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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

sainsmedika
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Published by Universitas Islam Sultan Agung

ISSN : 20851545 EISSN : 2339093X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.

Arjuna Subject : -

Articles 8 Documents

Search results for , issue "Vol 8, No 2 (2017): December 2017" : 8 Documents clear

Effect of Celery Extract Administration on 8-OHdG and Number of Foam Cell in Wistar Strain Rats With A High-Fat Diet Budiarto, Agnes; Nasihun, Taufiqurrachman; Hussaana, Atina
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

BACKGROUND: A high fat diet, accompanied by high frequency eating, results in hyperlipidemia. One prevention for hyperlipidemia is administration of celery extract.OBJECTIVE: to explore the effect of celery extract on the level of 8-OHdG (8 -Hydroxy-2â€™-Deoxy Guanosine) and the number of foam cell.METHODS: Experimental studies with post-test only control group design used Wistar rats, administered with adrenaline and high-fat diet forhyperlipidemic induction.Total of 35 rats were divided into 5 groups: negative controls (Neg-G); positive control treated with simvastatin (Nor-G); ES25-G,ES50-G, and ES75-G group were treated with 25 mg/200 g BW, 50 mg/200 g BW, and 75 mg/200 g BW celery extract, respectively. The treatment was given for 30 days. The 8-OHdG level was determined by ELISA, whereas the number of foam cells was determined by histopathologic preparations with HE staining. Data analysis was conducted by Kruskal-Wallis and Mann-Whitney.RESULTS: Mann-Whitney analysis showed levels of 8-OHdG in ES-25-G 12.13Â±0.21, ES-50-G 7.23Â±0.25, ES-75-G 4.41Â±0.45 significantly lowerthan the Nor-G 14.30Â±0.66, respectively p<0.001. The number of foam cells in the ES-25-G was 7.57Â±0.53, ES-50-G 6.57Â±0.79, ES-75-G 3.43Â±0.53,significantly lower than the Neg-G 13.57Â±1.27, respectively p<0.001.CONCLUSION: Celery extract capable of decreasing levels of 8-OHdG and the number of foam cells in Wistar rats induced with adrenaline and high-fatdiet.

Development of Anti Acne Cream (w/o/w Multiple Emulsion) Containing Green Tea Leaf Waste Widyaningrum, Naniek
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Background: To date, green tea leaf waste is not well utilized, the waste is remain considered as a waste. Previous studies found that green tea leaf waste still have a fairly high EGCG content. EGCG has benefits as an antibacterial. Utilization of green tea leaf waste started from formulation until the diversification of multiple emulsion w/o/w products has not been reported.Objective: To develop anti acne cream (W/O/W) multiple emulsion containing green tea leaf waste and evaluate its antibacterial activity against acne-inducing bacteria of Propionibacterium acnes (P.acnes).Methods: Phase one of this research was green tea leaves was extracted by infundation and fractionation method using ethyl acetate and prepared in different concentration (1% to 6%). The second stage was ethyl acetate fraction of green tea leaf extract was tested for its antibacterial activity against P.acnes. Third stage was tested physical properties of formulation with w/o/w multiple emulsion.Results: The optimal antibacterial activity of ethyl acetate fraction of green tea leaf extract against P.acne was at the concentration of 6%, with inhibition zone of 32.6 mm Â±0.57. The formula of w/o/w multiple emulsion loaded with green tea leaves waste of 6% active substance demonstrated a good physical properties which can spread 90.4 cm2 Â± 0.03, pH 5.00 Â± 0.02 and microscopic analysis showed multiple emulsion w/o/w.Conclusion: The concentration of 6% green tea leaf waste formulated in multiple emulsion had a good physical and antibacterial activity for a referred standard. It is necessary to test the stability of multiple emulsion formula.

The Effect of Reality Therapy on the Level of Anxiety and Depression in Army Wife Fourida, Ibrahim Nasrul; Sudiyanto, Aris; Fanani, Moh.
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

BACKGROUND: Anxiety and depression, are the most common psychopathological symptoms among army wives living in Kopassus (Indonesian army special force) dormitory, with the prevalence of 15-40%. Proper management with reality therapy for anxious and depressed army wives living in Kopassus dormitory is needed.OBJECTIVE: to determine the effect of reality therapy on anxiety and depression levels in army wives in Kopassus Group 2 dormitory.METHODS: This study was designed as a randomized control trial pretest and post-test two group design. Sampling was done by simple random technique. Thirty subjects were divided into two groups. Control group received regular interview, while experimental group received reality therapy. Respondents were asked to fill out The Lie Minnesota Multiphasic Personality Inventory questionnaire (L-MMPI), biodata, the Taylor Manifest Anxiety Scale questionnaire (TMAS), and the Beck Depression Inventory questionnaire (BDI). The Wilcoxon Rank Test and Mann-Whitney were applied for data analysis, with the significance level of p<0.05.RESULT: The Wilcoxon Rank Test in the TMAS (anxiety) and BDI (depression) showed a significant difference (p<0.05). The Mann-Whitney analysis of the anxiety and depression variables showed a significant difference between the reality therapy group and the control group (regular interview) (p <0.05). The experiment group has a TMAS and BDI score lower than that of the control group.CONCLUSION: The reality therapy is effective to lower the level of anxiety and depression in army wives.

Platelet Profile in Patients with Status Asmaticus in Kebumen Juwariyah, Juwariyah; Arjana, Adika Zhulhi; Rahayu, Ester Tri; Rosita, Linda; Irfan, Mohammad Rozan
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

BACKGROUND: Asthma has been considered as type 1 hypersensitivity disease, but actually asthma involves a variety of inf lammatory factors.Based on pro-inf lammatory cells, asthma is classified into eosinophilic, non-eosinophilic, neutrophilic, and non-neutrophilic. Platelet plays a role inÂ pathophysiology of asthma through inf lammation. However, platelet profile in patients with asthma have not been established.OBJECTIVE: to determine the platelet indices of patients with status asmaticus of different phenotypes.METHODS: a cross-sectional study was conducted among a minimum sample size of 67 patients. Data were collected from medical records of patients in RSUD Kebumen. Platelet indices included mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT).RESULTS: There was no significant difference in the value of MPV and PDW in patients with eosinophilic and neutrophilic asthma (p> 0.05). But,there was a significant difference in PCT between the two groups (P <0.05)CONCLUSION: There was difference only in plateletcrit (PCT) between patients with eosinophilic and netrophilic asthma.

The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats Jannah, Miftahul; Subagyo, Djoko Trihadi Lukmono; Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

BACKGROUND: Paracetamol may cause apoptosis in the renal tubules. Moringa leaf (Moringa oleifera. Lam) has been shown to have antioxidant effects due to its f lavonoids. In addition, f lavonoids also have biological effects to modulate the signal-transduction pathway.OBJECTIVE: to investigate the effect of Moringa oleifera Lam extract on Bcl-2 and Bax expression on paracetamol-induced renal tubular injury.METHODS: in this post-test only control group design study, 24 rats were divided into 4 groups: AqC-G (aquades), EtC-G (70% ethanol), MoL1-Gand MoL2-G (moringa leaf extract at the dose of 1.075 g/Kg BW and 2.150 g/Kg BW respectively). Expression of Bcl2 and Bax was determined using immunohistochemical staining. The data on the number of Bcl2 and Bax expressions tested with One Way Anova followed by the Post Hoc LSD test.RESULTS: Post Hoc LSD test showed that the expression of Bcl-2 in the experimental groups ((MoL1-G (9.1) and MoL2-G (13,683)) was significantly higher compared to that of controls (p<0.001). Bax expression in the experimental groups (MoL1-G (6,85) and MoL2-G (2,633)) was significantly lower compared to that of controls, p <0.001.CONCLUSION: The administration of Moringa leaf extract at the dose of 1,075 and 2,150 increases Bcl-2 expression and decreases Bax expression in paracetamol-induced renal tubular injury.

Ramadan Fasting, Health, and Autophagy: Is There any Relationship? Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Fasting, the voluntary abstinence from food intake for a certain period of time is a well-known practice in relation with spiritual purposes (Trepanowski, JF, 2010). Ramadan fasting (RF) is an obligation of Muslim across the world during the entire holy month of Ramadan. In this specified period, Muslim every day from dawn to dusk are prohibited to eat, drink, and sexual relation, by which Muslim seek an enhanced level of closeness to God (Alloh). This testament is referenced in the verse of Al Baqoroh 183 of Holy Qurâ€™an: â€œO you who believe! Fasting is prescribed for you, as it was prescribed for those before you, that you may become righteousâ€. In addition to closeness, RF in the Islamic perspective also believed capable of improving human health as prophet of Mohammad (peace be upon him) said that â€œfasting makes you healthierâ€. However, to the benefit of RF during the entire month of Ramadan on health remain circumstantial. There is germane question regarding RF, whether or not RF can elicit benefits or otherwise will compromise health status and physical activity performances in fasted people, considering total calorie and fluid intake were reduced (Aziz AR, et al. 2012; Bouhlel E, et al. 2006). Accordingly, in the last two decades, the health effects of RF have recently been the subject of scientific research, not only in health outcome (Trepanowski, JF, 2010; Moro T, et al. 2016), but also in exercise performance (Aziz AR, et al. 2012).

Comparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section Putro, Prabowo Wicaksono Yuwono; Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Background: Intrathecal morphine has been shown to be effective for pain after cesarean section with possible side effect including delayed respiratory depression, nausea vomiting and pruritus. Fentanyl continuous infusion fixed base infusion rate with disposable elastomeric pump is an alternative to intrathecal morphine but has not been been widely studied.Objective: to compare the effectiveness between fentanyl continuous infusion fixed base infusion rate using disposable elastomeric pump and intrathecal morphine.Methods: in a Randomized Controlled Trial (RCT), 56 patients meeting the inclusion criteria were divided into two groups: Morphine group (n=28): spinal anesthesia 10 mg Bupivacaine Heavy 0.5% + 100 mcg morphine; Fentanyl group (n=28): spinal anesthesia 10 mg Bupivacaine Heavy 0.5% + fentanyl continuous infusion 0.5 mcg/kg BW/hour using disposable elastomeric pump after delivery. Data analysis: Mann-Whitney test at the level of significance p<0.05.Results: Analgesic effect of Fentanyl group was as effective as that of Morphine group. NRS score difference was significant only in measurement taken 6 hours after surgery (p=0.034). Mean NRS score for Morphine and Fentanyl were 68Â±1.02 and 1.11Â±0.832, respectively. Both group were effective in preventing increased cortisol level measured 6 hours after surgery, mean value group Morphine and Fentanyl were 15.053Â±8.664 and12.162Â±8.623, respectively.There were no statistical significant difference between groups (p=0.114). No significant difference in side effect between the groups was found.Conclusion:Â Fentanyl continuous infusion 0.5 mcg/kg BW/hour using disposable elastomeric pump is as effective as intrathecal morphine 100 mcg/kg BW/hour

Administration of Mung Bean Extract (Phaseolus radiatus) in Increasing Hb and Ferritin Level and Decreasing Malondyaldehide (MDA) Level in Anaemic Rats Wijayanti, Heni; Nasihun, Taufiqurrachman; Hussaana, Atina
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

BACKGROUND: Mung bean, not only contains protein, carbohydrates, and fats, but also contains iron and vitamin C which are proven to overcome anemia in pregnant woman. High iron levels are potential to increase ROS production through fenton reaction.OBJECTIVE: to prove the administration of mungbean can increase Hb and ferritin levels and decreasing malondihaldehyde (MDA) in anaemic rats.METHODS: This research uses Post Test Only Control Group Design. A total of 25 anaemic rats were divided into 5 groups: normal group (Nor-G);negative control group (Neg-G), were given low Fe diet; and treatment group with low Fe and mung bean extract at dose of 0,18g/200g/days (GP-0,18), 0,36g/200g/days (GP-0.36), dan 0,72g/200g/days (GP-0.72). Low Fe diet and mung bean extract were administered for 14 days. Hb levels were measured using Sahli method, ferritine level using Immulite Ferritine Kit, and MDA were measured using TBA.RESULTS: Compare to Nor-G and Neg-G, levels of ferritin and Hb on groups with mung bean extract 0,18g (75.56), 0,36g (90.98) and 0,72g (95.87) were significantly higher (p < 0.05). While MDA levels on groups with mung bean 0,18g (4.646), 0,36g (3.396) and 0,72g (1.92) were significantly lower than on Nor-G and Neg-G groups (p < 0.05).CONCLUSION: The administration of mung bean extract can increase Hb and ferritin, also lower MDA level on anaemic rats.

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