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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 299 Documents
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Gangguan Fungsi Bahasa Meningkatkan Risiko Kualitas Hidup Buruk pada Lansia Piustan, Mas Eaufrat; Turana, Yuda; Handajani, Yvonne Suzy; Kristian, Kevin
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 4 (2025): Volume 41 Nomor 4, September 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i4.673

Abstract

Introduction: The quality of life of the elderly requires attention. Language function is closely related to identifying individuals who are vulnerable to a decline in quality of life. Aim: This study aims to examine the relationship between sociodemographic factors, language function, social engagement, and frailty with elderly’s quality of life. Methods: This study employed a cross-sectional method with 100 respondents aged ≥60 years. Quality of life was measured using the WHOQOL-BREF, language function was assessed using the CERAD Verbal Fluency Test, social engagement was evaluated using the Social Disengagement Index, frailty was measured using the Fried Frailty Index, and sociodemographic factors were assessed through interviews using validated instruments. Results: Chi-square analysis showed a significant relationship between language function and the psychological, social, and environmental domains (p<0.05). Gender was only significantly associated with the environmental domain. Frailty was associated with psychological, social, overall quality of life, and health satisfaction. Multiple logistic regression analysis shows that impaired language function is a risk factor for impairments in the psychological (OR=3.335; 95%CI=1.376-8.082), social (OR=3.473; 95%CI=1.376-8.763), and environmental domain (OR=4.649; 95%CI=1.057-20.442). Frailty was identified as risk factor for impairments in psychological domain (OR=3.274; 95%CI=1.069-10.022) and health satisfaction (OR=3.378; 95%CI=1.105-10.328). Being female served as protective factor against impairments in the environmental domain (OR=0.159; 95%CI=0.036-0.694). Discussion: Impaired language function increase the risk of psychological, social, and environmental impairments. Being female serves as protective factor against environmental domain impairment. Frailty increases the risk of psychological impairments and poor health satisfaction. Keywords: Age, elderly, frailty, language, quality of life
MAGNESIUM SULFAT DALAM TATALAKSANA TETANUS GENERALISATA: SEBUAH LAPORAN KASUS DAN TINJAUAN LITERATUR SINGKAT Danerdi, I Made Adhi Kresnayana
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 4 (2025): Volume 41 Nomor 4, September 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i4.685

Abstract

Background: Tetanus is a life-threatening neurologic disorder characterized by muscle spasms, hypertonia, and autonomic dysfunction. Magnesium sulphate is a widely available medication that can inhibit catecholamine release and antagonize calcium action in cardiomyocytes and neuromuscular junctions. Thus, this agent could be used as an adjuvant treatment to control spasms and prevent dysautonomic dysfunction in tetanus. However, the use of this medication in tetanus is still rare because of concerns about the adverse effects of muscle paralysis. Case Report: A 48-year-old male patient presented with trismus, neck stiffness, dysphagia, and abdominal rigidity a few days after poking his caries teeth with a nail clipper. There is no history of seizure, fever, trauma, or surgery. He was conscious, hemodynamically stable, and had normothermia. Thus, he was diagnosed with generalized tetanus and was treated with human tetanus immunoglobulin, antibiotics, sedatives, anticonvulsants, and analgetic. Magnesium sulphate infusion was also given since the first day of admission and maintained until seven days of hospitalization. During the first week of treatment, he was hemodynamically stable and clinically improved. On day 14, trismus and dysphagia significantly improved, while abdominal rigidity and neck stiffness were absent. The patient was then discharged. Conclusion: Timely diagnosis and management were vital to preventing mortality in tetanus. Despite concerns about the adverse effects of magnesium sulphate, this case report proved that magnesium sulphate is safe and effective in reducing muscle spasms and preventing autonomic dysfunction in tetanus patients. Keywords: Magnesium sulphate, MgSO4, Tetanus, Spasms
Tetanus HUBUNGAN ANTARA STATUS VAKSINASI DENGAN TINGKAT KEPARAHAN TETANUS DI RSUD BANTEN: Studi Retrospektif di Rumah Sakit Umum Daerah Banten Tahun 2022–2024 Pradyaharini, Zahra Adinda; Irwan Rusmana, Ahmad; Ivana Utami, Louisa
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 4 (2025): Volume 41 Nomor 4, September 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i4.791

Abstract

Introduction: Tetanus is an acute toxemia disease caused by tetanospasmin of Clostridium tetani. The Clinical symptoms of tetanus can be assessed using Phillips score, Dakar Score, and Ablett’s Score. Tetanus is still a public health problem in developed countries due to poor access to immunization. Aim: To analyze the association vaccination status and the severity of tetanus in patients. Method: The study used a retrospective cross-sectional design. Using secondary data from medical records of tetanus patients treated at Banten Regional Hospital during the period 2022 - 2024. Tetanus severity was assessed based on Ablett's Score. The study subjects consisted of a total sampling of all 73 tetanus patients of the year who met the inclusion and exclusion criteria, which were taken using the total sampling technique. Analysis of the relationship between vaccination status and severity was carried out using the Spearman correlation statistical test. Result: A total of 94.5% of patients had no history of tetanus vaccination. In the group of patients without vaccination, 55.1% had severe severity. All vaccinated patients (5.5%) experienced mild symptoms. Statistical test results showed no significant relationship between vaccination status and severity in tetanus patients at Banten Regional Hospital (p – value = 0,079; r = 0,207). Disscussion: There is no statistically significant association between vaccination status and the severity of tetanus (p = 0,079). However, the weak positive correlation (r =0,207) indicates a tendency for more severe symptoms among patients without a complete tetanus vaccination history. Keywords: Tetanus, Tetanus Vaccination, Tetanus Severity, Ablett’s Score
Neurointervensi Prabowo, Fajar
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 4 (2025): Volume 41 Nomor 4, September 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i4.842

Abstract

Sejarah Neurointervensi dimulai pertama kali oleh Prof. Egas Moniz, seorang kebangsaan Portugese yang mendapatkan perhargaan Nobel kedokteran melakukan penemuan prosedur angiografi pada tahun 1928 kemudian berkembang menjadi suatu prosedur minimal invasive. Prosedur ini dilakukan pada pasien dengan kelainan pembuluh darah otak dan medula spinalis seperti, stroke, aneurisma, malformasi pembuluh darah dan tumor otak. Di Indonesia, prosedur neurointervensi dilakukan oleh seorang neurologist, radiologist dan neurosurgeon yang telah menyelesaikan pendidikan tambahan fellowship neurointervensi vaskular, neuroradiologi atau bedah saraf vaskular. Khusus perkembangan neurointervensi di Indonesia tidak lepas dari perjuangan dr.Fritz Sumantri Usman pada tahun 2008 yang telah menyelesaikan pendidikannya dari Egas Moniz Neurointervention dan Stroke Fellowship di Sir Ganga Ram Hospital New Delhi India, kemudian dari seorang diri menjadi 10 orang pada tahun 2011, hingga pada tahun 2025 ini telah terdapat 152 neurointervensionis yang tersebar di seluruh Indonesia. Pendidikan fellowship yang ditempuh saat ini tidak hanya berasal dari India, tetapi juga dari Korea Selatan, Vietnam, Cina, Austria dan terdapat 8 Rumah Sakit di Indonesia yang menyelenggarakan pendidikan fellowship neurointervensi vaskular. Berbagai tindakan endovakular yang dilakukan seorang neurointervensionist seperti mekanikal trombektomi telah menjadi standar pelayanan dalam penanganan stroke akut, begitu juga dengan berbagai prosedur endovaskular lainya dengan minimal invasif menawarkan keuntungan dibandingankan tindakan operasi. Semoga neurointervensi Indonesia dapat terus berkembang dan memberikan pelayanan kesehatan yang terbaik bagi masyarakat Indonesia. Sesuai yang tercantum dalam mars derap neurointervensi, mula cita menanjak dan mendaki, bukan mudah satukan langkah kaki, tekad baja demi ibu pertiwi, bangun Neurointervensi. Jaya Neurointervensi.
FAKTOR-FAKTOR YANG MEMPENGARUHI OUTCOME TROMBOLISIS INTRAVENA PADA STROKE ISKEMIK AKUT DI RS DR.M.DJAMIL : FACTORS INFLUENCING OUTCOMES OF INTRAVENOUS THROMBOLYSIS IN ACUTE ISCHEMIC STROKE AT DR.M.DJAMIL HOSPITAL kinasih, Fanny Pratami
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 2 (2025): Vol 41 No 2 (2025): Volume 41, No 2 - Maret 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i1.603

Abstract

Introduction: Two-thirds of stroke cases in Indonesia are acute ischemic strokes. Intravenous thrombolysis therapy is one of treatment options for acute ischemic stroke. Aims: To determine the factors influencing outcomes of intravenous thrombolysis in patients with acute ischemic stroke at Dr.M.Djamil Hospital Padang. Methods: A descriptive-analytical study using total sampling of medical records of patients with acute ischemic stroke who underwent intravenous thrombolysis at Dr.M.Djamil Hospital from January 2023 to March 2024. Data analysis using SPSS, bivariate analysis using chi-square followed by multivariate analysis using multiple logistic regression to identify the most influential factors outcomes of intravenous thrombolysis based on mRS scores <2 (good outcome) and mRS scores >2 (poor outcome). Results: Out of 45 patients included in the study, 62.2% were male and 37.78% were female. The mean onset time was 3.5±1.50 hours with a mean door-to-needle time of 42.33±7.125 minutes, and a mean rt-PA dose of 46.31±9.774 mg. Bivariate analysis results six influential factors are diabetes mellitus (p=0.188), GCS (p=<001), NIHSS (p=<0.001), length of hospital stay (p=0.106), stroke type (p=0.148), and initial CT scan (p=0.002). Multivariate analysis identified the most influential factors outcomes of intravenous thrombolysis as NIHSS score (OR=27.982), GCS (OR=8.268), diabetes mellitus (OR=6.792), and CT scan results (OR=6.635). Discussion: NIHSS is the most influential factor outcomes of intravenous thrombolysis. Intravenous thrombolysis therapy is one of treatment options for acute ischemic stroke, but shows worse outcomes in patients with large vessel occlusion (LVO), low GCS, hyperglycemia, and high NIHSS scores. Keywords: Intravenous Thrombolysis, Ischemic Stroke, NIHSS
KONSEP BARU DALAM BIOLOGI MOLEKULER PADA NEUROPATI DIABETIK PERIFER Widyadharma, I Putu Eka; de Liyis, Bryan Gervais
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.859

Abstract

SKOR RISIKO POLIGENIK, STATUS APOE, DAN TERAPI DENGAN TARGET AMILOID PADA PENYAKIT ALZHEIMER Vidyanti, Amelia Nur; Rahman, Rifki Habibi; Astuti
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.860

Abstract

CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY: KONSEP TERKINI DALAM PATOFISIOLOGI Marcello, Macho; Harahap, Indra Sari Kusuma
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.861

Abstract

Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) adalah gangguan autoimun yang ditandai dengan kelemahan simetris proksimal dan distal serta defisit sensorik yang progresif atau kambuhan selama lebih dari 8 minggu. Patofisiologinya kompleks dan heterogen, melibatkan imunitas seluler (inflitrasi sel T dan makrofag yang melintasi sawar darah saraf, menyebabkan demielinasi melalui sitokin dan fagositosis) dan imunitas humoral, termasuk aktivasi komplemen. Meskipun demielinasi yang diinduksi makrofag adalah kaarakteristik utama, pemicu autoantibodi spesifik belum sepenuhnya teridentifikasi. Panduan European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) tahun 2021 mengklasifikasikan CIDP menjadi bentuk tipikal dan varian, yang menunjukkan pola demielinasi berbeda yang mencerminkan dominasi variabel dari respons imun seluler versus humoral. Penelitian terbaru menyoroti autoantibodi terhadap protein nodal/paranodal (contohnya, neurofascin-155, contactin-1). Pasien dengan antibodi ini sering memiliki fenotipe klinis yang berbeda dan respons parsial terhadap imunoglobulin intravena (IVIg), yang menyebabkan reklasifikasi mereka dalam panduan sebagai "nodopati autoimun" yang terpisah. Pemahaman yang lebih mendalam tentang imunopatogenesis CIDP yang beragam ini sangat penting untuk pengembangan strategi diagnostik dan terapeutik yang lebih spesifik. Kata Kunci: CIDP, demielinasi, imunopatogenesis, kriteria diagnostik EFNS/PNS, nodopati autoimun
PERAN LABELATOL DALAM MANAJEMEN HIPERTENSI EMERGENSI PADA STROKE AKUT Setyopranoto, Ismail; Gofir, Abdul; Paryono
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.862

Abstract

PERAN CLINICAL PATHWAY DALAM PERAWATAN STROKE Paryono; Anindhita, Edina Ufairah; Ar Rochmah, Mawaddah
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.863

Abstract

Stroke remains a leading cause of disability and mortality worldwide, demanding a comprehensive, structured, and evidence-based approach across the full continuum of care. Clinical pathways (CPs) are integrated, multidisciplinary protocols that operationalize guidelines into day-to-day practice—linking prehospital prenotification, emergency triage, acute treatment, early rehabilitation, and discharge planning. This narrative review synthesizes the rationale, design steps, core components, and clinical evidence for CP implementation in stroke care. Key pathway elements include time-critical targets (e.g., rapid brain imaging for reperfusion candidates), standardized assessments (e.g., National Institutes of Health Stroke Scale / NIHSS), complication prevention bundles (dysphagia screening, venous thromboembolism prophylaxis, glucose and temperature control), mobilization and nutrition plans, patient–caregiver education, and follow-up coordination, all embedded within audit/variance tracking for continuous quality improvement. Evidence indicates that CPs can reduce in-hospital complications, shorten length of stay, lower costs, increase documentation completeness, strengthen adherence to guidelines, and enhance patient satisfaction and team collaboration. Effects on hard clinical outcomes (mortality, long-term disability) are more variable and appear contingent on stroke-unit infrastructure, resource readiness, team training, and local adaptation. Overall, CPs remain a strategic tool within organized stroke systems, translating evidence into timely, coordinated care and supporting iterative improvements in quality and efficiency. Keywords: Clinical pathway, stroke, evidence-based medicine, multidisciplinary care, patient outcomes

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