cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
mahardika
Contact Email
p3i@umsida.ac.id
Phone
6282143483630
Journal Mail Official
perpus@umsida.ac.id
Editorial Address
jl. Mojopahit No. 666B Sidoarjo, Jawa Timur
Location
Kab. sidoarjo,
Jawa timur
INDONESIA
Indonesian Journal Health Science and Medicine
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health Veterinary
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 268 Documents
 23   24   25   26   27 
Investigating the Hepatoprotective Properties of Rutin Against Oxidative Stress and Liver Injury Induced by Paclitaxel in Rats Jasim, Mohammed Maseer; Neamah, Nadheerah F; Ghanem , Waleed Khaled
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.292

Abstract

General Background: Liver toxicity remains a critical adverse effect of many chemotherapeutic agents, significantly limiting their clinical utility. Specific Background: Paclitaxel, a potent anticancer drug, is known to induce hepatic injury through oxidative stress, inflammation, and apoptosis. However, effective strategies to prevent such hepatotoxicity are limited. Knowledge Gap: While rutin, a natural flavonoid, exhibits antioxidant and anti-inflammatory effects, its protective role against paclitaxel-induced liver injury has not been fully elucidated in vivo. Aims: This study aimed to investigate the hepatoprotective potential of rutin against paclitaxel-induced hepatic damage in male rats through biochemical, oxidative, and histopathological assessments. Results: Rutin administration markedly reduced serum ALT, AST, and MDA levels while increasing GPx activity, restoring hepatic architecture, and alleviating necrosis, sinusoidal congestion, and apoptosis compared with paclitaxel-only groups. Novelty: This study provides novel experimental evidence demonstrating that rutin counteracts chemotherapy-induced hepatotoxicity primarily via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms. Implications: The findings suggest that rutin could serve as a promising adjunctive therapy to protect against drug-induced liver injury in cancer patients undergoing paclitaxel treatment, warranting further clinical evaluation.Highlight : Rutin reduced oxidative stress and normalized liver enzymes in paclitaxel-treated rats. Co-administration of rutin preserved hepatic structure and improved antioxidant status. Rutin showed hepatoprotective effects against paclitaxel-induced liver injury. Keywords : Rutin, Paclitaxel, MDA, GPx, ALT, AST
Immune Modulation of Vitamin D Levels in Pediatric Celiac Disease Patients Jomah, Ashraf Fadhil
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.294

Abstract

General Background: Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion in genetically susceptible individuals, leading to intestinal damage, nutrient malabsorption, and systemic complications. Among its nutritional consequences, vitamin D deficiency is highly prevalent and affects bone metabolism and immune regulation. Specific Background: Serological markers such as anti-tTG and anti-EMA antibodies are established diagnostic and monitoring tools for CD; however, the relationship between antibody titer strength and vitamin D status has not been fully clarified, particularly in children. Knowledge Gap: Limited studies have quantitatively explored the association between immune response intensity and serum vitamin D concentrations in pediatric CD populations. Aims: This study aimed to investigate the relationship between the magnitude of anti-tTG/anti-EMA antibody responses and serum vitamin D levels in community-based pediatric CD patients. Results: Vitamin D concentrations were significantly lower in children with strong positive antibody responses compared to those with weak positivity (p < 0.05), suggesting an inverse correlation between immune activity and vitamin D status. Novelty: This study introduces a quantitative link between antibody response strength and vitamin D deficiency severity in pediatric CD, providing an immunologic perspective for assessing nutritional risk. Implications: The findings highlight the potential for antibody titers to serve as prognostic indicators for vitamin D deficiency, guiding early nutritional interventions and individualized patient management in clinical practiceHighlight : Strong anti-tTG and anti-EMA responses are associated with lower vitamin D levels in pediatric celiac disease. The strength of immune response may indicate susceptibility to vitamin D deficiency. Findings suggest clinical importance for early monitoring and nutritional management. Keywords : Vitamin D, Celiac Disease, Pediatric, Anti-tTG, Anti-EMA
Native Mycorrhizal Fungi for Salt Tolerance and Nutrient Uptake in Tomato Plants Hassan, Maha Muthana; Katia, Marwa Kadhim; Hassan, Sarah Satar
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.295

Abstract

General Background: Soil salinity poses a major constraint to crop productivity in arid and semi-arid regions, particularly in southern Iraq, where tomato cultivation suffers from osmotic stress, nutrient imbalance, and reduced photosynthesis. Specific Background: Arbuscular mycorrhizal fungi (AMF) are known to enhance plant stress tolerance through symbiotic root associations that improve nutrient and water uptake. However, native AMF species adapted to saline Iraqi soils remain underexplored for their potential benefits in tomato cultivation. Knowledge Gap: Limited research has addressed how native AMF species contribute to salinity mitigation and soil enzyme activity in Iraqi agricultural systems. Aims: This study aimed to evaluate the effects of two native AMF species—Glomus mosseae and Rhizoglomus intraradices—on growth performance, nutrient uptake, stress alleviation, and soil microbial activity of tomato plants grown under saline conditions. Results: R. intraradices increased plant height and biomass by over 30%, enhanced phosphorus and potassium uptake by 43% and 36%, reduced proline accumulation by 28%, and significantly improved antioxidant enzyme and soil phosphatase activity. Novelty: The study demonstrates, for the first time, the superior efficiency of native R. intraradices under Iraqi saline conditions. Implications: Native AMF inoculation offers a sustainable, low-cost strategy to enhance tomato resilience and productivity in saline-prone regions, supporting environmentally friendly agriculture in Iraq.Highlight : Native AMF effectively enhance tomato growth, nutrient uptake, and stress tolerance under saline conditions. Rhizoglomus intraradices shows higher efficiency than Glomus mosseae in improving plant performance. Utilization of native AMF offers a sustainable approach to manage soil salinity in southern Iraq. Keywords : Soil Salinity, Tomato Productivity, Arbuscular Mycorrhizal fungi, Salt Tolerance, Saline Soils
Synthesis and Characterization of Nanostructured Copper Oxide Thin Films Prepared by Home-Made DC Magnetron Sputtering for Gas Sensor Applications Dawood, Basima Saleem
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.296

Abstract

In this research, high-quality nanostructured copper oxide (CuO and Cu2O) thin films were prepared by home-made dc magnetron sputtering technique. The properties and characterizations of the prepared nanostructure films have been determined by the ratios of gases (argon and oxygen) inside the discharge chamber, and heat treatment (annealing) of these films around 400 Co. These parameters were effectively realized important to control the structural characteristics of the prepared nanostructures, especially the energy band gap Eg which was determined by using uv-visible measurements, and particles size. The phase structures of cupric and cuprous were examined by X-ray diffraction to compare between two phases. The type of copper oxide semiconductors two distinct phases: cuprous oxide (Cu2O), and tenorite (CuO) was determined through Hall effect measurement which was indicated in P-type binary copper oxide. The phases of copper oxide nanostructures were successfully verified for gas sensing applications and they exhibited reasonably high sensitivity with increasing temperature (up to 96% at 350°C). This work can be good attempt to use copper oxide nanostructures in such important application. Highlights: Nanostructured CuO and Cu₂O thin films were successfully fabricated using a home-made DC magnetron sputtering technique under varying Ar:O₂ gas ratios. XRD and FTIR analyses confirmed the formation of distinct CuO and Cu₂O phases with controlled crystallinity and optical band gaps of 2.33 eV and 2.9 eV, respectively. The prepared films exhibited high gas sensitivity, reaching 96% at 350 °C, particularly toward NO₂, demonstrating strong potential for gas sensor applications.
Helicobacter pylori: the Progression of Gastritis to Stomach Cancer Abdulla, Namaat R.; Khudair , Zainab W.; T.S, Al-Amery; Abdulla, Noor R.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.297

Abstract

General Background: Gastric cancer remains one of the most prevalent malignancies worldwide, with nearly one million new cases and over 700,000 deaths annually, largely linked to Helicobacter pylori infection. This gram-negative bacterium colonizes the gastric mucosa, causing chronic gastritis that can progress to malignancy. Specific Background: H. pylori is recognized as a Class I carcinogen by the International Agency for Research on Cancer due to its strong association with gastric adenocarcinoma. The infection triggers inflammatory and genetic responses that facilitate carcinogenesis through bacterial, host, and environmental interactions. Knowledge Gap: Despite decades of research, the molecular mechanisms linking H. pylori virulence factors to gastric epithelial transformation and the synergistic role of host and environmental cofactors remain insufficiently elucidated. Aims: This study reviews how H. pylori infection progresses from gastritis to gastric cancer by detailing bacterial virulence determinants, host inflammatory responses, and environmental contributors. Results: Key virulence factors such as CagA, VacA, BabA, and OipA disrupt epithelial integrity, modulate signaling pathways (e.g., NF-κB, Wnt/β-catenin), and trigger cytokine overexpression, fostering neoplastic changes. Novelty: The review integrates molecular, immunologic, and environmental dimensions of H. pylori pathogenesis, highlighting their collective role in carcinogenic transformation. Implications: Understanding these multifactorial mechanisms underscores the need for early detection, eradication therapies, and targeted prevention strategies to reduce gastric cancer mortality.Highlight : H. pylori infection can progress from gastritis to gastric cancer through chronic inflammation and mucosal damage. The bacterium’s virulence factors and host immune response play crucial roles in disease progression. Early detection and eradication of H. pylori are vital to prevent gastric cancer development. Keywords : Helicobacter Pylori, Gastritis, Gastric Cancer, Virulence Factors, Cytokines
Molecular Detection of Some Virulence Genes in E. coli Isolated from Urinary Tract Infections Al-Wakeel, Mays Ibrahim; Alnasrawi, Abeer M.; Al-Mamoori, Zahraa Z.; Al-Ghanimi, Ali Abdul Kadhim
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.298

Abstract

General Background: Urinary tract infections (UTIs) are among the most prevalent bacterial infections worldwide, predominantly affecting women and often caused by Escherichia coli (E. coli). Specific Background: The pathogenicity of E. coli in UTIs is primarily associated with its virulence genes, which enable bacterial adhesion, toxin production, and iron acquisition, thus facilitating colonization and persistence in the urinary tract. Knowledge Gap: Despite extensive research, the prevalence and distribution of major virulence genes among E. coli isolates in specific regions, such as Karbala, Iraq, remain insufficiently characterized. Aims: This study aimed to detect five virulence genes (HlyA, papC, iutA, CNF-1, and Sfas) in E. coli isolates obtained from women with UTIs, using molecular PCR techniques. Results: Among 24 isolates, the genes HlyA, papC, CNF-1, and Sfas were detected in 45.83%, 50%, 37.5%, and 37.5% of samples respectively, while iutA was absent. Novelty: This is one of the few studies providing molecular evidence of virulence gene distribution in UTI-associated E. coli within Iraq, highlighting regional variation compared to previous international reports. Implications: The findings enhance understanding of the molecular basis of UTI pathogenicity and may inform the development of targeted diagnostic and therapeutic strategies.Highlight : The study identifies the distribution of five major virulence genes in E. coli isolated from UTI cases. PCR analysis reveals variation in gene frequency, indicating differing pathogenic potentials among isolates. The findings emphasize the importance of gene detection for improving therapeutic and preventive strategies against E. coli infections. Keywords : CNF-1, HlyA, iutA, papC, Sfas, UTI
Serum Inflammatory Cytokines as Dual Biomarkers in Systemic Lupus Erythematosus and Breast Cancer Progression Hassan, Abdulrhman M.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.299

Abstract

General Background: Chronic inflammation plays a critical role in both autoimmune diseases and cancer, where cytokines act as key mediators of immune dysregulation. Specific Background: Systemic Lupus Erythematosus (SLE) and breast cancer, despite differing etiologies, share overlapping mechanisms of cytokine imbalance that drive disease progression and immune modulation. Knowledge Gap: However, the potential of inflammatory cytokines as dual biomarkers reflecting both autoimmune and tumor-related processes remains underexplored. Aims: This study aimed to evaluate serum levels of IL-6, TNF-α, IL-1β, IL-8, IL-10, and TGF-β in SLE and breast cancer patients compared to healthy controls, and to analyze their correlation with disease duration. Results: Findings demonstrated significantly elevated pro- and anti-inflammatory cytokine levels in both patient groups (p < 0.001), with strong positive correlations between cytokine concentration and disease duration. Breast cancer patients showed higher IL-6, TNF-α, and TGF-β levels, while SLE patients exhibited pronounced immune activation. Novelty: The study provides the first integrated evaluation of cytokine profiles revealing shared inflammatory signatures in autoimmunity and oncogenesis. Implications: These results highlight cytokines’ potential as diagnostic and prognostic biomarkers, suggesting that cytokine modulation may offer novel therapeutic targets for both SLE and breast cancer.Highlight : Cytokines act as dual biomarkers indicating immune activation in both SLE and breast cancer. Pro- and anti-inflammatory cytokines correlate positively with disease duration and progression. The study highlights cytokines’ potential roles in diagnosis, prognosis, and therapeutic targeting. Keywords : Systemic Lupus Erythematosus, Breast Cancer, Inflammatory Cytokines, IL-6, TNF-α
Fatigue Levels and it is Impacts on Physical, Cognitive and Psycho-social Wellbeing in Patients with Breast Cancer Undergoing Chemotherapy Athbi, Hassan Abdullah; Rukaya Aqeel Hassan; Ayam Abbas Ali; Baneen Fadhil Khudhr; Hussein Khelf Kitab
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.301

Abstract

Fatigue is a highly prevalent and debilitating symptom among patients with breast cancer undergoing chemotherapy, profoundly affecting multiple dimensions of health and functioning. Chemotherapy-related fatigue in this population negatively influences physical capacity, cognitive performance, and psychosocial well-being, yet its multidimensional impact within the Iraqi clinical context remains insufficiently examined. Few studies have comprehensively evaluated the combined physical, cognitive, and psychosocial consequences of fatigue among Iraqi breast cancer patients, nor assessed its associations with demographic and clinical characteristics. This study aimed to determine the levels of fatigue and examine its impact on physical, cognitive, and psychosocial domains among patients with breast cancer receiving chemotherapy. A descriptive study of 106 female patients at Imam Al-Hussein Oncology Center revealed that 71.7% experienced severe fatigue and 28.3% moderate fatigue. The overall mean fatigue score was high (MS = 4.0). Fatigue showed severe impact across all domains, with 96.2% of patients classified within the severe-impact category. Physical limitations included muscle weakness, reduced functional ability, and increased need for rest; cognitive impairments involved diminished alertness, reduced attention, and slowed thinking; psychosocial effects included decreased motivation, social withdrawal, and emotional distress. A significant association was found between fatigue level and the three impact dimensions (p = 0.003). This study provides one of the first multidimensional assessments of chemotherapy-related fatigue among Iraqi breast cancer patients. Routine fatigue assessment and multidisciplinary management are essential to mitigate its extensive effects and improve quality of life for patients undergoing chemotherapy. Highlights Severe fatigue was highly prevalent among breast cancer patients undergoing chemotherapy, affecting 71.7% of the sample. Fatigue had a significant negative impact on physical, cognitive, and psychosocial functioning, with 96.2% experiencing severe impairment. A strong association was found between fatigue severity and multidimensional functional decline (p = 0.003).
Glutathione Transferase Response to Platinum Doped Titanium Dioxide in Aedes aegypti Pupae Al-Salih, Moatasem; Al-Salih , Moatasem; Samsudin, Syakirah; Misnan, Rosmilah bt
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.302

Abstract

General Background: Aedes aegypti is a major vector of arboviruses, and increasing resistance to chemical insecticides demands novel control strategies. Specific Background: Photocatalytic nanoparticles such as Pt-doped TiO₂ generate reactive oxygen species under light, inducing oxidative injury in mosquitoes; however, the biochemical defense response, particularly glutathione S-transferase (GST), remains insufficiently understood at the pupal stage. Knowledge Gap: No study has simultaneously assessed lipid peroxidation and GST activity in Ae. aegypti pupae exposed to Pt-TiO₂ under different light conditions. Aims: This research examined malondialdehyde (MDA) levels and GST activity in pupae exposed to Pure TiO₂ and Pt-TiO₂ under light and dark conditions. Results: Light exposure significantly amplified oxidative stress and GST activity, with Pt-TiO₂ producing the highest MDA and strongest GST induction, while dark conditions showed no meaningful biochemical alterations. Novelty: The study provides the first integrated evidence linking enhanced photocatalytic ROS generation by Pt-TiO₂ to concurrent oxidative damage and compensatory antioxidant activation in pupae. Implications: These findings clarify the mechanism of Pt-TiO₂ toxicity and support its use as an efficient light-activated nano-insecticide for vector control.Highlight : Highlights the strong light-dependent oxidative stress induced by Pt-doped TiO₂ nanoparticles. Emphasizes GST upregulation as a key biochemical response to nanoparticle exposure. Shows that lipid peroxidation remains elevated despite antioxidant activation. Keywords : Aedes aegypti; Pt-doped TiO₂ nanoparticles; oxidative stress; glutathione S-transferase; malondialdehyde
Random Amplified Polymorphic DNA - Polymerase Chain Reaction (RAPD-PCR) Technique of Genetic Diversity of Silurus glanis Al-Omairi, Majeed Sh. S.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.303

Abstract

General Background Genetic diversity is essential for ensuring species resilience and supporting long-term ecological stability. Specific Background Silurus glanis, an ecologically and economically important freshwater fish in Iraq, is increasingly exposed to environmental pressures that may shape its genetic composition. Knowledge Gap Yet, information on the genetic variation between populations inhabiting the Euphrates and Tigris Rivers remains limited, particularly when assessed using RAPD-PCR molecular markers. Aims This study aims to evaluate the genetic diversity of S. glanis from both rivers using five RAPD primers to identify patterns of genetic similarity and differentiation. Results Analysis of 120 samples revealed 13 genetic loci, with 83.842% similarity and 16.154% genetic variation, indicating low diversity but high interpopulation resemblance. Novelty The study provides an updated genetic profile demonstrating the influence of local environmental conditions on the species’ genetic structure and suggesting potential gene flow between riverine populations. Implications These findings highlight the need for strengthened river ecosystem management and the application of molecular biomarkers to guide conservation strategies capable of preventing further genetic erosion and supporting the long-term sustainability of S. glanis populations.Highlight : The results show measurable genetic variation and high similarity between the two river populations. RAPD-PCR markers detected differences across loci that reflect environmental influences on genetic structure. The findings highlight the importance of monitoring river conditions to maintain the species’ genetic stability. Keywords : Genetic diversity, RAPD-PCR, Silurus glanis, Euphrates and Tigris populations, molecular markers

Page 26 of 27 | Total Record : 268

 23   24   25   26   27 

Filter by Year

2024 2025


Reset
Filter By Issues
All Issue Vol. 2 No. 3 (2025): Desember Vol. 2 No. 2 (2025): Oktober Vol. 2 No. 1 (2025): July Vol. 1 No. 3 (2024): Desember Vol. 1 No. 2 (2024): October Vol. 1 No. 1 (2024): July