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Fakultas Farmasi UMI, Kampus II UMI, Jl. Urip Sumoharjo No.225, Panaikang, Panakkukang, Kota, Makassar,, Panaikang, Kec. Panakkukang, Macassar, Sulawesi Selatan 90231
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MPSJ
Published by Universitas Muslim Indonesia
ISSN : -     EISSN : 29870887     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Makassar Pharmaceutical Science Journal merupakan salah satu jurnal yang dikelola oleh Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Maret 2023. Makassar Pharmaceutical Science Journal merupakan jurnal ilmiah yang terbit secara on-line dan menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang farmasi sains.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 10 Documents
 1 
Search results for , issue "Vol 1 No 3 (2023)" : 10 Documents clear
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kayu Jawa (Lannea coromandelica (Houtt.) Merr.) Terhadap Bakteri Penyebab Infeksi Kulit Dengan Metode Difusi Agar Kayla, Aulia Putri; Fitriana, Fitriana; Nuryanti, Siska
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.40

Abstract

The purpose of this study was to determine the antibacterial activity of ethanol extract of Java wood leaves (Lannea coromandelica (Houtt.) Merr.) against bacteria that cause skin infections. The research method begins with an extraction process using the maceration method with 96% ethanol solvent and evaporated using a rotavapor. Java wood leaf ethanol extract was screened with a concentration of 0.1%; 0,5%; and 1% against bacteria Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Propionibacterium acnes. MIC and MBC tests were carried out and antibacterial activity tests were continued using the agar diffusion method with a concentration variation of 0.8%; 1,6%; 3,2%; 6,4%; and 12.8%. Screening test results of Staphylococcus aureus bacteria at 0.5% and Propionibacterium acnes bacteria at 0.1%. MIC value against Staphylococcus aureus bacteria at 0.2% and Propionibacterium acnes bacteria at 0.05%. While the MBC value against Staphylococcus aureus bacteria at 0.8% and Propionibacterium acnes bacteria at 1.6%. The results of testing the antibacterial activity of ethanol extract of Java wood leaves against Staphylococcus aureus and Propionibacterium acnes bacteria had the largest inhibitory zone diameter at a concentration of 12.8% of 11.32 mm and 12.83 mm respectively. Based on the results of research, ethanol extract of Java wood leaves has potential as an antibacterial.
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAUN KARET KEBO (Ficus elastica) DENGAN MENGGUNAKAN METODE FRAP Hasyim, Amita; Suhaenah, Asriani; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.76

Abstract

Free radicals are atoms, molecules or compounds that can stand alone, having one or more unpaired electrons in their outermost orbitals. Antioxidants are molecules that are able to deactivate or stabilize free radicals. The kebo rubber leaf plant is known to have benefits as an antioxidant because it contains ingredients such as glycosides, flavonoids, phenolic acids, alkaloids, steroids, saponins, coumarins, tannins, and triterpenoids. The aim of this research was to test the antioxidant activity of the ethyl acetate fraction of kebo rubber leaves (Ficus elatica) using the FRAP (Ferric Reducing Antioxidant Power) method. The rubber kebo leaf extraction method uses the maceration method with 96% ethanol solvent. The ethanol extract was fractionated using the liquid-liquid partition method to obtain the ethyl acetate fraction. the sample fraction was added with several FRAP reagents and then measured using a UV-Vis spectrophotometer at a maximum wavelength of 712 nm with quercetin as a comparison. The results showed that the ethyl acetate fraction of kebo rubber leaves for antioxidant activity was 26.692 mgQE/g fraction.
AKTIVITAS INHIBISI ENZIM ALFA-GLUKOSIDASE DARI EKSTRAK BUNGA KERSEN (Muntingia calabura L.) SECARA IN VITRO Azzahra, Resqinah; Maryam, St.; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.80

Abstract

The cherry tree is one of the plants that has great potential to be utilized because it contains several beneficial bioactive compounds, one of which is flavonoids.. The purpose of this research is to determine the alpha-glucosidase enzyme inhibition activity of an ethanol extract of cherry blossoms (Muntingia calabura L.) in vitro using a microplate reader instrument. The research method begins with preparing the sample by maceration using 96% ethanol as a solvent, followed by testing the inhibition of alpha-glucosidase enzyme activity using p-nitrophenyl- α-D-glucopyranoside (PNPG) substrate and acarbose as a comparison. The potential of a compound to inhibit enzyme activity can be determined by calculating the IC50. The results showed that the ethanol extract of cherry blossoms (Muntingia calabura L.) has an IC50 value of 135.53 µg/mL, higher than the IC50 value of acarbose at 41.17 µg/mL.
AKTIVITAS ANTIBAKTERI FRAKSINASI EKSTRAK DAUN ASAM JAWA (Tamarindus indica L.) (Tamarindus indica L.) TERHADAP BAKTERI Salmonella thyphi DAN Escherichia coli DENGAN METODE KLT-BIOAUTOGRAFI Rusli, Rusli; Faradila, Aulia; Kosman, Rachmat
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.87

Abstract

Tropical infectious diseases are often caused by viruses, bacteria, fungi or even parasites. Indonesian people use medical plants to treats diseases. One of them is tamarind leaves which have the ability as an antibacterial. The purpose of this study was to determine the antibacterial activity of the fractionated extract of tamarind leaves (Tamarindus indica L.) against Salmonella thyphi and Escherichia coli. Tamarind leaf simplicial was extracted using the maceration method and evaporated with a rotary evaporator to obtain thick extract. Then fractionated using n-hexane and ethyl acetate and evaporated again with a rotary evaporator. After that, ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) was used for antibacterial screening test with a concentration of 0,1% and 0,5%. Then, the TLC-Bioautography test was carried out and followed by the identification of chemical components. The results of the screening test of the ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) showed antibacterial activity against Salmonella thyphi and Escherichia coli. TLC-Bioautography test result showed that it was active on Salmonella thyphi and Escherichia coli with an Rf value of 0,81. Then the results of the identification of the chemical component of the ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) were positive for alkaloid and taninns. Based on this study, tamarind leaves have the potential as an antibacterial.
PROFIL PENYIMPANAN OBAT DI INSTALASI FARMASI RSUD ANDI DJEMMA MASAMBA, KABUPATEN LUWU UTARA achyar, lukman; Aztriana, Aztriana; Ririn, Ririn
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.88

Abstract

Pharmaceutical services, such as management including drug storage, must be considered because the treatment of various types of drugs or preparations is not the same. Drug storage is highly essential stage to maintain the quality of medicines, that drug storage must ensure the quality and safety of drugs in accordance with pharmaceutical requirements. The purpose of this study was to determine the profile of drug storage at Pharmaceutical Installation of Andi Djemma Masamba Hospital, North Luwu Regency and its compliance with applicable regulations in Indonesia. This research conducted qualitative and quantitative methods. The informants in this study consisted of the Head of Pharmaceutical Installation, Accompanying Pharmacist, and Head of Pharmacy Installation Warehouse of Andi Djemma Masamba Hospital, North Luwu Regency. The data were collected from observation, in-depth interviews, and data analysis. Presentation of conformity regarding facilities and infrastructure was found 100%. Next, the presentation of the storage place of narcotics, psychotropic substances and precursors was classified 100%. However, the presentation of drug storage methods was 88.8% which confirmed drugs were not arranged based on therapy class. The percentage of high alert drug storage methods of 80% was identified not to use the tall man lettering method. at last, presentation of 100% stock card recording has been performed on every drug mutation process.
UJI AKTIVITAS ANTIBAKTERI FUNGI ENDOFIT PADA DAUN SENGGANI (Melastoma malabathricum L.) ASAL LAMPARA MONCONGLOE TERHADAP BAKTERI PENYEBAB INFEKSI SALURAN PENCERNAAN Hamdani, Nina; Kosman, Rachmat; Rusli, Rusli
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.91

Abstract

Senggani leaf (Melastoma malabathricum L.) is a plant that has antibacterial activity. The purpose of this study was to determine the isolate of the endophytic fungus senggani leaves (Melastoma malabathricum L.) which has antibacterial activity against digestive tract bacteria using the TLC-Bioautography method. The results of this study showed two isolates of senggani leaf endophytic fungi (Melastoma malabathricum L.). IFDS 6 obtained spots with Rf value = 0.58 for Eschericia coli bacteria, Rf value 0.67 for Vibrio cholerae, Salmonella typhi and Shigella dysentriae bacteria. Meanwhile, IFDS 8 obtained spots with an Rf value 0.78 on the bacteria Eschericia coli, Vibrio cholerae, Salmonella typhi, and Shigella dysentriae
Aktivitas Antibakteri Fraksinasi Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius) Terhadap Bakteri Escherichia coli Menggunakan Metode KLT-Bioautografi Latif, Safira Kartika Handayani; Naid, Tadjuddin; Fitriana, Fitriana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.93

Abstract

Fragrant pandan leaves (Pandanus amaryllifolius) have antibacterial abilities, which have secondary metabolites of alkaloids, flavonoids, tannins and saponins. The purpose of this study was to determine the antibacterial activity of extract fractionation from pandan leaves (Pandanus amaryllifolius) against Escherichia coli bacteria. This study used fragrant pandan leaf simplicia (Pandanus amaryllifolius) and extracted using the maceration method with 96% ethanol solvent and evaporated with a rotavapor, after which it was fractionated with ethyl acetate solvent and evaporated again using a rotavapor. The ethyl acetate fraction of fragrant pandan leaves (Pandanus amaryllifolius) was subjected to a screening test with a concentration of 2% against Escherichia coli bacteria, and a TLC-Bioautography test was carried out followed by identification of the chemical components. The result of the 2% concentration screening test on the ethyl acetate fraction of fragrant pandan leaves (Pandanus amaryllifolius) showed activity against Escherichia coli bacteria. TLC-Bioautography test result showed activity on Escherichia coli bacteria with Rf values of 0,94 and 0,65. The result of chemical identification of the ethyl acetate fraction of fragrant pandan leaves (Pandanus amaryllifolius) were positive for containing chemical compounds of flavonoids and tannins which can be used as antibacterials.
Profil Peresepan Obat Diabetes Melitus di RSUD Prof. Dr. H. M. Anwar Makkatutu Kab.Bantaeng Periode Agustus – Oktober 2022 hayat, Nur; Herman, Hendra; Zulkarnain, Iskandar
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.94

Abstract

Diabetes mellitus (DM) is a progressive chronic disease characterized by the body's inability to metabolize carbohydrates, fats and proteins, causing hyperglycemia (high blood sugar). At Prof. Hospital Dr. H. M. Anwar Makkatutu Diabetes Mellitus is a disease that has the highest prevalence based on previous observations. The purpose of this study is to obtain data on prescribing profiles through administration screening, pharmaceutical screening and clinical screening on diabetes mellitus drugs given to patients at Prof. Hospital. Dr. H. M. Anwar Makkatutu, Bantaeng Regency for the period August-October 2022. The research method used is descriptive. The population used was all diabetes mellitus prescriptions (255 recipes) during the study period. Administrative screening showed that 100% of prescriptions did not include height. Pharmaceutical screening yielded 100% of prescriptions did not include instructions for using the drug. Clinical screening found potential drug interactions in 69 cases. Of the 69 cases of interaction that occurred, 89.86% were moderate. The conclusion of this study is the profile of diabetes mellitus drug prescribing in patients at Prof. Hospital. Dr. H. M. Anwar Makkatutu, Bantaeng Regency, has not met the standards of pharmaceutical services in hospitals.
PENETAPAN KADAR FLVONOID EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) DENGAN MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-Vis RISMA, WA ODE; Abidin, Zainal; Rahmawati, Rahmawati
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.96

Abstract

Avocado (Persea americana Mill.) is a plant that can thrive in tropical areas such as Indonesia. The use of avocado (Persea americana Mill.) as a medicinal plant has been widely used. People usually use avocado seeds as traditional medicine. Avocado seeds (Persea americana Mill.) are plants that contain flavonoid compounds. This study aims to determine the levels of flavonoids in the ethanol extract of avocado (Persea americana Mill.) seeds using the UV-Vis spectrophotometry method. This research was conducted experimentally with qualitative and quantitative methods using UV-Vis spectrophotometry. The results showed that the average flavonoid content of the ethanol extract of avocado seeds was 46.953 mgQE/g extract.
PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL DAUN TANAMAN JONGI (Dillenia serrata) MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS Ananda, Savitri; Pratama, Mamat; Baits, Muzakkir
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.101

Abstract

Jongi leaves (Dillernia serrata) is a type of medicinal plant which is used as an anti-inflammatory, antioxidant, antimicrobial, antitumor, anti-ulcer, immunoprevention, cancer chemoprevention, medicine for thrush, vomiting blood, fever, and wound medicine because it contains polyphenolic compounds, such as tannins and flavonoids. This study aims to determine the total flavonoid content of jongi leaves (Dillenia serrata) using the UV-VIS spectrophotometry method. This type of research is laboratory experimental using a spectrophotometer method based on the determination of extract levels and quarcetin standards. The stages of this research began with sample preparation, qualitative testing of flavonoid compounds, and ended with the determination of total flavonoid content of the sample and quarcetin standard. This study obtained results that positive jongi leaf extract contained flavonoids based on the results of identification using FeCl3 reagents and on the results of quantitative testing using UV-VIS spectrophotometry jongi fruit extract had a percentage of flavonoid content of 16.8633%.

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