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JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Published by Badan Analisis dan Pengembangan Ilmiah Nasional ISMKI
ISSN : 23026391     EISSN : 27211924     DOI : https://doi.org/10.53366/jimki
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI) adalah jurnal yang dikelola oleh Badan Analisis dan Pengembangan Ilmiah Nasional (BAPIN). JIMKI berfokus menjadi wadah untuk publikasi penelitian mahasiswa kedokteran.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 326 Documents
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POTENSI PITAVASTATIN DENGAN NANOPARTIKEL POLY(DL-LACTIDE-CO-GLYCOLIDE) (PLGA) DRUG DELIVERY SYSTEM SEBAGAI TERAPI ADJUVAN PADA PENYAKIT JANTUNG KORONER Visakha Vidyadevi Wiguna; Abiyyu Didar Haq; Luh Gde Sri Adnyani Suari
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.453

Abstract

ABSTRACT Background: During COVID-19 pandemic, people’s mobility is decreased. This phenomenon leads to the increase of sedentary lifestyle hence increasing the risk of cardiometabolic diseases. One of the disease that has a strong connection with sedentary lifestyle is Coronary Artery Disease (CAD). CAD is the most common cardiovascular disease that causes death contributing as much as 12% of all death in the world. Percutaneous coronary intervention (PCI) therapy in the acute phase of myocardial infarct can lower the infarct area but the risk of ischemic-reperfusion injury limits its therapeutic effect. Methods: This literature review uses journal articles that are sourced from online databases such as PubMed and Google Scholar. The literature search utilized several keywords such as “pitavastatin”, “drug delivery system”, “nanoparticle”, “PLGA”, “myocardial infarction”, “ischemic-reperfusion injury”. The search yielded 34 relevant literatures which used in this literature review Discussion: Pitavastatin is a statin which possesses a significant effect on LDL-C, TG, and HDL-C. Furthermore, pitavastatin also possess cardioprotective effect on ischemic-reperfusion injury by decreasing oxidative stress and increasing intracellular antioxidant. PLGA nanoparticle is proven to increase the therapeutic effect of pitavastatin because of its ability to deliver timely and its anti-inflammatory effect. . Conclusion: Pitavastatin encapsulated by PLGA nanoparticle has the ability to prevent ischemic-reperfusion injury. Current therapeutic strategy has not been able to deliver pitavastatin into the infarct site adequately in the timely manner hence PLGA needed as drug delivery system.
POTENSI PROBIOTIK SEBAGAI REGULATOR SITOKIN INFLAMASI DALAM PERBAIKAN KLINIS PASIEN COVID-19 WILLIAM SUCIANGTO; Ahmad Taufik Fadillah Zainal; Nada Indira Ramadhani Nasrum
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.456

Abstract

ABSTRACT Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several recent studies have shown that cytokine storm, robust viral replication, and delayed Interferon type 1 (IFN-I) signaling contribute to the severity of COVID-19 . The slow response of IFN-I leads to the increased accumulation of pathogenic monocytes resulting in pulmonary immunopathology, vascular leakage, and suboptimal T cell response. In addition, other studies have reported that administration of probiotics can mediate antiviral responses against human coronavirus. We discuss about the potential of probiotics to regulate cytokine storms and the production of type-1 Interferon that implicates to clinical improvement in COVID-19 patients. This review is made from the results of a qualitative synthesis from various valid sources. The results show that several types of probiotics can supress the production of pro-inflammatory cytokines involved in cytokine storms and enhance the production of type-1 IFN. Through the mechanism of preventing cytokine storms and increasing type-1 production, probiotics are expected to become a regulator of immune system that can improve clinical performance in COVID-19 patients. Although further detailed research on a larger scale is still required to prove that probiotics can be a solution for the treatment of viral infections.
Potensi Ekstrak Moringa Oleifera Untuk Mengatasi Gastroenteritis Bakteri: Pemanfaatan herbal dalam tindakan preventif, kuratif, dan rehabilitatif penyakit gastrointestinal pada komunitas agrikultur Yemima Billyana Kusbijantoro; Nabila Atika Naufizdihar; Arga Setyo Adji
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.460

Abstract

ABSTRACT Bacterial gastroenteritis is a disease in the tropics in the form of inflammation of the stomach and intestines due to several bacteria, such as Salmonella,Campylobacter, Shigella, E. coli, Vibrio, Yersinia, and Listeria with symptoms of diarrhoea without or with vomiting, and frequent fever. Gastroenteritis is a global disease with the highest prevalence in the agricultural community, especially farmers and fishermen. This reasearch to determine the potential of leaf and seed extract Moringa oleifera as an alternative therapy for bacterial gastroenteritis. Methods: The journal writing method uses a literature review approach derived from the analysis and synthesis of various related references. The author selects journals full text and books published in the last ten years maximum through several databases, namely PubMed, Google Scholar, Science Direct, and Cochrane with the keywords: diarrhoea, gastroenteritis, and Moringa oleifera. Results: seed and leaf extract Moringa oleifera played a role in preventing some of the effects of the pathogenesis of diarrhoea due to bacterial infection. Methanol, N-hexane, ethyl acetate, flavonoids, phenols, saponins, alkaloids, tannins, and steroids from seed and leaf extract Moringa oleifera have antibacterial effects. The content of quercetin has an anti-inflammatory effect. The content of tannins, flavonoids, and alkaloids has antidiarrheal activity. The content of ethanol and tannins has an antiulcer effect. This potential can help cure patients with bacterial gastroenteritis.
HUMAN EMBRYONIC STEM CELL DERIVATIVE SUBRETINAL PIGMENT EPITHELIAL TRANSPLANTATION AS A TREATMENT FOR DRY-TYPE MACULAR Muhammad Thifan Satyagraha; Andhwika Afif Fahrezi; Rafi Annisa Ulum; Gibran Chandra Syarif Hidayatullah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.463

Abstract

Age-related Macular Degeneration (AMD), is the fourth disease which causes blindness in the world, will potentially increase in 2020. Therefore, alternative treatment is needed to be developed, such as Human Embryonic Stem Cell-derived Retinal Pigment Epithelium (hESC-RPE) transplantation in a subretinal layer. The purpose of this literature review is to identify AMD pathogenesis, especially dry type, to know the impact of hESC-RPE transplantation towards acuity of vision, and to understand its therapeutic effect, safety, also tolerability based on the literature cited. Articles were collected by google search engine through Pubmed, Sciencedirect, Proquest, and Springer link. Inclusion criteria are literature that was published between 2010-2020, clinical trial study, systematic review, and meta-analysis. the topic of these sources is focused on regenerative therapy in AMD patients. Whereas exclusion criteria are literature that published under 2010. According to our research, hESC-RPE transplantation in a subretinal layer can increase the acuity of vision in dry-type AMD patients by improving RPE pigmentation, which protects its photoreceptor cells. Safety and tolerability are proof that there are no abnormalities in proliferation and immunity. In conclusion, these findings are beneficial in the improvement quality life of AMD patients. Therefore, in the future, subretinal hESC-RPE can be effective in the alternative treatment of dry-typed AMD patients.
HUBUNGAN KONSENTRASI HEMOGLOBIN DARAH DENGAN KEJADIAN INFARK MIOKARD AKUT DI RUMAH SAKIT UNIVERSITAS SUMATERA UTARA PERIODE 2018-2019 Sugiono Namli
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.468

Abstract

Background: Coronary Heart Disease (CHD) is the biggest cause of mortality and morbidity worldwide, and Acute Myocardial Infarction is the major form. The major cause of myocardial infarction is the mismatch of myocardial oxygen demand and supply. Decreased in hemoglobin concentration will result in decreased oxygen delivery in coronary blood flow. The objective is to know the association of hemoglobin concentration with acute myocardial infarction at Rumah Sakit Universitas Sumatera Utara within the periods of 2018–2019. Method: This research uses an analytic method with a cross-sectional design, and takes place at Rumah Sakit Universitas Sumatera Utara from March to December 2019. This research is conducted by looking at secondary data, using the medical records of inpatients with acute myocardial infarction at the cardiology department of Rumah Sakit Universitas Sumatera Utara within the periods of 2018–2019. The data is then analyzed using a computer program. Results: From research, there are 19 AMI patients, mostly at the age of 51–60. AMI patients are dominated by males. P-value of 0.864 is obtained through the Chi-Square method of bivariate analysis, which means statistically there is no correlation between hemoglobin concentration and acute myocardial infarction. Discussion: This study is in accordance with the findings of Sarnak et al., who stated that hemoglobin is an independent risk factor for CHD but is not significant when combined with other risk factors which is a limitation in this study. Conclusion: There was no association between hemoglobin values and the incidence of acute myocardial infarction.
HUBUNGAN KUALITAS TIDUR DENGAN FUNGSI KOGNITIF PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS SUMATERA UTARA Melly Leman; Lokot Donna Lubis; Milahayati Daulay; Cut Adeya Adella; Eka Roina Megawati
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.474

Abstract

ABSTRACT Background: Sleep is an essential need in daily lives with abundant functions, especially neuron restoring process in neocortex after various activities. Poor sleep quality is often found, resulting from the needs of work, education, lifestyle, and sociocultural demand. It could hinder cognitive function thus affecting daily life quality. Thus, the objective of this study is to assess the risk factors of poor sleep quality and its relation to cognitive function of college students at Faculty of Medicine, Universitas Sumatera Utara. Method: This research uses an analytic method with cross-sectional design where the collection of data is simultaneously taken at one time. The data are primarily obtained from interviews utilising validated questionnaires, Pittsburgh Sleep Quality Index (PSQI) for sleep quality and Montreal Cognitive Assessment (MoCA) for cognitive function, with stratified random sampling technique. Results: The incidence of poor sleep quality of the samples is 69% with the predominance of being male, aged 17-19, having higher body mass index, and consuming caffeinated beverages. Meanwhile, the incidence of mild cognitive impairment is 42%. The Chi-Square and Spearman Rank tests show a significant relation (p=0.009) and weak correlation (r=0.262, p=0.008) between age groups and sleep quality, whereas there is no association of gender (p=0.517) and body mass index (p=0.322) with sleep quality. The Fisher’s Exact test yields no relation between consumption of caffeine (p=0.778) and sleep quality. According to the Chi-Square test, sleep quality is not associated with cognitive function as well (p=0.993). Conclusion. There is no association of sleep quality with cognitive function, however there is a significant relation and weak correlation between age groups and sleep quality.
Bahasa Inggris Kevin Lim
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.475

Abstract

Background: Depression is a mood disorder that causes loss of motivation to stay or to do daily activities. Research on depression prevalence indicates that approximately 4.4% of the worldwide population suffers it. The mechanism in which depression occurred due to fast foods is the excessive fat content disturbs neurogenesis in the brain. This research is carried out to look into the connection among fast food intake with the incidence of depression. Method: An analytical study with a cross-sectional design is the method chosen to conduct this research. The samples include college students from the Faculty of Medicine in University of Sumatera Utara admitted in 2018 and acquired with total sampling. The tools used in this research were the CES-D and FFQ questionnaire. Results: The incidence of depression among applicants in 2018 was 48.3%.The statistical calculations indicates that there is a significant relationship between fast food consumption and depression (p=0,043); but not significant to family income (p=0,684) and physical activity (p=0,289). Conclusion: Excessive consumption of junk food can increase the risk of depression.
PENELUSURAN POTENSI FASXIATOR SEBAGAI ANTIKOAGULAN ALTERNATIF YANG MENCEGAH TROMBOSIS MELALUI INHIBISI SISTEM AKTIVASI KONTAK: Terobosan Penggunaan Racun Ular dalam Mengencerkan Darah yang Terkoagulasi secara Patologis Nadine Aurelie
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.476

Abstract

Thrombosis, an imbalanced interaction between blood components, contributes greatly to deaths that occur worldwide. Therefore, treatment that can reverse the condition of blood clotting and hypercoagulability is essential. However, the drugs used to treat thrombosis-based diseases have side effects that can be seen in short and long term, particularly an increased risk of bleeding. Therefore, an alternative treatment is needed to overcome the problem of thrombosis without causing significant side effects that can endanger the lives of anticoagulant drug users. The solution to this problem is none other than nature provided, a protease inhibitor obtained through the venom of the Bungarus fasciatus snake, Fasxiator. Fasxiator can dilute blood through the inhibition of Contact Activation System (CAS) mechanism, specifically inhibiting factor XIa. The advantage of blood clotting inhibition through the CAS method is that it does not affect normal hemostasis, thereby minimizing the bleeding problems that are common with other anticoagulant drugs. Animal studies in rats demonstrated properties of high target selectivity for factor XIa, effectiveness, and high safety profile of Fasxiator, enabling the application of Fasxiator as an anticoagulant in the future. Therefore, based on the discussion that has been explained above, Fasxiator has the potential to be used as an anticoagulant on humans in the future due to its high selectivity, effectivity, and safety in previous animal studies.
SOMASCAN PROTEOMIC ASSAY: Teknologi Mutakhir dan Inovatif dalam Deteksi Dini Asbestos-Related Malignant Pleural Mesothelioma Yemima P.; Catherine Laura Johansyah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.477

Abstract

ABSTRACT Introduction: Asbestos, as an air pollutant, is a global health problem. Asbestos exposure has been a cause of lung disease since 1930 and the number of cases continues to increase along with the use of asbestos in industry. Asbestos-Related Malignant Pleural Mesothelioma (MPM) is a primary pleural neoplasm caused by asbestos exposure, which has a high malignancy rate, and has diagnostic challenges so that the prognosis of MPM tends to be worse than other neoplasms. Therefore, an early detection is needed for high-risk groups exposed to asbestos in order to reduce the risk of morbidity and mortality from MPM. This literature study aims to review a SOMAscan Proteomic Assay tool as a cutting-edge and innovative technology for early detection of MPM. Methods: This literature was written using the literature study method using trusted search engines, such as Science Direct and PubMed. Discussion: SOMAscan Proteomic Assay (SOMALogic, Inc.; Boulder, CO, USA) is an aptamer-based multiplex proteomic technology capable of detecting protein biomarkers. This tool uses 13 types of serum-based proteins with an accuracy of 92% to detect mesothelioma cancer in high-risk populations exposed to asbestos. The sensitivity of this tool to detect MPM will be correlating even more the higher pathological stage is. Conclusion: With high accuracy in the early stages, the SOMAscan Proteomic Assay is a promising tool for early diagnosis of MPM so that it has a greater chance of successful multimodality therapy with better prognosis.
INTEGRASI ANALISIS UJI CETAK NAPAS BERBASIS E-NOSE SEBAGAI SOLUSI BARU DETEKSI DINI PENYAKIT PARU OBSTRUKTIF KRONIK AKIBAT POLUSI UDARA DI LINGKUNGAN RUMAH PADA MASA PANDEMI COVID-19 Ayers Gilberth Ivano Kalaij
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.478

Abstract

Background: Although 64 million people has suffered from COPD, studies have shown that 70% of COPD patients worldwide was underdiagnosed due to many reasons. Adequate and fast detection are crucial in determining prognosis of this disease. However, many lungs function test still have disadvantages and limitations. Covid-19 pandemic era has limited our mobility and increase the risk of household air-pollution exposure which increase the risk of COPD. Thus, alternative solutions are needed to detect and screened household air pollution related COPD patients as fast as possible. Discussion: E-nose technology has been proven to effectively detects various respiratory diseases. This could be the alternative solution to provide COPD diagnostic tests which usually use spirometry with its disadvantages. Breath-print based VOC detection could be sensor biomarker for respiratory diseases, even COPD. If this is integrated with primary care systems in Indonesia during Covid-19 pandemic era, it could be the solution in early detection of COPD. Conclusion: Integration of e-nose based breath-print test is potential to be the solution of early and accurate detection of COPD which are non-invasive and patient-well with its advantages.

Page 20 of 33 | Total Record : 326

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