil dominance over amoxicillin is inconsistent with national therapeutic guidelines recommending amoxicillin as first-line therapy for ARTI. These findings emphasize the need for an Antimicrobial Stewardship Program (ASP) at the primary health care level
Drug Related Problems (DRPs) pada pasien hipertensi rawat jalan di Puskesmas Ridge Kecamatan Distrik Samofa Kabupaten Biak Provinsi Papua Tahun 2025 Bambang Hendrawan; Fitria Fitria; Syarifah Yanti Astryna; Nurhayati Nurhayati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1659

Abstract

Background: Hypertension is a chronic condition requiring long-term pharmacotherapy, which increases the risk of Drug-Related Problems (DRPs), particularly in outpatient settings. Limited data exist regarding DRPs in primary healthcare facilities in eastern Indonesia, especially Papua Province. Objective: This study aimed to identify and describe DRPs, including subtherapeutic dosage, supratherapeutic dosage, ineffective drug, inappropriate drug combination, and drug interactions, among hypertensive outpatients at Ridge Community Health Center, Samofa District, Biak Regency, Papua Province, in 2025. Methods: A non-experimental descriptive study with a retrospective design was conducted using medical records and prescription data from hypertensive outpatients. A total of 96 prescriptions were selected through simple random sampling from the January–May 2025 period. DRPs were evaluated based on the National Guidelines for Medical Services (PNPK) for Hypertension 2021, the British National Formulary (BNF), and the Drug Information Handbook, while drug interactions were assessed using Lexicomp® Drug Interactions and Medscape. Data were analyzed descriptively and presented as frequencies and percentages. Results: No DRPs were identified in the categories of subtherapeutic dosage, supratherapeutic dosage, or ineffective drug. Inappropriate drug combinations were observed in 15 patients (15.6%), while 81 patients (84.4%) had no such issues. Drug interactions were also identified in 15 patients (15.6%), involving amlodipine-simvastatin and candesartan-ibuprofen combinations. All cases of inappropriate drug combinations concurrently exhibited potential drug interactions. Conclusion: DRPs among hypertensive outpatients at Ridge Community Health Center were predominantly characterized by inappropriate drug combinations and drug interactions, while dosage-related problems were absent. These findings underscore the need for systematic prescription review and routine drug interaction screening in primary care settings to optimize antihypertensive therapy outcomes and ensure patient safety.
A Dampak dan Keefektivitasan Penggunaan Rekam Medis Elektronik dalam Pemantauan serta Manajemen Penyakit Pernapasan: Sebuah Tinjauan Literatur Sistematis Garis Gemilang; Muhammad Fachri; Nurmalia Lusida
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1686

Abstract

Chronic and acute respiratory diseases such as asthma, COPD, COVID-19, ARDS, and acute respiratory infections (ARI) pose a substantial global health burden. Conventional surveillance systems are reactive and limited in early detection. Electronic Health Records (EHRs) offer great potential as a longitudinal data source for more effective respiratory disease monitoring and management. This systematic review aims to evaluate the impact and effectiveness of EHR use in monitoring disease trends, early detection, and optimizing clinical management of patients with various respiratory conditions. This systematic review followed the PRISMA 2020 guidelines. Literature searches were conducted in PubMed, Scopus, Web of Science, and Google Scholar (2016--2025). The research question was formulated using the PICO framework. A total of 40 articles meeting the inclusion criteria were analyzed thematically. The majority of studies originated from high-income countries (USA, UK, Denmark, Netherlands, Spain, Australia), with diverse study designs (retrospective cohort 35%, model development 25%, cluster RCT 5%). Types of EHR interventions included real-time surveillance systems, NLP/AI-based prediction models, CDSS, and data quality evaluations. EHRs were shown to detect SARI case surges up to 8 days earlier, predict ARDS with an AUROC of 0.84, reduce unnecessary antibiotic prescribing by 12--16%, and extract asthma symptoms with an F1-score >0.95. However, significant challenges remain regarding data quality (completeness <50% for some variables) and geographic gaps (no studies from Indonesia). EHRs, particularly when integrated with NLP and artificial intelligence, are effective for surveillance, early detection, and clinical management of respiratory diseases. However, data quality challenges and the lack of evidence from developing countries still need to be addressed. Data standardization, interoperability investments, and technology adaptation for local contexts such as Indonesia are required.

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