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Contact Name
Vonny Kurnia Utama M
Contact Email
vonny.utama@univrab.ac.id
Phone
+62761-38762
Journal Mail Official
jika@univrab.ac.id
Editorial Address
Gedung Academia Jl. Riau Ujung No. 73 Pekanbaru Riau
Location
Kota pekanbaru,
Riau
INDONESIA
JIKA
Published by Universitas Abdurrab
ISSN : 2987873X     EISSN : 29880009     DOI : https://doi.org/10.36341/jika
Core Subject : Health, Science,
JIKA (Jurnal Ilmu Kesehatan Abdurrab) has been published since March 2023 by the Abdurrab University Research and Community Service Institute in Pekanbaru. It is released four times a year: in March, June, September, and December. This journal focuses on the fields of nursing, midwifery, medicine, pharmacy, physiotherapy, health analysis, and public health. The aim of JIKA is to provide a platform for authors to publish their research findings that are beneficial to the community. The journal offers opportunities for researchers and practitioners in various health disciplines to share knowledge, ideas, and the latest findings in those fields. With its regular publication, JIKA is committed to being a sustainable and influential source of information in the academic and healthcare practice domains. Articles published in JIKA (Jurnal Ilmu Kesehatan Abdurrab) cover various topics relevant to the health field. Authors are invited to contribute research articles, literature reviews, case studies, and other scientific contributions related to nursing, midwifery, medicine, pharmacy, physiotherapy, health analysis, and public health. By publishing high-quality articles, JIKA aims to promote the development and understanding of health sciences. The journal also plays a role in disseminating up-to-date information, facilitating dialogue among researchers, practitioners, and academics, and making meaningful contributions to the improvement of healthcare quality. Thus, JIKA (Jurnal Ilmu Kesehatan Abdurrab) serves as an important platform for the development of health sciences, promoting collaboration among researchers and encouraging the application of beneficial knowledge for the advancement of health and well-being in society.
Articles 151 Documents
Analisis Bioinformatika Polimorfisme ABCC4 terhadap Respons Terapi Tenofovir pada Populasi Asia Rahman Sianu; Subardi Bali; Adrian Mulya; Erda Wati; Sisri Novrita; Muslim Suardi; Toto Marzuki
Jurnal Ilmu Kesehatan Abdurrab Vol. 4 No. 3 (2026): Volume 4 Nomor 3 September 2026
Publisher : LPPM Universitas Abdurrab

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Abstract

Tenofovir merupakan antiretroviral lini pertama untuk HIV dan hepatitis B kronis, namun penggunaannya, khususnya tenofovir disoproxil fumarate, berisiko menimbulkan nefrotoksisitas yang bervariasi antarindividu. Variasi ini diduga dipengaruhi oleh polimorfisme gen transporter ginjal, terutama ABCC4 yang mengkode protein efflux MRP4. Penelitian ini bertujuan mengkaji peran farmakogenetik gen ABCC4 dalam terapi tenofovir pada populasi Asia melalui pendekatan bioinformatika terintegrasi menggunakan database ClinPGx, STRING, GTEx, dan dbSNP. Data varian gen dikumpulkan dari ClinPGx, diseleksi berdasarkan populasi Asia, kemudian dianalisis interaksi protein, fungsi biologis, jalur metabolisme, status missense, dan pola ekspresi jaringan ADME. Hasil analisis menunjukkan ABCC4 berinteraksi dengan SLC22A8, SLC22A7, SLC22A11, ABCC5, dan PDZK1, serta berperan dalam ion transport dan organic anion transmembrane transport pada membran plasma sel tubulus ginjal. Dua varian signifikan, rs3742106 dan rs1059751, berturut-turut berkaitan dengan peningkatan konsentrasi plasma tenofovir dan peningkatan risiko penyakit ginjal, meskipun keduanya bersifat non-missense. ABCC4 memperoleh skor anotasi fungsional tertinggi (5) sehingga diprioritaskan sebagai kandidat biomarker farmakogenetik. Temuan ini mendukung potensi ABCC4 sebagai dasar personalisasi terapi tenofovir yang lebih aman, meski validasi eksperimental dan klinis lebih lanjut tetap diperlukan.