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INDONESIA
Indonesian Journal Health Science and Medicine
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health Veterinary
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 268 Documents
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Adenovirus Genotype 7 Detection in Adults with Respiratory Infection and Elevated IL-6: Deteksi Genotipe Adenovirus 7 pada Dewasa dengan Infeksi Pernafasan dan Kadar IL-6 yang Tinggi Ahmed Tofiq, Wirya; Saadoon, Israa Hashim
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.258

Abstract

Background (General): Human adenoviruses are widespread pathogens responsible for a significant proportion of respiratory tract infections, with genotype 7 (HAdV-7) associated with severe outcomes. Background (Specific): Despite its clinical importance, limited data exist regarding the prevalence and immunological impact of HAdV-7 among adult patients in Iraq. Knowledge Gap: The relationship between HAdV-7 infection and interleukin-6 (IL-6) levels in adults with respiratory illness has not been well characterized. Aim: This study aimed to detect HAdV-7 in adult patients with respiratory infections using RT-PCR and to evaluate its association with IL-6 levels. Results: Among 100 patients and 50 healthy controls, HAdV-7 was detected in 7% of cases, with no significant association with age, sex, or residence. Patients infected with HAdV-7 exhibited significantly elevated IL-6 levels (101.75 ± 25.17 pg/mL) compared with controls (39.26 ± 11.09 pg/mL, p ≤ 0.05). Novelty: This is one of the first molecular investigations in Iraq to link HAdV-7 infection with heightened IL-6 responses, highlighting the virus’s role in driving inflammatory pathways. Implications: Monitoring IL-6 levels may serve as a biomarker for disease severity in HAdV-7 infections and support timely therapeutic interventions to reduce complications.Highlight : HAdV-7 detection by RT-PCR shows its link with increased IL-6 levels. Molecular methods enhance sensitivity for early diagnosis. IL-6 monitoring can guide prognosis and therapy. Keywords : ELISA, RT-PCR, HAdV, Respiratory Infection, IL-6
Relationship between Females’ Demographic Data and Pap Smear Test at Basrah City Mansoor, Elaf Zuhair; Lamis Aziz Hameed; Hayat Yahya Shubbar
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.259

Abstract

Abstract. The most popular and economical screening technique for identifying cervical cancer is the Pap test, which has also proved successful in lowering the incidence and related death rates in women. Aims this research to identify the Relationship between Females’ Demographic Data and Pap Smear Test at Basrah City. A cross-sectional research design. The study population consisted of all women who visited the screening center between January 1, 2013, and December 31, 2015. During this time, 677 women had pap smears and cytological examinations; of these, approximately 60.7% had normal results, 18.8% had LSIL, 4.3% had HSIL, 1% had SCC and adenocarcinoma, 1.2% had ASC-US and AGS-US, and 14% had inflammation. The prevalence of abnormal Pap smear increases with an increase in age, about 27.6% of LSIL and HSIL at age 40 and older. A significant relationship between Pap smear results of women who attended the cervical cancer screening center in Basrah and the following factors: passive smoking, duration of marriage, and parity. No significant relationship was found between Pap smear results and the following factors: age at first marriage and first pregnancy, number of husbands’ wives, socioeconomic status, and education level. Highlights: Abnormal Pap smear results were detected in 39.3% of women, with the prevalence increasing significantly after age 40. Significant associations were found between Pap smear outcomes and parity, duration of marriage, and passive smoking. No significant relationship was observed with age at first marriage, first pregnancy, socioeconomic status, or education level.
Coffee Drinking and Liver Enzyme Levels with Gallbladder Hormone Activity: Konsumsi Kopi dan Tingkat Enzim Hati dengan Aktivitas Hormon Kandung Empedu Kadhum, Hanaa Salman; Alessa, Ahmed Hatem Ahmed; Abdulqader, Marwa Jasim
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.260

Abstract

General Background: Coffee is among the most consumed beverages worldwide, with reported benefits and risks on metabolic and hepatobiliary health. Specific Background: Previous research has suggested protective roles of coffee against liver disease and gallstone formation, yet contradictory evidence highlights possible adverse enzymatic changes. Knowledge Gap: Limited studies have simultaneously examined the effects of coffee on both liver enzyme activity and gallbladder hormone secretion in habitual coffee consumers. Aims: This study aimed to evaluate the impact of regular coffee consumption on liver enzymes (ALT, AST, ALP, bilirubin) and the gallbladder hormone cholecystokinin (CCK). Results: Among 32 participants, coffee intake was associated with significant increases in ALP and AST levels (p<0.05), particularly in males and individuals over 25 years, while ALT, bilirubin, and CCK largely remained within normal ranges. Novelty: The study provides integrated evidence that excessive coffee consumption (>2 cups/day) may simultaneously alter hepatic enzyme profiles and modulate gallbladder hormonal response. Implications: These findings underscore the need for cautious monitoring of liver health in heavy coffee drinkers and highlight the dual metabolic effects of coffee, suggesting that moderate intake may balance its hepatoprotective potential with risks of enzyme elevation.Highlight : Coffee consumption is linked to increased ALP and AST levels. Age and gender influence the degree of liver enzyme changes. Coffee stimulates CCK, affecting gallbladder function. Keywords : Coffee Drinking, Liver Enzymes, Gallbladder, Cholecystokinin, Health Effects
Assessment of Radionuclide Activity (238U, 232Th, 40K) in Airborne Dust from Dust Storms in Wasit and Al-Qadissiya, Iraq Al-Yasiri, Mohammad Yahya R; Abdullah Ahmed Khalaf; Hadi D. Alattabi
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.262

Abstract

In dry areas like Iraq, dust storms are a common occurrence that can have serious health effects on people.  The radioactivity of dust particles gathered in the air during recent dust storms in the Wasit and Al-Qadissiya Governorates is assessed in this study.  The levels of uranium-238 (238U), thorium-232 (232Th), and potassium-40 (40K) were measured using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES).  The results showed significant geographical variation, with 40K ranging from 1125.9 to 3546.9 Bq/kg, 232Th from non-detectable levels to 1.58 Bq/kg, and 238U concentrations from 12.1 to 113.5 Bq/kg.  The highest 238U and 40K concentrations were found in Al-Qadissiya.  These results emphasize the possible risks of dust inhalation for radiological health issues and the significance of ongoing environmental monitoring and public health readiness. Highlights: Highest uranium (238U) and potassium (40K) levels found in Al-Qadissiya indicate possible geological or human sources All measured radionuclide values remain within international safety limits Continuous environmental monitoring is vital to address long-term radiological health risks
Assessment of Selected Physiological and Immunological Parameters in a Sample of Obese Patients in Samarra City Khalida Khaleel Abdullah; Hadeer Hussein Alwan; Asmaa Ismael Hussein; Saif al deen Mamdoh Khatlan
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.263

Abstract

The present study was conducted to assess the hormone's levels (nesfatin-1, leptin, resistin and adiponectin) on some of inflammatory cytokines or the so-called adipokines which exert a variety of biological activities (tumor necrosis factor alpha: TNF-α and interleukin-6 IL6), as well as BMI & lipid profile in serum of obese women in Samarra 10. The present study had included (50) samples, and they were divided into: 25 samples of obese women age ranged between (25-45) years, and (25) samples for the control group that constituted from women with normal weight. The results of the study demonstrated a marked elevation in the levels of leptin and resistin hormonal levels, inflammatory cytokines, i.e., tumor necrosis factor-α (TNF-α) interleukin -6 (IL-6), lipid profile evaluated by body mass index ) as well as significant decline in nesfatin-1 and adiponectin at the significance level represented by mean± SD: (P≤0.05) among obese women compared with control group. Highlights: Obese women showed significantly higher serum levels of leptin, resistin, TNF-α, IL-6, and lipid profile abnormalities compared to controls. Nesfatin-1 and adiponectin levels were markedly reduced in obese patients, indicating impaired appetite regulation and anti-inflammatory response. Findings confirm obesity as a state of chronic low-grade inflammation, linking it to increased risk of diabetes and cardiovascular disease.
Novel Biomarkers for Early Detection of Bacterial Meningitis: Penanda Biologis Baru untuk Deteksi Dini Meningitis Bakteri Hommood, Ahmed Kadhim
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.264

Abstract

General Background: Bacterial meningitis is a life-threatening disease that demands rapid and accurate diagnosis to reduce morbidity and mortality. Specific Background: Conventional methods such as CSF culture, Gram staining, and biochemical tests often lack sensitivity, specificity, or require long processing time, limiting their usefulness in urgent clinical settings. Knowledge Gap: There remains limited evidence on the comparative diagnostic accuracy of novel biomarkers against routine laboratory parameters in early bacterial meningitis detection. Aims: This study aimed to evaluate the diagnostic value of Procalcitonin (PCT), Interleukin-6 (IL-6), and C-Reactive Protein (CRP) for early identification of bacterial meningitis compared to conventional laboratory markers. Results: Conducted as a case-control study in Iraq involving 100 patients and 50 controls, the findings showed significantly elevated serum levels of PCT, IL-6, and CRP in patients (p < 0.001). PCT demonstrated the highest diagnostic accuracy (AUC = 0.95), followed by IL-6 (0.93) and CRP (0.90), with all biomarkers correlating strongly with disease severity. Novelty: The study highlights PCT and IL-6 as highly reliable early diagnostic tools that surpass traditional parameters. Implications: Incorporating these biomarkers into diagnostic protocols can facilitate earlier interventions, improve monitoring, and reduce long-term complications in bacterial meningitis.Highlight : Procalcitonin has the strongest diagnostic value. IL-6 and CRP are reliable indicators of severity. Biomarkers support timely and accurate detection. Keywords : Bacterial Meningitis, Procalcitonin, Interleukin-6, C-Reactive Protein, Early Diagnosis
Estimation of Oxidative Stress Markers and Immune Response in Patients with Salmonella Typhi Infection: Penilaian Marker Stres Oksidatif dan Respons Imun pada Pasien dengan Infeksi Salmonella Typhi Al-Zubaidy, Zainab H.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.265

Abstract

Background: Oxidative stress has an important role in the pathogenesis of Salmonella Typhi infection, disrupting host defense and contributing to tissue damage. Specific Background: Assessing oxidative stress markers together with immune response indicators may provide a clearer understanding of disease severity and host–pathogen interactions. Knowledge Gap: However, limited evidence exists on how these markers correlate and contribute to the progression and severity of typhoid fever. Aims: This study aimed to evaluate oxidative stress markers (MDA, TAC, SOD, GSH) and immune response parameters (IL-6, TNF-α, CRP, WBC) in patients with confirmed S. Typhi infection compared with healthy controls. Results: Patients showed significantly higher MDA, IL-6, TNF-α, CRP, and WBC levels, with reduced antioxidant indices, and strong correlations between oxidative stress and inflammatory mediators. Severe cases exhibited the highest oxidative and inflammatory imbalance. Novelty: This study demonstrates a direct relationship between oxidative damage and immune activation in typhoid fever. Implications: These biomarkers could serve as diagnostic and prognostic indicators, supporting the development of adjunctive therapies that restore oxidative–immune balance.Highlight : Infection increases oxidative stress and reduces antioxidant capacity. Elevated IL-6, TNF-α, and CRP indicate a strong inflammatory response. The relationship of biomarkers with severity is useful for prognosis. Keywords : Salmonella Typhi, Oxidative Stress, Antioxidants, Immune Response, C-Reactive Protein
Endocrinopathies' Prevalence in Beta-Thalassemia Major Patients Al-Zamili, Sadeq Lafta Mousa
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.266

Abstract

Chronic anemia is a hallmark of thalassaemia major, a hereditary hemoglobinopathy. Iron deposits in a variety of tissues, including endocrine glands, as a result of excessive iron overload and inadequate chelation. Calculate the number of patients with thalassemia major who have endocrinopathies. The research design used in this study is an observational retrospective cohort. All BTM patients older than two who visited the Dubai Thalassemia Center between December 2023 and June 2024 had their electronic medical records searched for retrospective data. This evaluation comprised fasting glucose, morning cortisol, bone profile (including parathyroid hormone), pituitary and gonadal function, and thyroid function. In order to rule out diabetes mellitus, hypogonadism, hypothyroidism, hypoparathyroidism, and hypoadrenalism, these profiles were examined. Forty individuals with transfusion-dependent thalassemia had an average age of 17.43 ± 2.76 years. Of them, 53.3% were women. Approximately 76.92% had an endocrine problem of some kind. The most frequent endocrine presentation, occurring in 50% of individuals under the age of 20, was hypogonadotropic. Hypoparathyroidism (10.0%), hypothyroidism (3.3%), and glucose intolerance (26.7%) were present in one-third. Among adult Iraqi patients with beta-thalassemia, endocrine problems are highly prevalent. This highlights the significance of monitoring for early detection and replacement therapy, as well as awareness for their development. There was no correlation seen between serum ferritin and the onset of endocrinopathy. Highlights: Endocrinopathies were highly prevalent (76.9%) among beta-thalassemia major patients, with hypogonadism being the most common (50%). Additional endocrine disorders included glucose intolerance (26.7%), hypoparathyroidism (10%), and hypothyroidism (3.3%). Findings underscore the need for routine endocrine monitoring and early intervention to improve quality of life in thalassemia patients.
Incidence of Congenital Heart Disease in Pediatric Age Group Following Maternal Use of Luteal Supportive Hormonal Therapy During Pregnancy Huntush, Zina Saleam
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.267

Abstract

The most prevalent birth abnormality, congenital heart disease (CHD), affects 9.4 out of 1000 babies, Certain medications, such as phenytoin, lithium, amphetamines, warfarin, oestrogen, or progesterone, have been shown to raise the risk of congenital heart disease in offspring when used by the mother during pregnancy. Identify the incidence of Congenital Heart Disease in pediatric Following Maternal Use of luteal supportive Hormonal Therapy During Pregnancy. Retrospective research was conducted at a private cardiologist's clinic between February 12 and May 1, 2025. A pre-tested questionnaire was used to interview the mother or caregiver of each kid. It asked about the mother's medical history about associated conditions, the child's sociodemographics, and whether the mother had taken luteal supporting hormone during pregnancy. The kind of CHD and the history of progesterone usage (time, duration, and route) were ascertained by echo. This study regarding socio-demographic characteristics and showed that females were more than males (55%, 45%, respectively), found that 71.76% of the patients were under one year old, VSD was the most prevalent kind of CHDs in this study (28% of the cases), also, study reflect positive correlation between progesterone and CHD. Conclude of study result most of child with CHD was less than 1 years in age and there is associate between maternal progesterone intake and fetus born with CHD. Highlights: Ventricular septal defect (VSD) was the most common congenital heart disease observed, accounting for 28% of cases. A positive correlation was found between maternal progesterone intake during pregnancy and the occurrence of CHD in offspring. Most affected children were under one year old, with a slight female predominance (55%).
Clinical Severity and Eosinophillic Count in Asthmatic Patients Al-Husseiny, Auday Abd Al-Razaq
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.268

Abstract

Inflammatory effects are caused by eosinophils, which are activated by allergens. Persistent airflow restriction is caused by ongoing airway remodeling and eosinophilic airway inflammation Although recent studies have failed to confirm this as a measure of severe asthma among adult asthma patients, high blood eosinophil levels were linked to severe asthma. Therefore, this study's goal was to ascertain whether a high blood eosinophil count and the severity of asthma are related. In 2024, a cross-sectional poll was carried out from January to December. A pre-tested structured questionnaire was used to collect data on clinical, behavioral, and sociodemographic traits. Four milliliters of venous blood were extracted from asthmatic patients in order to perform a complete blood count and assess peripheral morphology. Fifty-five (55.0%) of the 100 patients that were included in the trial were female, and forty-five (45.0%) were male. They ranged in age from 13 to 70. The range of the absolute eosinophil count was 70/mm3 to 1400/mm3. According to the severity criteria for asthma, 15 patients (15.0%) had severe asthma, 56 patients (56.0%) had moderate asthma, and 29 patients (20.0%) had mild asthma. This study aimed to evaluate the relationship between the eosinophil count in the blood and the severity of the illness. However, the study discovered a link between these two variables, indicating a relationship between peripheral eosinophil count and asthma severity. Highlights: Among 100 asthma patients, 15% had severe asthma, 56% moderate, and 29% mild, with higher eosinophil counts linked to greater severity. Patients with eosinophil counts >1000/mm³ showed the strongest association with severe asthma (p = 0.001). Findings support blood eosinophil count as a useful indicator for predicting asthma severity and guiding management.

Page 23 of 27 | Total Record : 268

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