cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
mahardika
Contact Email
p3i@umsida.ac.id
Phone
6282143483630
Journal Mail Official
perpus@umsida.ac.id
Editorial Address
jl. Mojopahit No. 666B Sidoarjo, Jawa Timur
Location
Kab. sidoarjo,
Jawa timur
INDONESIA
Indonesian Journal Health Science and Medicine
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health Veterinary
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 268 Documents
 23   24   25   26   27 
The Importance of Neurophysiology in the Study of Predators and Herbivores: A Neuroecological Perspective Hasan, Hasanain Mohammed
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.304

Abstract

Predator–herbivore interactions are central to ecological dynamics, shaping species evolution, population stability, and ecosystem function. Recent advances in neurophysiology have revealed mechanistic layers underlying these interactions, encompassing sensory processing, stress and fear responses, decision-making, learning, and memory. This review synthesizes findings from the past five years to highlight how neural circuits mediate predator detection, prey evasion, and adaptive behaviors, emphasizing individual variation, sex differences, and developmental plasticity. We discuss sensory neurophysiology in both predators and herbivores, showing how multimodal integration, context-dependent processing, and plasticity influence behavior in natural environments. Stress neurobiology and fear responses are explored, illustrating the role of the hypothalamic–pituitary–adrenal axis, limbic circuits, and neurotransmitter dynamics in shaping acute and long-term responses to predation risk. Decision-making, learning, and memory are examined as mechanisms by which experience modifies predator and prey strategies, with implications for co-evolution and ecological fitness. Evolutionary and ecological implications are considered, including the role of neurophysiology in driving selective pressures, shaping trophic interactions, and mediating non-consumptive effects that influence community structure. Finally, we highlight emerging technological advances—such as portable neural imaging, electrophysiology, genomic analyses, and machine learning approaches—that enable integration of neurophysiological data with behavioral and ecological research. Understanding these neurobiological mechanisms not only uncovers hidden layers of predator–herbivore dynamics but also provides actionable insights for wildlife management, conservation planning, and ecosystem restoration. By bridging mechanistic neuroscience with ecological and evolutionary theory, this review emphasizes the value of neurophysiology as a critical tool for predicting behavioral responses and resilience in changing environments. Highlights Neurophysiology reveals how sensory processing, stress circuits, and learning mechanisms shape predator detection, prey avoidance, and behavioral adaptation. Predator cues drive significant neural and hormonal responses—often sex-specific and long-lasting—that influence decision-making and ecological fitness. Integrating neural mechanisms with ecological models enhances predictions of predator–herbivore dynamics, especially under environmental and anthropogenic change.
Transition Metal Complex of Oxadiazole as Dual Antidiabetic and Anti Hyperthyroid Agent Alnawas, Zahraa Ali Nashoor
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.305

Abstract

General background: 1,3,4-oxadiazole derivatives are well-established heterocycles with broad pharmacological potential, and metal coordination frequently enhances their therapeutic profiles. Specific background: Recent studies highlight the need for compounds capable of dual modulation of metabolic and endocrine disorders, particularly diabetes and hyperthyroidism, where single-target therapies often yield limited outcomes. Knowledge gap: Despite promising reports, few studies have integrated experimental pharmacology with quantum chemical modeling to explain how metal coordination influences biological potency. Aims: This research synthesized a new oxadiazole–indolinone ligand and its Co(II), Ni(II), Cr(III), and Fe(III) complexes and evaluated their antidiabetic and anti-hyperthyroid activities through in vivo assays supported by DFT calculations and molecular docking. Results: All complexes demonstrated dose-dependent activity, with Co(II) exhibiting the strongest glucose reduction (120 ± 7 mg/dL) and T₄ suppression (7.1 ± 0.4 µg/dL), consistent with superior docking affinities and favorable electronic descriptors. Novelty: This study correlates spectroscopic, computational, docking, and pharmacological findings in a unified structure–activity interpretation. Implications: The results indicate that metal coordination significantly boosts biological efficacy, positioning Co(II) complexes as strong candidates for future dual-action therapeutics in diabetes and hyperthyroidism.Highlight : Metal complexation improves biological effectiveness of the ligand. Co(II) complex shows the strongest dual activity based on results. Docking findings align with experimental data, supporting the SAR. Keywords : 1,3,4-Oxadiazole, Transition Metal Complexes, DFT, Molecular Docking, Antidiabetic and Anti-Hyperthyroid Activity
Correlation Between Tissue Changes and Clinical Outcomes in urinary Bladder Carcinoma patients in Babylon Alsaqi, Sabreen Saleem Abd Alkreem
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.306

Abstract

General Background: Urinary bladder cancer is among the most prevalent malignancies worldwide, with its progression strongly influenced by clinicopathological characteristics. Specific Background: Despite extensive documentation of urothelial carcinoma behavior, variations in tissue morphology and their clinical correlations remain insufficiently clarified in regional populations. Knowledge Gap: Limited data exist regarding how histopathological patterns relate to tumor grade, stage, and patient demographics in Iraqi cohorts. Aim: This study examined the key pathological alterations in 50 bladder cancer patients to determine the association between tissue characteristics, tumor aggressiveness, and clinical outcomes. Results: High-grade tumors were predominant (80%), with most cases invading the deep muscle (78%). Men were disproportionately affected, and smoking emerged as a major risk factor. A significant correlation was observed between patient age and both tumor grade and stage, indicating that older individuals tend to present with more advanced disease. Novelty: The study highlights distinct high-grade T1 variants that may offer additional prognostic value, emphasizing heterogeneity within early-stage tumors. Implications: These findings underscore the need for improved risk-stratification strategies, earlier detection, and larger prospective studies to refine diagnostic and management protocols for bladder carcinoma.|Highlight : The study shows most cases present as high-grade and advanced stage. Smoking and chemical exposure appear as major contributing risks. Tumor grade and invasion depth remain key indicators for diagnosis and management. Keywords : Bladder Cancer, Papillary Carcinomas, Histopathological Features, Tumor Grade, Age
Effect of Feeding Hay Treated with Urea on The Reproductive Efficiency of Local Female Goats in The Northern Part of The Governorate Nasser, Sakain Aidan; Mohammed Mousa Ouda
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.307

Abstract

Nutritional deficiencies, particularly protein shortage, negatively affect reproductive performance and metabolic functions in ruminants. Urea-treated roughages are increasingly used as an economical non-protein nitrogen source to enhance feed quality and improve reproductive efficiency in goats. However, evidence on their physiological and reproductive effects in local goat breeds remains limited. Few studies have systematically evaluated how different urea concentrations in treated barley straw influence reproductive efficiency, metabolic biomarkers, hormone profiles, and offspring performance in female local goats. This study aimed to determine the effects of feeding barley straw treated with 1% and 3% urea on feed intake, reproductive efficiency, blood biochemical parameters, reproductive hormones, and offspring growth in local female goats. Twenty-one goats were divided into three equal groups (control, 1% urea, 3% urea). The 3% urea group showed the highest roughage intake and final body weight (55.28 kg). Fertility and reproductive efficiency varied among groups, with the 3% group achieving notable performance. Blood urea concentrations significantly increased in urea-treated groups (P < 0.01), while total protein, albumin, globulin, creatinine, estrogen, LH, and progesterone showed no significant differences (P > 0.05). AST increased and ALT decreased non-significantly. FSH levels increased significantly in urea-treated groups (P < 0.05). Offspring in the 3% urea group recorded the highest birth and weaning weights. This study provides one of the first detailed physiological and reproductive assessments of urea-treated barley straw in local Iraqi goats. Urea treatment at 1–3% can enhance feed quality and support reproductive and growth performance without adverse metabolic effects, offering a cost-effective feeding strategy for local goat production. Highlights Feeding goats with 3% urea-treated barley straw improved roughage intake, final body weight, and offspring birth and weaning weights. Urea treatment significantly increased blood urea and FSH levels, while other biochemical and hormonal parameters remained within normal ranges. Urea-treated straw enhanced reproductive efficiency without causing adverse metabolic effects, supporting its use as a cost-effective feeding strategy.
Ionic Liquids in Pharmaceutics: Biocompatibility, Physicochemical Properties, and Applications of API-ILs in Modern Drug Delivery Systems Abdulnabi, Shams A.; Allami , Mohammed S.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.308

Abstract

General Background: Ionic liquids (ILs) have emerged as highly versatile solvent systems distinguished by tunable physicochemical properties, negligible vapor pressure, and broad solvation capacity, positioning them as promising alternatives to conventional organic solvents in pharmaceutical science. Specific Background: Increasing proportions of drug candidates exhibit poor aqueous solubility, polymorphic instability, and limited bioavailability, challenges that hinder formulation efficiency and therapeutic performance. Knowledge Gap: Although ILs have been widely explored as green solvents and catalysts, their potential as active pharmaceutical ingredient–ionic liquids (API-ILs) remains insufficiently characterized, particularly regarding biocompatibility, pharmacokinetics, and translational feasibility. Aims: This review synthesizes current advances in IL design, physicochemical behavior, and biomedical applications, with a focus on API-ILs as emerging platforms for drug delivery and solubility enhancement. Results: Evidence shows that ILs can significantly improve solubility, permeability, stability, and crystalline behavior of diverse APIs, while certain API-ILs exhibit dual pharmacological activity and enhanced antimicrobial or transdermal performance. Novelty: The work consolidates the evolution of IL generations, mechanochemical synthesis strategies, and structure–activity relationships governing their pharmaceutical utility. Implications: API-ILs represent a transformative approach for overcoming long-standing formulation barriers, underscoring the need for expanded in vivo studies to validate their safety, biocompatibility, and therapeutic potential in modern drug-delivery systems.Highlight : API-ILs address solubility, bioavailability, and polymorphism issues in poorly water-soluble drugs. Ionic liquids offer tunable physicochemical properties that support improved drug delivery and stability. Biocompatible ILs provide greener alternatives for synthesis while enhancing permeability and therapeutic performance. Keywords : Ionic liquids (ILs), API-ILs, Dissolution, Poorly Water-Soluble Drugs, Drug Development
Knowledge, Attitude and Practice of Diabetic patients about diabetic retinopathy Almasoudy, Moaiad Abdullateef; Wahoodi, Zahraa Ali; Mohammed, Israa Adil
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.309

Abstract

General Background: Diabetic retinopathy (DR) is a leading microvascular complication of diabetes mellitus, resulting in progressive retinal damage and vision loss worldwide. Specific Background: Despite the availability of effective screening and treatment options, many patients remain unaware of the risks and preventive measures, particularly in middle-income countries. Knowledge Gap: Limited data exist on the knowledge, attitudes, and practices (KAP) of diabetic patients in Iraq regarding DR, which hinders the development of targeted educational and preventive strategies. Aims: This study aimed to assess the KAP of diabetic patients toward DR at Imam Hassan Center for Diabetes and Endocrinology in Kerbala. Results: Among 368 participants, poor blood sugar control was the most recognized risk factor (59%), while over half (51.1%) were unfamiliar with treatment options. Only 41% believed eye exams were necessary even with controlled blood sugar, and although 83.7% reported regular eye checks, most visits were for spectacle adjustments rather than DR follow-up. Novelty: This is one of the first studies in Iraq to comprehensively evaluate patient KAP toward DR, highlighting systemic gaps in awareness and practice. Implications: Findings underscore the urgent need for structured educational programs and improved screening strategies to enhance patient understanding, promote preventive care, and reduce DR-related vision loss.Highlight : The study highlights limited patient knowledge about diabetic retinopathy. Attitudes toward regular eye exams remain inconsistent among participants. Practices show gaps in routine screening and treatment awareness. Keywords : Diabetic Retinopathy, Knowledge, Attitude, Practice, Diabetic Patients
Dental Knowledge, Behaviors, and Patterns of Missing Teeth waleed, Rayan Waseem; Abdulwahab , Nagwan Ali; Mahdi , Aya Hamid
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.312

Abstract

General Background: Oral health knowledge and daily behaviors are essential determinants of tooth retention, yet limited awareness of preventive practices continues to contribute to avoidable tooth loss. Specific Background: In many communities, dental floss use, fluoride awareness, and dietary control remain inadequate despite regular toothbrushing habits. Knowledge Gap: Few studies have examined how these behavioral and knowledge-related factors correspond with the number and distribution of missing teeth among adults. Aim: This study assessed dental knowledge, oral hygiene behaviors, and dietary habits in relation to the number of missing teeth in adult patients. Results: Most participants had more than five missing teeth, predominantly in the lower posterior region. Very few used dental floss, many consumed sweets and sweetened drinks between meals, and awareness of fluoride was notably low. Participants often visited the dentist only when in pain and lacked proper instruction on flossing technique. Novelty: The study provides combined behavioral–knowledge profiling linked to quadrant-specific tooth loss within a middle-aged population. Implications: Findings underscore the need for strengthened preventive programs emphasizing dietary counseling, proper interdental cleaning, and improved fluoride awareness to reduce future tooth loss. Highlights: Most missing teeth were located in the lower posterior region. Fluoride and flossing knowledge remained low despite frequent brushing. High intake of sweets and delayed dental visits contributed to tooth loss. Keywords: Dental Knowledge; Oral Hygiene Behavior; Missing Teeth; Fluoride Awareness; Dietary Habits
Novel Coumarin–β-Thio Carbonyl Derivatives with Potent Antioxidant Activity Abdulhussein, Ali Mohammed; Raheem, Leaqaa Abdulredha; Suwaid, Maan Abdul-Razzaq
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.313

Abstract

General Background: Antioxidants play a key role in mitigating oxidative stress–related disorders, driving interest in developing synthetic molecules with strong radical-scavenging capacity. Specific Background: Coumarin-based scaffolds exhibit diverse biological activities, yet limited studies have explored their β-thio carbonyl hybrids as potential antioxidant agents. Knowledge Gap: Despite the therapeutic promise of coumarin hybrids, their structure–activity relationships and antioxidant effectiveness remain underexplored. Aim: This study synthesized and characterized five novel coumarin–β-thio carbonyl derivatives and assessed their antioxidant potential using the DPPH assay. Results: Structural confirmation was achieved through ¹H-NMR, ¹³C-NMR, and mass spectrometry, verifying the successful formation of all compounds. Notably, compound 11 displayed the strongest radical-scavenging capacity (IC₅₀ = 17.89 μM), surpassing ascorbic acid (IC₅₀ = 23.04 μM). Novelty: This work provides the first comprehensive structural and biological evaluation of a new series of coumarin–β-thio carbonyl hybrids featuring various electron-donating and electron-withdrawing substituents. Implications: The findings highlight these derivatives, particularly dimethylamino-substituted analogues, as promising candidates for further development in antioxidant-based therapeutic applications.Highlights: Five new coumarin–β-thio carbonyl derivatives were successfully synthesized and validated. Compound 11 exhibited the strongest radical-scavenging activity among all tested molecules. Electron-donating substituents improved antioxidant performance. Keywords: Coumarin Derivatives, β-Thio Carbonyl, Antioxidant Activity, DPPH Assay, Heterocyclic Synthesis

Page 27 of 27 | Total Record : 268

 23   24   25   26   27 

Filter by Year

2024 2025


Reset
Filter By Issues
All Issue Vol. 2 No. 3 (2025): Desember Vol. 2 No. 2 (2025): Oktober Vol. 2 No. 1 (2025): July Vol. 1 No. 3 (2024): Desember Vol. 1 No. 2 (2024): October Vol. 1 No. 1 (2024): July