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INDONESIA
SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
Published by Universitas Islam Sultan Agung
ISSN : 20851545     EISSN : 2339093X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.
Arjuna Subject : -
Articles 235 Documents
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Clinical and epidemiological characteristics of pediatric solid tumours at Sultan Agung Islamic Hospital (2018–2023) Mayangsari, Citra Primavita; Raharjo, Rudi Yuwono; Ardelia, Alinda; Pramudya, Raihan Daffa Setiyo
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.39770

Abstract

A tumour is an abnormal mass of tissue that does not contain cysts or fluid. According to the Global Cancer Statistics, approximately 275,000 children worldwide were diagnosed with cancer in 2022. Among pediatric solid tumours, the most common types include neuroblastoma, rhabdomyosarcoma, retinoblastoma, osteosarcoma, and Ewing sarcoma. This study aims to analyse the prevalence and characteristics of solid tumours in children treated at Sultan Agung Islamic Hospital in Semarang. A descriptive quantitative approach was employed, utilising retrospective data from medical records. The study population comprised pediatric inpatients and outpatients aged 0 to 17 years who underwent pathological or radiological examinations between 2018 and 2024. Data analysed included demographic details (age, gender), presenting symptoms, and blood test results. The study identified 22 pediatric patients with solid tumours, with Rhabdomyosarcoma and Teratoma being the most common types. The gender distribution was evenly split between males and females. Notably, 73% of the patients showed recovery. Common presenting symptoms included palpable lumps (45%) and pain (41%). Blood tests revealed that haemoglobin levels in children aged 2-9 years were below the usual lower limit (8.21 ± 4.88 g/dL). White blood cell counts in the same age group were abnormal, averaging 11.20 ± 8.36  103/µL. Platelet counts across the age span of 1 month to 17 years were elevated, with a mean of 412.33 ± 224.11 103/µL. In conclusion, the supporting laboratory examinations frequently indicated anaemia, leukocytosis, and thrombocytosis among pediatric tumour patients. These findings underscore the importance of comprehensive diagnostic assessments in managing pediatric solid tumours.
Exploring the clinical studies of surgical acne scar management: a 10-year systematic review of modalities and outcomes Pramudita, Adelia Wuri; Asaduddin, Aiman Hilmi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v%vi%i.34560

Abstract

Acne scars are permanent sequelae of acne vulgaris, classified into hypertrophic, keloid, and atrophic types. Treatment strategies include non-invasive, minimally invasive, and invasive modalities. This systematic review evaluates clinical studies from the past decade on surgical and related interventions for acne scars. Using PRISMA guidelines, searches were conducted on PubMed, Scopus, and Epistemonikos with keywords related to "acne scar" and "surgical therapy." Twenty-four studies met the inclusion criteria out of 396 screened articles. The modalities examined encompass TCA CROSS, radiofrequency (RF) micro-needling, fractional microplasma RF, fractional bipolar RF, fractional CO₂ laser, erbium YAG (2940 nm), 1550 nm erbium, 1540 nm erbium glass, subcision, punch techniques, microdermabrasion, needling, platelet-rich plasma (PRP), hyaluronic acid fillers, hybrid energy devices, trifractional technology, and human adipose-derived stem cell exosomes (ASCE). Results demonstrated variable efficacy, with predominantly positive outcomes across modalities. Specific treatments showed better suitability for certain scar types; however, all carry potential risks of adverse effects, emphasizing the need for cautious application and patient management. Limitations include small sample sizes and heterogeneity among studies, which may affect the generalizability of findings. This review highlights the diversity of surgical and minimally invasive options for acne scar management, supporting tailored treatment approaches based on scar morphology and patient factors.
Community-based zinc supplementation for linear growth recovery in stunted under-five children in Indonesia Yuniarti, Heny; wibowo, Joko Wahyu; Purjaningsih, Shofi Khofsoftun
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.47046

Abstract

Stunting remains a significant nutritional challenge in Indonesia and across Southeast Asia, with zinc deficiency identified as a contributing factor to impaired linear growth in early childhood. Zinc is critical for growth hormone synthesis, bone development, and immune regulation. Despite existing intervention programs, stunting prevalence in Indonesia remained at 19.8% in 2024. This study evaluated the effect of zinc supplementation on the linear growth of stunted children aged 0–5 years attending Bangetayu and Genuk Public Health Centres in Semarang. Employing an observational analytic design with a one-group pretest-posttest approach, 42 stunted toddlers received a daily oral dose of 20 mg zinc sulfate syrup for two months. Anthropometric measurements were recorded before and after the intervention, with paired T-tests applied to normally distributed data and Wilcoxon signed-rank tests to non-normal data. After two months of supplementation, 86% of the participants demonstrated improvements in both height and weight. The mean height increased from 79.9 cm to 81.0 cm (p < 0.001), while the mean weight increased from 9.28 kg to 9.74 kg (p < 0.001). These findings indicate that zinc supplementation significantly enhances linear growth among stunted toddlers. Consequently, integrating zinc supplementation into national nutrition intervention strategies could be pivotal in reducing early childhood stunting.
Correlation between haemoglobin, leukocytes, HbA1c, and albumin levels with diabetic foot ulcer severity: a cross-sectional study Sadyah, Nur Anna Chalimah; Nugroho, Heri; Putra, Agung; Riwanto, Ignatius
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.41423

Abstract

Diabetic foot ulcers (DFUs) represent a serious complication of diabetes mellitus, associated with significant morbidity and healthcare costs. The progression of DFUs is influenced by systemic and local factors, including haemoglobin levels, leukocyte count, glycated haemoglobin (HbA1c), and serum albumin. This study aims to explore the relationship between these clinical parameters and the severity of DFUs. We enrolled 62 patients with DFUs and classified ulcer severity as mild, moderate, or severe according to the Wagner classification system. Using Spearman’s rank correlation, we found significant associations: lower hemoglobin and albumin levels correlated with more severe ulcers (ρ = -0.34, p= 0.0065; ρ = -0.41, p = 0.00084, respectively), while higher HbA1c and leukocyte counts were associated with increased ulcer severity (ρ = 0.62, p = 0.000; ρ = 0.40, p = 0.0013, respectively). These findings suggest that hematologic and biochemical markers may serve as valuable indicators of DFU progression, potentially guiding clinical decision-making and improving patient outcomes. Further research is needed to elucidate the underlying mechanisms and evaluate targeted interventions for this high-risk population.
Bioinformatics study of the A222V substitution in SARS-CoV-2 Spike Protein Ariesaka, Kiky Martha; Nuryady, Moh Mirza; Rini, Ika Agus
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.39242

Abstract

COVID-19, caused by SARS-CoV-2, has infected over 200 million people and caused 4.3 million deaths globally, with over 3.7 million cases and 110,000 deaths in Indonesia. SARS-CoV-2, a single-stranded RNA virus, has a genome encoding proteins such as Spike (S), Envelope (E), Membrane (M), and Nucleocapsid (N). The S protein, comprising S1 and S2 domains, facilitates ACE2 receptor binding and membrane fusion. This study examines the phylogenetic relationship of the A222V substitution in the S protein with various global isolates. We collected 25 complete SARS-CoV-2 sequences from the GISAID database, performed multiple sequence alignments using Clustal W in MEGA-X software, and constructed phylogenetic trees using the neighbor-joining method. The urgency of this paper lies in understanding the impact of the A222V mutation on the virus's infectivity and spread, which is crucial for developing targeted treatments and vaccines. The A222V variant, first identified in Spain in summer 2020, has spread rapidly across Europe, raising concerns about its potential to increase transmissibility or affect vaccine efficacy. The A222V variant likely affects protein conformation or stability rather than receptor binding or membrane fusion. Understanding these changes is essential as it can influence the virus's behavior and efficacy of public health interventions. The study found high mutation rates in the S gene with diverse point mutations. Phylogenetic analysis revealed that A222V isolates clustered closely with D614G variants. In conclusion, not all mutations result in amino acid changes, and A222V has minimal impact on ACE2 binding but may influence protein stability.

Page 24 of 24 | Total Record : 235

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