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Jurnal MedScientiae
Published by Universitas Kristen Krida Wacana
ISSN : -     EISSN : 28291166     DOI : https://doi.org/10.36452/jmedscientiae
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal MedScientiae adalah jurnal yang dikelola oleh Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Krida Wacana. Jurnal ini mempublikasikan artikel-artikel secara open access dalam lingkup bidang kedokteran dan kesehatan seperti kedokteran dasar, bioetika kedokteran, biologi sel, biologi molekuler, genetika, fisiologi, biokimia, bioinformatika, anatomi, farmakologi, kesehatan masyarakat, dan ilmu biomedik lainnya. Tim editorial menerima naskah berupa artikel penelitian, literature dan systematic review, dan laporan kasus. Naskah yang dikirimkan hendaknya belum pernah diterbitkan sebelumnya di jurnal maupun media yang lain dan disiapkan sesuai dengan template atau format yang telah ditentukan. Setiap naskah yang memenuhi kriteria jurnal akan direview oleh pakar yang sesuai (peer reviewer). Jurnal MedScientiae tidak mengenakan biaya selama proses mulai dari penerimaan naskah hingga publikasi. Jurnal MedScientiae terbit 3 kali dalam satu tahun, yaitu pada bulan April, Agustus dan Desember dengan cakupan keilmuan yang telah disebutkan di atas. Edisi pertama jurnal akan diterbikan di bulan Mei tahun 2022 dengan nomor ISSN 2829-1166.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 219 Documents
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KEPARAHAN AKNE VULGARIS DENGAN PENGGUNAAN PROBIOTIK ORAL Elvantie; Arini Astasari Widodo; Budiman Hartono
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v2i1.2797

Abstract

Background. Oral probiotics are microorganisms that have various benefits based on theoretical evidence of the skin, brain, and gut. Oral probiotics are an effective choice in the management of acne vulgaris, which has been proven by studies that state that oral probiotics can reduce the degree of acne, inflammatory lesions, non-inflammatory lesions and reduce excess sebum production. Method. The research articles reviewed are in the form of analytical reviews through the PubMed and Google Scholar databases. Results. A total of 6 research articles were selected according to the purpose of writing this literature review. Conclusion. The use of oral probiotics can reduce inflammatory lesions, the degree of severity of acne vulgaris, total inflammatory lesions, and reduce excessive sebum production. Oral probiotics, in some cases, can cause side effects such as gastrointestinal disturbances in the form of bloated. Probiotics are measured in colony-forming units (CFU) which indicate the number of viable cells. The dosage concentration of each probiotic varies, but oral probiotics still provide an effective effect on the treatment of acne vulgaris.
PENYEBAB DAN TATALAKSANA DALAM MENGATASI KELOID Dea Amelia Glorie; Wiwi Kertadjaya; Reni Angeline
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2798

Abstract

Pathological wound healing and pathological scar formation lead to functional and aesthetic losses. Keloids are excessive scars that grow beyond the boundaries of the original wound which is a fibroproliferative disorder. Keloids are difficult to treat because of the recurring nature of keloids and imperfect treatment of keloids can make keloids worse. Based on this description, this literature review was created by the author to explain the causes and treatments for keloid. The research articles reviewed are in the form of analytical reviews through the PubMed database. A total of 20 research articles were selected according to the purpose of writing this literature review. The main cause of keloids is trauma, injury or infection of the skin. Monotherapy for keloids isn’t recommended because of the higher recurrence rate compared to combination therapy. Several modalities for the treatment of keloids are surgical procedures, radiotherapy, antitumor/anticancer, calcium electroporation, corticosteroids, intermittent magnetic pressure, silicone gel, laser, Plasma Skin Regeneration, and cryotherapy. Excision is a modality that provides instant reduction in keloid size, but due to the high recurrence, other therapies must be given as combination therapy, namely corticosteroid injections or radiotherapy, which can reduce the recurrence rate after excision.
Laporan Kasus: Tantangan Pengelolaan Krisis Hiperglikemia Pasien Penyakit Ginjal Kronik (PGK) Tahap Akhir dalam Hemodialisa Rutin Davin Takaryanto; Maya Kusumawati; Nenny Agustanti; Rudi Supriyadi; Ervita Ritonga; Nanny N. M. Soetedjo; Hikmat Permana
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v2i1.2800

Abstract

Introduction Hyperglycemic crisis is a life threatening medical emergency which occur in any individuals, including end stage renal disease (ESRD). The altered renal, glucose, electrolyte, and body fluid dysregulation seen in ESRD patients affects the management. Objective: Hyperosmolar hyperglycemic state (HHS) and diabetic ketoacidosis (DKA) are life threatening hyperglycemic emergencies that warrant immediate and adequate management. The incidence of hyperglycemic crises among ESRD patients who undergo routine hemodialysis remains unknown. Furthermore, several available studies reported in case reports. Methods: We hereby report a case of hyperglycemic crisis of 61years old woman with medical history of type 2 diabetes mellitus (DM) and ESRD as the complication, she undergoes routine hemodialysis. Results: The patient was admitted with decreased consciousness that was preceded by dyspnea, active cough and fever. Then, the patient treated for the hyperglycemic crisis as in ESRD patient and for the with septic shock due to pneumonia. Conclusion: The management of hyperglycemic crises consist of fluid, potasium corection and insulin administration, however there were some adjustment in ESRD patients. At present therere were no spesific guidelines to manage hyperglicemic crisis and ESRD which is challenging.
Hubungan Kadar Vitamin D dengan Kasus Preeklamsia pada Kehamilan Aryn Shadira Anesti; Adrian Setiawan; Elli Arsita
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae/v2i1.2806

Abstract

Preeclampsia is a pregnancy disorder with serious complications marked by hypertension and proteinuria finding. Vitamin D deficiency is one of the risk factors of preeclampsia with a prevalence of 18-84% worldwide. The objective of this literature review is to determine the relationship between vitamin D levels in with occurrence of preeclampsia in pregnancy. The database that were used was PubMed with “Preeclampsia”, “Level'', and “Vitamin D” as keywords. Inclusion and exclusion criteria were applied in choosing journals that are used. The results of this paper indicates that patient with 25(OH)D serum levels below 30 ng/mL are more at risk of experiencing preeclampsia. This literature review indicates that there is a correlation between vitamin D levels and preeclampsia. Vitamin D supplementation is recommended as one or other ways to prevent preeclampsia. Nonetheless, is no research proving that consuming vitamin D supplement during pregnancy regularly and consistently can significantly increase 25(OH)D serum levels status. The optimal levels of vitamin D serum before pregnancy can minimalize the risk of preeclampsia. Further research is needed to inspect the dose of vitamin D supplementation that is effective to reduce preeclampsia incidence.
Gambaran Kadar Glukosa Darah Sewaktu pada Kalangan Biksu Buddhis di Kota Jakarta Barat dan Jakarta Pusat pada Tahun 2022 Arya Elbert Neil; Gracia J.M.T Winaktu; Rebecca Noerjani Angka; Luciana Budiati Sutanto
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2807

Abstract

The lacto-ovo vegetarian diet (VLO) is a diet consisting of plant-based foods such as vegetables, fruit and accompanied by the consumption of eggs and milk. There are many benefits of this diet, such as maintaining blood glucose levels, body fat levels, body weight, body mass index, pancreatic beta cell performance which can maintain normal blood glucose levels. This research was conducted at the Ekayana Arama Temple in West Jakarta and the Mahayana Temple which is located in Central Jakarta. The method for this research is descriptive research with cross sectional study using purposive sampling method. The results of the study consisted of 19 men and 12 women with 21 years as the youngest age and the oldest age is 77 years. The conclusion of this study is that the hypothesis is accepted, the lacto-ovo vegetarian diet can maintain blood glucose levels remain normal, mean 115.84 mg/dL with a minimum value of 82 mg/dL and 164 mg/dL as the maximum value.
Manfaat Pemeriksaan Biomarker B-Rapidly Accelerated Fibrosarcoma (BRAF) pada Pasien Preoperatif dengan Kanker Tiroid Edvano Adam Herbudi; Fanny Indarto; Purnamawati Purnamawati
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v2i1.2811

Abstract

Thyroid cancer is the most common cancer of the endocrine system. In the detection of thyroid cancer, the gold standard examination is using fine-needle aspiration (FNA), where the cytology results are used in 60% - 80% of cases. FNA examination performed preoperatively determine the initial management of thyroid cancer. However, the FNA technique is limited by insufficient samples in about 2% - 20% of cases and about 10% - 30% of FNA results are classified as indeterminate (ITN) in the Bethesda system. Therefore, molecular tests such as BRAF biomarker screening are expected to help improve the detection of cases in this category. Methods: A literature search conducted from 4 databases (PubMed, ProQuest, ScienceDirect, and Google Scholar) published in the last 10 years with the keywords "preoperative", "braf" or "braf kinases", and "thyroid cancer". Results: Ten studies with total of 11,239 specimens classified in Bethesda III - VI showed increased sensitivity of 34.8% - 96.62% in the combination of FNA and BRAF techniques. Conclusion: The combination of preoperative FNA and BRAF examination increase sensitivity and help in the initial management of thyroid cancer in ITN or Bethesda III and IV group thyroid nodules in the detection of malignancy in the thyroid.
Tinjauan Pustaka Faktor Risiko Penyebab Terjadinya Hepatoseluler Karsinoma Akibat Hepatitis B Gitana Gezatania; Suzanna Ndraha; Marcel Antoni
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2817

Abstract

Hepatitis B is a liver infection caused by the hepatitis B virus (HBV) which has the potential to threaten a person's life. According to WHO, hepatitis B is a major global health problem that causes acute and chronic infections. Chronic hepatitis B has a very high risk of developing hepatocellular carcinoma. The purpose of writing this literature review is to determine the risk factors for the occurrence of hepatocellular carcinoma in someone who is infected with HBV. Methods of data collection through the Pubmed website, Wiley Online Library, and Springer Link from 2012-2022, 10 journals were found to be analyzed in writing this literature review. From the 10 journals analyzed, it can be concluded that type 2 diabetes mellitus in someone who is infected with HBV is an important risk factor that increases the risk of developing hepatocellular carcinoma.
Bimekizumab Sebagai Pengobatan Pilihan Psoriasis Vulgaris Tipe Plak Jenifer Putri Sianto; Rompu Roger Aruan; Grace Pudjiadi Widodo; Arini Astari Widodo
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2818

Abstract

Psoriasis is a chronic inflammatory skin disease which is associated with genetic predisposition and autoimmune pathogenic traits. This disease is characterized with erythematous plaque and silvery scales that is severely itchy, swells, and is painful, which causes patients to have a poor quality of life. In the last years, there has been several effective therapies that is developed to treat psoriasis, but despite this, a proportion of patients do not respond or lose respond over time towards these therapies. However, there is a novel therapy found which is Bimekizumab, it is the first monoclonal antibody that is designed to target both IL-17A and IL-17F simultaneously. Bimekizumab is proved as the choice of therapy for psoriasis that reduces psoriasis plaque patients PASI score up to 100 with a minimal and mild side effects, and no immunogenicity detected. It also works in a shorter amount of time to reach PASI 90 as early as week 4 and can maintain response up to week 52. This objective of this literature review is to discuss about the superiority of bimekizumab compared to other therapies for psoriasis vulgaris.
Uji Daya Hambat Ekstrak Teh Hijau (Camellia sinensis) Terhadap Pertumbuhan Candida albicans Secara In Vitro Chaidir Ali Paradise; Dian Ayu Fitriani; Rolly Riksanto Bahtiar
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2819

Abstract

Candidiasis is any  infection  caused by Candida albicans and other species of the genus Candida. Bioactive compounds such as flavonoid, tannin and saponin have antifungal activity. Several studies have investigated the bioactive compounds  in green tea leaves (Camellia sinensis). Objective is to determine the ability of  green tea leaf extract (Camellia sinensis) to combat the growth of Candida albicans. A true experimental study. Green tea leaf (Camellia sinensis) and Candida albicans extract were used as the sample. Results According to the Davis and Stout method, green tea (Camellia sinensis) extracts at concentrations of 25% and 75% showed moderate inhibition of Candida albicans growth on the first day of  Candida albicans incubation. , while 50% concentration showed strong inhibition. against the growth of Candida albicans and on the second day at concentrations of 25%, 50% and 75%  the growth of Candida albicans was not prevented. While the positive control using nystatin strongly inhibited and the negative control did not inhibit the growth of Candida albicans on the second day. first and second. Green tea leaf (Camellia sinensis) extract effectively inhibits the growth of Candida albicans during incubation.
Literatur Riview Urinary Tract Infection in Children: Infeksi Saluran Kemih pada Anak Angela Angela
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v2i1.2820

Abstract

Urinary tract infection is an infection that is mainly found in children and can affect the upper and lower parts of the urinary tract. Urinary tract infection is one of the most common causes of fever experienced by children, especially girls. The infection is classified into upper urinary tract infections (pyelonephritis), lower tract (cystitis), and asymptomatic bacteriuria. This study aims to explore the symptoms, diagnosis, and management of UTI in children. It was found that urinalysis and urine culture were needed in diagnosing UTI by considering urine sampling. Urinalysis could diagnose UTI if positive esterase or nitrite leukocytes and urine culture were found. Managing urinary tract infections in children could be challenging because of the vague and non-specific symptoms. However, it must consider the level of resistance, the child's age, the location of the infection, the severity, and the antibiotics given. The study found that the treatment of UTI was carried out to prevent sepsis in children, where antibiotics were still one of the primary therapies to treat urinary tract infections in children. The use of antibiotics in children with Vesicoureteral Reflux (VUR) aimed to reduce the recurrence of urinary tract infections, so a low dose of antimicrobials was recommended.

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