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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
Published by Universitas Islam Sultan Agung
ISSN : 20851545     EISSN : 2339093X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.
Arjuna Subject : -
Articles 249 Documents
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Adverse effects of short-term regimens in multidrug-resistant tuberculosis patients with treatment failure in Central Java, Indonesia Muhamad Zakki Saefurrohim; Intan Henda Ardiani; Alma Feriyanti; Intan Zainafree; Fildza Huwaina Fathnin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 1 (2026): June 2026
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v17i1.45038

Abstract

Recent evidence shows high rates of treatment failure among multidrug-resistant tuberculosis (MDR-TB) patients on short-course regimens. This clinic-based case–control study used Tuberculosis Information System (SITB) data from Central Java, Indonesia (2021–2023) to examine associations between employment status, HIV status, baseline sputum examination, and body mass index (BMI) with specific categories of treatment failure (treatment failure, diagnostic change, regimen modification, loss to follow-up, and death). Overall treatment failure was 70.59%, including 15.3% deaths. Employment status was significantly associated with failure category (p=0.022), with unemployed patients disproportionately experiencing loss to follow-up (82.5%) and death (59.6%). HIV-reactive patients were more likely to undergo regimen modification (p=0.009; 1.8%). Baseline sputum results showed the strongest association (p<0.001): negative sputum was linked to diagnostic change (49.1%) and unknown sputum status to loss to follow-up (66.7%). Low BMI (<18.5 kg/m2) was also associated with failure category (p=0.037), particularly loss to follow-up (75.4%) and death (33.3%). These findings implicate socioeconomic vulnerability, HIV co-infection, absent or negative baseline sputum results, and undernutrition as important determinants of distinct short-course MDR-TB treatment failures and support integrated, patient-centred interventions to improve outcomes.
Validity and Reliability of Indonesian Version of Diabetes Self-Management Questionnaire in Patients with Type 2 Diabetes at Primary Care Akhmad Azmiardi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.39337

Abstract

Introduction: Diabetes self-management is critical for effective diabetes mellitus management. This study aimed to assess the validity and reliability of the Indonesian version of the Diabetes Self-Management Questionnaire (DSMQ) among patients with type 2 diabetes in a primary care setting.Methods:This cross-sectional study was conducted among patients with type 2 diabetes at primary health care facilities in Singkawang City, West Borneo, Indonesia. Data were collected through interviews or face-to-face meetings with 30 patients diagnosed with type 2 diabetes mellitus undergoing outpatient treatment. The selection criteria included: patients aged 20-75 years, not pregnant or breastfeeding, free from complications affecting physical, mental, and emotional states, and willing to participate voluntarily. The DSMQ assesses self-management behaviors through a multidimensional questionnaire rated on a four-point scale. Construct validity was evaluated using Pearson’s r correlation values, and reliability was assessed using Cronbach’s alpha coefficient, with thresholds set at >0.361 and >0.70, respectively.Results:The study population primarily consisted of women (76.7%), with most respondents aged 50 years and older (53.3%) and predominantly married (93.3%). Educational levels were generally low, with 40% having primary education. The DSMQ showed high validity and reliability across its subscales. Pearson’s r values ranged from 0.393 to 0.865, indicating significant correlations. Cronbach’s alpha coefficient for the DSMQ was 0.930, reflecting excellent internal consistency.Conclusions: The Indonesian version of the DSMQ demonstrated strong validity and reliability for assessing diabetes self-management behaviors in patients with type 2 diabetes
Clinical isolates from ICU patients show high rates of biofilm production: A descriptive study Wignyo Santosa; Herinto Himawan; Dian Ayu Listiarini; Ahmad Umar Alfaruq
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.40814

Abstract

Biofilm formation on indwelling devices promotes antimicrobial resistance and complicates management of ICU infections; comprehensive profiling of biofilm-producing pathogens in ICU settings is needed to inform infection control and stewardship.  Cross-sectional study (June–September 2023) of clinical isolates from ICU patients with sepsis, pneumonia, urinary tract infection, or wound infection at Sultan Agung Islamic Hospital, Semarang. Sixty-two isolates from sputum (endotracheal aspirates), pus/wound swabs, urine, and blood were identified by standard culture and biochemical methods. Biofilm production was assessed by the 96‑well microtiter plate crystal violet assay. All isolates produced biofilm: 50/62 (80.6%) strong, 9/62 (14.5%) moderate, and 3/62 (4.8%) weak. Gram‑negative organisms predominated: Klebsiella pneumoniae 18/62 (29.0%), Pseudomonas aeruginosa 17/62 (27.4%), and Escherichia coli 10/62 (16.1%). All P. aeruginosa isolates (17/17; 100%) exhibited strong biofilm formation across clinical conditions. K. pneumoniae was the most frequent cause of pneumonia (15/62; 24.2%), with 13/15 (86.7%) strong biofilm producers.  ICU isolates showed a high prevalence of strong biofilm production, primarily among Gram‑negative pathogens. These findings support the implementation of targeted surveillance, strict device care protocols, and antimicrobial stewardship strategies to address biofilm-associated resistance; larger multicenter longitudinal studies are recommended.
Effects of isoflavones soybean extract on luteinizing hormone, follicle- stimulating hormone levels, and ovarian antral follicle diameter in female mice Riri Emilia; Taufiqurrachman Nasihun; Titiek Sumarawati
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 1 (2026): June 2026
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v17i1.50721

Abstract

Hormonal contraceptives can cause side effects, prompting interest in natural compounds such as soybean isoflavones, which may interact with estrogen receptors and influence reproductive hormones. This study evaluated the effects of soybean extract isoflavones on luteinizing hormone (LH), follicle-stimulating hormone (FSH), and ovarian antral follicle diameter in female mice. Fifteen healthy mice were randomised into three groups (n = 5 each): control (aquadest), P1 (4.5 mg isoflavone per dose), and P2 (9 mg isoflavone per dose). Treatments were administered orally twice daily for 15 days. LH and FSH were measured by ELISA, and antral follicle diameter was assessed histologically. The Kruskal–Wallis’s test showed no significant differences among groups for LH (H = 1.982, p = 0.371), FSH (H = 1.123, p = 0.570), or antral follicle diameter (H = 1.220, p = 0.543). Although descriptive variations were observed, they were not statistically significant. These results suggest that 15-day oral administration of soybean extract isoflavones at the tested doses does not significantly alter LH, FSH, or ovarian antral follicle diameter in healthy female mice; larger, longer, and better-controlled studies are recommended.
Thrombocytopenia after treatment for nasopharyngeal carcinoma: a comparison of radiotherapy and chemoradiotherapy Agnes Yohana; Willy Yusmawan; Zulfikar Naftali; Kanti Yunika
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 1 (2026): June 2026
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v17i1.36863

Abstract

Nasopharyngeal carcinoma (NPC) arises from the nasopharyngeal epithelium. Radiotherapy is the mainstay for locoregional NPC, while concurrent chemoradiotherapy is standard for advanced locoregional disease. Both modalities can affect hematopoiesis and alter platelet counts, but comparative data on treatment-related thrombocytopenia are limited. We retrospectively reviewed medical records of 66 NPC patients treated at Dr Kariadi General Hospital between 2016 and 2023. Collected variables included age, sex, histopathological type, stage, and platelet counts before and after therapy. Descriptive statistics summarised patient characteristics. Paired T-tests were used to evaluate within-patient changes in platelet count pre- versus post-treatment. The association between treatment modality (radiotherapy vs chemoradiotherapy) and occurrence of thrombocytopenia was assessed using the Chi-Square test. Most patients were male (75.8%) and ≥40 years old (75.8%). WHO type 3 histology comprised 83.3% of cases; stage IVA was the most common stage (42.4%). Mean platelet counts decreased from 364.18 × 103/µL to 248.76 × 103/µL after radiotherapy, and from 390.18 × 103/µL to 209.24 × 103/µL after chemoradiotherapy. Thrombocytopenia occurred in 5/33 patients (15.2%) receiving radiotherapy and 13/33 patients (39.4%) receiving chemoradiotherapy. In this cohort, NPC predominantly affected males ≥40 years with WHO type 3 histology and stage IVA disease. Both radiotherapy and chemoradiotherapy were associated with reductions in platelet count, with a higher observed incidence of thrombocytopenia following chemoradiotherapy. Prospective studies with larger samples are warranted to confirm these findings and to identify risk factors for clinically significant thrombocytopenia.
Malignant triton tumour of the distal femur: imaging features of a rare entity Reni Ibrahim; Muchtar Hanafi; Amelia Tjandra Irawan
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 1 (2026): June 2026
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v17i1.40815

Abstract

Malignant Triton tumour (MTT) is a rare rhabdomyoblastic variant of malignant peripheral nerve sheath tumour (MPNST), characterised by striated muscle differentiation, with an incidence of approximately 0.001%. We report a 40-year-old woman with a rapidly painful, enlarging mass of the left distal femur and associated palpable lesions in the left calf and abdomen. Multislice CT demonstrated multiple solid lesions with peripheral contrast enhancement infiltrating adjacent tissues. MRI showed a large (>5 cm) heterogeneous lesion measuring 9.4 × 8.4 × 9.2 cm with lobulated margins, heterogeneous contrast enhancement, and mass effect on surrounding structures. Diagnosis and treatment: Histopathology and immunohistochemistry confirmed the diagnosis of MTT. The patient underwent two wide tumour excisions followed by adjuvant chemotherapy. Despite treatment, chest radiography one and a half years later revealed pulmonary metastases. MTT is an aggressive tumour with rapid growth and a high propensity for early metastasis. Radiologic features that should raise suspicion include large size, lobulated margins, peripheral calcifications, and internal heterogeneity. Correlation of imaging with clinical and histopathological findings is essential for timely diagnosis and treatment planning.
Peripheral blood-derived expression of IL-6, IL-1β, and TNF-α in patients with ruptured intracranial aneurysms Reza Aditya Digambiro; Dewi Hastuty; Florinda Ilona; Julian Chendrasari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 1 (2026): June 2026
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v17i1.44749

Abstract

  Introduction: Ruptured intracranial aneurysms (IAs) are a devastating cause of subarachnoid hemorrhage (SAH), often driven by complex inflammatory mechanisms. Pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α have been implicated in vascular wall degeneration leading to rupture.Methods: A cross-sectional study was conducted on 30 patients with radiologically confirmed ruptured IAs in Satya Negara Hospital and Mitra Keluarga Hospital. Blood samples were collected within 72 hours post-ictus. Expression of IL-6, IL-1β, and TNF-α mRNA was quantified using real-time PCR at Hopkins Clinic and Lab, with GAPDH and β-actin as reference genes. CT values were analyzed and correlated with clinical severity based on Hunt & Hess grading.Results: Mean CT values were IL-6: 32.56 ± 1.15, IL-1β: 31.47 ± 1.23, and TNF-α: 30.69 ± 1.15. Strong inverse correlations were observed between CT values and Hunt & Hess scores: IL-6 (r = -0.891), IL-1β (r = -0.930), and TNF-α (r = -0.919), all with p < 0.0001.Conclusion: Expression of IL-6, IL-1β, and TNF-α is significantly elevated in ruptured IAs, correlating with clinical severity. These cytokines may serve as biomarkers and therapeutic targets in aneurysmal SAH.
Preoperative anemia and malnutrition predict postoperative complications in stage III colorectal cancer: a cross‑sectional study Vito Mahendra; Naufal Aditya Ramadhan; Mohammad Dhanny Akbar; Abdullah Rizky; Chodidjah Chodidjah
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 1 (2026): June 2026
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v17i1.43739

Abstract

Colorectal cancer remains a major cause of morbidity and mortality. We conducted a cross‑sectional observational study of 65 consecutive stage III colorectal cancer patients from medical records at Sultan Agung Islamic Hospital (data collected 3–27 Dec 2024) to examine associations between treatment, preoperative haemoglobin, BMI‑defined nutritional status, CEA, Karnofsky Performance Status, and postoperative complications. Postoperative complications occurred in 11/14 (78.6%) patients with mild malnutrition, 2/6 (33.3%) with moderate malnutrition, and 8/8 (100.0%) with severe malnutrition; malnutrition was significantly associated with complications (p = 0.016). Among anaemic patients, 24/26 (92.3%) experienced complications, and anaemia was also significantly associated with complications (p = 0.020). CEA and Karnofsky Index were not significantly associated with postoperative complications. These findings indicate that preoperative anaemia and malnutrition are important predictors of postoperative morbidity in stage III colorectal cancer and support routine preoperative screening and timely correction of haemoglobin and nutritional deficits to improve surgical readiness and perioperative outcomes.
Early-life environmental exposures and pediatric cardiovascular health I Ketut Alit Utamayasa; Ayurveda Zaynabila Heriqbaldi; Shabrina Nur Imanina; Prima Hari Nastiti
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 1 (2026): June 2026
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v17i1.52124

Abstract

Environmental exposures in early life are increasingly recognised as key determinants of pediatric cardiovascular health. Beyond genetic susceptibility, insults during fetal development and childhood can shape risk for congenital and acquired cardiac conditions. This review synthesizes epidemiological data and plausible biological mechanisms linking four exposure domains to pediatric cardiovascular outcomes: (1) climate-related maternal heat exposure and other prenatal stressors associated with increased risk of congenital heart defects; (2) air pollution, especially traffic-related pollutants and sulfur dioxide, as a trigger for Kawasaki disease via immune activation and systemic inflammation; (3) early-life heavy metals, notably prenatal lead exposure, associated with modest but clinically meaningful increases in childhood blood pressure; and (4) endocrine-disrupting chemicals that promote early alterations in adiposity and metabolic regulation, elevating cardiometabolic risk. Collectively, the evidence highlights critical developmental windows when environmental insults exert lasting cardiovascular effects and supports incorporating environmental risk reduction into early-life prevention strategies.

Page 25 of 25 | Total Record : 249

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