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Nanang Yunarto
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Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Kementerian Kesehatan RI Jl. Percetakan Negara No. 23 - Jakarta 10560
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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "VOLUME 2, NOMOR 1, FEBRUARI 2012" : 5 Documents clear
Efek Pemberian Ekstrak Etanol Akar Kolesom (Talinum triangulare Willd) terhadap Spermatogenesis Tikus Putih Nugroho, Yun Astuti; Rahayu, Lestari; Susanti, Ratna Indah
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3713

Abstract

In Indonesia infertility is still a problem for married couples, because 10-15% of married couples suffer from infertility. Infertility can be caused by the husband and wife, but in reality 40-60% are caused by the husband. Data infertility based on analysis of cement, which is one important way to determine the level of male fertility. Cement circumstances that can cause infertility, among others, the less the number of spermatozoa, sperm motility is low, the velocity of spermatozoa and so on. Kolesom (Talinum triangulare Willd) can increase the number and motility of spermatozoa and to increase testosterone levels. The study aims to determine the effect of kolesom root extract on spermatogenesis of male Wistar rats. The effect of kolesom root extract on spermatogenesis using the WHO (2000) with animal white mouse. 225 doses of ethanol extract; 675 and 2025 mg / kg. administered orally for 45 days. Distilled water as a control and comparative dosage Korean Ginseng 225 mg / kg. The results of the study, kolesom extract doses 225; 675 and 2025 mg / kg BB given for 45 days did not lose reproductive organ testis and epididymis can still increase the number of A spermatogonia, pachytene stage primary spermatocytes and the diameter of seminiferous.
Kajian Potensi Penggunaan Bioreaktor terhadap Senyawa Ajmalisin Suatu Contoh Produksi Metabolit Sekunder Tanaman Obat Saraswati, Ratih Dian
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3714

Abstract

The limited availability of medicinal plants as well as their limitations in cultivation as a source of medicinal compounds can lead to excessive harvesting, habitat destruction and destructive exploration. This led to the extinction of rare plants and caused the condition of natural resources worse. The purpose of this study is to elucidate the potential of bioreactor in terms of its ability to increase the active compounds of plant obtained from C. roseus ajmalicine. The data was obtained from various references. The main references discuss about ajmalicine and bioreactor.In general, the concentration of compounds produced by cell suspension is higher than its original concentration in the plants. In study cases of ajmalicine, the compounds were produced as much as seven times more than these compounds in native plants. Other studies show that the use of different plant organs, the addition of elicitor, the weight ofinitial cells as well as aeration rate can affect the concentration of ajmalicine obtained from medium in the bioreactor. Tissue cultured plants in bioreactor can produce secondary metabolites in a short time with high yields. However, previous optimazation should be carried out in terms of adding elicitor, aeration rate and pH condition of the bioreactor
Tingkat Aktivitas Sel Endokrin Penghasil Folikel Stimulating Hormon (FSH) Terkait Pemberian Pasak Bumi (Eurycoma Longifolia JACK) Pratomo, Hurip; Supriatna, Iman; Winarto, Adi; Manalu, Wasmen
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3715

Abstract

Pasak bumi is popular as an aphrodisiac. Traditionally, pasak bumi infusion is used to increase libido and duration of erection. The research was focused on: Activity level of FSH cells after three days of pasak bumi treatment. The research was carried out by evaluation using immunohistochemistry method via antibody anti FSH staining. The result of the research showed that a dosage of 18 mg/200 g body weight (bw) orally of pasak bumi maintained certain endoceine positive cells e.g. FSH production cells and were found stabile in the third days. Pasak bumi serves a stabilizer for intracellular levels of FSH in the anterior hipophysis/pituatary.
Isolasi Biflavonoid Baru dari Garcinia tetranda Pierre Berdasarkan Jalur Biogenesis dan Aktivitas terhadap Antibakteri Sulistyaningrum, Novi; Ersam, Taslim
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3716

Abstract

Garcinia tetranda Pierre (Clusiaceae) is a plant that is widely used to treat various diseases and its chemical compounds has not been much studied. Compound isolation using the three methods of chromatography (Vacuum Liquid Chromatography Column (VLCC), preparative Thin Layer Chromatography (pTLC) and TLC) generate novel compound 5,7,4 ', 5'', 7'', 3''', 4 '''-heptahidroksi-2'''-methoxy-flavanon [ 3,8 ]-flavone'' which is different from the compounds that had been found previously in Garcinia tetranda Pierre. Structure identification was conducted using UV, IR and NMR spectroscopic data and by comparing the 13C and 1H-NMR data of the isolate compound and known biflavonoid compounds. Biogenesis pathway analysis of the new compound showing relationship with molecular compounds which have previously been found in Garcinia. Antibacterial test of the novel compound using Kirby-Bauer agar diffusion methode against Gram-negative bacteria Salmonella typhi showed that the compound is not potentially used as antibacterial agent compared to chloramphenicol.
Kajian Peraturan Perundang-Undangan Tentang Pemberian Informasi Obat dan Obat Tradisonal di Indonesia Supardi, Sudibyo; Handayani, Rini Sasanti; Herman, M. J.; Raharni, Raharni; Susyanty, Andi Leny
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3739

Abstract

Lack of information or inappopriate of information on medicine and traditional medicine caused unsuitable utilization of them. The objective of this study was analyzing the regulation of the medicine and traditional medicines information announcement and the implementation of the relevant institutions as well, even in the central, provincial and district level. Cross sectional study with qualitative approach due to the regulation of medicine and traditional medicine information announcement, as well as the related institutions. The study carried out at 2009, in Jakarta, Yogyakarta, Denpasar, Medan and Banjarmasin. The samples ofthis study were pharmacists as officers on The National Agency of Drug and Food Control (Badan POM), Provincial Health Offices, District Health Oflices, pharmaceutical companies, hospitals, pharmacies, and other relevant institutions. Data collecting has been conducted by depth interviews, focus group discussions, while the secondary data has been collected by multiplies of the document needed. Descriptive and qualitative analyzed the data, and final results completed by round table discussion. NADF C announce the information of medicine and traditional medicine to the community and pharmaceutical companies. Provincial Health Office and District Health Ojfice announce the information to the community by socialization, and announce directly to the patients in Primary Health Care, While the pharmaceutical companies provide their own products information. Besides, the hospitals and pharmacies provide the medicine information to the patients; Announcing the information to the community by the government has not been optimal yet to compensate traditional medicine advertizing, since the advertizing services to the community has not been used eflectively; The Indonesian Consumer Organization is one of the institution that participate in announcing information to the community. Besides, the pharmaceutical colleges and pharmacies has also provide information to the community.

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