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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
Published by Universitas Islam Sultan Agung
ISSN : 20851545     EISSN : 2339093X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.
Arjuna Subject : -
Articles 235 Documents
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Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats Fernandi, Ryan; Sudartana, I Ketut; Sueta, Made Agus Dwianthara; Mahayasa, I Made; Yasa, Ketut Putu; Wibawa, I Gusti Agung Bagus Krisna
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.36698

Abstract

Peritoneal lavage with normal saline is common in abdominal surgeries, yet recent studies indicate that it increases intraperitoneal adhesion risks. This study compares the effects of peritoneal lavage with normal saline versus sterile water on interleukin-1 (IL-1) levels and intraperitoneal adhesion following laparotomy in rats. In this post-test control group study, 20 adult Wistar rats were subjected to laparotomy before being randomly divided into two groups to receive either intraperitoneal lavage with normal saline (0.9% NaCl) or sterile water. After 7 days, IL-1 level and degree of adhesion were evaluated. The saline group had higher adhesion levels (4 rats with grade 4, 5 with grade 3, 1 with grade 2) than the sterile water group, which had lower levels (2 rats with grade 3, 5 with grade 2, 3 with grade 1). There was a significant difference in IL-1 levels between the sterile water group (37,111.6 ± 6,535.61 pg/ml) and the normal saline group (57,456.3 ± 10,583.41 pg/ml). There was a significant correlation between IL-1 levels and adhesion grade (p=0.008). Intraperitoneal lavage with sterile water results in significantly lower adhesion grade and IL-1 levels than normal saline, suggesting its potential for reducing postoperative adhesions. Further studies are needed to elucidate the mechanism of reduced adhesion and inflammation associated with sterile water lavage.
Antioxidant activity and phytochemical profiling of peaches, Arabica coffee, and their combination Putri, Dhea Angela; Marsiati, Himmi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.33505

Abstract

Antioxidant compounds scavenge unstable free radical reactions and are abundant in certain plants. Peaches (Prunus persica L.) are rich in phytochemicals such as carotenoids, anthocyanins, phenolic acids, and flavonoids, while Arabica coffee (Coffea arabica) contains alkaloids, flavonoids, tannins, steroids, and terpenoids. This study evaluated the antioxidant activity and phytochemical profile of peaches, Arabica coffee, and their combination using ethanol, ethyl acetate, and water as solvents. Extraction was performed via maceration with 96% ethanol and fractionation using water and ethyl acetate. Antioxidant activity was assessed using the DPPH (1,1-Diphenyl-2-picrylhydrazyl) assay, and phytochemical tests evaluated secondary metabolites such as alkaloids, flavonoids, phenolics, steroids/terpenoids, tannins, and saponins. Results indicated that the ethyl acetate extract of peaches showed moderate antioxidant activity (IC50 = 141.91 ppm), while the water extract of Arabica coffee exhibited robust activity (IC50 = 22.30 ppm). Notably, combining water extracts from both sources demonstrated enhanced antioxidant capacity (IC50 = 37.85 ppm), improving peach extract activity by over threefold. These findings underscore the potential synergistic effects of combining these natural sources for health-promoting antioxidants.
Locally sourced supplementary feeding programs as a strategic intervention to address weight faltering in children: insights from a primary health center study Haryani, Deby Aprilia; Amanda, Qorry; Sabjan, Novita
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.40402

Abstract

Pemberian Makanan Tambahan (PMT), a supplementary food program using local ingredients, is a targeted intervention to address toddler malnutrition and weight faltering in Indonesia. Despite its widespread implementation, the long-term efficacy of the 14-day PMT program in sustaining growth recovery remains to be determined. This study aimed to evaluate the impact of a 14-day PMT intervention on weight gain and growth stability in children aged 6–59 months experiencing weight faltering. A prospective cohort study was conducted from May to August 2024 at Primary Health Center (Puskesmas) Ajibarang 1 in Banyumas, Central Java, Indonesia. The intervention consisted of 11 snacks and 3 main meals to meet 30–50% of daily caloric needs. Anthropometric measurements, including body weight (BW) and mid-upper arm circumference (MUAC), were collected pre- and post-intervention. 120 children participated, with baseline averages of 11.2 ± 1.5 kg for BW and 13.4 ± 1.7 cm for MUAC. Significant improvements were observed post-intervention, with averages of 12.9 ± 1.2 kg (BW) and 15.0 ± 1.4 cm (MUAC). A moderate positive correlation was identified between BW gain and MUAC (Spearman analysis). In conclusion, the PMT program effectively improves BW and MUAC in children at risk of growth faltering, highlighting its potential as a scalable intervention. These findings emphasize the importance of tailored nutritional programs during early childhood, a critical period for ensuring long-term health and developmental benefits. Advocacy and policy reforms are essential to support consistent implementation and global accessibility of nutritional interventions.
Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy Mahendra, I Nyoman Bayu; Winata, I Gde Sastra; Setiawan, William Alexander; Putra, Ida Bagus Agung Widnyana; Darmayasa, Putu Bagus
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.28943

Abstract

Cervical cancer is the second leading cause of cancer-related deaths among women worldwide. Despite advancements in screening programs and vaccination efforts, a significant proportion of patients present with advanced-stage disease, characterized by severe manifestations and a poor prognosis. Clinical evidence highlights substantial variability in the sensitivity of chemotherapy regimens among cervical cancer patients, often resulting in suboptimal therapeutic outcomes and increased risk of complications. This underscores the need for reliable molecular markers to predict prognosis and optimize therapy. Angiogenesis plays a pivotal role in the development and progression of solid tumors, including cervical cancer. Key tumor angiogenesis markers, such as vascular endothelial growth factor (VEGF) and its receptor (VEGFR), are critical in driving tumor progression in advanced cervical cancer. Studies have demonstrated significant correlations between VEGF levels and important prognostic parameters, including tumor size, metastasis, and chemotherapy response. Consequently, tumor angiogenesis markers like VEGF and VEGFR hold potential as valuable predictive tools to guide the management of advanced cervical cancer, particularly in patients undergoing chemotherapy.
Culture and sensitivity analysis in rhinitis atrophic: case series Tjahyadewi, Shelly; Aditomo, Rano; Rahayu, Rahayu; Sulistyanto, Agung; Pasaribu, Nurfauziati
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.39391

Abstract

Atrophic rhinitis is a rare condition affecting the nasal mucosa, characterized by progressive nasal congestion, foul odor, and thick nasal secretions. It is classified into two types: primary (idiopathic), where the cause remains unknown, and secondary, which develops due to another underlying condition. Primary atrophic rhinitis, often called ozaena (from the Greek word for "stench"), has also been described as acute necrotizing rhinitis, catarrhal atrophic rhinitis, or coryza foetida. This condition predominantly affects women, with a reported ratio of 6:1.5. It is more prevalent in tropical regions and among populations with low socioeconomic status and poor hygiene, although its exact etiology remains unclear. Diagnosis is primarily clinical, based on a triad of symptoms: fetor, greenish nasal crusts, and an abnormally wide nasal cavity, often observed in advanced cases. This case series presents two rare instances of atrophic rhinitis, highlighting distinct characteristics and risk factors while contributing valuable insights into understanding this uncommon disorder.
Inhibitory effects of rambutan (Nephelium lappaceum l.) leaves ethanolic extract on Methicillin-Resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes Rizkita, Leonny Dwi; Ariani, Rizka; Farid, Muhammad; Rastrani, Ardestya; Ramadhania, Widya Aryana; Putri, Ratna Aprillia Eka
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.40155

Abstract

Antimicrobial resistance poses a global health threat, with Methicillin-Resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes contributing to the highest mortality rates among Gram-positive pathogens over the last three decades. The search for alternative antimicrobial agents has increasingly concentrated on natural products. Rambutan (Nephelium lappaceum L.), a widely used ethnomedicinal plant in Indonesia, is recognized for its numerous health benefits, including its antimicrobial properties. Despite extensive phytochemical studies on various parts of rambutan, the specific inhibitory effects of its leaf extract against MRSA and S. pyogenes have yet to be explored. This study aimed to evaluate the antimicrobial activity of ethanolic rambutan leaf extract against MRSA and S. pyogenes. The extract was prepared using maceration with 96% ethanol, followed by qualitative phytochemical screening, which confirmed the presence of flavonoids (blackish-blue reaction with FeCl3) and tannins (reddish hue with HCl). Antibacterial activity was assessed by measuring inhibition zones on agar plates and determining the minimum inhibitory concentration (MIC) through UV-vis spectrophotometry. The 100% ethanolic extract demonstrated significant inhibitory effects, with a mean inhibition zone of 14.6 mm against MRSA, outperforming the 5% (p = 0.0004) and 10% (p = 0.0402) concentrations. For S. pyogenes, the 100% extract produced the largest inhibition zone (24 mm), showing superior activity compared to the 5% (p = 0.0005) and 10% (p = 0.0485) concentrations. MIC analysis indicated optimal antimicrobial activity at both 50% and 100% concentrations for the two pathogens. These findings underscore the potential of rambutan leaf extract as a natural antimicrobial agent against resistant Gram-positive bacteria, warranting further investigation into its bioactive compounds and mechanisms of action.
Association between extramarital sexual activity, number of sexual partners, and HIV incidence among productive-age adults at H. Adam Malik general hospital, Medan Erwina, Bella Putri; Ismah, Zata
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.33191

Abstract

HIV/AIDS remains a critical global health challenge, characterized by significant morbidity and mortality. In 2022, Medan reported 1,543 HIV/AIDS cases, with the majority occurring in individuals aged 15–64 years. This study investigates the associations between extramarital sexual activity, the number of sexual partners, and the incidence of HIV among productive-age adults treated at H. Adam Malik General Hospital, Medan, Indonesia. An analytical observational case-control study was employed with 108 participants (54 cases and 54 controls). The analysis identified significant associations between extramarital sexual activities, the number of sexual partners, and HIV infection risk. These findings highlight the urgent need for strengthened global initiatives such as the "Getting to Zero" campaign, youth empowerment through NGOs, and enhanced public health education. Collaborative efforts involving the healthcare sector and government agencies are critical to improving HIV prevention strategies and reducing transmission rates.
Effect of turbinate reduction surgery on allergic rhinitis symptoms in hospitalized patients Dewa, Yusuf Kusuma; Sardjana, Andriana Tjitria Widi Wardani; Suprijono, Moch. Agus
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.35561

Abstract

Allergic rhinitis is characterized by nasal congestion, rhinorrhea, sneezing, and itching, significantly impacting patients' quality of life. Turbinate reduction surgery is a therapeutic option for allergic rhinitis refractory to pharmacological treatments. This study aimed to evaluate the effectiveness of turbinate reduction surgery in alleviating allergic rhinitis symptoms. An experimental one-group pretest-posttest design was employed, utilizing primary data collected from 19 patients diagnosed with allergic rhinitis (SFAR = 7) who underwent turbinate reduction surgery at the ENT Clinic, Sultan Agung Islamic Teaching Hospital, Semarang, from April to July 2023. Participants aged 18–55 years were included after providing informed consent. Allergic rhinitis was diagnosed using the Score for Allergic Rhinitis (SFAR), and symptom severity was assessed using the Total Nasal Symptom Score (TNSS). Results showed a significant reduction in the mean TNSS score from 7.79 ± 2.070 pre-surgery to 1.00 ± 0.745 post-surgery (p = 0.000). Scores for allergic rhinitis symptoms also decreased significantly (p < 0.05). These findings suggest that turbinate reduction surgery effectively alleviates allergic rhinitis symptoms in hospitalized patients. Future research should consider larger sample sizes, extended study periods, inclusion of comparison groups, and evaluation of potential surgical complications.
Factors affecting quality of life in patients undergoing hemodialysis in Semarang, Indonesia Lusito, Lusito; Utami, Kamilia Dwi; Yuliyanti, Suryani; Nurmalita, Ar-Rahmah; Amaliyah, Laily Rezky
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.39560

Abstract

The quality of life in patients with chronic kidney disease (CKD) reflects how well an individual's needs are met across three physical, psychological, and social dimensions. Measuring a patient's quality of life (QoL) helps evaluate the effectiveness of CKD therapies. This study compares patients' clinical conditions categorised by their quality of life while undergoing hemodialysis therapy for chronic kidney failure. This study compares the clinical conditions of CKD patients undergoing hemodialysis based on their QoL, using a cross-sectional design involving 82 patients from Sultan Agung Islamic Hospital, Semarang. QoL was assessed with the WHOQOL-BREF questionnaire, and demographic data were collected through interviews. Clinical data was sourced from electronic medical records. Logistic regression analysis identified influencing variables on QoL. The sample was predominantly female (62.2%), with most patients over 45 years old, meeting minimum education standards (61%), and 67.1% unemployed. Most identified as Muslim and married, with 98.8% reporting strong family support. While bivariate analysis showed no significant impact of demographic or clinical variables on QoL, multivariate analysis indicated a significant relationship with haemoglobin levels. While other factors like family support and knowledge contribute to well-being, further research with larger, more varied samples is needed to better understand the quality-of-life influences for CKD patients on hemodialysis.
Successful treatment of umbilical granuloma in infants using topical application of common salt: a serial case report Prihaningtyas, Rendi Aji; Ardhanariswari, Zubaity; Rini, Muji Retnaning; Faizi, Muhammad
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.35793

Abstract

An umbilical granuloma is a small, granulation tissue-filled swelling at the base of the umbilicus, commonly occurring in newborns. Various treatment options are available, including the topical application of common salt; however, its availability varies across healthcare facilities, and the most effective method remains uncertain. This serial case report describes infants presenting with umbilical masses accompanied by discharge. Physical examination revealed a flesh-like, protruding mass from the umbilicus, associated with yellowish and reddish discharge and surrounding normal skin. The granuloma was resolved entirely through the topical application of common salt. Our findings suggest that common salt is an effective, simple, and inexpensive treatment for umbilical granuloma. With regular monitoring, this approach could serve as a viable alternative to more advanced therapies.

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