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Jurnal MedScientiae
Published by Universitas Kristen Krida Wacana
ISSN : -     EISSN : 28291166     DOI : https://doi.org/10.36452/jmedscientiae
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal MedScientiae adalah jurnal yang dikelola oleh Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Krida Wacana. Jurnal ini mempublikasikan artikel-artikel secara open access dalam lingkup bidang kedokteran dan kesehatan seperti kedokteran dasar, bioetika kedokteran, biologi sel, biologi molekuler, genetika, fisiologi, biokimia, bioinformatika, anatomi, farmakologi, kesehatan masyarakat, dan ilmu biomedik lainnya. Tim editorial menerima naskah berupa artikel penelitian, literature dan systematic review, dan laporan kasus. Naskah yang dikirimkan hendaknya belum pernah diterbitkan sebelumnya di jurnal maupun media yang lain dan disiapkan sesuai dengan template atau format yang telah ditentukan. Setiap naskah yang memenuhi kriteria jurnal akan direview oleh pakar yang sesuai (peer reviewer). Jurnal MedScientiae tidak mengenakan biaya selama proses mulai dari penerimaan naskah hingga publikasi. Jurnal MedScientiae terbit 3 kali dalam satu tahun, yaitu pada bulan April, Agustus dan Desember dengan cakupan keilmuan yang telah disebutkan di atas. Edisi pertama jurnal akan diterbikan di bulan Mei tahun 2022 dengan nomor ISSN 2829-1166.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 220 Documents
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Hubungan Antara Vulva Hygiene Dan Penggunaan Alat Kontrasepsi Dalam Rahim dengan Keputihan pada Wanita Usia Subur Petri Damiani Anindyajati; Ade Dharmawan; Nicolas Layanto; Monica Cherlady
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v2i1.2821

Abstract

Pathological vaginal discharge is an abnormal disorder that often occurs in women of childbearing age and is characterized by a white discharge with a thick, white-yellow or white-greenish consistency, sometimes accompanied by an unpleasant odor and itching, often caused by several problems such as vulvovaginal infections. This happens because the composition of the vaginal microflora changes, which is influenced by internal factors (age, hormonal changes during menarche, menstruation, and pregnancy) and external factors (hygiene practices, sexual relations, and contraceptive use). The purpose of this article is to look at the relationship between vulva hygiene and intrauterine contraceptives with the incidence of vaginal discharge in women of childbearing age. The data was searched using Google Scholar and PubMed and found 8 articles that met the criteria. Various risk factors that affect the occurrence of vaginal discharge due to the use of non-hormonal intrauterine contraceptive devices that occur in women of childbearing age and through good vulvar hygiene behavior, can reduce the risk of physiological and pathological vaginal discharge. Based on the analysis conducted, it was concluded that there is a relationship between vulva hygiene and the use of intrauterine contraceptive devices with vaginal discharge in women of childbearing age
The Potential of Adeno-associated virus Vector Gene Therapy for Achromatopsia Farianti Wiranda; Grace Marta Tanjung; Yudha Pandapotan; Santi Anugrahsari
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2828

Abstract

Achromatopsia, also known as color blindness, is the inability to distinguish certain colors. Where this is the inability of the eye cone cells to capture a certain color spectrum due to genetic factors and certain diseases. Abnormalities in the anatomical structure of the eye located on the retina and inherited recessively. These mutations lead to functional loss and slowly progressive degeneration of the cone photoreceptors. Treatment for color blindness is currently limited to genetic counseling, glasses or colored contact lenses. Genetic therapy methods are currently being developed targeting the retinal organs using recombinant adenovirus vectors. The results of research conducted on animals found an improvement in the function of cone cells so that gene therapy is a promising modality in the future.
Tinjauan Pustaka terhadap Tatalaksana Terkini Ulkus Kornea Jamur Akibat Salah Penggunaan Lensa Kontak Satrio Arief Setiawan; Muhamad; Santi Anugrahsari Anugrahsari
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2842

Abstract

Microbial keratitis can cause corneal ulcers that can threaten vision. Keratitis is the leading cause of global corneal blindness with an estimated incidence of 2.5-799 cases per 100,000 population/year. Corneal ulcers contribute 5% of blindness worldwide and are the most common cause of corneal blindness in the developing countries. This is a review over articles from electronic databases which focuses on the topic relevance, research methods, subjects, and the results. The data were collected from NCBI, AAOJournalt and Google Scholar with keywords “Fungal”, “Corneal Ulcer”, “Treatment”, “Contact Lens”, “Jamur”, “Ulkus Kornea”, “Terapi”, and “Lensa Kontak”. The inclusion criteria are published from January 2012 to July 2022, a study of humans, available in full text, written English or Indonesian. Natamycin 5% is effective in the treatment of fungal keratitis, voriconazole is more effective against fungal keratitis, and oral posaconazole can serve as an effective treatment for refractory Paecilomyces keratitis, which is resistant to conventional therapy. If the use of drugs that are not enough to treat fungal keratitis, requires action intervention. In treatment with action there is novelty in the action of the combination of CLX and acellular porcine corneal stroma (APCS). Keywords: literature review, management, microbial keratitis
Mekanisme Kerja Prostaglandin Analog Terhadap Jalur Uveosklera dan Efeknya Untuk Menurunkan Tekanan Intra Okular Julian Tanri; Daberto Andrias; Edgar Christoffer Hasoloan; Yunia Gracia Sesa; Santi Anugrahsari
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2844

Abstract

High Intraocular Pressure (IOP) which is > 21 mmHg could damage optical nerves which could results in blindness. High IOP is often caused by an obstruction of the eye ball fluid circulation which is called the Aquoeus Humour. In this era, decreasing IOP is still a main focus during therapy. The application of this therapy however is still a challenge because of the lack of drug obedience especially because of the side effects. This review is intended to provide patient a complementary medication to fulfill their therapy. Literature references are acquired through online science database search engine using Google Scholar, Science Direct, and Pubmed. This review includes 9 journals, with all articles conlcuded that prostaglandin analogues are the best choice in order to decrease IOP. Prostaglandin analogue functions as to repair the outflow of the uveoscleral pathway. Latanoprost 0.005% and latanoprostene bunod 0.024% are the best choice of prostaglandin analogue as a therapy for glaucoma, ocular hypertension, and many other diseases that increases IOP. The side effects of the prostaglandin analogue don’t appear often in patients and the side effects were shown to be mild which is considered preferable and safe decision for therapy.
Prevalensi Hipertensi pada Aplikator Pestisida dan Faktor yang Berkontribusi: Studi Potong Lintang Jen Fuk Liem; Apricylia Gloria Elizabeth Lumanauw; Yosephin Sri Sutanti; Johannes Hudyono
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2855

Abstract

The purpose of this study is to determine the prevalence of high blood pressure (HBP) and the contributing factors in pesticide applicators in Cibodas Village, where chemical pesticides are widely utilized. This cross-sectional study included 90 pesticide applicators in total. The information on individual and occupational characteristics was gathered using a structured interview-administered questionnaire. An upper-arm digital blood pressure monitor was used to measure blood pressure. Data were presented descriptively, and statistical analysis was performed using the chi-square and multiple logistic regression. The majority of participants were men. 94% of individuals used a combination of pesticides on a regular basis. In this study, the prevalence of HBP was 48.9%. High BP was associated with age > 44 years, and a high exposure group. These results support the idea of the importance of multisectoral collaboration in providing knowledge about the potential health effects of exposure to pesticides and comprehensive training on the proper handling of pesticides in agriculture.
Correlation Between Vulva Hygiene And Intrauterine Device Use And The Event Of Vaginal Discharge In Women Of Reproductive Age Petri Damiani; Ade Dharmawan; Nicolas Layanto; Donna Mesina Rosadini Pasaribu
Jurnal MedScientiae Vol. 2 No. 3 (2023): Desember
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2857

Abstract

Pathological leucorrhoea is an abnormal disorder in women of childbearing age that occurs in the body in the form of thick white, yellowish, greenish discharge. This is because the composition of the vaginal microflora fluctuates as a function of internal factors such as age,hormonal changes during menarche,menstruation,and pregnancy. External factors such as hygiene practices, sexual relations, and contraceptive use.In the use of Intrauterine devices, there is vaginal discharge that occurs as a result of the initial reaction to the presence of a foreign body, the use of intrauterine contraceptives which can change the chemical balance of the vagina and is thought to cause vaginitis. The research method for this literature review analyzed 8 research articles and assessed the articles based on predetermined inclusion and exclusion criteria. This literature reviews various risk factors that influence the occurrence of vaginitis due to the use of non-hormonal intrauterine contraceptive devices that occur in women of childbearing age and through good vulva hygiene behavior,can reduce the risk of physiological and pathological vaginal discharge.Based on these sources,it can be concluded that there is a relationship between vulva hygiene and the use of Intrauterine device with the incidence of vaginal discharge in women of childbearing age.
THE RELATIONSHIP OF BMI WITH THE MENSTRUAL CYCLE IN KRIDA WACANA CHRISTIAN UNIVERSITY STUDENTS FOR THE PERIOD OF MARCH – JULY 2022 Alice Orine Ximenes de Jesus Sarmento; Irene Maria Elena; Luciana Budiati Sutanto; Gracia J M T Winaktu
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i1.2859

Abstract

Body mass index (BMI) data from RISKESDAS shows that many women of childbearing age in Indonesia experience BMI problems and there are also several studies showing a significant relationship between BMI and the menstrual cycle. FKIK UKRIDA students with analytic research type and crosssectional design. From the data collection, there were 86 subjects from affordable populations who had been filtered according to the inclusion and exclusion criteria and the distribution of BMI data with menstrual cycles, namely there were no thin and normal BMI subjects who had oligomenorrhea, while the fat ones who experienced oligomenorrhea were 1.2%, for thin BMI with normal menstrual cycles there were 16.3%, normal BMI with normal menstrual cycles were 52.3%, and obese BMI with normal menstrual cycles were 24.4%. Meanwhile, thin BMI with polymenorrhea was 1.2% and there were no normal BMI subjects who had polymenorrhea, but in obese BMI with polymenorrhea there was 4.7%, in data analysis using Fisher's test there was P value = 0.010. Conclusion: there is a significant relationship between BMI and the menstrual cycle of FKIK UKRIDA students with P value = 0.010.
Efektivitas Obat Tetes Mata Sodium Hialuronat Pada Dry Eye Disease Grace Raveena Widelia Worumi; Jois Mauren Lumantobing; Michael Usup; Santi Anugrahsari
Jurnal MedScientiae Vol. 2 No. 3 (2023): Desember
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2875

Abstract

Dry eye disease (DED) or keratoconjunctivitis sicca is a multifactorial disease of the ocular surface characterized by loss of tear film homeostasis, inflammation and damage to the ocular surface as well as neurosensory abnormalities with symptoms such as the sensation of a foreign body in the eye, dry eyes, irritation, itching and sensitivity to light, which can impact a patient's daily activities and life.  The prevalence of DED is between 5% and 50% in the adult population which can be caused by factors such as female, cataract surgery, use of contact lenses, computers, thyroid disorders, hypertension, and use of antihistamines and antidepressants. One of the DED therapies is the provision of artificial tears where polymers such as hyaluronic acid can be used because they can increase tear volume and eye moisture.  This literature review was made with the aim of knowing the effectiveness of sodium hyaluronate eye drops in treating dry eye disease. 8 journals were selected through the PubMed, ProQuest and Google Scholar journal databases and then presented in the form of a literature review. Based on the analysis results, sodium hyaluronate eye drops are effective in relieving dry eye symptoms.
Microscopic Analysis of E-Cigarette Vapors Effects on the Eyes Lolinia Agustina Florensia; Purnamawati Purnamawati; Erma Mexcorry Sumbayak
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2888

Abstract

Recently, e-cigarettes or VAPE have become a new trend among smokers. Known as a modern cigarette with a wide selection of flavors and aromas such as vanilla, raspberry and spearmint as well as abundant steam, making vaping a favorite activity among teenagers. This research is a literature study on various medical research journal databases such as PubMed, Science Direct, Cochrane and Google Scholar. Based on research results, it is known that the vapor from vaping causes dryness, thickening and even damage to the cornea. The occurrence of lipid peroxidation by free radicals contained in vaping vapor causes the eye protective layer "tear film" consisting of lipid, aqueous, and mucin layers to be damaged. Dry eye syndrome and damage to the eye epithelium are characterized by a decrease in the number of goblet cells and inflammation of the corneal tissue, even an increased of potential for cataracts can occur either by direct exposure or by inhalation of vapors which causes a systemic increase in oxidant levels.
Gambaran Makroskopik dan Mikroskopik Pankreatitis Kronis dalam Pemeriksaan Postmortem Djai Yen Liauw; Vionita Simanjuntak; Lura Maharani; Clara Widjaja; Patricia Amanda Widjaja; Tirza Amelia SH; Jacinda Phowen; Gabriela Geby Wisal; Bernaditha Feby Shela Siburian; Nadya Calista Kimberly; Ireina Karyn; Vera Olivia
Jurnal MedScientiae Vol. 2 No. 3 (2023): Desember
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2893

Abstract

Pancreatitis is a disease of the pancreas due to an inflammatory process. Chronic pancreatitis often causes complications that increase both morbidity and mortality. Postmortem examination can provide macroscopic and microscopic findings that allow to determine the etiology of chronic pancreatitis. This article aims to comprehensively understand the macroscopic and microscopic features of chronic pancreatitis in the postmortem context, as well as identify the relevant implications of the findings. This article is a literature review research with database sources from PubMed, Google Scholar, ProQuest, and EBSCO research databases. Fibroinflammatory changes and ductal dilation (corkscrew appearance) are the macroscopic features of chronic pancreatitis, while microscopic changes can be found as loss of asinus, ductal dilation, and chronic inflammatory infiltrates. These findings can detect the underlying diseases of chronic pancreatitis due to excessive alcohol consumption or genetic disorders, and it has important forensic implications, such as genetic counseling or assessment of alcohol use that has the potential to contribute on death. In conclusion, chronic pancreatitis can be identified through macroscopic and microscopic findings on postmortem examination, and the findings have important implications in determining the cause of death and understanding the underlying disease condition.

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