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JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia

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Published by Badan Analisis dan Pengembangan Ilmiah Nasional ISMKI

ISSN : 23026391 EISSN : 27211924 DOI : https://doi.org/10.53366/jimki

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI) adalah jurnal yang dikelola oleh Badan Analisis dan Pengembangan Ilmiah Nasional (BAPIN). JIMKI berfokus menjadi wadah untuk publikasi penelitian mahasiswa kedokteran.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 326 Documents

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CLINICAL OUTCOMES OF IVERMECTIN IN COVID-19 TREATMENT: AN EVIDENCE-BASED CASE REPORT FROM SYSTEMATIC REVIEWS AND META-ANALYSES Jason Theola; Muhammad Ikrar Hermanadi; Kahlil Gibran; Syarifaha Ihsan
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.411

Background: Ivermectin has demonstrated beneficial results on clinical outcomes in COVID-19 patients. Several countries have included ivermectin in their guidelines, though WHO recommended against its usage. Therefore, this study was aimed to establish the clinical outcomes of ivermectin in COVID-19 patients by an evidence-based method. Method: Article searching was completed in PubMed, Cochrane, and Scopus from July 9 - 10 2021. The results were limited to only systematic reviews and meta-analyses. Hand searching was conducted to obtain relevant studies from external resources. The results were evaluated using inclusion and exclusion criteria. The full texts were obtained and critically reviewed using Oxford Centre for Evidence-Based Medicine critical appraisal tools. Result: Three systematic reviews and meta-analyses were selected and critically reviewed. All three studies were considered valid, important, and applicable. However, the quality of these studies varied from low to high. Conclusion: Overall studies showed that ivermectin has the potential to improve clinical outcomes in COVID-19 patients.

Hubungan Faktor Risiko Tuberkulosis Terhadap Kadar Vitamin D Serum Pada Penderita Tuberkulosis di RSUP Haji Adam Malik Medan Dan Puskesmas Kota Medan Tahun 2019 Fadlan Hafizh Harahap
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.415

Background: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis which attacks various organs. Tuberculosis has risk factors for age, sex, nutritional status, HIV infection, history of diabetes, corticosteroid use, and history of primary TB. Prolonged tuberculosis causes a decrease in vitamin D levels in blood serum.Objective: This study aims to look at the association of risk factors to serum vitamin D levels in TB sufferersMethod: Research conducted is analytic with cross-sectional design. The sample of the study were 30 patients with TB in Haji Adam Malik General Hospital, Teladan and Amplas primary health center Medan who had met the inclusion and exclusion criteria. Results: Pearson correlation test showed there was an inverse correlation between BMI and vitamin D levels (p = 0.007; r = -0.482) and there was no significant relationship between age and vitamin D levels. Fisher exact test found no association between vitamin D levels on corticosteroid use (p = 1,000), history of diabetes (p = 0.469), HIV coinfection, and primary TB (p = 1,000). Conclusion: In conclusion, there is an inverse correlation between the BMI value and vitamin D levels. No association was found between vitamin D levels and age, corticosteroid use, and history of diabetes.

CORRELATION BETWEEN CLUSTER OF DIFFERENTIATION 4 (CD4) WITH RADIOLOGICAL FEATURES OF TB-HIV PATIENS Angiesta Pinakesty
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.423

ABSTRACT Background: Tuberculosis (TB) is an opportunistic infection the most often found in Human Immunodeficiency Virus (HIV) infection and is the leading cause of death among Orang Dengan HIV / AIDS (ODHA). The risk of TB transmission is 26 to 31 times greater in people with HIV than people without HIV. TB-HIV patients tend to have negative acid-resistant bacteria (AFB) laboratory tests and atypical radiological images. Both of these become obstacles in determining the diagnosis and management. The heavier level of immunosuppression in TB-HIV patients as indicated by a decrease in the level of cluster of differentiation 4 (CD4), the less characteristic the radiological picture was. CD4 count is associated with clinical manifestations of HIV patients that can be seen from radiological images, so that it can be used in accelerating diagnosis and management of TB-HIV. This study aims to determine the relationship between CD4 and the radiological picture of TB-HIV patients at PKU Muhammadiyah Hospital of Surakarta. Methods: This study used a cross sectional research design and was conducted from November to December 2020 at the PKU Muhammadiyah Hospital of Surakarta. The number of research subjects as many as 30 patients who were taken with a non-probability purposive sampling technique. Retrieval of data using patient medical record data. Data were analyzed using Fisher's exact test. Results: Fisher's exact test showed no association between CD4 cell count and radiological features of TB-HIV patients (p = 1,000). Conclusion: There is no significant association between CD4 cell count and radiological features of TB-HIV patients.

KARAKTERISTIK MORFOLOGI ARCUS PALATOGLOSSUS DAN ARCUS PALATOPHARYNGEUS TERHADAP SKOR KUESIONER BERLIN PADA MAHASISWA FK USU ANGKATAN 2016 Vani Wulan Dari
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.424

Obstructive sleep apnea (OSA) is a major public health problem, with a high prevalence. The Berlin Questionnaire is a questionnaire aimed at OSA screening. Palus palatoglossus and arcus palatopharyngeus are located in the oropharynx which is the most frequent place of OSA. The purpose of this study was to determine the morphological characteristics of the palatoglossus arcus and palatopharyngeus arcus on the Berlin questionnaire on 2016 USU FK students to facilitate OSA screening. This study used a descriptive approach with cross sectional design, while the sampling used primary data, namely in USU FK 2016 students. The palatoglossus arcus and arcatopharyngeus arcus high-risk group classification OSA arcus 1/2 classification (8.8%) . As many as 19.1% of 2016 USU FK students experienced a high risk of OSA. The arcus classification group of 10 respondents at high risk of OSA is arcus 1/2 classification (8.8%). The BMI group of respondents who were at high risk of OSA was obese 1 (8.8%). The neck circumference group of respondents at high risk of OSA is the large neck circumference (14.7%). Based on the nasal congestion group respondents who are at high risk of OSA that is with nasal congestion (17.6%). The palate classification group of respondents at high risk of OSA is the low palate classification (10.3%). From the results of this study it was concluded that respondents with arcus 1/2 classification were the most respondents and also a high risk of OSA.

HUBUNGAN ANTARA BERAT LAHIR DENGAN REFLUKS GASTROESOFAGUS PADA BAYI USIA 0–1 TAHUN Hamzah Haryo Prakoso; Evi Rokhayati; Dwi Hidayah,
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.426

Background: Low birth weight babies are population at risk for gastroesophageal reflux and its complications due to physiologic immaturity of digestive system. However, the pathomechanism remains unclear. There is no similar study conducted in Surakarta City and still lack of studies on 0-1 year infants. The aim of this study is to evaluate Gastroesophageal reflux risk in low birth weight infants age 0–1 year. Method: Case control study on infants aged 0–1 year in Ngoresan Public Health Center, Surakarta. Samples were obtained by purposive sampling method in April–May 2021 with a questionnaire on infant characteristics and the Infant-Gastroesophageal Reflux Questionnaire as research instruments. Results: There were 60 samples divided into case and control groups with a 1:1 ratio. There was no significant relationship between birth weight and gastroesophageal reflux (p = 0.612). Discussion: Research conducted in Semarang and Italy declared no correlation between birth weight and gastroesophageal reflux. The relationship is more visible if infants have a birth weight <1,500 grams and a history of the disease such as bronchopulmonary dysplasia or chronic lung disease. Conclusion: There is no relationship between birth weight and gastroesophageal reflux in infants aged 0–1 years

Potensi siRNA Terenkapsulasi Nanopartikel sebagai Agen Silencing sflt-1 dan nrf-2: Inovasi Terapi Efektif terhadap Preeklamsia: Inovasi Terapi Efektif terhadap Preeklamsia Sanjaya Winarta; Raimond Loa; Renaldo Thosal
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.433

ABSTRACT Background: Maternal death could happen during pregnancy or termination of pregnancy. In 2017, there were around 295.000 maternal death around the world. Indonesia itself is a country with the third largest maternal mortality rate in Southeast Asia. One of the biggest cause of maternal death is preeclampsia. Preeclampsia is usually experienced by pregnant mother with a pregnancy period more than 20 weeks, where there is an elevated blood pressure, proteinuria, and many complications. Nowadays, the only definitive preeclampsia treatment is termination of pregnancy which could cause many bad things to infant, likes preterm birth, intrauterine growth retardation, and intrauterine fetal death. Plenty of reserach shows that small interfering RNA (siRNA) molecule has a potential to become a treatment agent for preeclampsia Therefore, this literature review intends to analyze the potential of siRNA as an innovation of preeclampsia treatment. Method: This literature review was carried out on articles from several databases such as NCBI pubmed, Elsevier, Google Scholar, and Clinical Key with the keywords use are “Nanoparticle”, “Nrf2”, “Preeclampsia”, “sFlt1”, and “siRNA”. Discussion: 6 major journals that correlate with the aim of this literature review were yielded. siRNA molecule can do a silencing to Soluble fms-like tyrosine kinase-1 (sFlt-1) dan Nuclear factor erythroid 2-like 2 (Nrf-2), components that are contribute to pathophysiology of preeclampsia. Furthermore, stabilization of this formulation can be increased by encapsulating the siRNA in a nanoparticle. Conclusion: The formulation of siRNA against sFlt-1 and Nrf-2 can be a novel formulation of therapeutic agent to treat preeclampsia effectively.

POTENSI KOMBINASI NANOPARTIKEL FULLERENOL DAN INHIBITOR UREASE DALAM TATALAKSANA FARMAKOLOGIS INFEKSI HELICOBACTER PYLORI: SEBUAH KAJIAN LITERATUR Nathaniel Gilbert Dyson; Aldithya Fakhri
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.441

Background: Over 50% of global population have been infected by Helicobacter pylori. However, current pharmacological management of Helicobacter pylori infection still possess many challenges, especially antibiotic resistance and side effects of PPI drugs usage. Recent studies have found that fullerenol nanoparticles and urease inhibitors are potential to eradicate Helicobacter pylori infection. Methods: Literature search is done from three international databases, namely PubMed, Scopus, and Google Scholar, independently with previously stated inclusion and exclusion criteria. The final search results in 5 eligible studies which will further be discussed. Discussion: Fullerenol nanoparticles can undergo a pinacol rearrangement and have carboxyl or carbonyl functional group that can act similarly like peroxidase enzyme activity to destroy polysaccharides in the cell wall of Helicobacter pylori. Biotoxicity of the fullerenol nanoparticles in the toxicity test with the Drosophila melanogaster showed no significant side effects. On the other hand, urease inhibitors such as catechol and p-benzonequinol, can decrease ammonia synthesis and lower the pH in the gastric lumen. This condition inhibit growth of Helicobacter pylori and increase the work of fullerenol nanoparticles. Biotoxicity of urease inhibitors are also very low, proved by the morphological changes of human glioblastoma cells (GL-15) in vitro at concentrations above 200 M. Conclusion: Fullerenol nanoparticles act similarly like proxidase enzyme to destroy the cell wall of Helicobacter pylori. On the other hand, urease inhibitors decrease ammonia synthesis and lower gastric lumen pH to prevent infection. Combination of fullerenol nanoparticles and urease enzyme inhibitors are highly potential as pharmacological treatment of Helicobacter pylori.

CARDIAC STEM CELL DENGAN INDUKSI TNFR1-BLOCKER DAN NRG-1/ERB-B4 SEBAGAI TERAPI PEREMAJAAN GAGAL JANTUNG AKIBAT PENYAKIT JANTUNG ISKEMIK Aiman Hilmi Asaduddin; Annisa Syarifa Istighfarini; Alya Sabilah Siregar; ‘Aininna ‘Izzah Zafira; Farah Nur Adiba
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.442

Heart Failure (HF) is a complex clinical syndrome because of cardiac abnormalities. The incidence of heart failure could reach 37.7 million in 2010. Meta-analysis research showed that stem cell can improve cardiac function. Cardiac stem cell (CSC) therapy on HF can be optimized using Tumor Necrosis Factor-? receptor type-1 (TNFR1)-Blocker and Neuregulin-1 (NRG-1)/ Erythroblastic leukemia viral oncogene homolog 4 (Erb-B4)induction. Thus, the aims of this literature review are to determine CSC potency on HF and TNFR1-Blocker and NRG-1/Erb-B4 effects on CSC therapy optimization. The method used was using medical subject headings, namely CSC, TNFR1-Blocker, NRG-1/Erb-B4, and heart failure. The inclusion and exclusion criteria have been used to eliminate inappropriate journals so there were 40 journals used for this article. The results showed that CSC could differentiate into three major cardiac lineage, cardiomyocyte, endothelial cell, and smooth muscle cell. Those components are essential for cardiac rejuvenation therapy. Besides, TNF-? have a role for contractile dysfunction and induce hypertrophy and apoptosis of cardiac myocyte. Expression level of TNFR1 was significantly increased in ischemic HF. Interaction between TNF-? and TNFR1 led to apoptosis via Receptor Interacting Protein 1 (RIP1) and inhibited CSC proliferation. Thus, TNFR1 blockade will potentially leads to apoptosis prevention and induce proliferation. In the other hand, NRG-1 proved to plays some cellular mechanism via Erb-B4. NRG-1/Erb-B4 also could increase cell mobility and inhibit apoptosis via activation of PI3K/Akt. In conclusion, signaling induction of TNFR1-blocker and NRG1/Erb-B4 have potential role to optimized CSC therapy on ischemic HF rejuvenation.

KADAR C-REACTIVE PROTEIN, D-DIMER, DAN LAKTAT DEHIDROGENASE SEBAGAI PREDIKTOR LUARAN COVID-19 PADA ANAK: SEBUAH KAJIAN SISTEMATIS: sebuah kajian sistematis Macmilliac Lam; Laureen Celcilia
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.446

Background: Coronavirus Disease (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). During a surge in COVID-19 cases, Indonesia has the highest child mortality rate due to COVID-19. Until now, there have not been many studies that explain the laboratory characteristics of COVID-19 in children. This systematic review aimed to assess the significance of laboratory findings, specifically c-reactive protein (CRP), D-dimer, and lactate dehydrogenase (LDH), to predict the severity of COVID-19 in children. Methods: A systematic review was conducted through PubMed, Scopus, Cochrane, and Google Scholars to search for studies analyzing the prognostic value of c-reactive protein (CRP), D-dimer, and lactate dehydrogenase (LDH) in children with COVID-19. Quality assessments of studies were performed using the Newcastle-Ottawa Scale. Discussion: The search yielded 11 studies with a total of 3424 subjects. C-reactive protein (CRP) levels were significantly increased in pediatric patients with severe/critical COVID-19. The concentration of CRP can reflect the severity of the disease and the magnitude of the acute inflammatory response. Moreover, children with complications had higher levels of c-reactive protein (CRP) and D-dimer. Conclusion: In conclusion, c-reactive protein (CRP) levels can be a potential biomarker to improve early identification and treatment of severe COVID-19 disease in children. Further studies on D-dimer and lactate dehydrogenase (LDH) levels as markers of COVID-19 severity are still needed to provide strong recommendations.

PENGARUH VARIASI JENIS STIMULUS INFORMASI PADA MEMORI JANGKA PENDEK Soufika Zamharira Rokan; Aldy Safruddin Rambe
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.451

Background: Memory acts as a storage mechanism for obtained knowledge which can be remembered later. Especially for students who spend most of their time to study, short-term memory is often being used before the information consolidated to long-term memory.The past researches have indicated that individual’s attention level whom receive multisensory stimuli will be higher than those who receive unisensory stimulus. In which attenion is closely related to memory, thus stimuli can affect individual’s short-term memory performance Method: This present study is an analytic-experimental study with posttest only design. Short-term memory performance is measured by Digit Span test. Each of the three groups were given three different stimuli namely auditory, visual, and audiovisual. The score would be analyze using one-way ANOVA statistical test. In which the p-value ? 0,05 is considered significant. Results: There is a significant difference of the Digit Span total score among three groups with different stimuli. The p-value is 0.003 on ANOVA test. On Bonferroni statistical test, the audiovisual group obtained the highest score with p-value 0.016 compared to the auditory group and 0.005 compared to the visual group. Discussion: Two stimuli of information provided a better impact on short-term memory than giving one stimulus. This occurs because of the integration in the parietal-temporal-occipital association cortex to two or more stimuli that are given simultaneously. Processing the input received by the brain becomes easier and a more complete memory output is obtained. Conclusion: There is a significant result on this study by giving different type of stimuli towards short-term memory performance

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Contact Name Norbertus Marcell Prayogi

Contact Email editor.jimki.bapin@gmail.com

Phone +6281372545321

Journal Mail Official editor@jimki.bapin.or.id

Editorial Address Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

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Contact Name
Norbertus Marcell Prayogi

Contact Email
editor.jimki.bapin@gmail.com

Phone
+6281372545321

Journal Mail Official
editor@jimki.bapin.or.id

Editorial Address
Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA