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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
Published by Universitas Islam Sultan Agung
ISSN : 20851545     EISSN : 2339093X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.
Arjuna Subject : -
Articles 235 Documents
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Knowledge, religiosity, and decision to use Sharia hospital services among residents in Central Java, Indonesia Wilda, Amelia; Putri, Sabrina Mutiara; Vinalisa, Bintang Ananda Afrilianti; Salsabila, Reefa Dyah; Nafisatussalimah, Putri Sirry; Santoso, Arifin; Sulistyaningrum, Indriyati Hadi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.33510

Abstract

The increasing tendency of society to apply Sharia principles in all aspects of life today is supported by the presence of Sharia hospitals that integrate Sharia values in administration, healthcare services, and patient care standards as regulated in the fatwa of the National Sharia Council (Dewan Syariah Nasional) No. 107/DSN-MUI/X/2016. Knowledge refers to everything known by an individual that can affect behavior. Meanwhile, religiosity is an individual's level of religious commitment that reflects the extent of belief in the values and expectations of the religion they adhere to or practice; in this study, it is the Muslim community. This research aims to examine the effect of the community's knowledge about Sharia hospitals and the religiosity of the Central Java community on their decision to seek medical treatment at Sharia hospitals. The research method used in this study was analytical observational with a cross-sectional study approach. Data was collected through direct questionnaires from the Central Java community using the snowball sampling technique. The research results indicate that knowledge and religiosity, both partially and simultaneously, affect the decision of the Central Java community to choose Sharia hospitals for medical treatment, with a p-value of 0,000. Partially, it is found that knowledge has an effect of 10,2%, while religiosity has an effect of 23% on the community's decision to seek medical treatment at Sharia hospitals. The conclusion of this study suggests that knowledge and religiosity significantly impact the Central Java community's decision to opt for Sharia hospitals for medical treatment.
The effect of Lactobacillus acidophilus,Streptococcus thermophilus, and Bifidobacterium longum probiotics on bilirubin levels of neonates with hyperbilirubinemia Abbas, Pujiati; Mayangsari, Citra Primavita; Gunawan, Robby
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v14i2.34029

Abstract

Hyperbilirubinemia, a common illness in newborns that can lead to hospital readmission, has been treated with blue light phototherapy. This treatment, either on its own or in combination with probiotics, has shown fast and significant decreases in bilirubin levels in the blood, helping to speed up the fading of jaundice. This study aims to examine the effects of combining phototherapy with probiotics containing Lactobacillus acidophilus, Streptococcus thermophilus, and Bifidobacterium longum on newborns with hyperbilirubinemia. The study was conducted at Sultan Agung Islamic Hospital (RSI Sultan Agung), Semarang, using a randomized controlled trial design. It included newborns who were hospitalized between August and November 2022. The control group was administered phototherapy, whereas the treatment group received both phototherapy and probiotics for 7 days. SPSS software analysis demonstrated a statistically significant reduction in average levels of total and indirect bilirubin in the intervention group (6.50 mg/dl and 7.20 mg/dl) compared to the control group (6.70 mg/dl and 7.48 mg/dl). These findings highlight the potential effectiveness of the combined approach in controlling hyperbilirubinemia. The study proposes using probiotics as a safe additional treatment for neonatal hyperbilirubinemia, showing that it is well-tolerated and safe for the participants. Although the combination of probiotics and phototherapy did not show a significant difference compared to phototherapy alone, it did result in a faster average decrease in hyperbilirubinemia. This could reduce the necessity for hospital readmissions to manage this condition. The findings underscore the potential of probiotics as a helpful supplement to established treatment methods for newborn hyperbilirubinemia.
Ovarian cyst mimicking acute appendicitis in children: a case report Noor, Hafni Zuchra; Wahyuni, Alfaina; Retnowati, Sulistiari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.31564

Abstract

Pediatric acute appendicitis is common; however, it is different from torsion ovarian cysts. The estimated incidence of ovarian torsion in children is 5 per 100,000 girls. Herein, we report two cases of ovarian torsion mimicking pediatric acute appendicitis mimicking ovarian cyst. In the first case, a girl who was being assessed for acute appendicitis was identified to have torsion of the ovarian cyst during the surgery. In the second case, a girl experienced a ruptured ovarian cyst but then got severe appendicitis following the surgical procedure. The simultaneous occurrence of appendicitis and ovarian cysts is rare. These two patients' acute gastrointestinal complaints and symptoms exhibit similarities and may coincide. Both patients underwent salpingo-oopherectomy and appendectomy. Both patients were healthy on hospital discharge in a healthy condition. Female patients with severe abdominal pain and amenorrhea should be evaluated for ovarian torsion. Diagnosing the condition may be challenging due to non-specific clinical signs.
Multiple intrathoracic thrombosis detected on ct scan in patient with antiphospholipid antibody syndrome: case report Safarini, Bekti; Intisari, Dewi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v14i2.1663

Abstract

Antiphospholipid antibody syndrome (APS) is the clinical correlation between antiphospholipid antibodies and hypercoagulability syndrome. The prevalence of APS in the general population is undetermined. APS disease carries a notable risk of vascular thrombosis. CT scan is the preferred imaging method for assessing thrombosis, although the timing of image acquisition should be considered. The case report detailed the discovery of many intrathoracic thromboses on a CT scan of a patient diagnosed with the uncommon condition APS. Case study: A 34-year-old woman was hospitalized due to dyspnea, cough, and a 3 kg weight loss over a three-month period. She has a background in Deep Vein Thrombosis (DVT). The test results showed abnormalities in protein C, protein S, and high D-dimer levels. The CT scan revealed numerous intrathoracic thrombi. Antiphospholipid syndrome (APS) is an immunological condition that elevates the likelihood of blood clot formation, resulting in thrombosis inside the arteries and veins. The approximate occurrence rate of APS is five occurrences per 100,000 individuals annually. Antiphospholipid syndrome (APS) leads to the formation of blood clots in the legs, a condition referred to as deep vein thrombosis (DVT). This patient had a history of deep vein thrombosis (DVT) and many blood clots within the chest cavity. A CT scan revealed persistent blood clots in the main pulmonary artery and the right and left pulmonary arteries. Antiphospholipid syndrome (APS) can lead to the formation of blood clots in both arteries and veins. CT scan is the preferred method for evaluating thrombosis, and numerous phases are required to examine all blood arteries.
Surveillance of pathogenic Leptospira among rodents and small mammals in enzootic areas of plague in Pasuruan Indonesia Febriani, Siti Amanah; Dhanti, Kurnia Ritma; Kurniawan, Kurniawan; Ristiyanto, Ristiyanto; Junaedi, Arief; Sukowati, Caecilia Hapsari Ceriapuri; Handayani, Farida Dwi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.37499

Abstract

Leptospirosis is a globally significant yet often overlooked zoonotic infection. Several regions in Indonesia are endemic for leptospirosis, including East Java. Pasuruan a region located in the East Java province of Indonesia, has been recognized as an enzootic area of plague infection. However, the presence of other rodent-borne diseases has not been reported. This study aims to detect the presence of pathogenic Leptospira in rats and small mammals in the enzootic plague area of Pasuruan in Indonesia. This study belongs to the type of observational analytic research with a cross-sectional study design. Simple random sampling was conducted to trap a total of 119 forms 107 rats and 12 small mammal kidneys were analyzed molecularly (PCR) to detect Leptospira bacteria with the LipL32 gene as the target. The study revealed that 7.6% (9/119) of rats in the enzootic areas of plague (Sedaeng, Tosari, Surorowo, Petren, Pakis Bincil, Kutukan) were found to carry Leptospira DNA, indicating a significant difference between infection rates per region (p < 0.0001).  Rattus tanezumi was identified as the Leptospirosis reservoir in settlements habitats with a percentage of 13.2%, Rattus tiomanicus was detected at 28.6% in forest habitats, and Rattus exulans was found at 4.4% in both habitats. The findings in our study, it is crucial for the community to increase awareness of the spread of rodent-borne diseases, including Leptospirosis.
Detection of human bocavirus (HBoV) in children with acute respiratory infection (ARI) during the covid-19 transition period Purnomosidi, Muhammad Abhi; Sjatha, Fithriyah; Yasmon, Andi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v14i2.36623

Abstract

Acute respiratory infections (ARIs) are the highest cause of death in children in the world. Based on the 2018 Riset Kesehatan Dasar Nasional, ARI cases in Indonesia showed a prevalence of 4.4%, with the highest cases occurring in children. One of the new viruses first identified in 2005 in human nasopharyngeal samples is the human bocavirus (HBoV). HBoV is a single-strand DNA virus belonging to the Parvoviridae family. This study aimed to assess the prevalence of HBoV in children presenting with ARI during the transitional period of the Covid-19 era. HBoV detection was conducted using multiplex PCR and reverse hybridization methods on nasopharyngeal and oropharyngeal swab samples collected from symptomatic children. This study reported a prevalence rate of 4.94% for HBoV in 2022 and 5.04% in 2023. Furthermore, the study identified favorable detection rates for HBoV in children with ARIs as 14.81% in 2022 and 8.45% in 2023. These rates ranked 2nd and 5th highest among other pathogens detected in ARIs. Additionally, there was an increase in positive HBoV samples from 4 samples in 2022 to 6 samples in 2023, which was attributed to the relaxation of nonpharmaceutical Covid-19 interventions by mid-2022. HBoV was identified at a significant rate among children with ARI in Jakarta during the transitional phase of the Covid-19 era (2022-2023). Given its potential to induce severe ARI, HBoV necessitates heightened attention as an etiological agent.
Traditional herbal medicine for hyperuricemia: A review of randomized clinical trials Darmanto, Arief Gunawan; Pribadi, Florence; Sucahyo, Yoselyn; Wiraputri, Arini; Mardhika, Della; Tambuang, Christ; Setiawan, Adinda; Habibah, Ummu; Luke, Kevin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v14i2.23678

Abstract

In the last decades, traditional herbal medicine for gout has been rapidly advanced. Numerous herbs have been identified for their hypouricidal effect. This review aims to explain the potential and mechanisms of traditional herbal medicine in reducing serum uric acid (sUA). This review included five RCTs and four traditional herbal medicine formulas from a previous systematic review. Articles published in non-English language were excluded for further analysis. Despite limited RCTs design, the formula of Chuanhu; Tufu, and ZinutriK® were beneficial for hyperuricemic individuals. While Yellow-dragon Wonderful-seed mixture showed limited hypouricemic feature. Based on these findings, traditional herbal medicine holds promising potential in treating hyperuricemia and gout. However, further studies are required.
Effect of Nigella sativa extract on nasal mucosal inflammation in rats exposed to cigarette smoke Alamanda, Fathika; Dewi, Anna Mailasari Kusuma; Marliyawati, Dwi; Santosa, Yanuar Iman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.22833

Abstract

Cigarette smoke contains toxic compounds that can initiate an inflammatory reaction and infiltrate inflammatory cells. The nasal mucosa is the initial part of the respiratory system that comes into contact with irritating chemicals such as cigarettes. Prior studies indicated that Nigella sativa extract (NS) has thymoquinone, a bioactive compound with anti-inflammatory properties. Our study aims to determine the effect of different doses of NS on inflammation of the nasal mucosa in Wistar rats exposed to cigarette smoke. The study employed an experimental post-test-only control group design. Twenty-five Wistar rats were randomly assigned to one of the five groups: negative control (K-), positive control (K+), and three treatment groups of P1, P2, and P3 receiving NS at the dose of 0.5, 1, and 1.5 g/kg bw/day, respectively. All treatment groups and the positive control group were exposed to smoke from 4 cigarettes/day for 28 days. The degree of inflammatory cell infiltration was evaluated using a histological scoring : 0 if normal; 1 if infiltration was less than 1/3; 2 if infiltration was between 1/2 and 2/3, 3 if infiltration of more than 2/3 indicating normal, less than 1/3, 1/3 to 2/3, and more than 2/3, respectively. The degree of inflammatory cell infiltration in group: K(-): 1.00 ±0.00, K(+): 1.00±0.00, P1: 1.00±0.00, P2: 1.00±0.37, and P3: 1.00±0.33. The Kruskal-Wallis test showed a p-value of 0.001, indicating a significant difference. The Mann-Whitney test revealed significant differences between the K+ and P2 groups (p=0.032), K+ and P3 groups (p=0.013), and P1 and P3 groups (p=0.049). In conclusion, NS can decrease the presence of inflammatory cells in the nasal mucosa in Wistar rats exposed to cigarette smoke.
Characteristics of body mass index and sodium intake of adults with hypertension family history in Yogyakarta Setyawati, Ika
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v14i2.32106

Abstract

Hypertension is a progression of prehypertension due to the accumulation of several non-genetic risk factors (environmental factors) that occur together (common underlying risk factors) or genetic factors or the interaction between the two. Risk factors for hypertension that can be controlled include high sodium intake, lack of physical activity, obesity, smoking, and alcohol consumption, while risk factors that cannot be controlled include increasing age, gender, and a family or genetic history of hypertension. This study aimed to determine the characteristics of Body Mass Index (BMI) and sodium intake in adults with a family history of hypertension in Yogyakarta. This study used a case-control design. Subjects studied were healthy individuals with a family history of hypertension as case subjects (n = 42), and control subjects were individuals without a family history of hypertension (n = 41). Body mass index (BMI) was measured with anthropometry, and sodium intake was measured using a quantitative food frequency questionnaire. Independent Sample T-test and Chi-Square test analyzed the data with a significance level of p < 0.05. The average BMI and sodium intake are higher in the case group than in the control group. There was no significant association between BMI and sodium intake and risk factors of hypertension (p>0.05). Body mass index and sodium intake in the case and control group were not significant differences (p>0.05). The BMI values and sodium intake levels were higher in the group of individuals with a family history of hypertension compared to those without a family history of hypertension, but not statistically significant.
Validation of sputum gram stain and culture for diagnosis of pneumonia in critically iii patient: a retrospective observational study Rahayu, Rahayu; Masfiyah, Masfiyah; Intisari, Dewi; Putri, Indri Hapsari; Hibatullah, M. Adam
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v14i2.32809

Abstract

Validation of culture results based on direct gram stain plays a vital role in differentiating pathogens' cause of infection or colonization in pneumonia cases. Our study aims to evaluate the validation of diagnostic microbiology based on gram stain and culture compared to chest radiography in critically ill patients with suspected pneumonia. This was a single-center retrospective data analysis in the Intensive Care Unit at Secondary Care Hospital in Central Java. The quality of sputum was determined by using a Modification Criteria of Bartlett and a Semi-Quantitative Score. The results of sputum culture with neutrophils count > 10 and bacterial count > 2 per field in Gram stain were considered the presumptive pathogen. Seventy sputum specimens were collected; however, only 58 were selected for further analysis in this study. In sputum specimens with Bartlett score +2 and Semi-Quantitave score 3 or 4, the chest x-ray results of all patients had positive infiltrates (100%). Diagnostics accuracy of the results of clinical microbiologist examination with chest X-ray had a sensitivity of 90%, specificity of 60.71 %, accuracy of 65.5%, a positive predictive value of 61.36%, a negative predictive value of 78.6%. It was concluded that validation of diagnostic microbiology based on gram stain and culture had susceptible and adequately specific results to differentiate between presumptive pathogens from colonization in pneumonia cases.

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