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The Indonesian Journal of General Medicine
Published by International Medical Journal Corp. Ltd.
ISSN : -     EISSN : 3048104X     DOI : -
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Public Health Veterinary
ims: The Indonesian Journal of General Medicine aims to advance the field of medicine by disseminating high-quality research findings that are accessible to a broad audience of healthcare professionals, researchers, and policymakers. The journal is committed to supporting the development of medical knowledge and practice in Indonesia and globally, fostering innovative research and evidence-based clinical practices. Scope: The journal covers a wide range of topics within the general medical field, including but not limited to: Clinical studies in various medical disciplines Epidemiological research and public health issues Innovations in diagnostic techniques and treatments Reviews on current practices and emerging trends in medicine Case studies and clinical trials Health policy and medical education The Indonesian Journal of General Medicine welcomes submissions from all areas of medicine, particularly those that have significant implications for patient care, public health, and policy-making. The journal encourages submissions that offer new insights, propose novel approaches, or address challenges pertinent to the Indonesian and international medical communities.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 190 Documents
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The Analysis Study of Safety and Outcome of Ureteroscopy During Pregnancy: A Comprehensive Systematic Review Adzana Yasadhy Hangga Prasetyo; Yosie Yulanda Putra
The Indonesian Journal of General Medicine Vol. 7 No. 1 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/17c34338

Abstract

Background: Symptomatic urolithiasis in pregnancy can result in significant morbidity, causing conditions such as renal colic, urinary tract infections, and ureteral obstruction. This systematic review aim to analyze the safety and outcomes of uretrhoscopy for pregnant women. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2014 to 2024. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were excluded. The literature search was conducted using PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 2,172 articles were initially identified through online databases (PubMed, SagePub, SpringerLink, and Google Scholar). After three rounds of screening, eight relevant studies were selected for full-text analysis. Conclusion: Ureteroscopy is a safe, effective, and cost-efficient treatment for ureteral calculi during pregnancy. Early intervention minimizes complications, and URS remains a successful option for managing obstructive uropathy. Future research should optimize protocols and assess long-term outcomes for improved care.
Use Of Glutathione As An Additional Supplement For The Treatment Of Fatty Liver Disease : A Systematic Review Pretty Grace Zalukhu; Widjaja Lukito
The Indonesian Journal of General Medicine Vol. 7 No. 1 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/jkw23v04

Abstract

Introduction : The liver normally contains fat tissue, but if it exceeds 5% of the liver weight, this condition is called fatty liver disease. Fatty liver disease is divided into two major groups, namely : Alcoholic Fatty Liver Disease (AFLD) and Non-Alcoholic Fatty Liver Disease (NAFLD). Fatty liver disease can potentially progress to liver cirrhosis, and this can be prevented by antioxidants, through their anti-inflammatory actions. Glutathione is a potent antioxidant, and naturally produced in our body, with the highest level in the liver, which is the main organ in the detoxification process. This study aimed to systematically review the importance of Glutathione as an adjunct supplement for the treatment of fatty liver disease, which is one of antioxidants, can help with fatty liver problems. Methods : This study applied a Systematic Review approach, that included published articles with Randomized Controlled Trials (RCTs). We searched these articles in two electronic databases, namely Google Scholar and PubMed. Based on the search, 1.141 cases of fatty liver were found and the author determined 2 (two) relevant literature/studies that focus on this research. Results : Based on 2 studies with a total of 208 patients and divided into 2 groups, namely the intervention group and the control group, it was found that the group that was intervened with glutathione supplementation for at least 3 months experienced a decrease in CAP, ALT, and IMT values. Especially if coupled with MHD/improved healthy lifestyle, the recovery process of fatty liver conditions can take place faster. Conclusions : Glutathione as an antioxidant and acts as a hepatoprotector, demonstrated the ability to potentially hold the progression of NAFLD, and improve liver function. The presence of MHD/improve healthy lifestyle synergized the efficacy of Glutathione against the progression of NAFLD.
The Analysis Study of Association of Dyslipidemia and Diabetic Retinopathy: A Comprehensive Systematic Review Anindi Putri Harjanti; Yuliani
The Indonesian Journal of General Medicine Vol. 7 No. 1 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/napbm925

Abstract

Introduction: Diabetic retinopathy (DR) is a leading cause of blindness in diabetic patients, and its progression is influenced by various factors, including dyslipidemia. This systematic review aims to assess the relationship between dyslipidemia and DR, focusing on lipid profiles such as LDL cholesterol, HDL cholesterol, triglycerides, and total cholesterol. Method: We conducted a systematic review of studies published between 2010 and 2023 that examined the association between dyslipidemia and DR in diabetic patients. Studies were selected based on inclusion criteria, including cross-sectional, cohort, and case-control designs. Data regarding lipid profiles, DR stages, and statistical significance were extracted and analyzed. Result: The literature search was conducted across reputable databases such as Science Direct, PubMed, and SagePub. After a rigorous three-level screening process, eight relevant studies were selected for detailed evaluation. These studies varied in design, including cross-sectional, cohort, and retrospective studies, and involved diverse sample sizes ranging from 45 to over 79 million participants.  The findings consistently indicated a significant association between dyslipidemia and diabetic retinopathy (DR). Several studies reported elevated levels of low-density lipoprotein (LDL) and triglycerides (TGs) and reduced levels of high-density lipoprotein (HDL) in patients with DR compared to those without. Additionally, certain studies suggested a protective effect of statins on non-proliferative diabetic retinopathy (NPDR), while medications such as pitavastatin and fenofibrate were associated with a reduced prevalence of proliferative diabetic retinopathy (PDR) and vitreous hemorrhage. Discussion: The findings suggest that dyslipidemia, particularly elevated LDL and reduced HDL cholesterol levels, contributes to the development and progression of DR. However, the lack of clear temporal precedence and the absence of control groups in some studies limit the ability to establish causality. The heterogeneity in study designs also affects the generalizability of the results. Conclusion: Dyslipidemia plays a significant role in the development and progression of diabetic retinopathy. Future research should focus on high-quality longitudinal studies that account for confounders and temporal relationships to better understand the causal link between dyslipidemia and DR.
A Comprehensive Literature Review of Effectiveness of Supplementary Calcium in Prevention of Preeclampsia Fajar Nurochman Sidik; Dhimas Muhammad Suharyo
The Indonesian Journal of General Medicine Vol. 7 No. 2 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/e3p9xq12

Abstract

Background: The literature on the effectiveness of supplementary calcium in preventing preeclampsia indicates a consensus among researchers about its potential benefits, although the evidence is nuanced and complex. Early discussions initiated by (López-Jaramillo et al., 2001) emphasized the necessity for large, controlled trials to establish a clearer understanding of the relationship between calcium supplementation and preeclampsia prevention. The variability in methodologies across studies complicates the ability to draw definitive conclusions, as highlighted by the inconsistencies in dosage, timing, and definitions of preeclampsia (removal of unmatched citation). Literature Review: The evidence presented by (Hofmeyr et al., 2014) indicates that low-dose calcium supplementation can significantly reduce the incidence of preeclampsia, particularly in populations at risk. This is echoed in the meta-analysis by (B. Adams et al., 2021), which highlighted the essential role of calcium in regulating blood pressure, particularly among women with low dietary intake. Furthermore, the exploration of calcium's physiological mechanisms, as discussed by (Perry et al., 2022), illustrates how calcium influences vascular function and may mitigate the risk of preeclampsia through various biological pathways. The findings from (Zavala et al., 2022) also affirm the protective effect of calcium supplementation, suggesting a substantial reduction in preeclampsia risk when higher doses are administered. Conclusion: In conclusion, while there is robust evidence supporting the role of calcium supplementation in preventing preeclampsia, the complexities surrounding dietary intake, individual risk factors, and the need for tailored supplementation strategies remain significant. Future research should aim to refine these recommendations and explore the optimal conditions under which calcium supplementation can be most effective in reducing the incidence of preeclampsia.
A Comprehensive Literature Review of Cost-Effectiveness of Uterine Tamponade Devices for The Treatment of Postpartum Hemorrhage Fajar Nurochman Sidik; Dhimas Muhammad Suharyo
The Indonesian Journal of General Medicine Vol. 7 No. 2 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/a0dwtt55

Abstract

Background: The literature on uterine tamponade devices for postpartum hemorrhage (PPH) reveals a complex interplay of efficacy, safety, and cost-effectiveness, particularly in low- and middle-income countries. Their modeling indicates that affordable UBT could significantly mitigate maternal morbidity and mortality, thus addressing a pressing healthcare challenge in resource-limited settings. Literature Review: Further expanding on this topic, (Pingray et al., 2021) conducted a systematic review that synthesizes various studies evaluating the effectiveness of uterine tamponade devices compared to standard care for refractory PPH. Their findings highlight the potential of these devices to reduce the necessity for surgical interventions and enhance maternal survival rates, presenting a strong case for the economic benefits of implementing UBT in clinical practice. Conversely, the article by (D. Weeks et al., 2022) brings a critical lens to the discussion, emphasizing the need for caution in adopting UBT widely. While acknowledging the high success rates associated with UBT, the authors raise concerns about the quality of the evidence, particularly the reliance on nonrandomized studies. They argue that the potential for increased need for further interventions post-UBT use necessitates a careful evaluation of the benefits versus risks. This perspective prompts a reevaluation of the implementation strategies for UBT, advocating for rigorous quality improvement measures within healthcare systems. Conclusion: Together, these articles provide a comprehensive understanding of the cost-effectiveness of uterine tamponade devices for PPH treatment. They highlight the urgent need for accessible interventions while emphasizing the importance of robust evidence and quality standards in their implementation. The discourse suggests that while UBT presents a promising solution, its successful integration into healthcare systems requires careful consideration of safety, efficacy, and the contextual challenges faced in diverse settings.
The Comprehensive Literature Review of Surgical Management of Omphalocele Yosie Yulanda Putra; Ririn Azhari
The Indonesian Journal of General Medicine Vol. 7 No. 2 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/a42kkh91

Abstract

Background: The surgical management of omphalocele has undergone significant evolution over the past decade, with various studies contributing to a deeper understanding of treatment modalities and outcomes.  Literature Review: In developing countries, challenges persist, particularly in managing ruptured omphaloceles where resources are limited. The adaptation of surgical techniques, such as employing simple suture methods in the absence of advanced materials, underscores the need for flexibility in surgical management (Komlatsè Akakpo-Numado et al., 2012). Furthermore, innovative conservative management approaches have shown promise, with gentian violet yielding satisfactory survival rates and reduced hospital stays, emphasizing the role of a multidisciplinary team in optimizing care (Rahman Mitul & Ferdous, 2012). The importance of individualized treatment plans is reinforced by findings from a tertiary care center, which advocate for conservative approaches in cases of giant omphalocele, utilizing staged management strategies that prioritize patient safety . Moreover, systemic inflammation's role in pulmonary hypertension related to isolated giant omphalocele further emphasizes the need for prenatal diagnosis and careful postnatal management, suggesting that a "paint-and-wait" approach can be beneficial (Teillet et al., 2022). Conclusion: In conclusion, the surgical management of omphalocele encompasses a variety of strategies that reflect the complexity of the condition and the necessity for individualized care. The literature collectively emphasizes the importance of adapting surgical techniques to specific patient needs, the benefits of conservative management in certain contexts, and the critical role of multidisciplinary teams in improving patient outcomes.
The Comprehensive Literature Review of Surgical Management of Gastroschisis Yosie Yulanda Putra; Ririn Azhari
The Indonesian Journal of General Medicine Vol. 7 No. 2 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/pzcy0v35

Abstract

Background: The surgical management of gastroschisis has evolved significantly over the years, reflecting advancements in both surgical techniques and neonatal care. The literature indicates a marked increase in the birth prevalence of gastroschisis, with a notable reduction in mortality rates from 60% in the 1960s to 3-10% by the mid-1990s, although recent studies suggest that mortality rates have plateaued (J Bradnock et al., 2011). Literature Review: Innovative approaches, such as the use of composite mesh, have emerged to address cases where traditional fascial closure is not feasible, thus highlighting the adaptability of surgical methods to meet patient-specific needs (K. Dikshit et al., 2015). Moreover, the focus on low- and middle-income countries (LMICs) emphasizes the need for accessible and practical surgical strategies, particularly the application of preformed silos that can be managed by trained healthcare personnel in resource-limited settings (J Wright et al., 2018). Emerging research on fetal surgical interventions highlights the potential for proactive management strategies that could improve outcomes by addressing the defect before birth (Durmaz et al., 2022). This shift towards minimally invasive techniques reflects a broader trend in surgical management, emphasizing the importance of careful patient selection and timing of intervention. Finally, the implications of umbilical cord graft closure and its association with umbilical hernia development underscore the need for meticulous postoperative assessment and management, highlighting the complexities involved in the long-term care of these patients (Taher et al., 2022). Conclusion: In conclusion, the literature on the surgical management of gastroschisis reveals a dynamic and evolving landscape characterized by innovation and adaptability in surgical techniques. The advancements in surgical care, particularly the integration of minimally invasive approaches and the focus on practical solutions for resource-limited settings, are pivotal in enhancing patient outcomes. However, ongoing research is essential to address existing gaps in knowledge and to refine management strategies further.
A Comprehensive Literature Review of Histopathology of Squamous Cell Carcinoma Wahyu Agus Prastyo; Artha Investari Nugraheni
The Indonesian Journal of General Medicine Vol. 7 No. 3 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/h70hva33

Abstract

Background: The literature on the histopathology of squamous cell carcinoma (SCC), particularly cutaneous squamous cell carcinoma (cSCC), has evolved significantly over the past decade, revealing a complex interplay of histopathologic features, molecular markers, and clinical outcomes.  Literature Review: The work by (K. El-Mofty, 2014) explores histopathologic risk factors associated with oral and oropharyngeal SCC variants, particularly those related to HPV. The identification of distinct morphological characteristics shared among keratinizing neoplasms is essential for accurate diagnosis and treatment planning. The article highlights the unique behaviors of HPV-related variants, which may exhibit either favorable prognoses or aggressive metastatic potential, thus necessitating careful evaluation. The role of immunohistochemical markers in the diagnosis and staging of cSCC is further elaborated by (Bălășescu et al., 2022), who identify key characteristics that predict disease progression. Their findings suggest that immunohistochemical markers can enhance diagnostic accuracy, particularly in poorly differentiated cases, thereby informing treatment strategies. Finally, (Gabriel Cocuz et al., 2022) provide a scientometric analysis of current research directions, highlighting the sustained interest in histopathology and immunohistochemistry of cSCC. Their work suggests an ongoing recognition of the importance of personalized diagnostics and targeted therapies to improve patient outcomes. Conclusion: In conclusion, the reviewed literature underscores the complexity of cSCC histopathology and the critical need for accurate diagnosis and staging. The integration of histopathological features with molecular markers and the continual evolution of diagnostic techniques are essential for refining our understanding of SCC behavior and enhancing treatment efficacy. Ongoing research is necessary to address existing challenges and optimize patient management strategies.
A Comprehensive Literature Review of Histopathology of Renal Cell Carcinoma Wahyu Agus Prastyo; Artha Investari Nugraheni
The Indonesian Journal of General Medicine Vol. 7 No. 3 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/g4852n71

Abstract

Background: The histopathology of renal cell carcinoma (RCC) encompasses a diverse array of subtypes, each characterized by distinct morphological and genetic features that have significant implications for clinical outcomes and treatment strategies. The evolution of our understanding of RCC has been reflected in a series of pivotal studies over the years, which have contributed to the molecular and histological classification of this malignancy. Literature Review: The exploration of ancillary techniques by (Pradhan et al., 2009) further enriched the discourse on RCC by emphasizing the significance of integrating histomorphology with molecular and cytogenetic analyses. This multifaceted approach is vital for improving diagnostic accuracy and tailoring treatment plans to individual patient needs ((Pradhan et al., 2009)). The comprehensive molecular characterization conducted by The Cancer Genome Atlas ((J. Ricketts et al., 2018)) revealed distinct genetic drivers associated with various RCC subtypes, emphasizing the importance of understanding these alterations for developing effective treatment strategies ((J. Ricketts et al., 2018)). Recent advancements in digital pathology, as discussed by (Zhu et al., 2020) and (Abu Haeyeh et al., 2022), highlight the potential of deep learning techniques to enhance diagnostic accuracy and streamline the classification of RCC subtypes, thus improving clinical outcomes ((Zhu et al., 2020); (Abu Haeyeh et al., 2022)). Conclusion: The analysis of papillary renal cell carcinoma by (S. Chawla et al., 2023) underscores the unique biological characteristics of this subtype and the challenges in advancing therapeutic strategies compared to clear cell RCC ((S. Chawla et al., 2023)). The literature collectively illustrates the dynamic and evolving nature of RCC histopathology, emphasizing the need for ongoing research to refine classification systems and enhance understanding of tumor biology, ultimately aiming to improve patient outcomes.
A Comprehensive Literature Review of Histopathology of Hepatocelullar Carcinoma Wahyu Agus Prastyo; Artha Investari Nugraheni
The Indonesian Journal of General Medicine Vol. 7 No. 3 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/xhcvh622

Abstract

Background: The literature surrounding hepatocellular carcinoma (HCC) reveals a complex interplay of histopathological features, molecular genetics, and clinical implications that shape the understanding and management of this prevalent malignancy. Literature Review: The molecular and genetic markers associated with HCC are explored by (El-Nakeep, 2022), who address the high mortality rates associated with HCC and the complex relationship between cirrhosis and HCC development. This discussion emphasizes the necessity for further investigation into the molecular pathways underlying HCC progression. The role of imaging in diagnosis and management is reinforced by (Chartampilas et al., 2022), highlighting the importance of dynamic imaging techniques in accurately staging HCC and assessing treatment responses. Moreover, localized studies, such as that by (Sweed et al., 2022), contribute to the understanding of HCC's heterogeneous nature, emphasizing morpho-molecular classifications that guide diagnosis and treatment. The immune landscape, as discussed by (Gryziak et al., 2022), introduces the implications of immune cell interactions within the tumor microenvironment, suggesting that immune profiles should be considered alongside histopathological features in tailoring treatment strategies. The mutational landscape of HCC and the potential for precision medicine are examined by (Gorji et al., 2023), advocating for personalized therapeutic strategies that account for the genetic diversity of HCC. Finally, (Hyuk Choi & N. Thung, 2023) synthesize recent advancements in histological and molecular classification, emphasizing the importance of accurate pathological classification for effective management and prognostication. Conclusion: In conclusion, the literature collectively underscores the critical integration of histopathological analysis with molecular insights and clinical practices to enhance the understanding of HCC. This multifaceted approach is essential for improving diagnosis, treatment, and patient outcomes in the context of this complex malignancy.

Page 10 of 19 | Total Record : 190

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