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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 25 Documents
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Search results for , issue "Vol 9 No 3 (2024)" : 25 Documents clear
REVIEW : OF SUPERDISINTEGRANT INGREDIENTS IN FAST DISINTEGRANT TABLET TABLET PREPARATIONS Fahmansyah, Lingga Pratama; Agus S; Suparman
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1292

Abstract

This study aimed to evaluate the potential of synthetic and natural disintegrating agents in fast-disintegrating tablet (FDT) formulations. The methodology used includes a comprehensive literature review on the definition, characteristics, working mechanisms, and applications of super disintegrants in the manufacture of FDTs. The results of the study showed that super disintegrants play an important role in facilitating rapid disintegration of tablets. Synthetic super disintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate have the advantage of lower concentrations and better intragranular effectiveness. On the other hand, natural superdisintegrants such as mucilages, gums, and polysaccharides from plants have easy availability, affordable prices, non-toxic properties, and biologically acceptable characteristics. In conclusion, the selection of an appropriate super disintegrant, whether synthetic or natural, is a key factor in effective FDT formulation and providing rapid disintegration. The combination of using super disintegrants at the granulation stage (intragranular) and before compression (extragranular) can produce better performance compared to a single method.  Keywords: FDT, Super disintegrant, Synthetic, Natural
EVALUATION OF AROMATERAPIC LILIN AIDE FORMULATION FROM AGRICULTURAL OIL OF AURISH (Cymbopogon citratus) AS AROMATERAPIC RELAXANT AND INSECT REPELLENT Hutahaen, Titi Agni; Nirmala, Atika; Nisa, Khoirotun; Saradewi, Amelya
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1295

Abstract

This study aimed to evaluate the formulation of aromatherapy candles using citronella essential oil (Cymbopogon citratus) as the active ingredient. Lemongrass essential oil was chosen because it has two main functions: as an aromatherapeutic relaxant and as an insect repellent. In this study, several candle formulations were prepared with varying concentrations of essential oils to determine the most effective and stable formulation. An effectiveness test was conducted by measuring the intensity of the scent, burning duration of the candle, and the ability to repel insects. The results showed that candles with 25% essential oil provided the best balance between scent intensity and insect repellent effectiveness. The candles also exhibited good stability during the storage. In conclusion, kitchen lemongrass essential oil is a potential ingredient for use in aromatherapy candles that not only provides a relaxing effect, but also functions as a natural insect repellent.  Keywords: kitchen lemongrass, aromatherapy candles, relaxants, insect repellent
CORRELATION OF COMMUNITY PHARMACIST KNOWLEDGE, ATTITUDES, AND PRACTICES IN THE DETECTION OF TUBERCULOSIS CASES IN WEST JAVA PROVINCE Mardhiyyah, Cut Ainul; Zuniarto, Ahmad Azrul; Amanatin, Alfitia Dwi; Ryansyah, Hardi; Antonia, Vonny
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1296

Abstract

Tuberculosis (TB) control is hampered by suboptimal case detection and treatment delays. Pharmacies are reported as a first-aid treatment for patients with TB. Therefore, researchers analyzed knowledge, attitudes, and practices (KAP) regarding TB case detection among community pharmacists, aiming to find innovative strategies to involve community pharmacists in TB case detection. The research aims to determine the level of knowledge, attitudes, and practices, and the relationship between knowledge and attitude, knowledge-practice, and attitude-practice of community pharmacists in detecting tuberculosis cases in West Java Province. This research uses a descriptive observational method with 419 pharmacists who practice pharmacies. The results showed that pharmacists had a sufficient level of knowledge (14.94 ± 1.99), an adequate level of attitude (63.58 ± 9.12), and a sufficient level of practice (20.58 ± 8.55) regarding TB case detection. There is a very low relationship between knowledge and attitude (p-value 0.024<0.05), knowledge and practice ( p-value 0.018>0.05), and attitude and practice ( p-value 0.000< 0.05). This study concluded that community pharmacists in West Java Province have sufficient knowledge, attitudes, and practices in detecting TB cases, but the level of relationship between knowledge attitude and detecting TB cases, and the level of association between knowledge attitude and knowledge practice was very low, while the relationship between attitude practice was low. Keywords: Pharmacist, Knowledge, Practice, Attitude, Tuberculosis
OPTIMIZATION OF VCO LOTION PREPARATIONS WITH VARIATIONS CETYL ALCOHOL AND CARRAGEEN CONCENTRATIONS USING SLD METHOD Sabiti, Farroh Bintang; Sholeh, Aries Badrus; Musyayadah, Zahrotul
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1303

Abstract

Lotion is a cosmetic preparation of an emollient group that contains a large amount of water. This formulation possesses several properties, namely, as a source of moisture for the skin, providing an oily layer that makes the hands and body soft. VCO is utilized as a natural skin moisturizer to prevent tissue damage and protect the skin. VCO has a very high moisture content, which prevents skin dryness. A lotion was formulated with an emulsifying agent to stabilize the emulsion system. One of the constituent ingredients of the lotion is cetyl alcohol, which functions as an emulsifying agent. Cetyl alcohol can be substituted by carrageenan, which serves the same function with the added benefit of being a humectant. The aim of this study was to identify the formulation of VCO lotion and to investigate the effect of different concentrations of the emulsifying agents cetyl alcohol and carrageen on physical evaluation tests, namely organoleptic tests, homogeneity tests, spreading tests, pH tests, adhesion tests, emulsion type tests, and viscosity tests in lotion formulations. An experimental method was employed in this study. The research was carried out by making lotions from various ingredients containing the active ingredient VCO at a concentration of 7%, as well as varying concentrations of cetyl alcohol (range 2-5%) and carrageenan (range 1-3%) as an emulsifying agent and additional ingredients for the preparations whose optimization had been determined using the simplex lattice design method ...
NANOSTRUCTURE LIPID CARRIER TECHNOLOGY IN DRUG DELIVERY: ROUTE OF ADMINISTRATION, PREPARATION METHOD, CHARACTERIZATION, AND APPLICATION FOR ANTI-AGING Muliana, Muliana; Alatas, Fikri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1319

Abstract

The new method, known as nanostructured lipid carrier (NLC) in drug delivery systems, has the potential to increase therapeutic efficacy, stability, and bioavailability. This systematic literature review aimed to provide a detailed summary of NLC technology in drug delivery systems, including routes of administration, preparation methods, characterization, and utilization for the delivery of anti-aging active ingredients in cosmetics. To collect scholarly articles on NLCs, we employed a systematic search method using Google Scholar and PubMed. After the screening process, 53 pertinent papers out of 102 articles were chosen for descriptive analysis. NLC exhibit significant promise in many drug delivery applications, including oral, topical, parenteral, and transmucosal routes, with many benefits, including improved bioavailability, stability, and drug penetration through the skin, cornea, and brain. Moreover, NLC technology has been effectively applied for the administration of drugs, including anti-aging drugs. Topical anti-aging preparations generally use synthetic or natural active ingredients. However, synthetic ingredients are often less stable and can irritate skin. NLC can protect and control the release of active ingredients, thereby reducing the risk of irritation. NLC can also improve the penetration of active ingredients into the deeper layers of the skin, allowing it to reach the dermis layer, which is responsible for most skin aging. The efficient absorption capacity of NLC technology in topical preparations presents new opportunities for anti-aging cosmetic product development owing to its effectiveness in skin penetration. Keywords: Nanostructured Lipid Carrier (NLC), drug delivery system, drug penetration, anti-aging

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