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INDONESIA
Indonesian Journal Health Science and Medicine
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health Veterinary
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 357 Documents
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Dual Modality Acupressure and Thermotherapy for Menstrual Pain Mitigation in Junior High Students: Terapi Akupresur dan Termoterapi Ganda untuk Meredakan Nyeri Haid pada Siswa Sekolah Menengah Pertama Evi Rinata; Vindiah Dwi W
Indonesian Journal on Health Science and Medicine Vol. 3 No. 1 (2026): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v3i1.488

Abstract

General Background Dysmenorrhea represents a highly prevalent gynecological condition among adolescent females globally, commonly driven by progesterone imbalances that induce painful uterine cramps. Specific Background Secondary school students frequently experience severe menstrual pain that interferes with daily school attendance and regular academic performance. Knowledge Gap Although separate non-pharmacological methods exist, the comparative performance of combined reflexology and thermal protocols remains under-explored in localized school environments. Aims This study evaluates the management of dysmenorrhea using integrated acupressure at SP6 and LV3 points alongside warm compresses among junior high respondents. Results Quantitative analysis of 33 participants revealed that combined therapy significantly decreased visual analogue scale scores ($p = 0.000$) compared to single acupressure or control groups. Novelty The evaluation demonstrates that dual-modality alternative care yields a more substantial physiological decline in pain intensity than isolated acupressure interventions. Implications School health services should adopt integrated non-pharmacological interventions as safe, accessible alternatives to conventional analgesic medications. Keyword: Sdysmenorrhea, Acupressure, Warm Compresses, Menstrual Pain, Adolescent Health Key Findings Highlights Visual analogue scale records reveal optimal pain reduction when combining meridian stimulation with deep tissue thermotherapy. Isolated acupressure targeting specific regional channels induces secondary relief compared to multi-modality approaches. Untreated control groups demonstrate an upward trajectory in menstrual distress during active observation cycles.
Transient Evoked and Distortion Product Otoacoustic Emission Comparison in Children Dhiaa Mohammed Yaseen; Qasim Ali Khalaf; Haider Kadhem Saeed
Indonesian Journal on Health Science and Medicine Vol. 3 No. 1 (2026): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v3i1.492

Abstract

General Background Otoacoustic emissions objectively evaluate outer hair cell function in pediatric populations. Specific Background Transient evoked and distortion product paradigms are widely used to assess cochlear responsiveness in pediatric hearing screening. Knowledge Gap Comparative evaluations of signal-to-noise ratio performance across matching frequencies, alongside ear asymmetry and gender dynamics in six-year-olds, remain limited. Aims This study compared screening pass rates, signal-to-noise ratios, and ear or gender variations between both emission paradigms in normal-hearing children. Results Among 130 children (260 ears), both paradigms showed identical 100% pass rates, though distortion product emissions yielded significantly higher signal-to-noise ratios at 2, 3, and 4 kHz ($p < 0.001$), with mostly nonsignificant ear side and gender variations. Novelty This work establishes normative baseline comparative parameters in six-year-olds, proving distortion product signal superiority at identical frequencies. Implications Superior distortion product signal strength provides a clinically advantageous paradigm for pediatric auditory assessment, particularly in noisy environments.   Keywords: Transient Evoked Otoacoustic Emissions, Distortion Product Otoacoustic Emissions, Pediatric Hearing Screening, Signal to Noise Ratio, Cochlear Function   Key Findings Highlights Both emission paradigms achieved equivalent hundred percent screening pass rates among healthy six-year-old pupils. Signal-to-noise ratios were significantly greater in distortion product measurements across identical testing frequencies. Gender and ear side variations remained absent across most frequencies, establishing baseline pediatric normative parameters.
Medication Adherence of Patients with Renal Failure at Al-Diwaniyah Hospital Haider Abd AL Ameer Twair
Indonesian Journal on Health Science and Medicine Vol. 3 No. 1 (2026): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v3i1.495

Abstract

General Background Chronic kidney disease presents a profound global public health challenge, imposing severe therapeutic burdens on healthcare systems and affected individuals. Specific Background In clinical settings like the Fatima Al-Zahraa Dialysis Center at Al-Diwaniyah Teaching Hospital, managing renal failure requires complex lifelong pharmacological regimens to control comorbidities and slow down disease progression. Knowledge Gap Although clinical regimens are strictly prescribed, the specific socio-demographic drivers and patient-side behavioral factors influencing medication compliance in this particular regional cohort remain under-examined. Aims This study evaluates the overall medication adherence levels among patients experiencing renal failure and examines how their socio-demographic characteristics correlate with treatment compliance. Results Empirical analysis of 70 participants revealed that 58.6% exhibited low medication adherence, 31.4% showed moderate adherence, and only 10.0% maintained good adherence, with low awareness found in 72.9% of the sample. Statistical testing confirmed that while age, gender, occupation, and monthly income showed no significant correlation with compliance, a patient's level of education had a statistically significant association with their adherence behavior. Novelty This evidence identifies a direct correlation between formal literacy and compliance rates, shifting the analytical focus from generalized socio-economic barriers to targeted health literacy needs within the local hemodialysis population. Implications These findings demonstrate that standard clinical prescriptions are insufficient without proactive hospital education programs, highlighting the urgent need for structured nursing interventions and simplified drug regimens to minimize clinical relapses and reduce institutional mortality rates. Keywords: Medication Adherence, Renal Failure, Patient Compliance, Health Literacy, Hemodialysis Key Findings Highlights Low medication adherence was identified in more than half of the surveyed renal failure patients. Formal educational attainment has a significant statistical correlation with patient treatment compliance. Insufficient understanding of renal conditions directly drives non-adherence patterns in hemodialysis units.
Hearing Loss in Children: Prevalence, Causes, and Management Nassar Jabbar Mokhtath Al- Najem
Indonesian Journal on Health Science and Medicine Vol. 3 No. 1 (2026): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v3i1.496

Abstract

General Background Hearing loss is a common neonatal abnormality where early detection is crucial for normal speech and language development. Specific Background Children referred to audiology clinics often present with diverse impairments that can be objectively evaluated using auditory brainstem response testing. Knowledge Gap The specific incidence, severity distribution, and anatomical location of auditory deficits within this referred pediatric population require continuous clinical documentation. Aims This study aims to determine the incidence, severity, and location of auditory impairment in youth referred for assessment. Results Among 309 patients aged 1 to 17 years undergoing testing, 91.3% exhibited impairment, whereas 8.7% demonstrated normal bilateral function. Within the impaired cohort, 56% were male and 44% were female. Profound and severe degrees of impairment occurred most frequently, with both ears being predominantly affected. Novelty The documented burden of profound bilateral deficits in this specific clinical cohort highlights critical sex-based and severity distribution trends. Implications These findings strongly support the urgent need for universal newborn screening and early targeted rehabilitation, including cochlear implantation, to prevent irreversible language delays. Highlights A vast majority of referred patients exhibited significant auditory impairment. Profound bilateral deficits frequently presented during clinical assessments. Prompt cochlear implantation prevents permanent language development delays Keywords: Auditory Brainstem Response, Cochlear Implantation, Universal Newborn Screening, Language Development, Pediatric Audiology
CYP1A2 Genetic Variants and Breast Cancer Susceptibility in Women: Varian Genetik CYP1A2 dan Kerentanan Terhadap Kanker Payudara pada Wanita Ghasaq Abd Alkareem Nouri; Hassan Risan Al-Rikabi
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.342

Abstract

Breast cancer remains a leading cause of cancer-related morbidity among women worldwide, with genetic susceptibility playing a crucial role in disease development. Cytochrome P450 1A2 is involved in estrogen metabolism and has been implicated in carcinogenesis through genetic polymorphisms affecting enzymatic activity. This study aims to investigate the association between the CYP1A2 rs17861162 polymorphism, family history, disease stage, and breast cancer risk in women from Thi-Qar Province, Iraq. A case-control design was applied, including 40 breast cancer patients and 20 healthy controls. Genomic DNA was extracted from blood samples, and polymerase chain reaction was used for genotyping. Statistical analyses were conducted using Chi-square tests, odds ratios, and confidence intervals. The results showed no statistically significant association between CYP1A2 rs17861162 genotypes or alleles and breast cancer risk, although the G allele demonstrated a non-significant 1.5-fold increased risk. Family history and disease stage were also not significantly associated with breast cancer occurrence. The novelty of this study lies in providing population-specific genetic evidence from an underrepresented region, contributing to the growing body of literature on CYP1A2 polymorphisms and breast cancer. These findings suggest that CYP1A2 rs17861162 alone may not serve as a reliable genetic biomarker, highlighting the need for larger, multiethnic studies to clarify its role in breast cancer susceptibility. Keywords: Breast Cancer, CYP1A2 Polymorphism, Genetic Susceptibility, Estrogen Metabolism, Cancer Risk Highlights: CYP1A2 rs17861162 shows no significant association with breast cancer risk G allele demonstrates a non-significant increased susceptibility trend Population-specific genetic evidence expands breast cancer genomics literature
The Role of CD10 Expression in Basal Cell Carcinoma and its mimics: A Clinicopathological Study Dalya Abdul-Aziz Al-Hamdani; Nadwa Subhi Alazzo
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.347

Abstract

General Background: Basal cell carcinoma (BCC) represents the most prevalent form of nonmelanoma skin cancer, predominantly affecting sun-exposed areas with increasing incidence among middle-aged and elderly populations. Specific Background: Accurate histopathological differentiation between BCC and its morphological mimics, particularly trichoepithelioma, remains clinically challenging due to overlapping features, potentially leading to inappropriate therapeutic decisions. CD10, a cell surface marker expressed in various neoplasms and normal skin structures, has emerged as a potential diagnostic tool for distinguishing BCC from histologically similar lesions. Knowledge Gap: The diagnostic utility and expression patterns of CD10 in differentiating BCC from its mimics within Middle Eastern populations remain inadequately characterized. Aims: This study investigated CD10 expression patterns in 50 BCC cases and one trichoepithelioma case, correlating findings with clinicopathological parameters including age, gender, anatomical distribution, and histological variants. Results: Analysis revealed 80% CD10 positivity in tumor cells (32% strongly positive, 48% positive), while 42% showed stromal positivity; nodular BCC comprised 70% of cases, with 84% located in head and neck regions, affecting predominantly middle-aged females. Novelty: This investigation provides novel evidence that CD10 positivity in tumor cells distinguishes BCC from trichoepithelioma, which demonstrates exclusive stromal positivity. Implications: These findings establish CD10 immunohistochemistry as a valuable adjunct marker for resolving diagnostically challenging basaloid proliferations in routine pathological practice.Keywords : CD10 Immunohistochemistry, Basal Cell Carcinoma Diagnosis, Trichoepithelioma Differentiation, Nonmelanoma Skin Cancer, Histopathological MarkersHighlight : Middle-aged adults showed highest lesion frequency, predominantly affecting sun-exposed head and neck regions. Nodular histological pattern represented the most prevalent morphological presentation among examined biopsies. Immunostaining positivity within neoplastic components supported differential diagnosis, while stromal reactivity characterized trichoepithelioma.
Biochemical, Immunological, and Histopathological Assessment of Carbon Tetrachloride (CCl₄)-Induced Hepato-Renal Toxicity in Rats Mervat Kamel Kadhom
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.349

Abstract

General Background Carbon tetrachloride (CCl₄) is a well-established experimental toxicant known to induce liver and kidney injury through oxidative and inflammatory mechanisms. Specific Background CCl₄ metabolism generates reactive free radicals that disrupt biochemical homeostasis, provoke immune imbalance, and produce characteristic histopathological damage in hepatic and renal tissues. Knowledge Gap Despite extensive use of CCl₄ models, integrated evaluation combining biochemical, immunological, and histopathological parameters remains limited. Aims This study aimed to assess dose-dependent hepato-renal toxicity of CCl₄ in rats using biochemical markers, cytokine profiling, and tissue histology. Results CCl₄ exposure increased serum AST, ALT, urea, creatinine, cholesterol, and triglycerides, elevated TNF-α and IL-6, reduced IL-10, and induced marked hepatic and renal histopathological alterations. Novelty The study provides a consolidated multi-system assessment highlighting immune dysregulation alongside biochemical and structural injury. Implications These findings underscore the importance of combined biochemical, immunological, and histopathological approaches for mechanistic evaluation of chemical-induced hepato-renal toxicity.Keywords : Carbon Tetrachloride Toxicity, Hepatorenal Injury, Oxidative Stress, Proinflammatory Cytokines, Histopathological AlterationsHighlight : Dose-dependent enzyme, lipid, urea, and creatinine elevations indicate progressive liver and kidney dysfunction. Pro-inflammatory mediators increased while anti-inflammatory response declined, demonstrating marked immune imbalance. Tissue examinations revealed cellular degeneration, inflammatory infiltration, fibrosis, and tubular damage severity increased with dose.
Biosynthesized Silver Nanoparticles Demonstrate Hepatoprotective Biochemical Safety in Female Wistar Rats Suhad Khalid Sgheer; Ali Tariq Abdul Hassan
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.350

Abstract

General Background: Silver nanoparticles (AgNPs) are widely applied in biomedical and technological fields, yet conventional chemical and physical synthesis methods raise safety and environmental concerns. Specific Background: Biosynthesis using probiotic bacteria such as Lactobacillus rhamnosus has emerged as a green alternative with potential biocompatibility advantages. Knowledge Gap: Limited in vivo evidence exists regarding the biochemical and histological safety of biosynthesized AgNPs, particularly their hepatic effects. Aims: This study aimed to evaluate the biochemical and histological effects of AgNPs biosynthesized by L. rhamnosus in female Wistar albino rats. Results: Biosynthesized AgNPs significantly reduced liver enzymes (ALT, AST, and ALP), significantly increased vitamin B12 levels, showed no significant change in body weight, and preserved normal liver tissue architecture. Novelty: The study demonstrates the hepatic safety profile of L. rhamnosus–mediated AgNPs in vivo compared with risks reported for conventionally synthesized AgNPs. Implications: These findings support probiotic-mediated biosynthesis as a safer and environmentally friendly approach for developing silver nanoparticles for biomedical applications.Keywords : Biosynthesized Silver Nanoparticles, Lactobacillus rhamnosus, Green Nanoparticle Synthesis, Liver Enzyme Biomarkers, Wistar Albino RatsHighlight : Significant reductions in AST, ALT, and ALP without alterations in body mass. Serum vitamin B12 concentrations increased markedly following 30-day administration. Liver histology preserved normal architecture, indicating absence of hepatocellular damage.
Prevalence and Molecular Characterization of Helicobacter pylori in Patients with Chronic Diarrhea in Thi-Qar Province Hussain Adnan Hashim; Mohammed Mahdi Abd
Indonesian Journal on Health Science and Medicine Vol. 3 No. 1 (2026): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v3i1.352

Abstract

General Background: Helicobacter pylori is a globally prevalent bacterial pathogen increasingly linked to gastrointestinal and extra-gastric disorders. Specific Background: Its role in chronic diarrhea remains insufficiently characterized in Iraq, particularly in Thi-Qar Province, where epidemiological data are inconsistent. Knowledge Gap: Limited molecular evidence exists on local H. pylori strains and the performance of diagnostic methods in patients with chronic diarrhea. Aims: This study aimed to determine the prevalence of H. pylori and characterize circulating strains among chronic diarrhea patients using stool antigen testing and PCR targeting the cagA gene. Results: A high prevalence was detected by antigen testing, while PCR revealed lower positivity, and two local cagA-positive isolates were genetically characterized and registered in GenBank. Novelty: The study reports the first molecular registration of H. pylori strains from chronic diarrhea cases in Thi-Qar Province. Implications: These findings underscore diagnostic variability and highlight the relevance of local molecular data for epidemiological surveillance and future clinical research.Keywords : Helicobacter pylori, chronic diarrhea, stool antigen test, PCR detection, molecular characterizationHighlight : Rapid stool antigen testing revealed high Helicobacter pylori detection among chronic diarrhea patients. PCR targeting cagA gene showed substantially lower positivity, indicating diagnostic sensitivity variation. Genetic sequencing identified distinct local strains registered in international genomic databases.
Prevalence of Indolent Prostate Cancer in Iraq, an Autopsy Study: Prevalensi kanker prostat indolent di Irak, sebuah studi otopsi Dr. Ibrahim Mudhafar Saadoon; Dr. Yazan Amir Seulieman; Dr. Alaa Al-Deen Al-Dabbagh
Indonesian Journal on Health Science and Medicine Vol. 2 No. 3 (2025): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i3.353

Abstract

General Background Prostate cancer shows wide global variation in incidence and mortality, partly due to differences in detection strategies. Specific Background Autopsy studies provide an unbiased estimation of indolent prostate cancer prevalence by avoiding screening and reporting bias. Knowledge Gap Data on incidental prostate cancer detected through autopsy remain limited in Iraq. Aims This study aimed to estimate the prevalence of incidental or indolent prostate cancer in Iraqi men using autopsy specimens. Results One hundred male autopsies aged 40 years and above were examined, revealing prostate cancer in six cases, yielding a prevalence of 6%. All detected cancers were adenocarcinoma with Gleason score 6, confined to the prostate, and showed no capsular or seminal vesicle involvement. Cancer detection increased significantly with age. Novelty This study provides rare autopsy-based evidence on indolent prostate cancer prevalence in Iraq. Implications The findings support the need for improved prostate cancer detection, reporting systems, and public awareness programs tailored to the local context. Keywords: Indolent Prostate Cancer, Autopsy Study, Prevalence, Iraq, Gleason Score Key Findings Highlights: Occult prostate cancer was detected in a small proportion of autopsy cases Cancer detection increased consistently with advancing age All identified tumors were low grade and organ confined

Page 34 of 36 | Total Record : 357

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