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Department of Pharmacology and Therapy Radioputro Building 2nd Floor Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada Jl. Farmako Sekip Utara, Yogyakarta 55281 Indonesia
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INDONESIA
Indonesian Journal of Pharmacology and Therapy
Published by Universitas Gadjah Mada
ISSN : -     EISSN : 2745455X     DOI : https://doi.org/10.22146/ijpther.10147
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology
Indonesian Journal of Pharmacology and Therapy (IJPTher ) is a scientific journal which published by Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI). IJPTher is an open-access, and double-blind peer-reviewed journal published three Issues a year. IJPTher aims to communicate high-quality articles in the fields of pharmacology. IJPTher publishes original articles, review articles, case reports and book reviews in the fields of pharmacology including basic pharmacology, clinical pharmacology, pharmacotherapy, pharmacoepidemiology, pharmacogenetics, pharmacogenomics, pharmacoeconomic, toxicology and toxicogenomics.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 3 No 1 (2022)" : 5 Documents clear
The effects of probiotics in strengthening immunity against the COVID-19 infection Yuliana, .
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.2744

Abstract

A severe form of COVID-19 infection causes increasing in inflammatory cytokines, namely cytokine storm. Therefore, immunity of patients with COVID-19 should be strengthened in order against this infection. This paper aimed to evaluate the possible effects of probiotics in strengthening immunity patients with COVID-19. It is a narrative literature review papers based on PubMed, Science Direct, and Google Scholar databases. The keywords were COVID-19 pandemic, immunity, probiotics. Inclusion criteria were review and research paper. Exclusion criteria were not peer-reviewed journals and unavailable full text. Probiotics are beneficial live microbes, and they are well known for their immune and nutritional properties. The potential roles of probiotics to increase the immune system against the COVID-19 infection need to be studied in further clinical research. Most of the research related to the roles of lactic acid bacteria (LAB) are found in fermented food as probiotics. Many LAB are found in Indonesian fermented foods. Lactic acid bacteria roles are essential in the production of fermented foods. They also give some health benefits such as improving antioxidant activity, increasing antimicrobial agents production, and as probiotics.
Cytotoxic activity of hantap (Sterculia oblongata Mast) leaves extract against breast cancer cells line (MCF7/HER2): the effect on the expression of HER2 mRNA and the apoptosis Sitti Ayu Suhartina Yahya; Mustofa; Woro Rukmi Pratiwi; Adika Suwarman
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.3204

Abstract

Hantap leaves (Sterculia oblongata Mast) has been used traditionally to treat breast cancer in Palu, Central Sulawesi. However, its use is just based on empirical evidences rather than scientific evidences. The study aimed to investigate the cytotoxic activity of hantap leaves extracts against breast cancer cells line. The effect of this extract on the HER2 expression and the apoptosis was also evaluated. The hantap (S. oblongata Mast) leaves extracts were prepared by consecutive maceration method using n-hexane, methanol and water, respectively. The cytotoxic activity against MCF7/HER2 breast cancer cells line was evaluated using the MTT assay with doxorubicin as a positive control. The HER2 mRNA expression was examined using RT-PCR and the apoptosis after 24 h incubation was examined using a fluorescence microscope after AO-PI (acridine orange-propidium iodide) staining. Among three extracts tested, the methanolic extract exhibited the most cytotoxic against MCF7/HER2 cells with an IC50 of 91.25 μg/mL. Therefore, the methanolic extract was subjected to further study. The methanolic extract at concentration of 1/2IC50; 1IC50 and 2IC50 μM induced 6.8; 26.3 and 25.3% apoptosis of the MFC7/HER2 cell lines, respectively. The methanolic extract at concentration of 1/2IC50; 1IC50 and 2IC50 μM inhibited HER2 mRNA expression to be 0.6; 0.25 and 0.33 compared to control cells. In conclusion, the methanolic extract of hantap leaves (S. oblongata Mast) has cytotoxic activity against MCF7/HER2 breast cancer cell lines by induce cells apoptosis and inhibit HER2 mRNA expression. Further study, will be conducted to isolate active constituents as anticancer.
Efficacy and safety of antidiabetics agents in gestational diabetes mellitus (GDM): a literature review Rommy; Aldia Dwi Karinaningrum; Berliana Luthfiananda; Laduna Aniq; Lydia Sherly Evelina; Rifani Fauzi
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.3244

Abstract

One of the most common metabolic diseases during pregnancy period is gestational diabetes mellitus (GDM). It is associated with several perinatal complications, especially in those who have risk factors such as obesity, polycystic ovary syndrome, and a family history of type 2 diabetes mellitus (DM). Some research has shown that physical exercise and medical nutrition treatment can give beneficial effects to control glycemic and body weight for GDM affected women. Furthermore, pharmacological agents such as insulin and a specific oral antidiabetic can be prescribed safely during pregnancy to decrease maternal glucose blood. Therapy of GDM is needed to control blood for the wellness of the patient during and after the pregnancy. The main treatment therapy for GDM is lifestyle modification, which includes medical nutritional therapy and daily physical exercise. In the special case of disorder glucose level, drug therapy will be given to the patient. Insulin is the chosen drug because it is safe and does not cross the placenta. It is the gold standard pharmacological agent for GDM treatment. However, it still has some disadvantages such as the difficulties of how to use it, how many doses must be given, and the price that tends to be expensive. Consequently, the alternative drug may have to substitute it. Insulin can be substituted by metformin and glyburide (glibenclamide) in the form of oral antidiabetic. They are equal in terms of efficacy and safety compare to insulin as a treatment for GDM. Besides, they are also cheaper, and easy to use.
Effectiveness of nifedipine compared with other antihypertension on hypertension during pregnancy Juwita Permata Sari; Aisyah Nur Sapriati; Cyndi Yulanda Putri; Satya Prima Kustanto; Umu Kholifah
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.3248

Abstract

Hypertension is the most common complication of pregnancy. It is a major cause of maternal, fetal, and neonatal morbidity and mortality. In this article, the effectiveness of nifedipine compared with other antihypertensives in pregnant women with hypertension was reviewed. The randomized control trial (RCT) of nifedipine and other antihypertension in pregnancy without complications published from 2016 to 2021 in Google Scholar, Cochrane and PubMed were gathered. It was reported that antihypertensives administration to pregnant women with hypertension was very meaningful both for the mother herself and for the fetus or baby. Furthermore, nifedipine has better effectiveness in lowering blood pressure compared to other antihypertensives such as IV labetalol, oral labetalol, IV hydralazine, methyldopa in the treatment of preeclampsia, severe preeclampsia, severe pre-eclampsia/eclampsia, chronic hypertension, hypertension emergency, and severe hypertension.
Conventional synthetic disease-modifying antirheumatic drugs (csDMARD) in rheumatoid arthritis during pregnancy and lactation: a review Pulungan, Yulianasari; Saputra, Andy Kurniawan; Purnamasari, Desy; Wijayanti, Nunuk; Sari, Laras Ratna
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.3297

Abstract

Rheumatoid arthritis (RA) is an autoimmune and prominent inflammatory disorder that can affect wide of variety body systems, mainly joints. In Indonesia, the prevalence of RA is about 7.3% and mostly are women. The majority of women with RA are at childbearing and can be worsening throughout pregnancy and lactation. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) are the most common used medicine in RA for pregnancy and lactation. This scoping review was conducted using publications obtained from PubMed, Embase, The Cochrane Library, POPLINE, and Google Scholar concerning the safety of csDMARD in rheumatoid arthritis during pregnancy and lactation from 2011 to 2021. Among csDMARDs reviewed, sulfasalazine, hydroxychloroquine, chloroquine, and cyclosporine are relatively safe for pregnant and lactating women. However, they should be used in caution by considering the risk and benefit as well as under clinical supervision.

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