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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 935 Documents
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Uji Efektivitas Nanogel Kombinasi Ekstrak Daun Alpukat (Persea americana mill) Dan Daun Talas (Colocasia esculenta L.) Terhadap Penyembuhan Luka Bakar Pada Kulit Mencit Putih Jantan (Mus musculus) Ririn Anjelin; Indah Uminawati; Sukma Oktafiani Putri; Yova Aditiatama
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1808

Abstract

Burns are skin tissue damage that requires intensive treatment to prevent infection and accelerate cell regeneration. The combination of avocado leaf extract (Persea americana Mill.) and taro leaf extract (Colocasia esculenta L.) contains secondary metabolites such as flavonoids, saponins, and tannins that have the potential to heal burns. This study aims to formulate a nanogel preparation combining the extracts of the two plants and test its effectiveness in healing burns in male white mice. The extracts are combined in the form of nanogel preparations to increase the effectiveness of burn healing in mice. The preparations are made in three formula variations (F1, F2, and F3) and evaluated for their physical qualities including organoleptic, pH, spreadability, adhesion, stability (cycling test), irritation, and particle size (PSA). The results showed that the nanogel preparations met all physical quality standard parameters with particle sizes in the nano range. In vivo effectiveness tests for 14 days showed that all nanogel formulas were significantly able to accelerate burn healing compared to negative controls (p < 0.05).  Formula 3 (F3), with the highest concentration, provided optimal healing effectiveness, equivalent to the positive control, with a healing percentage of 70% on day 14 and characterized by the fastest reduction in wound diameter. In conclusion, the nanogel preparation combining avocado and taro leaf extracts is effective in healing burns and meets the physical characteristics standards for nanogel preparations.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Seroja (Nelumbo nucifera Gaertn.) terhadap Escherichia coli dan Staphylococcus aureus Khairani Fitri; Tetty Noverita Khairani; Ruth Mayana Rumanti; Sri Handayani; Mintaria Halawa
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1809

Abstract

Introduction: The increasing occurrence of bacterial infections and antimicrobial resistance has encouraged the investigation of medicinal plants as potential sources of antibacterial compounds. Lotus (Nelumbo nucifera Gaertn.) leaves contain several classes of secondary metabolites that may contribute to antibacterial activity. Objective: This study evaluated the antibacterial activity of lotus leaf ethanol extract against Escherichia coli and Staphylococcus aureus and identified the major classes of secondary metabolites present in the extract. Methods: This laboratory experimental study used lotus leaf extract prepared by maceration with 96% ethanol. The simplicia was characterized and subjected to phytochemical screening. Antibacterial activity was evaluated using the paper-disc diffusion method on Mueller–Hinton agar at extract concentrations of 10%, 15%, and 20%, with clindamycin as the positive control and dimethyl sulfoxide as the negative control. Each treatment was tested in triplicate. Inhibition-zone diameters were analyzed using one-way analysis of variance followed by Tukey's HSD test. Results: The lotus leaf material contained alkaloids, flavonoids, saponins, tannins, steroids, and triterpenoids. Against E. coli, the mean inhibition-zone diameters at concentrations of 10%, 15%, and 20% were 13.60, 15.40, and 16.60 mm, respectively; the corresponding values against S. aureus were 14.56, 15.21, and 18.13 mm. Differences among treatments were statistically significant for both test bacteria (p<0.001). Conclusion: Lotus leaf ethanol extract exhibited concentration-dependent antibacterial activity against E. coli and S. aureus, with the strongest inhibition observed at 20%. Further studies should determine the minimum inhibitory and bactericidal concentrations and characterize the active antibacterial constituents.
Penentuan Kadar Etanol Dan Asam Laktat Dari Hasil Fermentasi Susu Kefir Kambing Annisa Utami; Anny Sartika Daulay; Ridwanto Ridwanto; Ainil Fithri Pulungan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1812

Abstract

Goat-milk kefir contains lactic acid and ethanol formed through the symbiotic metabolism of lactic acid bacteria and yeasts; however, information on their changes during prolonged fermentation remains limited. This study aimed to characterize ethanol accumulation during six days of goat-milk kefir fermentation and to determine lactic acid after 24 h. Goat milk (250 mL) was heated at 75 °C, inoculated with 4% (w/v) kefir grains, and fermented at 25 ± 2 °C. Ethanol was screened using iodoform, acidified potassium dichromate, and esterification reactions, followed by visible spectrophotometric quantification at 443 nm after Conway microdiffusion. Lactic acid was quantified using HPLC-UV at 210 nm with 50 mM phosphate buffer (pH 2.8), a flow rate of 1 mL/min, and an injection volume of 20 µL. The pH decreased from 4.19 on day 1 to 2.15 on day 6, while ethanol increased from 0.227 to 0.657 g/dL (p<0.001). Commercial kefir contained 0.453 g/dL ethanol. The ethanol and lactic-acid calibration models showed R² values of 0.996; lactic acid in 24-h kefir was 3.923%. Prolonged fermentation therefore produced progressive acidification accompanied by ethanol accumulation, with the greatest change occurring during the first three days. These findings establish fermentation time as an important determinant of the metabolite profile of goat-milk kefir and provide a basis for subsequent studies using independent fermentation batches and fully validated analytical methods.
Identifikasi Drug-Related Problems (DRPs) pada Pasien Rawat Inap Stroke Iskemik dan Hemoragik: Studi Observasional Retrospektif di Rumah Sakit Rujukan Marizah Riska Putri; Erika Lutfia Tunnisaq
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1825

Abstract

Stroke remains a leading cause of mortality and long-term disability worldwide, requiring complex pharmacotherapy regimens that significantly increase the risk of Drug-Related Problems (DRPs). This study aimed to identify, categorize, and analyze the prevalence and patterns of DRPs among stroke inpatients using a retrospective observational approach. Data were collected from medical records of 98 hospitalized stroke patients treated between January and December 2025 at a referral hospital. DRPs were classified based on the Pharmaceutical Care Network Europe (PCNE) V9.1 system. The patient cohort comprised 55.1% males and 44.9% females, with 57.1% aged ≥ 60 years. Ischemic stroke accounted for 91.8% of cases, while hemorrhagic stroke constituted 5.1%. Hypertension (69.4%) and Type 2 Diabetes Mellitus (28.6%) were the predominant comorbidities. A total of 135 DRP events were identified in 82 patients (83.7%). The most frequent categories were potential drug–drug interactions (36.3%), untreated indications or need for additional therapy (29.6%), inappropriate drug selection (19.3%), and inappropriate dosing, including absent renal-dose adjustment (14.8%). Critical potential interactions included co-administration of clopidogrel with omeprazole and NSAIDs with antihypertensives. Untreated indications mainly involved the absence of high-intensity statin therapy in ischemic stroke patients. In conclusion, DRPs are highly prevalent among stroke inpatients, particularly driven by polypharmacy and complex comorbidities. Clinical pharmacist interventions are crucial to optimize therapeutic outcomes and minimize adverse drug events
Perbandingan Respons Penyembuhan Jaringan Periodontal pada Anak Stunting dan Status Gizi Normal Berdasarkan Profil Interleukin-6 Meiza Nerawati; Nila Kasuma; Fathurrahman Ariza Busril
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1716

Abstract

Introduction: Stunting has long-term effects on child growth and development and may be associated with oral health and immune responses. Gingivitis is an inflammatory periodontal condition characterized by the activation of various inflammatory mediators, including interleukin-6 (IL-6). This study was conducted among children aged 6–12 years in the working area of Lubuk Kilangan Community Health Center, Padang City, Indonesia.Objective: To compare the periodontal healing response following scaling and root planing (SRP) between children with stunting and those with normal nutritional status based on clinical parameters and salivary IL-6 levels.Methods:This experimental study employed a pretest–posttest group design involving 60 children aged 6–12 years with gingivitis who were selected using simple random sampling, comprising 30 children with stunting and 30 children with normal nutritional status. Clinical parameters included the Oral Hygiene Index (OHI) and Gingival Index (GI), while the molecular parameter was salivary IL-6 level. All parameters were assessed before SRP and four weeks after SRP.Results: Significant improvements in clinical periodontal parameters were observed after SRP in both groups. Salivary IL-6 levels also decreased significantly in the stunting and normal nutritional status groups, with mean reductions of 2.37 pg/mL (p<0.001) and 3.36 pg/mL (p=0.002), respectively.Conclusion: SRP resulted in improvements in clinical periodontal parameters and reductions in salivary IL-6 levels in both children with stunting and those with normal nutritional status. However, the clinical improvement in the stunting group was less pronounced than in the normal nutritional status group. These findings suggest that periodontal healing responses may be influenced by both local and systemic factors. Periodontal management in children with stunting should consider systemic conditions, including nutritional status and oral health education.
Hubungan derajat keparahan vitiligo dengan kualitas hidup pasien vitiligo di rumah sakit Aceh Utara Wizar Putri Mellaratna; Mohammad Mimbar Topik; Apriliani Khaira
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.801

Abstract

Vitiligo is an autoimmune disease that causes skin depigmentation through T-mediated destruction of melanocytes. The prevalence of vitiligo in Indonesia is currently around 0.1-2%. Skin depigmentation causes physical, psychological, and functional disorders in sufferers that can reduce quality of life. This study aims to analyze the relationship between the severity of vitiligo and quality of life. This research method is quantitative research with a cross-sectional study approach. The sampling technique is purposive sampling. The sample of this study consisted of 34 samples. The severity of vitiligo was measured using the Vitiligo Area Scoring Index (VASI) instrument and quality of life was measured using the validated Vitiligo Quality Of Life (VitiQOL) questionnaire. The results of the study obtained the characteristics of respondents in the study dominated by adult age (19-59 years) as many as 17 people (50%), female gender as many as 27 people (79.4%), last high school education as many as 17 people (50%) and vitiligo classification Non Segmental Vitiligo as many as 22 people (64.7%). Bivariate analysis using the Spearman correlation test obtained a p-value of 0.505 and a correlation coefficient (r) of -0.118. The conclusion of this study is that there is no relationship between the severity of vitiligo and the quality of life of vitiligo patients at the North Aceh Hospital
Uji Aktivitas Sitotoksik Daun Benalu Jeruk (Dendrophthoe glabrescens) terhadap Garis Sel Kanker Payudara: Studi In Silico: - Aditya Naova Sofyan; Rizal Maarif Rukmana; Andi Suhendi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1417

Abstract

This study aims investigate the potential of phytochemical compounds from citrus mistletoe leaves (Dendrophthoe glabrescens) leaves as anticancer candidates using an in silico approach. Phytocemical constituents identified by LC-MS and screened using Lipinski’s Rule of Five. Followed by Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) prediction using ProTox-3.0. The docking protocol was validated with root mean square deviation (RMSD) values of 1.80 Å for epidermal growth factor receptor (EGFR) (PDB ID: 1M17) and 0.69 Å  for estrogen receptor-α (ER-α) (PDB ID: 1A52). Tenylidone exhibited the strongest binding affinity toward EGFR (-8.12 kcal/mol), followed by quercetin (−7.48 kcal/mol) and kaempferol (−7.43 kcal/mol). For estrogen receptor alpha, fisetin showed the strongest affinity among the tested D. glabrescens compounds (−8.21 kcal/mol), followed by nomelidine (−8.16 kcal/mol) and tenylidone (−7.95 kcal/mol). Kaempferol showed the most favorable predicted acute toxicity profile among the leading compounds, with an estimated LD50 of 3919 mg/kg and toxicity class 5. Overall, tenylidone and fisetin were prioritized for epidermal growth factor receptor and estrogen receptor alpha, respectively, while kaempferol showed a favorable predicted safety profile.
Interpolated Melolabial Flap sebagai Pilihan Rekonstruksi Estetis dan Fungsional untuk Defek Nasal Akibat Karsinoma Sel Basal: Laporan Kasus Serial Utiya Nur Laili; Nugrohoaji Dharmawan; Putri Jati Utami; Larisa Sabrina Rahadiyanti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1616

Abstract

Basal cell carcinoma (BCC) is a malignant skin neoplasm primarily induced by prolonged ultraviolet (UV) radiation exposure. Various flap techniques, including rotation, transposition and advancement flaps are commonly employed for reconstruction. This report presents two cases of nasal BCC managed using an interpolated melolabial flap as a reconstructive option. The first case involved a 48 years old woman presenting with a progressively enlarging nodule on the left nasal area for one year. The second case was a 58 years old woman with a similar lesion on the right nasal side. Both patients were diagnosed with BCC based on clinical history, dermoscopic evaluation and histopathological confirmation. Wide local excision with adequate surgical margins was performed in both cases, followed by nasal ala reconstruction using an interpolated melolabial flap. Postoperative outcomes were favorable with minimal complications and no evidence of recurrence during follow up. The primary goal of BCC treatment is complete tumor excision with minimal recurrence while also preserving both function and aesthetic integrity. The choice of flap technique is guided by factors such as defect size, anatomical location, tissue characteristics and patient condition. The interpolated flap technique involves transferring tissue while maintaining a skin bridge (pedicle) to ensure sufficient vascular supply and making it a reliable option for complex nasal reconstructions. The interpolated melolabial flap offers excellent aesthetic and functional outcomes with rapid healing and minimal complications, making it a valuable reconstructive approach in the management of nasal basal cell carcinoma.  
Pemanfaatan Kerangka ICF dan Pemetaan Disabilitas Berbasis DASH untuk Menilai Dampak Keterlambatan Diagnosis terhadap Disabilitas Fungsional pada Pasien Kusta di RSUD dr. Moewardi Surakarta Larisa Sabrina Rahadiyati; Nugrohoaji Dharmawan; Putri Jati Utami; Utiya Nur Laili
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1622

Abstract

Background: Leprosy remains a significant public health problem in Indonesia. Leprosy-related nerve damage produces impairment of body function and structure, activity limitation and participation restriction as conceptualised in the International Classification of Functioning, Disability and Health (ICF). Objective: To analyse the association between diagnostic and treatment delay and functional disability, interpreted within the ICF-WHO 2021 disability components. Methods: This was an analytic observational study with a cross-sectional design involving 20 leprosy patients recruited between November 2025 and January 2026. Functional disability was measured with the validated Indonesian version of the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, whose items were linked to ICF body function, activity and participation codes. Associations were analysed using the Spearman rank correlation test, with the 95% confidence interval (CI). Results: Most patients were male (95%), with a mean age of 44.2 ± 13.7 years and a mean DASH score of 49.9 ± 21.1. Spearman analysis demonstrated a very strong positive correlation between delay and functional disability (rk = 0.802; 95% CI 0.547–0.921; p < 0.001). Mean DASH score increased progressively from 22.1 in patients treated within 6 months to 96.3 in those treated after more than 24 months. Conclusion: Delayed diagnosis and initiation of MDT are strongly associated with greater functional disability in leprosy patients. Because the analysis was bivariate in a single-centre sample of 20 multibacillary patients, and because DASH covers only part of the ICF framework and does not measure quality of life directly, these findings should be regarded as preliminary.
Proporsi Gangguan Fungsi Tubuh dan Struktur Tubuh, Keterbatasan Aktivitas, serta Faktor Lingkungan pada Jemaah Haji dengan Diabetes Melitus Tahun 2026 di Arab Saudi: Studi Deskriptif Berbasis ICF Syarief Hasan Lutfie; Ferial Hadipoetro Idris; Muhammad Alif Adril; Susanti Dharmmika; Arif Budi Santoso; Larisa Sabrina Rahadiyanti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1658

Abstract

The Hajj is a large-scale mass gathering that demands high physical activity and exposes pilgrims to extreme heat and crowding, increasing the risk of functioning problems, particularly among those with chronic diseases such as diabetes mellitus. Within the International Classification of Functioning, Disability and Health (ICF), disability is an umbrella term covering impairments of body functions and body structures, activity limitations, and participation restrictions, all of which arise from the interaction between a health condition and environmental and personal factors. This study aimed to determine the proportion of problems in four selected ICF categories among 2026 Hajj pilgrims with diabetes mellitus in Saudi Arabia. A descriptive cross-sectional study was conducted in May 2026 at the pilgrims' accommodation in Saudi Arabia on 109 pilgrims with diabetes mellitus selected through simple random on-site sampling. One representative category was assessed for each ICF component: consciousness functions (b110) for body functions, structure of areas of skin (s810) for body structures, religion and spirituality expressed as the ability to perform prayer (d930) for activities and participation, and drugs (e1101) expressed as the type of diabetes medication used for environmental factors. Data were collected using an ICF-based assessment form and analysed descriptively as proportions. The mean age of respondents was 60.22 years and the majority were female (54.1%). No impairment of consciousness functions was found (0.0%), as all respondents were fully conscious. Impairment of skin structure was found in 18.3% of respondents and activity limitation in performing prayer in 27.5%. All respondents used diabetes medication, predominantly oral antidiabetic drugs (71.6%), followed by insulin (14.7%) and oral antidiabetic drugs combined with other medication (13.8%); this reflects a universal need for continuous pharmacological support rather than a barrier in itself, so that availability, storage and access to medication constitute a decisive environmental factor for the entire group. Activity limitation was the most frequent problem among the categories assessed, underscoring the importance of supervising medication use, early identification of skin lesions and activity limitations, and structured health monitoring for Hajj pilgrims with diabetes mellitus. Because only one category was assessed per ICF component, these proportions should be read as a preliminary profile and not as a comprehensive assessment of functioning.

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