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Hamsu Kadriyan
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Lombok Medical Journal
Published by Universitas Mataram
ISSN : -     EISSN : 28277686     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Public Health
Lombok Medical Journal (LMJ) is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, community or public health research, and medical education to integrate researches in all aspects of human health. This journal publishes original articles, reviews, and case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures, treatment, or other health issues that is important for the development of health care system are also acceptable. Focus and Scope of Lombok Medical Journal (LMJ): Basic Science, Clinical Research, Community or public health research, Medical Education
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 176 Documents
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Evaluation of Solanum lasiocarpum Fruit Extract on Blood Glucose, Hematological Parameters, and Liver and Kidney Function in Alloxan-induced Diabetic Rats Syukriah; Nurlian Augustin Ningrum; Siti Amira
Lombok Medical Journal Vol. 5 No. 2 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/gq0svd83

Abstract

Hyperglycemia is an increase in blood glucose levels that leads to diabetes mellitus. Diabetes mellitus caused by insulin resistance and impaired insulin secretion. Eggplant (Solanum lasiocarpum) is an herbal plant used as a traditional remedy for diabetes mellitus. This study aims to determine the effect of Eggplant fruit extract (S. lasiocarpum) on blood glucose, blood profile, SGPT, SGOT, creatinine, and ureum levels in diabetic rats. This study used a completely randomized design with six groups (G1: normal control, G2: diabetes control, G3: metformin control, G4: extract dose 200 mg/kg BW; G5: extract dose 300 mg/kg BW; and G6: extract dose 400 mg/kg BW. Measurement of  SGPT, SGOT, Urea, and Creatinine levels using a spectrophotometer. Data analysis uses one-way ANOVA and Duncan at a significance level of 0.05. Statistical analysis revealed a significant difference (p<0.05) between the control group and extract therapy in blood glucose, blood profile tests, SGPT, SGOT, creatinine, and urem. The optimal dose of S. lasiocarpum fruit extract to reduce the effects caused by diabetes was  400 mg/kg BW.
Acute Kidney Injury in 43 Years Old Male Patient Caused by Severe Leptospirosis  Ajeng Sulistianing Utami; Amanukarti Resi Oetomo
Lombok Medical Journal Vol. 5 No. 2 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/adjgba31

Abstract

Leptospirosis is a zoonotic infectious disease commonly found in tropical regions, caused by Leptospira interrogans, a pathogenic spirochete. The main reservoir is rodents, especially rats. Human transmission occurs either directly through inoculation from infected animal tissues, body fluids and urine, or indirectly through contact via mucosal surfaces or abraded skin. The excretion of organisms through the urine of infected animals represents the most common source of Leptospira infection. As of mid-2024, 367 cases of leptospirosis with 42 deaths had been reported in Indonesia. However, the true incidence is likely underreported due to diagnostic challenges. In West Nusa Tenggara (NTB), no formal report exists; however, a data from Mataram City Hospital between 2013-2025 recorded three cases of leptospirosis involving renal impairment requiring hemodialysis (HD). The clinical course of leptospirosis is typically acute, following an incubation period of five to fourteen days. Most patients present with mild, anicteric febrile, but a smaller subset develop severe multiorgan involvement known as Weil’s Disease. The severe form is characterized by acute high-grade fever, acute kidney injury, hepatic failure, pulmonary involvement, cardiovascular instability, neurological deficits, and hemorrhagic diathesis.
Diagnosis dan Tatalaksana Prostatitis Ali Ramzi; Fatimah Firza; Hadijatul Qubro
Lombok Medical Journal Vol. 5 No. 2 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jzky2q15

Abstract

Prostatitis is a common urological condition in men of all ages, ranging from acute and chronic bacterial prostatitis to chronic pelvic pain syndrome (CP/CPPS) and asymptomatic inflammatory prostatitis. The condition is characterized by pelvic pain, lower urinary tract symptoms, and, in some cases, sexual dysfunction, significantly affecting quality of life. Major risk factors include bacterial infection, chronic inflammation, and functional obstruction. Pathophysiology involves bacterial invasion, immune response, and neuromuscular dysfunction in CP/CPPS. Management depends on the type of prostatitis and includes antibiotics for bacterial prostatitis, alpha-blockers, anti-inflammatory agents, and multimodal approaches such as the UPOINT system for CP/CPPS, while asymptomatic cases require monitoring. Early diagnosis and tailored therapy are essential to reduce complications and improve patient outcomes
Multiple Cranial Nerve Palsy (MCNP) in Cerebral Sinus Vein Thrombosis (CSVT) due to Bilateral Septic Cavernous Sinus Granulomatous Abscess and Multiple Sinusitis: A Case Report M. Ikhlas Muttaqin Aditiarman; M. Sofyan Faridi; I Wayan Tunjung; Dhesty Fadhilah Faatin
Lombok Medical Journal Vol. 5 No. 2 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/dbq0zm27

Abstract

Case reports about cavernous sinus venous thrombosis (CSVT) with ophtalmoplegia are relatively rare caused by a long-standing dental infection complicated by a history of long-term smoking, leading to granulomatous abscesses and multiple sinusitis. A 48-year-old man admitted to the Emergency Department presenting of an inability to lift his left eyelid and to move his eyeball in any direction for the past 3 days, the symptoms were experienced suddenly. Multiple cranial nerves palsy (MCNP) or ophtalmoplegia in CSVT is a neurological disorder involving more than two non-homologous cranial nerves simultaneously. CSVT in this case occurs as a result of inflammation in response to granulomatous abscess of the cavernous sinus and multiple sinusitis due to a longterm untreated history of dental infection with long history of smoking. Clinical accompanying was progressive headache, ophtalgia, ptosis and proptosis. This case report highlights the importance of neuroimaging examinations, particularly CT scans, MRI, and MRA of the head, as the primary standard for establishing a diagnosis of CSVT, thereby enabling appropriate evaluation therapy and substantially determining a favorable prognosis
Insiden Pneumotoraks setelah Prosedur Intervensi Paru: Systematic Review Syabila Andini; Gemilang Khusnurrokhman
Lombok Medical Journal Vol. 5 No. 2 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/dd3y8n39

Abstract

Diagnostic management of peripheral lung lesions and diffuse lung parenchymal disease faces major challenges in balancing diagnostic accuracy with the risk of complications. Pneumothorax is the most frequently reported iatrogenic complication and can increase morbidity, the need for emergency intervention, and patient length of hospital stay. This study aims to systematically evaluate the incidence of pneumothorax and the requirement for thoracic drainage in various lung intervention methods to provide safety-focused procedural selection guidance. This systematic review was prepared following PRISMA guidelines with a comprehensive literature search on PubMed, Cochrane Library, and Frontiers databases. Analysis revealed significant risk variation between intervention methods. CT-guided percutaneous transthoracic lung biopsy (CT-PTLB) procedures showed the highest risk, with pneumothorax rates reaching 25.9% and chest tube requirements at 6.9%. Conversely, transbronchial techniques offer a better safety profile, where conventional transbronchial lung biopsy has a pneumothorax incidence of 1-6%, r-EBUS approximately 1.4-5.0%, and transbronchial cryobiopsy between 6-10%. Risk factors such as emphysema, lesion depth >2 cm, and the use of larger needle sizes (18G) were identified as strong predictors of pneumothorax. Selection of the appropriate technique and patient positioning (biopsy-side down) are highly recommended to minimize complications while maintaining patient safety.
The Potency of Atorvastatin Nanoparticles Implementation in Human: A Pharmacokinetic Perspective from Basic to Clinical Literature Review Candra Dwipayana Hamdin; Vania Aisyah Aulia Syahda Haris; Steve Pratama Tanjaya; Shafira Khansa Haiba; Faolananda Qurrota A&#039;yun
Lombok Medical Journal Vol. 5 No. 2 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/e9cn9w04

Abstract

Atorvastatin is a biopharmaceutics classification system class II drug with good permeability but low solubility, thereby limiting its bioavailability and therapeutic efficacy. This study aims to analyze the effect of particle size reduction on the pharmacokinetic parameters (Cmax, Tmax, AUC, t½) of atorvastatin in various drug delivery systems and thepotency of its implementation in human through a literature review approach. Literature screening was conducted using online databases including Google Scholar, PubMed, ScienceDirect, and Springer Open, with inclusion criteria of national and international articles published in the last 10 years discussing atorvastatin formulations with various particle sizes and their pharmacokinetic parameters. Analysis of the 11 selected articles showed that nano-based delivery systems can increase the bioavailability of atorvastatin compared to conventional formulations. The results confirmed that particle size reductionthrough nanotechnology approaches increased the dissolution rate, membrane permeability, and absorption efficiency, thereby optimizing the pharmacokinetic profile of atorvastatin. This review provides evidence that nano-scale formulation strategies have a consistent positive impact on the bioavailability of atorvastatin. Despite these promising preclinical findings, the implementation of atorvastatin nanoparticles in humans remains limited due to the absence of clinical trials, although their potency to improve bioavailability and reduce dose-dependent toxicity at lower doses offers a strong rationale for futuretranslational research.
The Role of Galactose-induced Oxidative Stress on Cellular Aging: A Literature Review Putri Krishna Kumara Dewi; Ni Made Dwi Rosmiati; Citra Ariani
Lombok Medical Journal Vol. 5 No. 1 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/72mdav74

Abstract

Aging is a complex process impacted by both internal and external causes. Nutrition is a crucial extrinsic factor in the development of aging and degenerative disorders. D-galactose is involved in many aging mechanisms in the brain, heart, liver, kidney, and skin. Galactose-induced cellular aging is primarily caused by oxidative stress and a reduced antioxidant system. Overproduction of ROS can damage proteins, lipids, and DNA. The recommended daily dietary limit for D-galactose is 50 grams for healthy people who can completely remove it within 8 hours. An in vivo study revealed that consuming 150 mg/kg/day of galactose led to metabolic issues, heightened blood pressure, and disrupted cardiac sympathovagal balance. These outcomes resulted from compromised cardiac mitochondrial activity, elevated oxidative stress, inflammation, and mitochondrial dysfunction, which caused cell death and eventually cardiac failure. A diet high in carbohydrates, particularly those derived from dairy products and their derivatives, can lead to the accumulation of galactose and its metabolites within cells. This buildup subsequently increases reactive oxygen species and reduces antioxidant capacity, resulting in mitochondrial dysfunction and heightened oxidative and osmotic stress. The culmination of these processes is a decline in cellular function, senescence, and accelerated organ aging.
Optimalisasi Nanopartikel Lipid Eksopolisakarida Termodifikasi Asam Folat untuk Penghantaran Trastuzumab Biosimilar Target HER2 pada Kanker Payudara I Kadek Ari Sanjaya; Baiq Bunga Citra Pratiwi
Lombok Medical Journal Vol. 5 No. 1 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/7qkkvg78

Abstract

Breast cancer remains a leading cause of cancer-related mortality, with HER2-positive subtypes accounting for 20-30% of cases. While trastuzumab has revolutionized treatment, its efficacy is limited by poor tumor penetration, systemic toxicity, and high costs. This literature review explores folic acid-modified exopolysaccharide lipid nanoparticles (FA-EPS-LNPs) as a novel delivery system for trastuzumab biosimilar. Exopolysaccharides offer biocompatibility and biodegradability, while lipid nanoparticles protect therapeutic proteins and enhance cellular uptake. Folic acid conjugation enables dual targeting through folate receptors overexpressed in cancer cells and HER2-specific activity. The review examines physicochemical properties, optimization parameters including particle size, surface charge, encapsulation efficiency, and folic acid conjugation methods. Evidence demonstrates enhanced cellular uptake, improved cytotoxicity, reduced off-target effects, and superior pharmacokinetics compared to conventional formulations. Challenges include scale-up manufacturing, stability, immunogenicity, and regulatory considerations. This review identifies knowledge gaps and highlights FA-EPS-LNPs' potential to improve treatment outcomes, reduce costs, and enhance patient quality of life in HER2-positive breast cancer therapy.
Paparan Timbal dan Stres Oksidatif: Dampak Klinis dan Mekanismenya Rahmah Dara Ayunda; Ardiana Ekawanti; Fitriannisa Faradina Zubaidi; Khairil Pahmi; Arsy Muchlisa Putri; I Nyoman Rhino Raditya
Lombok Medical Journal Vol. 5 No. 1 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/98qdar52

Abstract

Lead (Pb) exposure is a significant global environmental health concern, as this heavy metal lacks physiological function in the human body and is toxic, leading to various health disorders. One of the primary mechanisms of lead toxicity is the induction of oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and the capacity of endogenous antioxidant systems to neutralize them. Lead enhances ROS generation through mitochondrial dysfunction and reduces the activity of critical antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT), resulting in oxidative damage to lipids, proteins, and DNA, which subsequently triggers cellular and tissue dysfunction. The clinical consequences of lead-induced oxidative stress are observed across multiple organ systems, including the nervous system (cognitive impairment, memory loss, neuropathy), kidneys (nephropathy, decreased filtration function), liver (hepatotoxicity, metabolic disturbances), and the hematopoietic system (anemia, blood cell dysfunction). This literature review indicates that lead exposure induces cellular and tissue damage through multiple cellular pathways related to oxidative stress, elucidating the fundamental mechanisms by which lead causes clinical disorders in these organs. In conclusion, understanding these cellular mechanisms provides a scientific basis for linking lead exposure to the development of multi-organ diseases.
Rasio Neutrofil - Limfosit sebagai Prediktor Hasil Klinis pada Pasien dengan PPOK Eksaserbasi Akut: Tinjauan Literatur Devi Chandra Juvitha; Ni Komang Ayu Swanitri Wangiyana; I Gusti Agung Ayu Eka Putri Sunari
Lombok Medical Journal Vol. 5 No. 1 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/kpa54229

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a lung disease characterized by chronic respiratory symptoms that cause progressive and persistent airflow obstruction. Numerous inflammatory markers can be used to assess the inflammatory state in COPD patients. Neutrophil-to-Lymphocyte Ratio (NLR) is an inflammatory marker that is easy and practical to examine, which is included in a complete blood count (CBC). We conducted a narrative literature review using a thematic synthesis approach on 12 articles. Five articles demonstrated that the NLR is a good predictor of mortality or death in hospitalized patients with COPD. Two articles stated that a higher NLR in COPD patients increases the likelihood of requiring intensive care (ICU), while the other five articles explained that the NLR can be a good predictor of exacerbations in COPD patients.

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