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Contact Name
Mawaddah Ar Rachmah
Contact Email
neurona.perdossi@gmail.com
Phone
+6282130377088
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baybasalamah@gmail.com
Editorial Address
SEKRETARIAT PP PERDOSSI Apartemen Menteng Square, Tower A Blok R-19 Jl. Matraman nomor 30E, RT.5/RW.6, Kenari, Kec. Senen, Kota Jakarta Pusat, Daerah Khusus Ibukota Jakarta 10430
Location
Kota adm. jakarta pusat,
Dki jakarta
INDONESIA
Neurona
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Articles 299 Documents
HUBUNGAN KADAR GULA DARAH SEWAKTU DENGAN NEUROPATI DIABETIK PADA PASIEN DIABETES MELITUS TIPE 2 Lisa, Mei; Lipinwati, Lipinwati; Istarini, Attiya; Syauqy, Ahmad; Shafira, Nyimas Natasha Ayu
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 4 (2025): Volume 41 Nomor 4, September 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i4.721

Abstract

ABSTRACT Introduction: Diabetes mellitus can cause microvascular complications, one of the most common being neuropathy, which is triggered by persistent hyperglycemia. Aims: To determine the relationship between random blood glucose levels and the incidence of diabetic neuropathy in Type 2 Diabetes Mellitus patients. Methods: This analytical observational study used a cross-sectional design involving 92 Type 2 Diabetes Mellitus patients. Neuropathy was assessed using the DNS-Ina questionnaire, while random blood glucose levels were obtained through laboratory tests. Data were analyzed using the Chi-square test. Results: Among the respondents, 53.3% did not experience hyperglycemia, while 82.3% had diabetic neuropathy. The Chi-square test revealed a p-value of 0.017 with an odds ratio of 4.568, indicating a significant association between random blood glucose levels and diabetic neuropathy. Conclusion: There is a significant relationship between random blood glucose levels and the incidence of diabetic neuropathy in Type 2 Diabetes Mellitus patients at H. Abdul Manap Regional Hospital, Jambi City. Keywords: diabetic neuropathy, random blood glucose, Type 2 diabetes mellitus
PERBEDAAN LUARAN MOTORIK PASIEN SINDROMA GUILLAIN BARRE DENGAN TERAPI IVIG DAN PLASMAFERESIS Nurhayati, Wulantika
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 2 (2025): Vol 41 No 2 (2025): Volume 41, No 2 - Maret 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i2.744

Abstract

ABSTRACT Introduction Guillain-Barré syndrome (GBS) is an acute autoimmune polyneuropathy characterized by progressive motor weakness and potentially fatal complications. In severe cases (disability scale ≥3), the standard immunotherapies are intravenous immunoglobulin (IVIg) and plasmapheresis. Studies on populations dominated by demyelinating subtype reported equal efficacy between both treatments, whereas studies on the axonal subtype indicated better motor outcomes with IVIg. However, to the best of our knowledge, such research has not been conducted in Indonesia. Aim To evaluate the difference motor outcomes between GBS patients treated with IVIg and plasmapheresis. Methods A retrospective cross-sectional study was performed using medical records of adult GBS patients admitted between November 2020 and September 2024. Clinical characteristics and Medical Research Council (MRC) motor scores at admission and discharge were analyzed. Motor outcome was categorized as “good” (MRC ≥36) or “poor” (MRC <36). Results Among 141 GBS patients, 12 received IVIg and 47 underwent plasmapheresis, and the rest were given supportive therapy and roborantia. The largest proportion was axonal subtype (43,3%). The proportion of good motor outcomes was higher in the IVIg group (83.3%) compared to the plasmapheresis group (59.6%), although this was not statistically significant (p>0.05). Lower initial MRC scores and higher mEGOS and EGRIS scores were associated with poorer outcomes. Discussion IVIg tends to yield better motor outcomes, particularly in GBS axonal subtype. Early identification of GBS subtype is beneficial for treatment decision. Bigger sample sizes and prospective studies are needed to confirm these results. Keywords Guillain-Barré Syndrome, IVIg, Motor Outcome, MRC Score, Plasmapheresis
Carotid Artery Stenosis as a Risk Factor for Crescendo Transient Ischemic Attack: Case Report Amry, Carissa Maharani; Imran, Yudhisman; Rahmansyah, Mulia; Rachmiyani, Irmiya; Khusfiani, Triasti
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i3.758

Abstract

Background A Transient Ischemic Attack (TIA) is an indicator of ischemic stroke. When the frequency, duration, and severity of TIAs increase, they are known as a Crescendo Transient Ischemic Attack (cTIA). Several risk factors, including carotid artery stenosis, can contribute to cTIA. Case Description A 49-year-old man presented to the Emergency Department (ED) after being referred from another hospital, complaining of sudden weakness on the left side of his body that started three days ago. The weakness on his left side was noted to be intermittent. The patient initially experienced sudden weakness on the left side of his body five days before his hospital admission at 2:00 PM, after which his condition improved. That evening, at 8:00 PM, the patient again experienced sudden weakness on the left side, but it improved to normal afterward. Four days before admission, at 12:00 PM, the patient experienced weakness on the left side along with slurred speech, which also improved. Before being referred, the patient underwent a non-contrast head computed tomography (NCCT), revealing no bleeding. The neurological physical examination was within normal limits. The patient was hospitalized and received dual antiplatelet therapy (Aspilet and Clopidogrel), Ranitidine, Citicoline, Mecobalamin, and Atorvastatin. He was discharged on the second day, with no neurological deficits observed during treatment. The patient was evaluated at the neurology clinic and underwent CT angiography of the carotid arteries, revealing moderate stenosis (50 - 69% NASCET Scale stenosis) in the right internal carotid artery and mild stenosis (<50% NASCET scale stenosis) in the left internal carotid artery. Conclusions Crescendo Transient Ischemic Attack (cTIA) is an important indicator of ischemic stroke requiring hospitalization. In cTIA, a supporting examination is needed, typically computed tomography angiography (CTA). This imaging technique has high sensitivity for detecting intracranial stenosis and occlusion, which are significant risk factors for recurrent TIA. In high-risk TIA patients, DAPT (aspirin and clopidogrel) should be started early to reduce the risk of recurrent ischemic stroke. Keywords: Transient Ischemic Attack, Crescendo Transient Ischemic Attack, computed tomography angiography
Luaran Klinis dan Komplikasi Terapi Endovaskular pada Pasien Stroke Iskemik Akut dengan Trombolisis Intra-Arteri dan Trombektomi Mekanik pada Setting Penanganan Kritis Retnaningsih, Retnaningsih; Tugasworo, Dodik; Kurnianto, Aditya; Tri Rahayu, Fitriani
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i3.774

Abstract

Introduction: Acute ischemic stroke (AIS) is a major cause of disability and death worldwide. Mechanical thrombectomy (MT) has become the standard endovascular therapy for AIS with large vessel occlusion, though incomplete reperfusion remains a concern. Intra-arterial thrombolysis (IA-T) has emerged as a potential adjunct therapy to enhance reperfusion. Aim: To evaluate clinical outcomes and complication rates between IA-T plus MT compared to MT alone in AIS patients treated in the ICU of Dr. Kariadi Hospital, Semarang. Methods: A total of 38 AIS patients with MCA occlusion who received endovascular reperfusion therapy were divided into two intervention groups: IA-T + TM (n=18) and TM alone (n=20). Outcomes according to Modified Rankin Scale (mRS) score and complication data were compared between groups. Results: Patients in both groups had similar baseline characteristics. A higher percentage of patients in the IA-T + MT group achieved favorable mRS scores (0–2) compared to the MT-only group (72.2% vs 65%), though the difference was not statistically significant (p=0.632). No significant differences in complication rates were found. Discussion: The combination of IA-T and MT showed a trend toward better functional outcomes without significantly increasing complications. This suggests potential benefit in selected cases. Keywords: ischemic stroke, intra-arterial thrombolysis, mechanical thrombectomy
TB Meningitis: Tantangan Diagnosis Dini dan Implikasi terhadap Morbiditas serta Mortalitas Gaharu, Maula Nuruddin
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 2 (2024): Vol 40 No 2 (2024): Volume 40, No 2 - Maret 2024
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.794

Abstract

Bulan Maret merupakan hari tuberkulosis (TBC) dunia yang di peringati setiap tanggal 24. Indonesia menempati urutan keduaterbanyak setelah India pada prevalensi tuberkulosis, Global TB Report 2023 mencatat sekitar 1 juta kasus baru dan kematian akibat TBCper tahun di Indonesia mencapai 100.000 kasus. Secara global, 8% kasus berasal dari Indonesia. TB meningitis (TBM) merupakanpenyebab mortalitas tersering pada kasus TB ekstrapulmonal, bahkan, dari TB pulmonal itu sendiri. TBM merupakan penyebab terseringpada kasus-kasus infeksi serebral. The Lancet Global Health Commision, melaporkan 50% mortalitas TBM disebabkan oleh buruknyalayanan kesehatan. Bermacam kendala dalam tata laksana TBM, mulai dari penegakan diagnosis, modalitas, regimen pengobatan, hinggafaktor kemampuan sarana kesehatan dalam menangani TBM.Manifestasi klinis yang kadang tidak khas terkadang tidak dikenali sebagai manifestasi TBM, seperti gangguan kognitif, manifestasiklinis menyerupai stroke, gangguan gerak bola mata, dan defisit neurologis lainnya, menyebabkan progresifitas infeksi yang semakinberat. Bahkan, tidak jarang tenaga kesehatan membuat diagnosis selain TBM pada tahap awal perjalanan penyakit. World HealthOrganization membagi keterlambatan diagnosis berdasarkan waktu, penegakan diagnostik, dan inisiasi medikamentosa antituberkulosa.Pada literatur, bahkan, disebutkan keterlambatan penegakan diagnosis dapat terjadi hingga 2 bulan. Hal-hal tersebut menjadi tantanganbagi para neurolog untuk meningkatkan kewaspadaan terhadap TBM, bahkan, pemahaman klinis TBM juga perlu diberikan pada dokterumum yang sering kali menjumpai pasien pada stadium awal. Literatur melaporkan 35% kasus pertama kali berobat pada praktek-praktekpribadi dan sisanya pada Pusat Kesehatan Masyarakat (Puskemas) bahkan fasilitas kesehatan informal seperti apotik, toko obat, dll.Jika kecepatan dan ketepatan diagnosis TBM dapat dilakukan pada tahap awal perjalanan penyakit, akan ada dampak besar padapenurunan morbiditas dan mortalitas TBM. Melengkapi sarana-sarana kesehatan mulai dari primer hingga sekunder dengan diagnostiklaboratorium hingga imajing. Selain itu tindakan lumbal pungsi juga penting dilakukan pada layanan Kesehatan sekunder, di sampingketersediaan diagnostik imajing CT scan kepala kontras. Peranan pemerintah dalam pembuatan kebijakan-kebijakan pada pembiayaanpenjaminanan nasional juga menentukan ketepatan dan kecepatan diagnosa.Kolaborasi yang baik akan memperkuat kewaspadaan dan kemampuan penanganan TBM, yang berdampak mengurangi morbiditasserta mortalitas TBM. Selamat hari tuberkulosis, bersama, kita bisa.
Gangguan Tidur Pada Lanjut Usia (Lansia) Asrini, Silvana
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 1 (2024): Vol 41 No 1 (2024): Volume 41, No 1 - Desember 2024
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i1.795

Abstract

Gangguan tidur pada umumnya sering kita temukan pada masyarakat awam, terutama pada orang dengan lanjut usia (lansia). Prevalensinya sekitar 76%. Kelompok lansia lebih sering mengalami sulit tidur (40%), sering terbangun malam hari (30%) dan sisanya gangguan pemenuhan kebutuhan tidur lain. Waktu tidur total harian relatif tetap stabil pada lanjut usia yang sehat, pada mereka dengan usia 60 tahun keatas yang memiliki waktu tidur rata-rata 6,5 – 7 jam per hari Siklus tidur dan bangun (irama sirkadian) berfungsi mempertahankan untuk tetap terbangun saat siang hari saat cahaya terang dan tidur sepanjang malam hari saat gelap. Jadi faktor kuncinya adalah adanya perubahan gelap dan terang. Stimulasi cahaya terang akan masuk melalui mata dan mempengaruhi suatu bagian di hipotalamus yang disebut nukleus suprakiasmatikus (NSC). NSC akan mengeluarkan neurotransmiter yang mempengaruhi sekresi berbagai hormon pengatur temperatur badan, kortisol, GH (growth hormone) dan lain-lain yang memegang peran untuk bangun dan tidur. NSC bekerja seperti jam, meregulasi segala kegiatan bangun dan tidur. Gangguan tidur pada populasi lanjut usia dihubungkan dengan beberapa faktor, termasuk gangguan tidur spesifik, perubahan dari irama sirkadian endogen, kelainan medis dan psikiatri, serta pengaruh obat-obatan Proses penuaan mempengaruhi berbagai irama fisiologis yang mempengaruhi tidur, seperti suhu tubuh, sekresi melatonin, dan fluktuasi sistem neuroendokrin (penurunan sekresi luteinizing hormone, growth hormone, dan thyroid-stimulating hormone, rendahnya kadar serotonin) Namun banyak kondisi medis yang dialami lansia yang dapat mengganggu tidur seperti diabetes, hipertensi, dan radang sendi. Hal ini meningkat seiring dengan pertambahan usia. Gangguan tidur dapat mempengaruhi kualitas hidup pada orangtua, menurunkan status imunologi, gangguan hormonal dan endokrinologi, serta penurunanfungsi kognitif. Gangguan tidur tersering pada lansia adalah kesulitan untuk mulai tidur (sleep onset problems),kesulitan mempertahankan tidur nyenyak (deep maintenance problem), bangun terlalu pagi (earlymorning awakening/EMA). Adapun penyakit gangguan tidurnya antara lain insomnia, gangguan tidur karena gangguan pernapasan (sleep-disordered breathing), gangguan gerakan tungkai yang periodik (periodic Llimb movements in sleep) atau sindrom kaki kurang tenang (restless legs syndrome), circadian rhythms sleep disorders, rapid eye movement sleep behavior disorder. Manajemen untuk gangguan tidur ini meliputi terapi non-farmakologis danfarmakologis. Perubahan perilaku dan modifikasi diet pada beberapa penyebab gangguan tidurterbukti efektif. Intervensi non-farmakologis seperti sleep hygiene dan terapi perilaku kognitif (Cognitive-Behavioral Therapy) merupakan terapi lini pertama pada berbagai gangguan. Selain itu dapat juga dengan Stimulus-Control Therapy dan Sleep-Restriction Therapy. Bila pengobatan hipnotik dibutuhkan tidur untuk pasien lanjut usia, harus mempertimbangkan beberapa hal berikut: (1) meresepkan dimulai dengan dosis terendah yang efektif, (2) mengunakan hipnotik dengan waktu paruh singkat, dan (3) evaluasi kemungkinan efek samping yang muncul
Menggali Potensi Terapi Sekretom Mesenchymal Stem Cell untuk Penyakit-penyakit Neurologi Ar Rochmah, Mawaddah
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 2 (2025): Vol 41 No 2 (2025): Volume 41, No 2 - Maret 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i2.797

Abstract

Ranah neurologi regeneratif berkembang pesat—dan sekretom serta eksosom dari mesenchymal stem cell (MSC) kini menempatiposisi terdepan dalam inovasi terapi. Terapi aselular ini, yang kaya akan molekul bioaktif dan vesikel ekstraseluler, menawarkanpotensi besar untuk menangani kompleksitas penyakit neurologis tanpa risiko yang terkait dengan transplantasi sel.Berbagai penelitian preklinis telah menunjukkan bahwa terapi sekretom MSC mampu meredakan peradangan, mendorongperbaikan jaringan saraf, dan meningkatkan fungsi neurologis. Efek ini tercatat baik pada kondisi akut seperti stroke dan cedera otakperinatal, maupun penyakit kronis seperti Alzheimer, Parkinson, multiple sclerosis, dan amyotrophic lateral sclerosis. Terapi ini telahdiujikan melalui berbagai metode pemberian, termasuk intravena, intranasal, hingga injeksi lokal, dengan fleksibilitas waktupemberian sesuai fase penyakit.Pada manusia, data awal dari uji klinis menunjukkan bahwa terapi ini umumnya aman dan dapat ditoleransi dengan baik. Sejumlahstudi tengah berlangsung untuk mengevaluasi efektivitasnya pada berbagai gangguan saraf, termasuk demensia dan gangguan gerak.Meskipun hasilnya masih awal, temuan sementara memberikan harapan akan manfaat klinis yang nyata.Namun, tantangan penting masih harus diatasi—mulai dari penentuan dosis optimal, frekuensi pemberian, hingga standarisasi danproduksi sekretom/eksosom dalam skala besar. Meski begitu, kemajuan yang pesat di bidang ini menunjukkan bahwa sekretom MSCberpotensi menjadi bagian penting dalam terapi regeneratif sistem saraf.Kedepannya, jika bukti klinis terus menunjukkan hasil positif, terapi sekretom dan eksosom MSC bisa menjadi alternatif aman,efektif, dan non-invasif bagi pasien yang saat ini memiliki pilihan pengobatan yang terbatas. Ini bisa menjadi lompatan besar menujuera baru pengobatan yang lebih personal, presisi, dan berbasis regenerasi untuk penyakit-penyakit neurologi.
NEURONA Supplement Edition in collaboration with National Congress of Indonesian Neurology Association
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia NEURONA Supplement Edition in Collaboration with National Congress of Indonesian Neurology Associati
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Abstract

NEURONA Supplement Edition in collaboration with National Congress of Indonesian Neurology Association
Edisi Suplemen Neurona Bekerjasama dengan PIN PERDOSNI 2025
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Edisi Suplemen Neurona Bekerjasama dengan PIN PERDOSNI 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

NEURONA, the sole scientific journal of the Indonesian Neurologists Association (PERDOSNI), published since 2007, has made a breakthrough by publishing this supplementary edition. In collaboration with the PERDOSNI 2025 National Scientific Meeting, this supplementary edition contains all abstracts of scientific posters submitted to the National Scientific Meeting (PIN). This supplementary edition covers 87 abstracts on various neurology-related topics, including stroke, neurointervention, neuroimaging, neurootology and neuroophthalmology, neurorestorative and neuroengineering, neuroepidemiology, and ethics and law. We sincerely hope this supplementary edition will broaden your knowledge and spark ideas for further publications in the field of neurology. Collaboration through media partnerships at neurology scientific events will ensure the sustainability of this journal, a resource for all Indonesian neurologists. We thank you for your support.
Tingkat Kejadian Carpal Tunnel Syndrome pada Penjual Rujak di Lokasi Wisata Pulau Ambon Tahun 2023 Krista, Imanuela
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 4 (2025): Volume 41 Nomor 4, September 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i4.512

Abstract

Introduction: Rujak is one of the famous traditional culinary delights. In the activity of kneading rujak, sellers use more wrist movements which can increase a risk of carpal tunnel syndrome (CTS) which is a symptom that arises due to repeated movements over a long period of time, causing stress on the median nerve that passes through the carpal tunnel. Aim: The prevalence of CTS in rujak sellers is not yet known with certainty, therefore the author conducted this research to determine the prevalence of carpal tunnel syndrome in rujak sellers at coastal tourist locations on Ambon Island in 2023. Methods: This research was held at Natsepa beach and Tapal Kuda beach in September 2023. This research is a descriptive study with data sources coming from primary data using a cross-sectional approach and using a total sampling method. Data collection was carried out by interacting directly with respondents in the process of filling out the Boston Carpal Tunnel Syndrome Questionnaire. Results: From the 43 samples of rujak sellers who were the subjects of this study, the results showed that the prevalence of carpal tunnel syndrome was 74% in rujak sellers and the highest prevalence in the age range 45-59 years, normal body mass index, 18 years of work and 40 hours work duration. Discussion: The prevalence of carpal tunnel syndrome in rujak sellers who have CTS is influenced by repetitive movements accompanied by other risk factors (age, body mass index, duration and length of work) Keywords: Carpal tunnel syndrome, Prevalence of CTS, Rujak seller.