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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 885 Documents
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Formulasi Dan Evaluasi Sediaan Sabun Cair Scrub Dari Sari Buah Melon (Cucumis melo L.) Ervina Syahfitri Lubis; Indah Pertiwi; Meiva Amelia Lubis
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1745

Abstract

Melon fruit (Cucumis melo L.) contains bioactive compounds such as vitamin C, β-carotene, flavonoids, polyphenols, pectin, and superoxide dismutase (SOD) enzyme that theoretically have potential antioxidant and skin care benefits in topical preparations. This study aimed to formulate and evaluate the physical quality of liquid scrub soap from melon fruit juice at varying concentrations of 0% (F0/blank), 5% (F1), 10% (F2), and 15% (F3), using coffee grounds as a natural exfoliating agent. Physical quality evaluations included organoleptic testing, foam height and stability, pH, and viscosity according to SNI 06-4085-1996. Data were analyzed using One-Way ANOVA followed by Tukey HSD post-hoc test (α=0.05). Organoleptic results showed all formulas were white, liquid, melon-scented, and contained brown scrub granules. One-Way ANOVA showed that melon fruit juice concentration significantly affected all tested parameters (p<0.05). The average pH of F1, F2, and F3 were 8.53±0.06ᵇ, 9.17±0.12ᶜ, and 9.77±0.06ᵈ, meeting SNI requirements (pH 8–11). Average foam heights of F1, F2, and F3 were 105.00±1.00ᵇ mm, 125.67±1.53ᶜ mm, and 154.00±2.65ᵈ mm, with foam stability of 82.27±1.76ᵃᵇ%, 85.13±0.32ᵇᶜ%, and 87.03±1.47ᶜ%, all meeting SNI standards (13–220 mm) and stability threshold ≥70%. Viscosity of F1, F2, and F3 were 1,633±57.74ᵇ cP, 2,000±100.00ᶜ cP, and 2,567±57.74ᵈ cP, within the acceptable range (400–4,000 cP). Tukey HSD confirmed significant differences among all formulas for pH, foam height, and viscosity parameters. It was concluded that melon fruit juice can be successfully formulated into a liquid scrub soap and all formulas met the established physical quality requirements. Formula F3 at 15% concentration produced the best results. Further research is needed to evaluate the biological activity of the preparation, including antioxidant testing, exfoliation efficacy, and skin irritation studies.
Efektifitas Pendidikan Kesehatan Seksual Dalam Meningkatkan Literasi Kesehatan Reproduksi dan Sikap Preventif Remaja Rifdha Wahyuni; Marisa Anggraini; Ratna Dewi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1746

Abstract

Adolescence is a developmental period characterized by physical, psychological, and social changes that increase vulnerability to risky sexual behaviors. Low reproductive health literacy and inadequate preventive attitudes among adolescents may contribute to various health problems, including unintended pregnancy and sexually transmitted infections. This study aimed to determine the effectiveness of sexual health education in improving reproductive health literacy and preventive attitudes among adolescents at SMP Negeri 32 Padang in 2026. This study employed a quasi-experimental design with a one-group pretest-posttest approach. The population consisted of 188 eighth-grade students, and 20 respondents were selected using a systematic random sampling technique. Data were collected using knowledge and attitude questionnaires administered before and after the sexual health education intervention and were analyzed using the Wilcoxon test. The results showed that the mean score of reproductive health literacy increased from 12.55 to 14.15, while the mean score of preventive attitudes increased from 8.10 to 9.65. Statistical analysis revealed significant improvements in reproductive health literacy (p=0.000) and preventive attitudes (p=0.000) following the intervention. In conclusion, sexual health education is effective in improving adolescents’ reproductive health literacy and preventive attitudes and can serve as a promotive and preventive strategy to support adolescent reproductive health in the school setting.
Faktor-Faktor Dominan yang Memengaruhi Kualitas Hidup Pasien Gagal Ginjal Kronis yang Menjalani Hemodialisis Diah Kartika Putri; Salsabila Jelita; Vicko Suswidiantoro; Hardono Hardono
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1754

Abstract

Patients with Chronic Kidney Disease (CKD) undergoing hemodialysis experience various physical, psychological, and social disturbances that negatively impact their quality of life. While hemodialysis sustains life, this study aimed to identify respondent characteristics and analyze the influence of age, gender, education, occupation, hemodialysis frequency, and duration of hemodialysis on the quality of life of CKD patients undergoing the procedure, as well as to determine the most dominant factor influencing their quality of life. A non-experimental research design with a cross-sectional approach was employed. The study involved 65 respondents selected via purposive sampling and was conducted at the Hemodialysis Unit in February 2026. Data were collected using the KDQOL-SF 36 questionnaire and analyzed using Pearson Correlation, Independent T-test, One-Way ANOVA, and Multiple Linear Regression. Bivariate analysis results indicated that age (p=0,004), occupation (p=0,005), and duration of hemodialysis (p=0,014) were significantly associated with the quality of life of CKD patients, whereas gender (p=0,656) and education level (p=0,117) showed no significant association. Multivariate analysis revealed that the duration of hemodialysis was the most dominant factor influencing patients' quality of life (β=6,781; p=0,028), with the model explaining 25% of the variation in quality of life (R²=0,25). Thus, the duration of hemodialysis is the dominant factor affecting the quality of life of CKD patients; the longer patients undergo hemodialysis therapy, the better their ability to adapt to the disease and treatment, leading to a tendency for improved quality of life.
Penetapan Kadar Katekin dan Uji Aktivitas Antioksidan Dari Seduhan dan Ekstrak Etanol Biji Kakao (Theobroma cacao L.) Secara Spektrofotometri Uv-Vis Dahnia Ayu Fitria; Anny Sartika Daulay; Ridwanto Ridwanto; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1763

Abstract

Introduction: Cocoa beans (Theobroma cacao L.) are widely recognized as a rich source of bioactive polyphenolic compounds, particularly flavan-3-ols such as catechin and epicatechin, which exhibit potent antioxidant properties. These secondary metabolites play a critical role in neutralizing free radicals, thereby mitigating oxidative stress implicated in various degenerative diseases. Objective: This study aimed to compare catechin equivalent content and DPPH radical scavenging activity between ethanolic extract (maceration with 70% ethanol) and aqueous infusion (90°C, 15 min) of cocoa beans. Methods: Phytochemical screening was conducted qualitatively. Catechin equivalent content was determined using UV-Vis spectrophotometry at 280 nm, while antioxidant activity was evaluated using the DPPH method at 515 nm with vitamin C as positive control. Results: Both samples contained alkaloids, flavonoids, saponins, tannins, triterpenoids/steroids, polyphenols, and glycosides. The ethanolic extract exhibited higher catechin equivalent content (37.15 ± 0.07 µg/mL) compared to the infusion (19.83 ± 0.10 µg/mL), corresponding to 12.53 ± 0.72 mg/g and 11.18 ± 1.72 mg/g, respectively. The DPPH assay revealed superior antioxidant activity for the ethanolic extract (IC₅₀ = 83.29 µg/mL; strong category) compared to the infusion (IC₅₀ = 192.65 µg/mL; weak category), with vitamin C showing IC₅₀ = 2.95 µg/mL (very strong). Conclusion: Ethanolic maceration is more effective than aqueous infusion for extracting catechin equivalents and achieving higher antioxidant activity from cocoa beans. Further confirmation using HPLC-DAD or LC-MS is recommended to validate specific catechin concentrations.
Aktivitas Antibakteri Ekstrak Daun Mangga Sengir (Mangifera indica L. Kultivar Sengir) terhadap Staphylococcus aureus: Studi In vitro dan Molecular Docking Yusrin Haniyyah; Md. Sanower Hossain
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1778

Abstract

The antibacterial potential of the underexplored Mangifera indica L. cultivar Sengir remains poorly understood. This study evaluated the antibacterial activity of Sengir mango leaf extract against Staphylococcus aureus using integrated in vitro and in silico approaches. Leaves were extracted by maceration with 70% ethanol. The extract contained 293.8 mg GAE/g extract of total phenolics and 34.8 mg QE/g extract of total flavonoids. Antibacterial activity was assessed using the disk diffusion method at extract concentrations of 40%, 60%, 80%, and 100%, corresponding to 488, 732, 976, and 1,220 mg/mL, respectively. Ampicillin and 10% DMSO served as the positive and negative control, respectively. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were also determined. For the in silico study, 60 M. indica phytochemicals from IMPPAT were screened using SwissADME and ProTox-III, and seven compounds were docked against penicillin-binding protein 2a (PBP2a; PDB ID: 4CJN) using PyRx. The extract produced concentration-dependent inhibition zones of 11.00–17.17 mm, whereas ampicillin produced a 34.50 mm inhibition zone and 10% DMSO showed no inhibition. MIC and MBC values were 48.87 and 73.20 mg/mL, respectively. Guaiol showed the lowest predicted binding energy (-7.0 kcal/mol), whereas PASS analysis identified Pogostol, Myrtenyl acetate, and Bicyclogermacrene as potential antibacterial compounds. Overall, Sengir mango leaf extract showed antibacterial activity against S. aureus, while computational analysis identified Guaiol and Pogostol as promising bioactive candidates for further validation.
Uji Efektivitas Anti-Aging Ekstrak Bunga Kembang Sepatu (Hibiscus rosa-sinensis L.) Dalam Sediaan Masker Clay Tetty Noverita Khairani; Khairani Fitri; Luthvia Luthvia; Leny Leny; Faizah Rahman
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1783

Abstract

Introduction: Skin aging is a natural degenerative process triggered by internal and external factors, particularly oxidative stress caused by free radicals. Hibiscus rosa-sinensis L. contains flavonoid and anthocyanin compounds which have potential as natural antioxidants to inhibit the skin aging process. Objective: This study aimed to formulate and evaluate a clay mask containing ethanol extract of Hibiscus rosa-sinensis flowers and to test its anti-aging effectiveness on skin condition parameters. Methods: This experimental study involved the preparation of clay masks with three variations of extract concentrations: 2.5% (F1), 5% (F2), and 10% (F3). Physical quality evaluations included homogeneity, pH, stability, drying time, emulsion type, and irritation tests. Anti-aging effectiveness testing was conducted on 15 female volunteers aged 35–60 years using a skin analyzer over 4 weeks with once-weekly application. Measured parameters included moisture, evenness, pore size, spots, and wrinkles. Data were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test. Results: All formulas met the physical quality requirements with pH values of 6.4–6.7, homogeneous, stable during 12 weeks of storage, and caused no irritation. Formula III (10% concentration) demonstrated the best anti-aging effectiveness with increases in moisture content of 67.5%, decreases in roughness of 42.3%, decreases in pore size of 30.9%, decreases in spots of 32.4%, and decreases in wrinkles of 36.0% after 4 weeks of treatment. However, the effectiveness of Formula III remained lower than that of the commercial clay mask. Conclusion: Ethanol extract of Hibiscus rosa-sinensis can be formulated as a stable and safe anti-aging clay mask. The 10% concentration formula exhibited the best effectiveness in improving skin aging parameters, although further formula optimization is still required to approach the effectiveness of commercial products.
Uji Efektivitas Ekstrak Etanol Kulit Jagung (Zea mays L.) Sebagai Antihiperglikemia Pada Mencit (Mus musculus L.) Yang Diinduksi Sukrosa Manuppak Irianto Tampubolon; Devina Chandra; Kesaktian Manurung
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1791

Abstract

Introduction: Hyperglycemia is a metabolic disorder characterized by elevated blood glucose levels and serves as a primary risk factor for diabetes mellitus and its associated complications, including cardiovascular disease, nephropathy, neuropathy, and retinopathy. Corn husk (Zea mays L.) contains flavonoid compounds that exhibit antihyperglycemic activity through inhibition of α-amylase and α-glucosidase enzymes. Objective: This study aimed to identify the presence of flavonoids in corn husk simplicia and evaluate the antihyperglycemic effectiveness of corn husk ethanol extract in sucrose-induced male mice (Mus musculus L.). Methods: An experimental design was employed using 25 male mice randomly assigned into five treatment groups (n=5): negative control (0.5% Na-CMC), positive control (glibenclamide 0.013 mg/20 g BW), and corn husk ethanol extract at concentrations of 10%, 20%, and 40% (equivalent to 500, 1000, and 2000 mg/kg BW, respectively). Hyperglycemia was induced by oral administration of sucrose solution at a dose of 0.81 g/20 g BW. Fasting blood glucose levels were measured at 0, 30, 60, 90, and 120 minutes using a glucometer. Phytochemical screening was performed to detect flavonoid compounds. Data were analyzed using One-Way ANOVA followed by Tukey HSD post-hoc test (α=0.05). Results: Phytochemical screening confirmed the presence of flavonoids in the ethanol extract. Statistical analysis revealed that extract concentrations of 10% and 20% did not produce significant antihyperglycemic effects (p>0.05). In contrast, the 40% concentration significantly reduced fasting blood glucose levels compared to the negative control (p=0.049), with a percentage reduction of 42.50% at 120 minutes. The glucose-lowering effect of the 40% extract was comparable to that of the glibenclamide positive control (p=0.821). Conclusion: Corn husk ethanol extract demonstrates antihyperglycemic potential in sucrose-induced mice, with the 40% concentration exhibiting the most effective glucose-lowering activity, comparable to glibenclamide. Further studies are warranted to elucidate the molecular mechanisms and conduct clinical trials in humans.
Efek Dosis–Respons Ekstrak Etanol Daun Cayratia trifolia Linn. pada Edema Kaki Tikus Terinduksi Karagenan Muzakkir Muzakkir; Bunga Rimta Barus; Meutia Indriana; Salman Salman
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1798

Abstract

Introduction: Leaves of Cayratia trifolia Linn. contain several secondary metabolites with potential anti-inflammatory activity. However, evidence regarding the dose–response relationship of their ethanolic extract in acute inflammation remains limited. Objective: To evaluate the anti-inflammatory activity and dose–response trend of Cayratia trifolia leaf ethanolic extract (CTLEE) in a carrageenan-induced rat paw edema model. Methods: Twenty-five male rats (Rattus norvegicus) were divided into five groups (n=5): a 0.5% Na-CMC negative control, a 0.2% diclofenac sodium positive control, and CTLEE treatment groups receiving 100, 200, or 300 mg/kg body weight. Treatments were administered orally, followed 30 min later by an intraplantar injection of 0.1 mL of 1% carrageenan. Paw volume was measured every 60 min for 360 min using a digital plethysmometer. Data were expressed as mean ± SD and analyzed using one-way ANOVA followed by Tukey's post hoc test (p<0.05p<0.05p<0.05). Results: CTLEE reduced paw oedema relative to the negative control and showed a trend toward greater activity as the dose increased. At 360 min, edema percentages were 38.25 ± 11.88%, 29.21 ± 5.36%, and 24.43 ± 6.60% for CTLEE at 100, 200, and 300 mg/kg, respectively, compared with 74.83 ± 13.77% in the negative-control group. The corresponding inhibition values were 48.74 ± 12.10%, 60.24 ± 8.57%, and 65.43 ± 13.96%. Significant differences in paw edema were observed among groups at all assessment times (p<0.001p<0.001p<0.001). Conclusion: CTLEE demonstrated anti-inflammatory activity with a dose-related trend. The 300 mg/kg dose produced the greatest edema reduction and inhibition among the tested extract doses; however, therapeutic equivalence with diclofenac sodium was not established.
Profil senyawa metabolit sekunder dari fraksi n-heksana dan etil asetat daun cengkeh (Syzygium aromaticum L.) menggunakan LC-HRMS Rezky Yanuarty; Siti Nurhaliza; Halik Alamsyah; Joni Tandi; Muthmainah Tuldjanah; Ayu Wulandari; Kevin Maengko; Recky Patala
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1138

Abstract

The diversity of plants available in nature, the majority have the potential as a source of traditional medicine due to the presence of secondary metabolites in various parts of the plant, especially the leaves. The object of the study was clove leaves (Syzygium aromaticum L.), a plant species abundant in secondary metabolites including alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids. This research aims to compare the profile of secondary metabolites in clove leaves (Syzygium aromaticum L.) in the n-hexane and ethyl acetate fractions. The research methodology includes phytochemical screening of secondary metabolites of the n-hexane and ethyl acetate fractions of clove leaves (Syzygium aromaticum L.) with dye reagents and LC-HRMS analysis. Phytochemical screening of the n-hexane fraction confirmed the presence of steroids, while the ethyl acetate fraction confirmed flavonoids, tannins, and steroids. The results of identification using the LC-HRMS instrument on the N-Hexane and Ethyl Acetate fractions of clove leaves (Syzygium aromaticum L) using LC-HRMS contained phenolic, flavonoid and phenylpropanoid compounds. In the results of the chromatogram in the N-Hexane fraction, Rhamnetin compound was obtained which had an area percent of 0.362% with the highest area of 10954249. Meanwhile, in the results of the ethyl acetate fraction chromatogram, eugenol compounds were obtained with an area percent of 0.37% with the highest area of 33151358.
Penerapan Metode EOQ, EOI, dan ROP dalam Manajemen Pengadaan Obat: Studi Kasus di Apotek Berkah Dalem 2 Kabupaten Semarang Fransisca Gloria; Anik Setyowati; Anisa Devi Kharisma Wibowo; Gilang Rizki Alfarizi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1468

Abstract

Background. Pharmacies play an important role in health services by providing quality and safe drugs, but uneven drug stocks still cause shortages and excess drug supplies, this is the main challenge. Purpose. This study aims to analyze drug planning and procurement at Berkah Dalem 2 Pharmacy using the Economic Order Quantity (EOQ), Economic Quantity Interval (EOI), and Reorder Point (ROP) methods. Analysis results. The EOQ method shows that the economic order quantity for Cataflam 50 mg tablets is 48 tablets, while for Zoralin tablets it is 118 tablets. The EOQ method can save costs by 9% per month. The ordering interval based on the EOI method for Cataflam tablets is 22 days and for Zoralin tablets is 30 days, with ROP of 4 tablets and 6 tablets, respectively. Analysis using SPSS shows a significant relationship between the EOQ value and the usage value, indicating that the higher the EOQ value, the higher the usage value (p <0.05). These findings emphasize the importance of effective medication stock management to improve efficiency and patient satisfaction in pharmacies. This research has no conflicts of interest and was not funded.

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