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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 314 Documents
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INTERAKSI HORMON DAN EPILEPSI Ahmad Sulaiman Alwahdy; Astri Budikayanti; Fitri Octaviana; Donny Hamid
NEURONA Vol 37 No 2 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i2.115

Abstract

HORMONE AND EPILEPSY INTERACTIONABSTRACTHormones are signaling chemical molecules between cells that circulated in blood within the human body and play important roles for human being. Unfortunately, not all their functions are known, especially in epilepsy. Studies reported interactions between hormones and epilepsy, also with antiepileptic drugs (AEDs). For example, seizures may be induced by estrogen, whileAEDs can decrease hormone level by inducing enzyme in P450 cytochrome and accelerating hormone clearance.These conditions are known as tridirectional interactions. Understanding the interactions between hormones, epilepsy and AEDs would raise an awareness and insight for clinicians especially neurologist for basic knowledges as considerations in treating patients with epilepsy.Keyword: Antiepileptic drugs, epilepsy, hormone, seizureABSTRAKHormon merupakan molekul pembawa pesan kimiawi antar sel yang berada dalam tubuh manusia, beredar di dalam darah dan sangat penting bagi kehidupan manusia. Perannya pada epilepsi belum seluruhnya diketahui, akan tetapi berbagai penelitian yang ada menunjukan adanya interaksi antara hormon dan epilepsi begitu juga terhadap obat antiepilepsi (OAE). Sebagai contoh, bangkitan epilepsi dapat dicetuskan oleh estrogen, namun beberapa OAE yang merupakan penginduksi enzim sitokrom P450 di hati, dapat menurunkan kadar hormon di dalam tubuh dan juga mempercepat pembersihan hormon terutama hormon steroid seks. Hubungan ketiga faktor ini menciptakan hubungan yang disebut hubungan tridireksional. Dengan memahami mengenai interaksi yang terjadi antara hormon, epilepsi dan OAE, diharapkan dapat membuka wawasan bagi neurologis untuk memiliki pengetahuan dasar sebagai pertimbangan dalam tata laksana pasien epilepsi.Kata kunci: Bangkitan,epilepsi, hormon, obat antiepilepsi
STROKE ISKEMIK DENGAN MANIFESTASI DIZZINESS/VERTIGO TERISOLASI Diyan Anita Sari; Sri Sutarni; Ismail Setyopranoto
NEURONA Vol 37 No 2 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i2.116

Abstract

ISCHEMIC STROKE PRESENTS WITH ISOLATED DIZZINESS/VERTIGOABSTRACTDizziness/vertigo, unstable walking or loss of balance are symptoms in about 50% of stroke cases. However, only about 20% are accompanied by focal neurological signs. In the last decade, there is increasing evidence that vertigo can be the only ischemic symptom of posterior circulation stroke without a focal sign. The purpose of this systematic review is to examine the literature on ischemic stroke with the manifestation of isolated dizziness/vertigo. The literature search is done through several electronic database (Pubmed, Ebscohost, and Proquest) from 2000 to 2017 using keywords; isolated vertigo, isolated dizziness, ischemic stroke, vertebrobasilar, posterior stroke, magnetic resonance imaging (MRI). Six articles were obtained that meet the criteria. Approximately 9-10% of patients with isolated dizziness/vertigo who had a history of vascular risk factors, found to have infarct lesions from MRI diffusion weighted  imaging (DWI) examination. In this case, the territory of posterior inferior cerebellar artery (PICA) is most often involved. Acute ischemic stroke can not be excluded only on the basis of negative DWI examination results. Head impulse, nystagmus, and test of skew (HINTS) plus examination may identify acute vestibular syndrome with a central cause with better accuracy than MRI DWI at the onset of symptom.Keywords: Acute vestibular syndrome, ischemic stroke, isolated dizziness, isolated vertigo, posterior circulation strokeABSTRAKDizziness/vertigo, berjalan tidak stabil atau kehilangan keseimbangan merupakan gejala pada sekitar 50% kasus stroke. Namun, hanya sekitar 20% disertai tanda neurologis fokal. Pada dekade terakhir, semakin banyak bukti bahwa vertigo dapat sebagai satu-satunya gejala iskemik sirkulasi posterior tanpa tanda fokal. Tujuan penulisan tinjauan sistematik ini adalah untuk mengkaji literatur tentang stroke iskemik dengan manifestasi hanya dizziness/vertigo terisolasi. Pencarian literatur dilakukan melalui database elektronik (Pubmed, Ebscohost, dan Proquest) dari tahun 2000 hingga 2017 dengan kata kunci; isolated vertigo, isolated dizziness, ischemic stroke, vertebrobasilar, posterior stroke, magnetic resonance imaging (MRI). Didapatkan 6 artikel yang memenuhi kriteria. Sebanyak 9-10% dari pasien dengan dizziness/vertigo terisolasi yang memiliki riwayat faktor risiko vaskular, ditemukan lesi infark dari pemeriksaan MRI diffusion weighted  imaging (DWI). Dalam hal ini, teritori posterior inferior cerebellar artery (PICA) yang paling sering terlibat. Stroke iskemik akut tidak dapat disingkirkan hanya berdasar hasil pemeriksaan DWI negatif. Pemeriksaan head impulse, nystagmus, and test of skew (HINTS) plus dapat mengidentifikasi sindrom vestibular akut dengan penyebab sentral dengan akurasi yang lebih baik dibanding MRI DWI di awal onset gejala.Kata kunci: Dizziness terisolasi, sindrom vestibular akut, stroke iskemik, stroke sirkulasi posterior, vertigo terisolasi
HEMICHOREA/HEMIBALISMUS DENGAN HIPERGLIKEMIA NONKETOTIK PADA STROKE ISKEMIK AKUT Safridawat Safridawat; Hidayaturrahmi Hidayaturrahmi; Natasya Wanda; Nova Dian Lestari; Syahrul Syahrul
NEURONA Vol 37 No 2 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i2.117

Abstract

HEMICHOREA/HEMIBALLISM ASSOCIATED WITH NONKETOTIC HYPERGLYCEMIC ON ACUTE ISCHEMIC STROKEABSTRACTHemichorea/hemiballism (HCHB) associated with nonketotic hyperglycemia in acute ischemic stroke is a well-recognized syndrome characterized by the sudden occurrence of hemichorea or more severe expression like hemiballism. The hyperkinetic movements involve the face, arm, or leg. HCHB in acute ischemic stroke is a movement disorder that is rarely reported with hyperkinetic movement. This case report aimed to describe patient with HCHB associated with hyperglycemia as prior sign of stroke ischemic and propose a possible pathophysiology. We report three patients who had HCHB accompanied by hemiparesis, facial and hypoglossus nerve palsy. Laboratory results showed increased serum glucose levels and negative urine ketones. Imaging findings of head CT scan found an infarction in the basal ganglia. Patients are treated with antiplatelet and or anticoagulant therapy and correction of hyperglycemia with additional therapy of dopamine receptor antagonistThe combination of a recent or old striatal lesion and hyperglycemia induce HCHB, causing increased inhibition of the subthalamic nucleus and causing decreased GABAergic inhibition of the thalamus. Diabetes mellitus should always be suspected in patients who develop HCHB movements. When hyperglycemia is detected and treated, movement disorders resolve within a few days and the administration of dopamine receptor antagonists can be considered.Keywords: Hemiballism, hemichorea, hyperglycemia, ischemic strokeABSTRAKHemichorea/hemibalismus (HCHB) yang  berhubungan  dengan  hiperglikemia nonketotik pada stroke iskemik akut adalah sindrom yang ditandai oleh munculnya  hemichorea yang terjadi secara tiba-tiba atau disertai dengan gejala yang lebih berat, seperti   hemibalismus. Pergerakan hiperkinetik meliputi wajah, lengan dan tungkai. HCHB pada stroke iskemik akut merupakan gangguan pergerakan hiperkinetik yang jarang dilaporkan. Laporan kasus ini bertujuan untuk menggambarkan pasien yang mengalami keluhan HCHB sebagai gejala awal terjadinya stroke iskemik disertai dengan hiperglikemia dan memperkirakan  penjelasan patofisiologi yang mungkin terjadi pada pasien ini. Kami melaporkan tiga pasien dengan keluhan HCHB sebagai gejala awal stroke iskemik akut yang disertai hiperglikemia. Pada ketiga kasus tersebut keluhan disertai dengan paresis nervus fasialis, hipoglossus serta hemiparesis ekstremitas kontralateral lesi. Kadar glukosa serum meningkat dan keton urin negatif. Gambaran CT scan menunjukkan adanya infark di ganglia basalis. Pada tata laksana kami menemukan bahwa koreksi hiperglikemi disertai pemberian terapi antikoagulan dan atau antiplatelet serta agen neuroleptik dapat menyebabkan perbaikan luaran pada gejala HCHB secara perlahan. Kombinasi lesi striatal baru dan hiperglikemia dapat menginduksi terjadinya HCHB karena kedua hal tersebut dapat menyebabkan peningkatan inhibisi inti subtalamik dan gangguan  inhibisi GABAergic talamus. Diabetes melitus harus selalu dicurigai pada pasien dengan keluhan HCHB. Ketika hiperglikemia terdeteksi dan ditatalaksana, gangguan  gerakan menghilang dalam beberapa hari dan dapat dipertimbangkan dengan pemberian terapi neuroleptik.Kata kunci: Hemibalismus, hemichorea, hiperglikemia, stroke iskemik
PENYAKIT CHARCOT MARIE TOOTH ONSET LANJUT Kenny Merryn; Jimmi Sabirin; Octaviani Octaviani
NEURONA Vol 37 No 2 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i2.118

Abstract

LATE ONSET CHARCOT MARIE TOOTH DISEASEABSTRACTCharcot Marie Tooth’s disease (CMT) is a hereditary sensoric motoric polineuropathy. Late onset CMT are rare reported in Indonesia. A woman 48 years old has numbness in her both arm and leg gradually since 5 years ago, followed by deformities and weakness. Her cousin has the same disease. In physical examination, there were flaccid type tetraparesis, socks and gloves hypesthesia, steppage gait, pes cavus, hammer toes, thenar, hypothenar, and extensor hallucis longus muscle atrophy bilaterally. Electrophysiology studies showed mixed sensoric and motoric polineuropathy with symetrically demyelinating and uniform slowing. Management were ascorbic acid, neurotrophic, physiotherapy, and occupational therapy.Keywords: Charcot Marie Tooth, hammer toes, pes cavus, steppage gaitABSTRAKPenyakitCharcot Marie Tooth (CMT) merupakan polineuropati motorik dan sensorik herediter. Kasus CMT onset lanjut di Indonesia masih sangat jarang dilaporkan. Seorang wanita 48 tahun mengalami kesemutan pada kedua lengan dan tungkai sejak 5 tahun secara perlahan diikuti perubahan bentuk tangan dan kaki serta kelemahan. Riwayat sepupu mengalami keluhan serupa. Pemeriksaan fisik didapatkan kelemahan kedua lengan dan tungkai tipe flaksid, hipestesi pola sarung tangan dan kaos kaki, steppage gait, pes cavus, hammer toes, atrofi otot tenar, hipotenar, dan ekstensor halusis longus bilateral. Pemeriksaan elektrofisiologi didapatkan polineuropati motorik sensorik dengan demielinisasi simetris dan perlambatan kecepatan konduksi seragam. Tata laksana pasien ini menggunakan asam askorbat, neurotropik, fisioterapi, dan terapi okupasi.Kata kunci: Charcot Marie Tooth, hammer toes, pes cavus, steppage gait
KADAR SUBSTANSI P SERUM TINGGI SEBAGAI FAKTOR RISIKO CHRONIC TENSION TYPE HEADACHE PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA Daniel Siagian; Made Oka Adnyana; Putu Eka Widyadharma
NEURONA Vol 37 No 2 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i2.119

Abstract

HIGH SUBSTANCE P SERUM LEVELS AS RISK FACTOR FOR CHRONIC TENSION TYPE HEADACHE AMONG MEDICAL STUDENT FACULTY OF MEDICINE UDAYANA UNIVERSITYABSTRACTIntroduction: Several studies revealed that serum substance P (SP) levels increase in people with headache, particularly chronic tension-type headache (CTTH). One of the examples of population at risk of CTTH is medical students because of their stressful academic load. Aim: To determine whether high serumSP levels are the risk factors of CTTH among medical students.Methods: A case-control study was conducted to medical students, aged 19 to 21, of the Faculty of Medicine, Udayana University from December 2018 to January 2019. Subjects were classified into case group (with CTTH) and control group (without CTTH). SP serum levels were measured on both groups. Analyses included univariate, bivariate with Fisher's test to calculate relative risk (RR), and multivariate logistic regression analysis.Results: Sixty-two subjects, predominantly female (51.6%), were involved in this study. In the case group, most of the subjects had mild depression (71%), mild stress (93.5%), pericranial tenderness (61,3%), and elevated SP serum levels (83.9%). From the multivariate analysis, a high level of SP serum (≥ 349,06ng/L) was the risk factor of CTTH (adjusted Odds ratio 9.9; 95% CI 1.06-93.16). Besides that, other factors, for example, mild stress, mild anxiety, mild depression, pericranial tenderness, and sleep disturbances, were related to the prevalence of CTTH(p=0.001).Discussion: This study concluded that high serum SP levels significantly increased the risk of CTTH occurrence among medical students.Keywords: Chronic tension-type headache (CTTH), medical student, SP serum levelsABSTRAKPendahuluan: Beberapa penelitian menunjukkan kadar substasi P (SP) serum meningkat pada penderita chronic tension type headache (CTTH). Salah satu populasi yang rentan mengalami CTTH adalah mahasiswa kedokteran karena beban akademik relatif tinggi yang diduga berkaitan dengan stres psikologis.Tujuan: Mengetahui apakah kadar SP serum merupakan salah satu faktor risiko CTTH pada mahasiwa kedokteran.Metode: Studi kasus kontrol dilakukan terhadap mahasiswa Fakultas Kedokteran Universitas Udayana berusia 19-21 tahun pada bulan Desember 2018 hingga Januari 2019. Subjek dikelompokkan ke dalam kelompok kasus (dengan CTTH) dan kontrol (tanpa CTTH), kemudian seluruhnya diperiksakan kadar SP serum. Analisis data dilakukan secara univariat, bivariat dengan uji Fisher untuk menghitung risiko relatif (RR), dan analisis regresi logistik multivariat.Hasil: Sebanyak 62 subjek yang mayoritas perempuan (51,6%) ikut serta dalam studi ini. Pada Pada kelompok kasus, sebagian besar mengalami depresi ringan (71%), stres ringan (93,5%), nyeri tekan perikranial (61,3%), dan memiliki kadar SP serum yang tinggi (83,9%). Berdasarkan analisis multivariat, kadar SP serum tinggi (≥ 349,06ng/L) merupakan faktor risiko CTTH (adjusted rasio Odds 9,9; IK 95% 1,06-93,16). Selain itu, faktor depresi ringan, stres ringan, ansietas ringan, nyeri tekan perikranial, dan gangguan tidur masing-masing berhubungan dengan kejadian CTTH (p=0,001).Diskusi: Kadar SP serum tinggi merupakan faktor risiko terjadinya CTTH pada populasi mahasiswa kedokteran.Kata kunci: Chronic tension type headache (CTTH), mahasiswa kedokteran, substansi P
EFEKTIVITAS DONEPEZIL TERHADAP FUNGSI KOGNITIF PASIEN TUMOR INTRAKRANIAL PASCAOPERASI Yusril Harun; Yunni Diansari; Selly Marisdina; Yuli Felistia
NEURONA Vol 37 No 2 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i2.120

Abstract

EFFECTIVITY OF DONEPEZIL IN COGNITIVE FUNCTION OFPOSTOPERATIVE INTRACRANIAL TUMOUR PATIENTSABSTRACTIntroduction: There is still a lack of effective therapy in improving cognitive dysfunction in intracranial tumour patients after surgery. Donepezil is an acetylcholinesterase inhibitor that has been a therapy of Alzheimer's disease and has a significant effect on improving cognitive function.Aim: To determine the effectiveness of donepezil on cognitive function in patients with postoperative intracranial tumours.Methods: A clinical, randomized, double-blind study was conducted on postoperative intracranial tumour patients categorized into two groups (donepezil and placebo). The intervention was donepezil 5mg once a day for three months. For assessment of cognitive function, Mini-Mental State Examination (MMSE) and Indonesian Version of Montreal Cognitive Assessment (MoCA-Ina) was checked at weeks 0 (baseline), 4 (end of the first month), 8 (end of the second month), and 12 (end of the third month). Data were analyzed using SPSS 22.Results: Twenty patients, equally distributed in two groups, were included in the study. Compared to baseline, MMSE and MoCA-Ina scores in the donepezil group increased significantly on the second and third month (p<0.001). There was a remarkable difference in cognitive function between two groups on the third month based on MMSE and MoCA-Ina scores (p=0.027 and 0.024, respectively). At post-intervention, orientation and recalldomain in MMSE showed marked improvement, while visuospatial and delayed recall domain experienced as well in MoCA-Ina. There were no significant side effects of donepezil.Discussion: This results can be considered for administration of donepezil in patients with intracranial tumours after surgery with impaired cognitive function.Keywords: Cognitive function, donepezil, intracranial tumour, MMSE, MoCA-Ina, surgeryABSTRAKPendahuluan: Saat ini belum ada terapi yang efektif dalam memperbaiki gangguan fungsi kognitif pada pasien tumor intrakranial pascaoperasi. Donepezil merupakan inhibitor asetilkolinesterase yang telah menjadi terapi dari penyakit Alzheimer dan memiliki efek yang bermakna dalam memperbaiki fungsi kognitif.Tujuan: Mengetahui efektivitas donepezil terhadap fungsi kognitif pasien tumor intrakranial pascaoperasi.Metode: Studi uji klinis, acak, tersamar ganda dilakukan pada pasien tumor intrakranial pascaoperasi dengan gangguan kognitif yang terbagi dalam dua kelompok (donepezil dan plasebo). Intervensi yang dilakukan berupa pemberian donepezil 5mg satu kali sehari selama 3 bulan. Evaluasi fungsi kognitif menggunakan Mini Mental State Examination (MMSE) dan Montreal Cognitive Assessment Versi Indonesia (MoCA-Ina) pada minggu 0 (awal), 4 (akhir bulan ke-1), 8 (akhir bulan ke-2), dan 12 (akhir bulan ke-2). Data dianalisis menggunakan perangkat SPSS 22.Hasil: Sebanyak 20 subjek yang terbagi sama pada dua kelompok diikutsertakan pada penelitian ini. Dibandingkan dengan kondisi awal, nilai MMSE dan MoCA-Ina pada kelompok donepezil meningkat secara signifikan pada bulan ke-2 dan ke-3 (p<0,001). Terdapat perbedaan bermakna fungsi kognitif antara kelompok terapi dengan placebo pada bulan ke-3 berdasarkan nilai MMSE (p=0,027) dan MoCA-Ina (p=0,024). Domain pada MMSE yang mengalami perbaikan bermakna setelah terapi donepezil adalah orientasi dan recall, sedangkan pada MoCA-Ina adalah domain visuospasial dan delayed recall. Tidak didapatkan efek samping donepezil yang bermakna.Diskusi: Hasil penelitian ini dapat menjadi pertimbangan dalam pemberian donepezil pada pasien dengan tumor intrakranial pascaoperasi yang memiliki gangguan fungsi kognitif.Kata kunci: Donepezil, fungsi kognitif, MMSE, MoCA-Ina, operasi, tumor intrakranial
PENGETAHUAN PESERTA PROGRAM PENDIDIKAN DOKTER SPESIALIS NEUROLOGI INDONESIA TENTANG SEMIOLOGI BANGKITAN EPILEPSI Suryani Gunadharma; Yovita Stevina; Anam Ong; Siti Aminah; Lisda Amalia; Uni Gamayani
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.159

Abstract

Introduction: Seizure semiology is an effective method for syndrome diagnosis, especially when electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) cannot provide sufficient information. Diagnosis of clinical epilepsy based on semiology required a comprehensive knowledge especially for neurology residentsandidate of neurology specialist. Aim: To assess the knowledge of Indonesian neurology resident about seizure semiology. Methods: This observational descriptive study was conducted from 4 choosen university in Indonesia from February to September 2019. Participants were neurology residents from 1st semester to 8th semester. Participants were asked to fill in that quetionnaire consist of 6 questions about the teaching of seizure semiology in their university. Five ictal videos were presented to be analyzed for semiology, lateralization, and localization. These videos were chosen by 3 epilepsy consultants from different universities. Results: The participants consist of 135 residents, 16 in the 1st semester, 21 in the 2nd, 18 in the 3rd, 14 in the 4th, 14 in the 5th, 15 in the 6th, 19 in the 7th, 18 in the 8th semester. Video semiology were already lectured from the 3rd semester in 66.7%-83%. Only 30.3% of semiology features from 5 videos can be recognized by the participants, semiology knowledge was improved from 2nd semester. An average of 55.6% participants could answer lateralization and 52% localization. Discussion: Neurology resident knowledge about seizure semiology is still insufficient, improvement and uniformity in teaching methodology of semiology is needed. Keywords: Indonesian neurology resident, knowledge, seizure semiology
PREVALENSI NYERI NEUROPATIK PADA PASIEN DENGAN NYERI KANKER DI RSUPN DR CIPTO MANGUNKUSUMO DAN PKN RS DHARMAIS Henry Riyanto Sofyan; Tiara Aninditha; Louis Kwandou; Jonathan Odilo; Rini Andriani
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.160

Abstract

Introduction: Cancer pain is one of the most common complications in cancer. As much as 30-50% of cancer patients experienced pain. Cancer pain patients have reported complaints of pain with a neuropathic component. Early diagnosis of neuropathic cancer pain has a clinical implication for patient management. However, the proportion of neuropathic cancer pain has not been studied in Indonesian population. Aim: The study was to get an overview of neuropathic pain prevalence among cancer pain patients in Cipto Mangunkusumo General Hospital and National Cancer Referral Dharmais Hospital. Methods: The design of this research was cross-sectional. The study was done in Cipto Mangunkusumo General Hospital and National Cancer Referral Dharmais Hospital in July-September 2019. The subjects in this research were adult cancer patients who consulted with the Department of Neurology. The data acquired were patient’s demography, cancer history, imaging, and pain assessment. PainDETECT questionnaire was employed to assess neuropathic pain. The data were processed and presented descriptively and analytically. Results: There were 57 subjects obtained in this research with average age of 45.91. As much as 31.6% subjects had neuropathic cancer pain. Breast cancer identified in 38.6% subjects. There were no differences of gender, age, cancer type, and pain intensity between subjects with and without neuropathic cancer pain. Radiating pain and subject with metastasis experienced neuropathic cancer pain more frequently. Discussion: The prevalence of neuropathic cancer pain in the Indonesian population is 31.6%. Radiating pain and patients with metastasis cancer tend to experienced neuropathic pain more frequently. Keywords: Cancer, Indonesia, neuropathic pain, prevalence
PASCAOPERASI ADENOMA HIPOFISIS: HUBUNGAN ANTARA DURASI AWITAN DENGAN LUARAN KLINIS VISUS DAN LAPANG PANDANG Renindra Ananda Aman; Reki Setiawan; Retno Asti Werdhani; Samsul Ashari; David Tandian; Syaiful Ichwan; Affan Priyambodo; Setyo Widi Nugroho
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.161

Abstract

Introduction: Pituitary adenomas can cause decrease of visual acuity (VA), narrowing visual field (VF). Several studies have showed that the duration of complaints were related significantly with clinical outcomes. As a national referral center hospital, all pituitary adenoma patients who came to our institution were referred from ophthalmologists, neurologists, and neurosurgeons from other institutions. Aim: In this study, we investigated the relationship between duration, which is calculated from the time of symptoms first appeared to the time of surgery, and outcome (VA and VF) in pituitary adenoma patients who underwent transsphenoidal surgery. Methods: A retrospective design was used on pituitary adenoma patients that underwent transsphenoidal surgery between 2015-2017 in Cipto Mangunkusumo Hospital. The duration between symptoms’ onset and surgery was calculated in months. VA and VF examinations were performed 1 day before surgery and within 1 to 2 months postoperatively. Results: There were 71 patients (36 male, 35 female) with decreased VA and narrowed VF, with a median age of 42 years (20-77 years). The median length of duration of onset for both symptoms was 12 months (1-108 months). 40.5% patients had improved VA postoperatively, with median duration of onset of 11 months. Improvement in VF was experienced in 67.6% patients, with median duration of onset of 12 months. Discussion: There was a statistically significant relationship between the duration of onset and the VF outcomes. Improvements in the VF were found in patients who underwent surgery up to 12 months after the time of onset. Keywords: Pituitary adenoma, transsphenoidal surgery, visual acuity, visual field
HUBUNGAN KADAR MAGNESIUM DENGAN VOLUME HEMATOMA DAN DERAJAT KLINIS PASIEN PERDARAHAN INTRASEREBRAL Bhetaria Santoso; Amiruddin Aliah; Susi Aulina
NEURONA Vol 37 No 3 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.162

Abstract

Introduction: High serum magnesium levels at hospital admission are associated with a small volume of incoming hematoma with a lower National Institutes of Health Stroke Scale (NIHSS) score. Aim: To assess the correlation between the serum magnesium levels, the hematoma volume, and the clinical degree in patients with acute supratentorial intracerebral hemorrhagic stroke. Methods: The study used a cross-sectional design of acute supratentorial intracerebral hemorrhagic stroke patients whose the levels of serum magnesium and clinical stroke degrees were examined using the NIHSS from January 2018 through April 2019 at Wahidin Sudirohusodo Hospital, Makassar. Results: There were 32 subjects (18 male, 14 female) obtained in this research with average age of 55.81+0.496 and average level of serum magnesium 1.9244+0.49657mg/dL. The results indicated that there was a significant correlation between serum magnesium levels and the hematoma volume and clinical degree in patients with acute supratentorial intracerebral hemorrhagic stroke. Through the Spearman correlation test, it was found that serum magnesium levels were correlated negatively and linearly with hematoma volume and NIHSS acute supratentorial intracerebral hemorrhagic stroke patients. Discussion: There was a significant correlation between serum magnesium levels, hematoma volume and clinical degree in patients with acute supratentorial intracerebral hemorrhagic stroke. Keywords: Acute intracerebral hemorrhage stroke, clinical degree of stroke (NIHSS), hematoma volume, serum magnesium level

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